News
Bridging the Gap Between Information Technology and Medicine
Steven Hester, a proud graduate of the University of Louisville School of Medicine, has been named the 2025 School of Medicine Alumni Fellow by the University of Louisville Wilson Wyatt Alumni Awards. His career journey, from a student fascinated by computers to a physician-executive driving innovation at Norton Healthcare, perfectly illustrates his pioneering efforts in using technology and medicine to transform patient care.
Early in his career, Hester became Norton Healthcare’s Chief Medical Information Officer, stepping into this role at a time when technology was only beginning to intersect with health care. One of his first assignments was the system-wide implementation of the electronic medical record (EMR) and the Picture Archiving and Communication System (PACS). While now commonplace, these digital tools were highly contested in the early stages of the process. Thanks to his persistence, physicians today can securely transmit and view X-ray films in real time with colleagues directly from their cell phones, making collaboration, second opinions and patient communication faster and more effective.
Since then, technology’s influence on medicine has only accelerated. EMR systems continue to evolve, and we are even starting to see artificial intelligence that can transcribe and document a visit, effectively limiting the physician’s reliance on a keyboard and allowing the physician to focus their attention on the patient. Advances in treatment and care delivery have also been remarkable: joint replacement patients now return home within hours of the procedure, many diseases have has shifted from a hospital-based to one managed largely in the community and new medications are transforming how physicians treat chronic illness.
“From surgeries to research, patient education and hospital care, information technology has significantly impacted all areas of patient care,” shared Hester. “We are in a fascinating time for medicine, and significant change is always on the horizon.”
Looking ahead, Hester sees AI as a powerful tool to enhance, not replace, physician care. “These technologies will help relieve the administrative burden and give physicians back the most important part of patient care: listening,” he explained. “More than ever, medicine is a field of technology. It is essential to embrace these technologies, master them and find new and innovative ways to get the best patient outcomes.”
Hester’s own journey reflects that philosophy. A first-generation college student, he completed 12 years of education at the University of Louisville, from undergraduate studies through residency, before joining Norton Healthcare. Today, he serves as Senior Vice President & Chief Clinical and Strategy Officer where his leadership continues to shape the future of health care in Kentucky and beyond.
The School of Medicine is proud to celebrate Steven Hester as a 2025 Wilson Wyatt Alumni Award winner, honoring not only his professional accomplishments but also his enduring impact on patients, providers and the field of medicine itself.
UofL, UofL Health investigate new pathways for treating ischemic strokes
Josh Abecassis, neurosurgeon with UofL Physicians – Neurosurgery, a part of UofL Health – Brain & Spine Institute, and associate professor in the Department of Neurological Surgery at the UofL School of Medicine
Every moment is critical when treating a stroke. Ischemic strokes, which account for 87% of all strokes annually, occur when a blood clot or other blockage disrupts blood flow to the brain. Without immediate treatment, brain cells are deprived of oxygen and begin to die, potentially causing lasting neurological damage, disability or even death.
According to the American Stroke Association, more than 750,000 people in the U.S. will have a stroke each year. In Kentucky, strokes are the fifth leading cause of death, underscoring their significant impact both locally and nationally.
Recognizing the urgent need for improved therapies, UofL Health – UofL Hospital and the University of Louisville are actively participating in a pivotal clinical trial known as the Strategy for Improving Stroke Treatment Response (SISTER). This study focuses on patients who come to the emergency department 4.5 to 24 hours after the onset of an ischemic stroke and who are not candidates for standard treatment methods, such as previously approved clot-dissolving medications or mechanical interventions.
Upon arrival, patients undergo a comprehensive evaluation and advanced imaging to determine eligibility. If they meet all criteria, they may be enrolled in the study and randomly assigned to receive one of five doses of the investigational drug TS23, a type of clot-dissolving drug, or a placebo. The treatment is delivered through a single 20-minute infusion, followed by close monitoring and imaging at 30 hours post-treatment, with additional follow-up evaluations at 30 and 90 days to assess outcomes and recovery.
Josh Abecassis, a neurosurgeon with UofL Physicians – Neurosurgery, a part of UofL Health – Brain & Spine Institute, and associate professor in the Department of Neurological Surgery at the UofL School of Medicine, leads the study at the Louisville site.
“By bringing this trial here, we are creating an opportunity for patients in town to get access to cutting-edge therapies that they otherwise could not access and at time windows during a stroke that typically prohibit them from getting a treatment drug. That is exciting,” Abecassis said.
Through innovative research initiatives like the SISTER trial, UofL Health and UofL School of Medicine are working to enhance recovery, reduce long-term neurological damage and expand access to advanced stroke care. These efforts create opportunities for more personalized treatment, offering hope to patients and their families facing the life-altering effects of stroke.
Recognizing the signs and symptoms of a stroke is crucial. The acronym BE FAST can help you remember the most common warning signs:
- Balance lost – sudden loss of balance or coordination
- Eyes blur – sudden trouble seeing or blurred vision in one or both eyes
- Face drooping – one side of the face droops or is numb
- Arm weakness – sudden weakness or numbness of an arm or leg, especially on one side of the body
- Speech difficulty – sudden confusion, trouble speaking, or difficulty understanding speech
- Time – note the time the symptoms started and call 911 immediately
If you or someone around you experiences any of these symptoms, seek emergency medical care right away. Quick action can make a significant difference in treatment and recovery.
From a terminal diagnosis to a chronic disease: How UofL Health – Brown Cancer Center is working to cut cancer deaths in half
Each year, cancer claims more than 600,000 lives in the United States. These are not just numbers.They represent children, young parents, individuals in the prime of their careers and older adults who had planned for a long and healthy retirement. More than half of cancer diagnoses occur during working years.Nearly every family in America is affected by cancer.
Cancer is far from rare. Statistically, one in two men and one in three women will face cancer in their lifetime. While these numbers are daunting, UofL Health – Brown Cancer Center is changing the narrative. The Brown Cancer Center uses cutting-edge treatment, innovative research, comprehensive education and outreach. Its goal is to transform cancer from a terminal diagnosis to a chronic disease.
“Our mission is to help patients live well into their nineties and ensure quality of life,” said Jason Chesney, director and chief administrative officer of the UofL Health – Brown Cancer Center. “We accomplish this through a combination of subspecialtiesand multidisciplinary cancer care programs. Our robust education programs train the next generation of cancer scientists and oncologists. Our translational laboratory and clinical research, along with comprehensive support services, supportpatients and families.”
Building on this mission, the UofL Health – Brown Cancer Center, together with the University of Louisville School of Medicine (ULSOM), serves as a training ground for future health care leaders. High school, undergraduate and graduate students gain firsthand experience alongside ULSOM faculty and staff from the UofL Health – Brown Cancer. They tackle today’s challenges, and they also develop tomorrow’s solutions.
This strong educational foundation supports the center’s globally recognized research and puts it at the forefront of discovery, especially in groundbreaking immunotherapies. This year, Chesney presented on the use of genetically engineered tumor-infiltrating lymphocytes for treating solid tumors. The study was recognized as one of the top five at the American Society of Clinical Oncology (ASCO) annual meeting.
