University of Louisville Hospital (ULH), which opened in 1983, serves as the major teaching hospital for University of Louisville students and housestaff officers. The hospital is provided a long-term funding commitment for hospital care of the medically indigent through the Quality Care Trust Fund as well as financial support for the University of Louisville School of Medicine. ULH is a contemporary acute, trauma care, and cancer care hospital. The hospital provides a full range of diagnostic, therapeutic, emergency, and surgical services. It is a designated Level One Trauma Center and has a 24-hour helicopter emergency medical service.

UofL Health announced a $144 million expansion to University Hospital with construction starting spring of 2022 and anticipated completion in 2024.

The Veterans Administration Medical Center

This facility is located about three miles east of the downtown Medical School campus. It has a capacity of 369 beds with an average daily census of 300 patients and provides over 80,000 ambulatory care visits per year. Members of the professional staff have full faculty appointments in the School of Medicine. The VA Medical Center furnishes a large and varied flow of inpatients and outpatients for study and is approved for over 80 residency positions in medicine, surgery, psychiatry, and most of the specialties and subspecialities dealing with adult patients. The addition of this Medical Center to the educational facilities of the School has not only increased the clinical opportunities available to students and for graduates to train for their specialty boards, but also has brought an increased number of highly trained physicians to our faculty. The VA Medical Center provides opportunities and support for major research activities for faculty. The close affiliation between the VA Medical Center and the School of Medicine is fostered by monthly meetings of the Dean's Committee, made up of those representatives from both institutions responsible for patient care, education and research activities at the VA Medical Center.

Norton Children's Hospital

Norton Children's Hospital is a 263-bed tertiary care pediatric facility located in the downtown Louisville medical center. It is Kentucky’s only freestanding, full-service children’s hospital. The hospital houses the pediatric and neonatal intensive care units, the general pediatric inpatient units and the pediatric emergency room. Norton Children's Hospital offers a full range of services, including a burn center, neonatal intensive care nursery, inpatient psychiatric unit, spine center, trauma center, bone marrow transplant program, outpatient clinics and regional poison center. The hospital is the primary teaching facility for the University of Louisville School of Medicine Department of Pediatrics. The affiliation benefits both physicians and patients through 24-hour in-house physician coverage and the immediate availability of pediatric specialists and subspecialists for consultation.

Jewish Hospital

This 462-bed, medical-surgical specialty hospital, is located in the Louisville Medical Center one block from the Medical School. Students, interns and residents work with clinical faculty who are in private practice in Internal Medicine and Surgery. Each program is supervised by a full-time University faculty member based at the hospital. Jewish Hospital is also the home of the University Hand Surgery Team, which trains residents and fellows in this specialty; one of the training sites for residents in surgery; and the facility at which kidney, heart, lung, liver and pancreas transplants are performed by the School's faculty. The Thomas Cardiovascular Laboratory, located in Jewish Hospital, is utilized as a teaching site for cardiac catheterization.