Amidst these achievements, it is essential to acknowledge Kentucky’s unique challenges. Historically, Kentucky has had the highest cancer death rate in the nation. But thanks to the pioneers of science at the UofL Health – Brown Cancer Center, we are entering a new frontier of medicine. With a goal of reducing Kentucky’s cancer death rate by 50% by 2035, the center is expanding access to high-quality care in rural Kentucky. The center is also increasing enrollment in clinical trials. It is building community-based comprehensive cancer screening outreach programs. Already, novel immunotherapy treatments are translating into measurable reductions in cancer-related deaths across the region.
"As we work toward cutting Kentucky’s cancer death rate in half, we are proud to expand our reach to rural communities with the new Center for Rural Cancer Education and Research,” said Jeffrey Bumpous, dean of the School of Medicine. “Opening in Bullitt County in summer 2026, this new UofL Health – Brown Cancer Centerwill bring high-quality care closer to home for rural Kentuckians, while also train the next generation of health professionals.The center will expand access to life-saving clinical trials.”
Ultimately, cancer may remain common, but it is no longer without hope. Through innovation, education and a steadfast commitment to community, the UofL Health - Brown Cancer Center and the School of Medicine are ushering in a new era of cancer care.Cancer is not a death sentence. It is a disease that can be treated, managed and ultimately overcome.
Mary Fallat selected to give Scudder Oration on Trauma at ACS
On Monday, October 6, Mary Fallat, professor in The Hiram C. Polk, Jr., Department of Surgerywill step up to the podium to deliver this year’s Scudder Oration on Trauma at the American College of Surgeons (ACS) meeting – an honor she describes as the greatest honor of her career.
She will become only the second pediatric surgeon ever to give this address. The first was Alex Haller, who began his career at the School of Medicine in 1959 as a cardiac surgeon before returning to John Hopkins to lead pediatric surgery and fellowship training. “To follow in those footsteps is both humbling and inspiring,” Fallat said.
Her focus is one that touches every surgeon, regardless of specialty: how we prepare, or fail to prepare, to care for injured children. Throughout her career, Fallat has worked to advance a vision of an integrated system of care for children. Today, she notes, significant gaps remain. Burn centers and trauma centers often operate in separate silos, and pediatric care and adult care do not always connect. In many communities, emergency departments see so few children that clinicians lack the training, supplies or confidence to treat them duringa crisis.
“Children are 22% of the population,” she says. “They deserve to be included and cared for with the proper plans and resources in place to do so.”
One promising effort she will highlight is the National Pediatric Readiness Program, which equips hospitals and EMS services with the tools, training and protocols needed to provide quality pediatric care. “It doesn’t take groundbreaking science,” she argues, “But it does take an intentional investment of time, training and the willingness to step up.”
The need has never been greater. From global conflict and natural disasters to the everyday risks of childhood, emergencies continue to expose the vulnerabilities in our system. “Our prognosis for disaster preparedness is guarded at best,” she cautions.
Still, Fallat remains optimistic. She envisions a future where adult and pediatric systems work together, where communication flows in both directions and where every hospital commits to a baseline of pediatric readiness. “Collaborationcan raise the standard of care for every child, no matter where they live,” she said.
Her perspective is shaped by a personal memory. As a child during the Cuban Missile Crisis, she remembers air raid drills at school and emergency kits at home. Preparation was seen as essential then. Now, she asks, how are we preparing our children for the unexpected?
Her message is intended for every surgeon in attendance: whether or not they operate on children, they have a stake in this issue. Every surgeon was once a child themselves, and most have children, grandchildren or loved ones whose lives could one day depend on the systems in place.
“You can’t blame them until you train them,” she will remind her colleagues, echoing the words of James Styner, who founded Advanced Trauma Life Support (ATLS) decades ago.
As she prepares to deliver this historic address, we congratulate Mary Fallat on this remarkable honor. Her impact is certain to be felt well beyond the podium and carry forward her lifelong commitment to care for the nation’s children.
UofL scientist and physician discuss the health effects of e-cigarettes
Many people believe that electronic cigarettes are less harmful than traditional cigarettes, but research at the University of Louisville School of Medicine has shown that electronic cigarettes have a variety of negative effects on the body. Physicians with UofL Health also have had significant experience treating patients who have experienced a wide array of negative effects from vaping.
Alex Carll, an associate professor in the Department of Physiology, studies the impacts of ingredients in vape liquids in the laboratory. Rodrigo Cavallazzi, professor of medicine in the Division of Pulmonary, Critical Care and Sleep Disorders, treats patients as director of the medical intensive care unit at UofL Health – UofL Hospital.
UofL News spoke with Carll and Cavallazzi about their findings and insights to understand how work in the laboratory echoes patients’ experience with e-cigarettes.
UofL News: Dr. Carll, what is the focus of your research and what have you discovered about the effects of vaping?
Alex Carll: We test the impacts of inhaled electronic cigarette aerosols on heart function and blood pressure. We have found that exposures to these aerosols in mice can rapidly disrupt heart rhythm, causing abnormal heart beats that occur either prematurely or are skipped.
Our studies in animal models indicate that vaping likely causes cardiac arrhythmias (abnormal heart beats) and does so by causing fight-or-flight stress responses. It increases blood pressure in humans and mice, as well. These abnormal heart beats can increase risk for fatal arrhythmias and sudden cardiac death, which have recently been associated with vaping in young adult patients.
Another recently published mouse study from our group indicates that vaping during pregnancy may cause peripartum arrhythmias, with these effects continuing well after e-cigarette cessation.
UofL News: Dr. Cavallazzi, have you seen these types of effects in your patients?
Rodrigo Cavallazzi: When I see patients, my focus is more on the respiratory system, but it is definitely conceivable that patients who vape have several consequences to their cardiovascular system, including arrhythmias, based on the load of nicotine and other potentially toxic chemical substances they are exposed to through vaping.
UofL News: What are the symptoms you most often see in patients who vape?
Cavallazzi: I see respiratory symptoms such as cough, shortness of breath, chest tightness and wheezing, which I am certain can be attributed to vaping in some patients. I also see exacerbation of underlying lung diseases such as asthma and COPD.
Some of these patients end up in the ICU. I have seen a few patients with acute respiratory failure that I believe was due to a very serious condition called “e-cigarette or vaping product use-associated lung injury” (EVALI). These patients develop acute respiratory failure that sometimes resembles severe pneumonia or a severe Covid-19 infection. The medical literature indicates that this happens when tetrahydrocannabinol (THC, the principal psychoactive constituent of cannabis) is added to an e-cigarette device and is contaminated with vitamin E acetate. It also has been reported in patients inhaling nicotine only.
The effects mentioned in Dr. Carll’s studies seem to corroborate what other authors have written on the cardiovascular effects of inhaled nicotine and other potentially toxic chemical substances through e-cigarettes.
UofL News: Dr. Carll, have you been involved in any human studies?
Carll: Yes, my lab has published two population studies detailing smoking’s adverse impacts on cardiac conduction, and we have associated some of our observations with long-term cardiovascular mortality.
Our population studies in smokers showed correlations between cotinine in the blood, a biomarker indicating nicotine exposure, and electrocardiogram (ECG) abnormalities. Some of these ECG abnormalities in smokers corresponded with increased cardiovascular mortality over a 25-year follow-up period. Additionally, some of the ECG effects associated with smoking and nicotine corresponded with changes in the fight-or-flight stress hormones norepinephrine, epinephrine and dopamine. Dopamine itself also appeared responsible for smoking-related shortening in the time between atrial and ventricular contraction.
I also have been involved in a yet-unpublished clinical trial focused on preventing smoking’s adverse impacts on heart conduction.
UofL News: Dr. Cavallazzi, how would the effects that Dr. Carll documented in the lab affect patients?
Cavallazzi: As a clinician, the chronic cardiovascular effects of combustible cigarette smoking I often see are myocardial infarction, stroke and peripheral vascular disease. The latter manifests as difficulty walking and erectile dysfunction.
UofL News: How does the knowledge we have about the effects of cigarette smoking translate to vaping? And what do you tell your patients about the health impacts of vaping and smoking?
Cavallazzi: I tell them the truth. Combustible cigarette smoking increases the risk of lung cancer development by 15 to 30 times. Up to 50% of people who smoke combustible cigarettes develop COPD. This is a much higher figure than previously thought.
Combustible cigarette smoking increases the risk of a heart attack by 4 to 7 times and increases the risk of other cancers and conditions, including peripheral vascular disease and stroke.
We are now starting to understand the risks of e-cigarette smoking: EVALI, exacerbation of asthma and COPD. There is data that daily users of e-cigarettes have more than double the odds of chronic lung disease, including chronic bronchitis, emphysema or COPD.
UofL News: How do you help your patients quit smoking or vaping?
Cavallazzi: I remind my patients that smoking combustible cigarettes or e-cigarettes is not a failure of character. It is never too late to quit smoking. Most people who quit for good tried a number of times before they were successful. Nicotine is highly addictive and is often listed as one of the most addictive substances out there.
Since nicotine is so addictive, I often offer pharmacological aids such as nicotine replacement – patches, gum and lozenges. The nicotine exposure obtained through these medications is sustained, low dose, designed to be of short term (weeks), not inhaled and not combined with other potentially toxic chemical substances.
There are also other medications that are sometimes offered, including an antidepressant called bupropion, which is often combined with nicotine replacement. And there is a medication called varenicline, which acts on the nicotine receptors.
UofL News: Cigarette smoking has been declining since 1965, which is great news. But e-cigarettes are a relatively new product. What is the most concerning trend in the use of e-cigarettes?
Cavallazzi: Unfortunately, the rates of e-cigarette use are moving in the opposite direction. From 2014 to 2022, current e-cigarette users increased from 3.7% to 6.0% of adults. From 2011 to 2022, the rates went from 0.6% to 4.6% among middle school students and from 1.5% to 10.0% among high school students. This is concerning. These pre-adolescents and adolescents are more vulnerable, and some of the vape companies have marketed their products in ways that attract young users.
Carll: The e-cigarette market is constantly evolving to dodge regulations and enhance appeal, nicotine delivery and the potential for addiction. New untested products and chemical combinations are routinely deployed to users with minimal safety testing. While the long-term risks of current vaping products remain unclear, this real-world uncontrolled experiment continues with little regulation. Our research remains critical to inform users, practitioners and regulators about the overall risks of e-cigarettes and the specific device types, settings and ingredients that pose the greatest harms.
Jason Smith selected for the prestigious AAMC Council of Deans Fellowship
Transforming healthcare takes leaders who understand both the bedside and the boardroom. Jason Smith, chief medical officer and interim chief executive officer for UofL Health and chief of the Division of General Surgery at the UofL School of Medicine, has been chosen for the Association of American Medical Colleges (AAMC) Council of Deans Fellowship, an opportunity that will amplify his impact on patients, learners and communities alike. This national honor recognizes rising leaders in academic medicine and equips them with the mentorship, training and networks to prepare them for future deanships.
The year-long fellowship is designed to be both immersive and practical. Smith will collaborate with the cohort of fellows to explorestrategies for addressing today’s most urgent healthcare challenges. His fellowship project will focus on aligning UofL Health and the School of Medicine’s shared priorities: expandingequitable access to care while improving outcomes for the patients and communities we serve.
“As a trauma surgeon, I have seen firsthand the impact of limited access to care, from rural patients facing hours-long transport to families in underserved neighborhoods struggling with follow-up and rehabilitation,” shared Smith. “These experiences have shaped my conviction that academic medicine must not only save lives in the moment, but also build innovative systems that provide timely, equitable and high quality care throughout the continuum of recovery. Through the Council of Deans Fellowship, I will gain insight from leaders who have successfully implemented systemic change and apply those lessons here at UofL.”
The project-based nature of the fellowship means that Smith will be working with actual School of Medicinepriorities throughout the program, translatinginformation into measurable outcomes like expanding access to care, growing leadership pipelines and advancing equity in patient outcomes. This is a huge first step in Smith’s goal of aligning the clinical, academic and community missions of UofL Health and the School of Medicine.
Smith’s acceptance into the Council of Deans Fellowship echoes the School of Medicine’s admiration for his leadership. His dedication to lifelong learning and leadership allows him to provide secure, evidence-based treatment at the bedside for every single patient while also addressing issues such as health inequities, workforce development and swift innovation.
Jeffrey Bumpous, dean of the School of Medicine, praised Smith’s selection, noting his steady leadership during pivotal moments. “Having a leader such as Dr. Smith walking our hallways is not just impactful for our school and our partner institution, UofL Health, it is meaningfulfor every single patient and every single community we serve,” Bumpous said. “For years, he has guided us through challenges including the COVID-19 pandemic and other community crises. We know that under his leadership, our friends, families and neighbors will have access to equitable, high-quality care for generations to come.”
Smith intends to leverage the fellowship to accelerate progress in reducing healthcare inequalities, improving access and fortifying community partnerships. By bringing home innovative models from across the country, he aims to ensure that every patient, regardless of where they live, has a fair chance at survival, recovery and long-term health.
Join us in congratulating Dr. Jason Smith for his continued excellence in service leadership and his recent acceptanceto the 2025-2026 Council of Deans Fellowship. His leadership is not just inspiring; it is transformative, and reflects our values of excellence, service and innovation at the School of Medicine.
UofL, Norton Children’s receive $2.5 million grant to hire pediatric cancer researchers
Michael Ferguson, chief of the Division of Hematology, Oncology and Stem Cell Transplantation in the UofL School of Medicine Department of Pediatrics and chief of Norton Children’s Cancer Institute
The University of Louisville has been awarded $2.5 million from the Kentucky Pediatric Cancer Research Trust Fund. The grant will be used to hire three new researchers who will help develop new therapeutics and conduct clinical trials for the UofL School of Medicine Department of Pediatrics and Norton Children’s Cancer Institute.
“This funding is another key resource in UofL and Norton Children’s ongoing work to build a cutting-edge pediatric cancer research program,” said Michael Ferguson, chief of the Division of Hematology, Oncology and Stem Cell Transplantation in the UofL School of Medicine Department of Pediatrics and chief of Norton Children’s Cancer Institute. “This will allow us to develop new pediatric cancer treatments and bring them to families in Kentucky and surrounding states before they are available anywhere else – ensuring children here have first access to the latest approved therapies.”
Previous grants funded some of the biggest findings within the UofL Department of Pediatrics and Norton Children’s Cancer Institute. One notable example is CAR T-cell immunotherapy research conducted by the late William Tse. The research involves reprogramming the immune cells of brain cancer patients to kill their own brain cancer cells that have resisted conventional therapy.
Previous grants funded a basic science program that helps researchers better understand how certain chemotherapy drugs impact the heart and what adjustments can be made to prevent those side effects, along with work that is helping children manage pain during cancer treatment. Earlier this year, the Kentucky Pediatric Cancer Research Trust Fund also awarded a grant to help establish the Norton Children’s Cancer Institute Resource Center, a space to support patients and families through every step of their cancer journey.
“The partnership between the University of Louisville School of Medicine and Norton Children’s creates an unparalleled environment for pediatric cancer care and research in Louisville and beyond,” said Jeffrey Bumpous, dean of UofL School of Medicine and executive vice president for health affairs. “Through Norton Children’s Cancer Institute, our dually employed faculty are able to offer innovative treatments and clinical trials while advancing research for our most vulnerable cancer patients and training the next generation of physician-scientists.”
The new researchers are expected to join UofL in early 2026.
Two ULSOM AHEC preceptors pull from traditional approaches to put a spin on modern clinical care
The Area Health Education Center (AHEC), a collaborative network of centers including the University of Louisville Health Sciences Center, the University of Kentucky Medical Center and eight regional centers, works to improve the recruitment, distribution and retention of health care professionals in medically underserved communities across Kentucky.
With dedicated preceptors guiding students in AHECs across Kentucky, the future of medicine is in exceptional hands. Two such preceptors, Michael Collins and Heath Cates, both gratis faculty at the UofL School of Medicine, are drawing from traditional approaches to deliver high-quality care in rural areas, while also preparing next generation of physicians to think differently about how care is delivered.
For Collins in Bowling Green, that means reviving home-based care.Once a common practice, home visits have declined as modern medicine shifted to office settings.Homebound patients require extensive preparation and incur large transportation costs for regular office visits, leading many to give up on going to their primary care appointments altogether.
“I remember a patient on a stretcher with multiple contractures and bedsores who I saw for 15 minutes and then was responsible for based on what little I could assess in that brief time,” Collins recalled. “In the home, I can evaluate both the patient’s and the caregiver’s needs by direct observation and provide support in a non-threatening environment. I hope I can inspire some students to think outside the exam room and do true family practice that not only begins in the nursery but continues in the nursing home or the patient's own home.”
While Collins focuses on home visits, Cates works with a different kind of patient. As a pediatrician, Cates advocates for families who must often travel hours to see subspecialists and ensures that his patients receive his care when hospitalized, something fewer community physicians do today. Importantly, he brings students along with him for hospital-based care, exposing them to experience they might not otherwise have in training.
“Seeing this type of care can be very valuable for our students,” shared Cates. “It can open them up to considering similar practices in the future, which would help meeta great need in many rural communities across Kentucky. I’ve had so many students tell me about loving their rotation in this more rural region and express how happy they were to have this experience.”
Dr. Cates connection to AHEC runs deep. As an undergraduate student at Murray State University, his early AHEC experience played a role in his medical school application. Now as a practicing physician, he embraces the opportunity to serve as a mentor, imparting the same knowledge unto clinical students like he once received, too.
“Our AHEC preceptors are driving forces in our goalas an institution to expandaccess to care and reduce provider shortages in rural areas,” said JeffreyBumpous, dean of the School of Medicine. “Through preceptors like Dr. Michael Collins and Dr. Heath Cates, we are preparing physicians who are both eager and equipped to serve rural communities. That progress is somethingwe are proud to support.”
By blending the wisdom of traditional medicine with the demands of modern practice, Drs. Collins and Cates embody the heart of the UofL School of Medicine: to serve. Their work not only transforms the lives of patients but also plants the seeds of stronger, more resilient communities.
Faculty Focus: Dr. Jessica Kline leads School of Medicine faculty forum
Jessica Kline, assistant professor in the Department of Obstetrics, Gynecology & Women's Health, named vice chair of Faculty Forum for 2025-2026
From the classroom to the clinic, Jessica Kline, assistant professor in the Department of Obstetrics, Gynecology and Women’s Health, has always been drawn to roles that connect people and create opportunities for growth. Her career path began with Teach for America, where she taught middle school science in Houston, Texas. Those two years revealed the deep connection between education and health – showing her how challenges at home and in the community could directly impact a student’s ability to learn. Inspired by this experience, she pursued medical school at the University of Louisville School of Medicine (ULSOM), where she found her calling in academic medicine.
Throughout medical school and residency, Kline consistently sought out leadership and teaching opportunities. She knew the team-based structure of academic medicine was right for her, and she joined ULSOM faculty as soon as she finished training. Since then, she has built a reputation as both a dedicated educator and an engaged leader.
This year, Kline begins her newest leadership role, the vice chair of the ULSOM’s Faculty Forum. After three years representing the Department of Obstetrics, Gynecology, and Women’s Health, she was nominated to serve as the vice chair for 2025-2026, a responsibility she describes as both an honor and an opportunity to serve.
“One of the best parts of serving on the Faculty Forum is hearing the perspectives of colleagues whose day-to-day work is very different from mine, but equally critical to the mission of the School of Medicine,” shared Kline. “I find it incredibly reassuring to know that all major changes that come from the School of Medicine administration have been made in consideration of all viewpoints, and I am proud to lead that charge.”
With nearly50 members, the Faculty Forum is one of the School of Medicine’s main venues for shared governance. Each department is represented, with additional members from larger departments, along with medical students, graduate students and residents. Forum representatives serve three-year terms and are only able to serve two consecutive terms, ensuring that a wide range of voices and experiences guide decision-making across the school.
Kline’s commitment to inclusive leadership stretches back to her time as a medical student, where she was actively involved in student government, curriculum development and the school’s LCME accreditation process. Those early experiences, she said, shaped her appreciation for how ULSOM values community input at every level.
“During my four years of medical school, I was impressed by how receptive the School of Medicine administration was to student input,” Kline reflected. “As a faculty member, I continue to feel supported by my department, graduate medical education and School of Medicine leadership. It is easy to work hard for an institution that pours just as much back into its academic community.”
Her leadership and service have not gone unnoticed. “Dr. Kline’s service to the School of Medicine is truly admirable, and we are proud to have her as the 2025-2026 vice chair for the Faculty Forum,” said Michelle Stevenson, vice dean for Faculty Affairs and Advancement. “From her time as a medical student to her current role as a faculty leader, she has consistently given back to our community. Her leadership is an inspiration to all of us, and we are stronger because of her.”
As September marks Women in Medicine Month, Dr. Kline’s story is a powerful example of the many ways women physicians shape the future of academic medicine through teaching, service and leadership that uplifts their colleagues and communities alike. Her commitment reminds us that leadership in medicine is rooted in service. We thank her, and all our faculty, for dedicating their time and talents to strengthening our school and the communities we serve.
The power of service in leadership
In medicine, true leadership is measured not only by knowledge or skill, but by commitment to serve. This philosophy drives our mission at the UofL School of Medicine and few leaders embody it more fully than Murali Ankem, vice dean of graduate medical education.
Since he first began his medical training in India, Ankem has been continuously inspired by the opportunity to serve people at their most vulnerable moments. When he was a young physician in hospitals with limited resources, he quickly learned the importance of community-centered care, where compassion and accessibility mattered as much as clinical skill. That lesson continues to guide him today, shaping his approach to academic medicine and community-engaged care.
“Service is at the core of my professional identity,” Ankem shared. “Through patient care, resident education and organizational leadership, I am reminded daily that everything we do must be rooted in improving lives.”
With every decision, Ankem leads by example, showing trainees and colleagues that leadership extends beyond the operating room or classroom. He models the idea that physicians holdboth the privilege and responsibility of shaping the communities they serve. His service includes participating in professional societies, advocating for educational policy and volunteering histime for broader institutional needs, Ankem’s leadership shows that physicians can drive change at every level.
“What excites me the most is the growing recognition that medicine cannot be siloed within hospitals and clinics,” shared Ankem. “Partnerships between universities and communities, physicians and policymakers and health systems and patients are shifting medicine towards community-engaged care. Together, we can address not only disease, but also the social determinants of health, creating a more equitable and impactful health care system. I am energized to be part of shaping that transformation.”
Ankem serves the School of Medicinein multiple capacities, including as professor and chair of the department of Urology, vice dean ofgraduate medical education, and as the ACGME Designated Institutional Official, where he oversees the training of nearly 800 residents and fellows across the health system. Beyond the university, he provides care as a staff urologist at the Robley Rex VA Medical Center and serves nationally throughroles such as a Chair-Elect on the AMA Academic Physician Section Governing Council, on the Finance Committee of the Endourologic Society and on committees of the Southeastern Section of the AUA.
Across each role,Ankemis dedicated to mentoring, collaboration and improving care. His leadership strengthens connections between academic medicine and communitypractitioners, directly improving patient care in Kentucky. His dedication to patients, trainees and the wider community continue to inspire those around him.
“My advice is simple: let service guide your decisions, not just achievement,” he said.“Excellence in medicine will come with time and training, but a true career of impact is built on relationships, humility and community commitment.”
Please join us in thanking Dr. Ankem for his ongoing commitment to supporting both learners and communities while strengthening the future of medicine.
Explore how leaders like Dr. Ankem are training the next generation of physicians through ourgraduate medical education programs.
UofL School of Medicine begins second year of the Distinction Track in Urban Primary Care
As we reiterate the need for primary care physicians across the state, we focuson the fact that 107 out of 120 counties in Kentucky are Health Professions Shortage Areas (HPSA). While many associate this shortage with rural communities, urban areas like Louisville face the same challenge. Families living just minutes from major hospitals often lack access to consistent, nearby primary care.
To address this critical need, the University of Louisville School of Medicine(ULSOM) launched the Distinction Track inUrban Primary Care , now entering its second year. The track prepares students to become competent, compassionate primary care physicians who understand both the challenges and strengths of the communities they care for. By pairing rigorous medical education with community-based learning, the track ensures students graduate with the tools to improve health equity in urban environments.
Led by Jennifer Porter, associate professor in the department of pediatrics, and Clayton Smith, associate professor of internal medicine, the curriculum highlights how social and environmental factors, such as food insecurity, transportation barriers and exposure to pollution, directly shape health outcomes. Students don’t just learn these concepts in the classroom; they step into the community to experience them firsthand. In one exercise, students navigate Louisville’s public transportation system to simulate traveling to a clinic appointment. The experience builds empathy for patients who face delays or missed visits due to factors outside their control, reinforcing the importance of designing care that meets patients where they are.
“Primary care can be challenging due to the number of issues patients may have that cannot be remedied by a prescription,” shared Jennifer Porter. “The track encourages long-term commitment to primary care through learning how vital it is to understand the challenges patients face and the resources that are available to help them. By teaching our students how to help the whole patient, they are empowered to see primary care not as overwhelming, but as essential and deeply rewarding.”
Students also connect with local community partners to learn about the plethora of resources available for patients around Louisville. These collaborations not only deepen student understanding but also reassure community organizations that the next generation of physicians is invested in improving health beyond the clinic walls.
“Our responsibility as a medical school extends outside the classroom and into the neighborhoods around us,” said Kelli Bullard Dunn, vice dean of community engagement. “This track shows our students that medicine is not just about diagnosing and treating; it’sabout listening, partnering and finding solutions together with the community. That’s how lasting impact is made.”
As the Distinction Track in Urban Primary Care grows, it reflects ULSOM’s broader commitment to training physicians for all environments, from rural counties to urban neighborhoods. The program strengthens the medical school’s mission to advance student success in undergraduate medical education while improving health outcomes for Kentuckians.
Because everyone deserves access to quality care, wherever they live.
Unparalleled Partnership: UofL Department of Pediatrics, Norton Children’s Hospital create unmatched learning environment and top-notch cancer care for pediatric oncology patients
As Kentucky’s only free-standing children’s hospital and only level I pediatric trauma center, Norton Children’s Hospital serves as the primary pediatric teaching facility for the University of Louisville School of Medicine (ULSOM). This unique partnership provides a rich learning experience for future pediatricians while delivering nationally recognized care to children and families across the region.
At the heart of this collaboration is ULSOM’s Department of Pediatrics, home to a number of unique and impressive programs, including a comprehensive Hematology and Oncology Fellowship. Basedwithin Norton Children’s Hospital, fellows gain hands-on experience managing complex cases under faculty supervision. They serve as primary care providers in the outpatient clinic, learning to follow oncology patients through every stage of care. Beyond clinical training, fellows may pursue independent research or earn a Master’s Degree in Clinical Investigation Sciences from the School of Public Health & Information Sciences (SPHIS), creating a deeper specialization in pediatric cancer research and care.
This dual role of physicians as educators, researchers and clinicians ensures patients benefit directly from the latest discoveries. “When physicians teach and investigate as part of their daily practice, innovation moves from the lab to the bedside more quickly, giving children access to the best possible care,” said Jeffrey Bumpous, dean of the School of Medicine.
In addition to the clinical partnership, ULSOM and Norton Children’s research is integrated under Norton Children’s Research Institute, which unites clinical and laboratory studies, resources and staff to maximize the success of pediatric investigators. Within this structure, ULSOM faculty in the division of pediatric hematology and oncology play a leading role in the Norton Children’s Cancer Institute.
Norton Children’s Cancer Institute is part of both the Beat Childhood Cancer research consortium, a group of more than 40 universities and children’s hospitals that offer a worldwide network of childhood cancer clinical trials andalso is a long-standing member of the Children’s Oncology Group, the world’s largest group of hospitals devoted to treating children with cancer. These affiliations give patients access to proven treatment regimens and cutting-edge clinical trials close to home.
The impact of this work is evident. Thanks to Norton Children’s Cancer Institute, we are seeing groundbreaking advancements in pediatric cancer treatment. The late Dr. William T. Tse was well-known for his CAR T-cell research program, a groundbreaking advancement that revolutionized how we fight childhood cancers. His work continues today under the direction of Michael Ferguson,chief of the division of pediatric hematology, oncology and stem cell transplantation, and Jun Cai, associate professor of pediatrics in the pediatric research institute. Additionally, Ye Tan, associate professor of pediatrics and Carol B. McFerran Endowed Chair of Pediatric Diabetes Research is working to prevent common chemotherapy drugs from causing heart damage in pediatric cancer survivors, and Lauren R. Hayes, assistant professor of pediatrics, is working to manage pain during treatment. Together, these efforts are expanding possibilities for childhood cancer treatment and survivorship.
“The legacies of the School of Medicine and Norton Children’s Hospital are each impressive, but together,they form an unparalleled coalition of physician-scientists redefining pediatric cancer care,” said Bumpous.
As we recognize Childhood Cancer Awareness Month, the powerof this partnership is evident. By uniting comprehensive training, innovative research and nationally recognized clinical care,UofL’s Department of Pediatrics and Norton Children’s Hospital are shaping the future of pediatric oncology and bringing hope to children and families for generations to come.
A legacy of healing
This fall, the University of Louisville School of Medicine celebrates an incredible milestone: Jesse Wright, professor of psychiatry and founding director of the UofL Depression Center, marks 50 years of service to the field of academic psychiatry. An internationally recognized expert in cognitive behavioral therapy (CBT), Dr. Wright’s half-century of work has not only shaped the training of thousands of physicians but also transformed the way mental health care is delivered and understood across the Commonwealth and beyond.
What began as a fascination with the human mind evolved into a lifelong commitment to improving the mental health of individuals and communities. Dr. Wright’s career has spanned eras of significant transformation in psychiatry, from the early days of institutional care to today’s integrated, patient-centered approaches. Through it all, one thing has remained constant: his dedication to service.
“When I started, there was a deep stigma around mental illness, even within the medical community,” Wright reflected in a recent national interview. “Over the years, I’ve seen that stigma slowly give way to greater compassion and scientific understanding. But there’s still work to be done.”
Dr. Wright became a pioneer of implementing CBT into mainstream practice, helping countless patients gain tools to manage depression, anxiety and trauma. His work in digital mental health tools, including interactive software programs that extend therapy beyond the clinic, positioned UofL as a leader in innovation. His efforts helped establish partnerships and programs that extended care to underserved populations and equipped clinicians with more adaptable, evidence-based methods.
Beyond his clinical and research contributions, Dr. Wright’s impact is most deeply felt in the generations of physicians he has mentored. He has trained hundreds of residents and medical students consistently emphasizing the importance of compassion, curiosity and community engagement.
“Mentorship is one of the greatest privileges of academic medicine,” he said. “I want the residents I train to not only become excellent clinicians, but also advocates for their patients, their communities and for the mental health care.”
Throughout his career, Dr. Wright has earned international accolades, published widely and led professional organizations, but he remains grounded in the local impact of his work. From counseling patients during moments of personal crisis to shaping statewide public health campaigns, his belief in psychiatry as a tool for service has never wavered.
“Dr. Wright’s legacy is not only measured in decades, but in lives changed,” said Jeffrey Bumpous, dean of the School of Medicine. “He exemplifies the spirit of service that defines our school. His unwavering commitment to mental health education, research and advocacy has made him a cornerstone of our institution and our community.”
As the School of Medicine honors Dr. Wright this fall, his 50 years of service stand as a testament to the power of persistence, empathy and community-focused care. His legacy is not only in what he has built, but in the many hands he has guided to carry that work forward.
About Dr. Jesse Wright
In addition to being the founding director of the UofL Depression Center and the recipient of several major multi-million-dollar grants from the National Institute of Mental Health (NIMH) throughout his career, Dr. Wright is the Gisela and Gottfried Kolb Endowed Chair of Outpatient Psychiatry at UofL and has received the Dean’s Distinguished Educator Award for Lifetime Achievement in Teaching.
Dr. Wright, in addition to research and teaching, is dedicated to providing more avenues of learning for those interested in psychiatry. A published novelist, Dr. Wright writes about key issues in psychiatry, including trauma and stigma. Additionally, the Jesse H. Wright, MD, PhD research endowment at UofL funds research grants annually to UofL faculty and students for fundamental studies on mood disorders.
ULSOM Faculty Shares About Rural Care as Impactful as a Level 1 Trauma Center
“There may not be helicopters flying out here every day to deliver us patients in critical need, but the care that is being delivered in rural areas all around Kentucky is as important as the care found in a tertiary hospital,” shared Brent Wright, associate dean for rural health innovation.
The University of Louisville School of Medicine is affiliated with a number of excellent, newsworthy hospitals that provide high-quality, sub-specialized care to patients dealing with elevated, difficult-to-treat illnesses, injuries and conditions. What many don’t realize, though, is that ULSOM is also connected to a number of rural hospitals and family medicine practices around the state—and those teams are delivering care that is equally impactful.
Wright is an advocate for these rural care teams, especially the teams tied to the Family Medicine Residency Programs in Glasgow and Owensboro. As both an administrator and a practicing family medicine physician in Glasgow, Wright sees firsthand the impact that family medicine and rural care teams have on communities across the state, whether they are filled with dirt roads or have only the basic signs of rurality.
While specialists in major cities perform organ transplants and conduct complex surgeries, Wright is called daily to serve in rural settings. His commitment extends beyond his own practice – he is dedicated to training the next generation of physicians to choose this path, too.
“We are on the frontlines of health care, keeping blood pressures low, managing medications and educating patients about the importance of regular screenings,” explained Wright. “We are giving our patients an extra twenty years at home with their families as we work diligently to prevent serious illnesses and catch conditions before they do require trips to bigger cities with larger hospitals.”
The numbers speak for themselves. The Glasgow and Owensboro Family Medicine Residency Programs together graduate 10 residents each year. In their first year of independent practice, each graduate will see approximately 5,000 patient visits. That’s 50,000 patient appointments in just one year, impacting lives across Kentucky before these physicians even reach their second year in practice.
As more family medicine physicians spread throughout the state, more prevention, education and impact will happen in every corner of Kentucky. These efforts, driven by the School of Medicine’s training programs and outreach initiatives are creating healthier communities with each new day, all thanks to an esteemed team of service-driven physicians.
Though the University of Louisville’s campus sits in the heart of the city, its influence reaches far beyond Metro Louisville. Faculty like Wright ensure that Kentuckians receive high-quality care, whether they live in Louisville, in the hills of Eastern Kentucky or between the lakes in Western Kentucky.
On behalf of the School of Medicine, we extend our gratitude to the rural physicians who keep patients healthy, close to home and surrounded by the people they love.
ULSOM recognized nationally for commitment to rural health and physician shortage areas
In their 2025 edition of Best Graduate Schools, U.S. News & World Report recognized the University of Louisville School of Medicine (ULSOM) for its lasting impact on communities that need it most. ULSOM ranked among the top schools in the country for graduates entering primary care (52nd), practicing in rural areas (52nd) and serving health professional shortage areas (57th).
These rankings affirm ULSOM’s deeply rooted mission of training compassionate, skilled physicians committed to serving where the need is greatest.
“We’re not just educating physicians. We’re shaping a workforce that understands the needs of every community, from the largest cities to the most rural towns,” said Kelli Bullard Dunn, vice dean of community engagement. “Our programs are designed to instill not only clinical excellence, but also a deep-rooted commitment to service, particularly in areas that have faced physician shortages.”
INVESTING IN A HEALTHIER KENTUCKY
More than 85% of Kentucky’s counties are currently designated as full or partial health professional shortage areas. In some communities, one family medicine physician may care for more than 5,000 patients each year. ULSOM has taken bold steps to reverse this trend by expanding pathways into primary care and rural health careers – and by removing barriers for students who want to serve in these regions.
Programs like the Kentucky Area Health Education Centers (AHEC) Network, supported by HRSA and KY CHFS grants, give students first-hand exposure to life and practice in rural communities. All third-year medical students participate in a four-week AHEC rotation, living and working in medically underserved communities and learning from a dedicated volunteer family medicine physician.
“These experiences inspire many of our students to pursue careers in primary care in rural or underserved regions,” explained Bullard Dunn. “Some students come to us with a vision of returning home to serve, but many discover this passion through the AHEC rotation. It’s a transformative experience.”
Additional funding from the HRSA Medical Student Education Training Program grant has enabled the creation of new programs such as a new summer primary care externship for first-year students and a new Distinction in Urban Primary Care track, as well as increased the Trover Rural Track class size and expanded primary care electives. This grant also helps defray some of the overwhelming cost of medical training for those entering primary care fields.
RURAL TRAINING, REAL IMPACT
ULSOM is not just preparing students to serve rural areas; it’s putting them there. The Trover Rural Track, located in Madisonville, Kentucky allows third- and fourth-year medical students to complete their clinical rotations in a rural environment. And it works: nearly 48% of Trover graduates go on to rural practice — a stark and impressive difference from the nation’s 2%.
“It’s not just big cities that need physicians; it is every town, every city, and every neighborhood,” reflected William Crump, associate dean of the Trover Campus. “Bringing medical students back to their roots and showing them the life-saving power they can have in their hometowns is a transformative experience that directs them right back to their rural roots to serve.”
The commitment extends beyond medical school. Residents also have the unique opportunity to complete their training serving rural regions in Kentucky through the Glasgow Family Medicine Residency Program and Owensboro Family Medicine Residency Program, where residents receive personalized instruction taking care of patients from rural communities. These physicians often become anchors in their communities, providing continuity of care and generating millions in economic impact.
“Family medicine physicians are saving lives in their own ways,” explained Brent Wright, associate dean for rural health innovation “Family medicine physicians are actively working with and educating patients to prevent strokes, heart attacks, and other major issues from happening in the first place. What would we do without them?”
A VISION FOR THE FUTURE
ULSOM’s approach is working, but the work is far from over. With a persistent shortage of physicians across most of Kentucky’s 120 counties, the need for thoughtful, mission-driven training has never been more urgent.
“Access to health care shouldn’t depend on your zip code,” said Bullard Dunn. “We are training the next generation of physicians to go where they’re needed the most: to return to their hometowns, or discover new ones, and make a real difference.”
ULSOM’s recognition by U.S. News & World Report is more than just a national ranking; it’s a reflection of a promise kept: to train physicians not just to be excellent, but to make a difference where it matters most.
A Renaissance in Medicine: UofL School of Medicine Shapes Health, Community and Economy
As a medical student, Jeffrey Bumpous, was focused on becoming a skilled physician. Today, as executive vice president for health affairs at the University of Louisville and dean of the School of Medicine, his perspective has broadened to the full “lifespan” and “ecosystem” of physicians—recognizing their roles not only as clinicians, but also as scientists, educators, advocates and leaders in their communities.
“Society expects us to help, and we must deliver,” he said.
That charge is at the heart of academic medicine nationwide, which prioritizes expanding the health care workforce, developing innovative treatments and improving access and outcomes for historically underserved communities. At the UofL School of Medicine, these priorities are guiding efforts to train the next generation of physicians and physician-scientists, while also meeting urgent health care needs across Kentucky.
The school has expanded programs such as the MD/PhD, MD/MBA and MD/MPH, equipping graduates with the skills to advance discovery and address clinical, organizational and public health challenges. These efforts are gaining national attention: U.S. News & World Report recently recognized UofL for excellence in Primary Care, Rural Health and Physician Shortage Areas. The school’s residency match rate also exceeds the national average, with 44% of graduates entering primary care and 36% choosing to stay in Kentucky—impacting care where it is most needed.
Bumpous calls this moment a “renaissance in medicine,” as solutions increasingly require collaboration across disciplines like engineering, social sciences and the arts. This holistic approach is evident in ULSOM initiatives addressing public health challenges and advancing personalized treatments for chronic diseases and cancer. Patients treated in teaching hospitals consistently achieve better outcomes, underscoring the value of academic medicine in improving health.
The School of Medicine’s impact also extends beyond health care. Every dollar invested in UofL generates $1.62 in economic return, with a recent $24.5 million NIH grant adding more than $25 million to Kentucky’s economy. Altogether, the School of Medicine contributes $777 million annually—an impact equivalent to hosting the Kentucky Derby twice each year.
“This is the work of academic medicine,” Bumpous said. “And it is a mission we are proud to lead at the University of Louisville School of Medicine.”
Visit our website to view the full Dean’s Message and watch the 2025 Dean’s Address to learn more about the successes and priorities at the UofL School of Medicine.
UofL School of Medicine expands residency programs to UofL Health – Mary & Elizabeth Hospital in Southwest Louisville
In the heart of every community hospital, you will find patients and employees who take great pride in their hospital. But at UofL Health – Mary & Elizabeth Hospital, that’s not all you’ll find. At the community hospital located in Southwest Louisville, there is a cohort of residents who take just as much pride in their hospital as those who have grown up living in the community—and the residency programs are now expanding, bringing even more excitement to the hospital.
The hospital alreadyhosts awiderange of residency programs. From the Family Medicine Residency program in an adjacent medical plaza to the 24/7 inpatient rotations through the hospitalist program, the hospital has long been providing a unique and fulfilling residency option for residents. Currently, residents are training in areas including General Surgery, Vascular Surgery, Urogynecology, Urology, Podiatry, Orthopedics, Neurology, Cardiology and more. While UofL Health – Mary & Elizabeth Hospital may be a community hospital, it’s rich with specialists who are committed to academic medicine and to preparing the next generation of physicians.
That commitment is set to deepen. Melisa Adkins, CEO of UofL Health – Mary & Elizabeth Hospital, shared that the hospital is preparing to expand residency opportunities through UofL Department of Psychiatry and Behavioral Sciences in the Medical Detox and Medical Behavioral Health units. She also hopes to have a robust resident pipeline in the Center for Women’s Health through the UofL Department of Obstetrics & Gynecology.
“Partnering with the School of Medicine and being part of an academic health system provides the communities we serve with research-driven, evidence-based care, which in turn provides better outcomes for our patients,” Adkins explained. “We are always excited to show the community how the School of Medicinehas integrated academic-based care into the communities we serve.”
As more and more residents join the hospital, the culture and environment shift to reflect continuous learning and excitement for the future of medicine. As the physicians and residents work together, teamwork and an interdisciplinary approach come to the forefront of patient care, creating a happier and healthier patient population. There is no secret that the residents bring a new energy to the campus at UofL Health – Mary & Elizabeth Hospital, and they have no plans of slowing down.
"We believe the best training happens when residents are fully immersed in the communities they will one day serve,” said Jeffrey Bumpous, executive vice president for health affairs and dean of the School of Medicine. “That’s why our partnership with UofL Health – Mary & Elizabeth Hospital is so meaningful. There, residents bring energy, curiosity and dedication that blend seamlessly with the expertise of experienced physicians. This collaboration ensures our patients benefit today, while also supporting the future of medicine.”
With a prime location in Southwest Louisville, the hospital provides trainees and physicians alike with the best of both worlds: an urban hospital setting with the close-knit feel of a community environment.That balance not only enhances the resident experience but also helps retain future physicians to the region.
“Mary & Elizabeth Hospital will play a pivotal role in retaining physicians in our area.We are poised for growth and offer a vast array of opportunities for manyspecialties,” Adkins shared. “Patients want care close to home, and I believe we provide that for them in a friendly, academic-based community environment right in Louisville. Our residents, who will eventually be out on their own as practicing physicians, love this settingjust as much as our patients.”
The University of Louisville School of Medicine is proud to partner with UofL Health and UofL Health – Mary & Elizabeth Hospital to create innovative, academically driven training environments. Whether in the heart of downtown Louisville or in Southwest Louisville, our residentsreceive exceptional training from compassionate physicians and hospital leaders dedicated to shaping the future of medicine.
Heartwheels! initiative continues to inspire the future of medicine
Even when the future of medicine feels far away, ULSOM’s Heartwheels! program knows that the future starts today.
Children are natural explorers, fascinated by the world around them and theircuriosity is what allows themto be exposed to so much of the world, whether that be a fuzzy caterpillar munching on a leaf or a bright yellow backhoe digging up interesting rocks down their street. Yet, opportunities to engage with healthcare beyond routine check-ups are limited.
Heartwheels! bridges this gap by making healthcare more accessible, engaging and hands-on. Through interactive activities like manipulating water-filled tubing to simulate cardiovascular dynamics, participants of all ages grasp complex concepts in a fun, memorable way.
“The more hands-on, colorful, and silly we can make the activities, the better,” shared Dr. Steven Koenig, co-director of Heartwheels! “If it is fun and memorable for us, then it is sure to be fun and memorable for the children that we work with.”
As Heartwheels! exposes people of all ages, backgrounds and groups to healthcare and medicine, they are able to envision themselves as a future physician, nurse or researcher, empowered by their experiences in health care simulations. While many people, both young and old, never have the opportunity to roleplay working in health care, Heartwheels! provides that opportunity and inspires the next generation of caretakers.
The program also exposes young participants to things that might otherwise be scary or difficult to understand in a relaxed and fun way. Many events include a real heart that kids can see and touch to learn more about it. While at first, most kids are apprehensive, they become comfortable with the topic the more they learn about it. Since heart disease is the leading cause of death in Kentucky, it is important that people of all ages are comfortable talking about heart disease and understand what it means to keep your heart healthy.
“It brings us great joy to have repeat participants at our events who can come back and tell us what they learned last time,” shared Dr. Gretel Monreal, co-director of Heartwheels! “This gives us hope that our participants are leaving our events and sharing what they learned with the world. The more advocates for STEM education we can create today the more physicians, researchers and health professionals we will have tomorrow.”
Heartwheels! continues to be a fan favorite. Parents, teachers and the participants themselves are excited about the collaborative partnerships Heartwheels! has with local schools and educators. As we work towards inspiring the next generation of health professionals, we are proud of faculty members Drs. Gretel Monreal and Steven Koenig for spearheading this initiative and being a driving force of STEM education in our community.
Heartwheels! is a mobile STEM outreach program that can visit your school, event or location. For inquiries, reach out to Drs. Gretel Monreal and/or Steven Koenig.
Future Physician-Scientist Sarah Belcher embarks on MD/PhD journey at ULSOM
Many students dream of becoming a doctor. But Sarah Belcher is taking it a step further, by pursuing both an MD and a PhD through the University of Louisville School of Medicine’s physician-scientist training program.
Just months after completing her undergraduate degree at UofL, Belcher joined the latest cohort of MD/PhD students, a path that will prepare her to combine clinical care with high-impact research. She will graduate with both degrees and a career uniquely positioned to make a difference in patient care and population health.
Belcher was a Grawemeyer Scholar in her undergraduate years, a distinction that offered her hands-on research that revealed to her the power of contributing to something greater than yourself. This experience revealed how scientific inquiry could reach beyond the walls of a clinic and shape health outcomes on a broader scale.
In addition to being a Grawemeyer Scholar, Belcher was also a GEMS student, meaning she was selected for Guaranteed Entrance to Medical School while she was still in high school. Through GEMS, Belcher became part of the School of Medicine community long before her first day of class. She credits the program for making the School of Medicine feel like home and for connecting her with mentors who encouraged her to pursue the MD/PhD track.
That encouragement continued last summer during theMD/PhD Summer Undergraduate Research Fellowship (SURF)and further solidified Belcher’s decision. Thanks to her experience with the GEMS and SURF programs, Belcher feels confident as she enters this new rigorous journey. The GEMS program introduced her to the medical school early on, meaning she already feels comfortable in the environment and understands what resources are available to her as a student. The SURF program helped her to prepare for the MD/PhD program and showed her what to expect from such a meticulous program.
“Being part of the University of Louisville has been one of my greatest blessings,” Sarah Belcher reflected. “The support I received through the School of Medicine as a GEMS student made me feel at home in a new city. Having that same support available through both the medical school and the MD/PhD program is invaluable and made me want to continue my educational journey here.”
Originally from Eastern Kentucky, Belcher plans to focus on the intersection of poverty and cardiovascular health. She hopes to make a real difference when it comes to population health for her area and others that are underserved. She feels confident that her position as a physician-scientist will allow her to break down barriers that exist in health care.
The University of Louisville School of Medicine MD/PhD program includes two years of pre-clinical medical training, followed by graduate training in research and two years of medical rotations for clinical training.
The School of Medicine offers a variety of dual degree programs to meet diverse career goals, including MD/MBA and MD/MA options. From high school outreach to advanced research training, we are committed to supporting future leaders in medicine and science at every stage.
As Belchercontinues her work with ULSOM faculty and forms new relationships with her class of physicians and scientists, we are proud to share her story. The University of Louisville School of Medicine isn’t just for medical students. With programs for high schoolers, undergraduate students, medical students, residents, fellows and more, we are proud to be leaders in medical education for all.
UofL research shows combined exposure to alcohol and “forever chemicals” increases liver damage
Exposure to “forever chemicals” combined with alcohol consumption can worsen liver damage according to recent research from the University of Louisville.
Have you ever wondered why some people who drink alcohol develop serious liver problems while others don't? A study from University of Louisville researchers published last month in Toxicological Sciences suggests that the answer might be hidden in everyday sources such as drinking water, food packaging or even non-stick cookware.
Scientists at UofL, along with colleagues from Boston University and the University of Massachusetts Lowell, have identified perfluorooctane sulfonate (PFOS) as a potential environmental factor that worsens alcohol-associated liver disease.
PFOS is a man-made chemical belonging to the group known as per- and polyfluoroalkyl substances (PFAS), often referred to as "forever chemicals" because they do not readily break down in the environment or the human body. These substances have been used for decades in products such as non-stick cookware, water-resistant clothing, fast-food packaging, stain-resistant carpets and upholstery, and firefighting foams. Their extensive use has led to widespread contamination in the environment. Recent data from National Health and Nutrition Examination Survey show that PFAS can be detected in approximately 95% of Americans, sparking increasing concern about their long-term health effects.
At the same time, alcohol consumption remains a significant global health issue. According to the World Health Organization, alcohol contributes to nearly 3 million deaths worldwide each year, and its consumption continues to rise globally. In the U.S. alone, excessive alcohol use is responsible for approximately 95,000 deaths annually, making it one of the leading causes of preventable death and a major contributor to liver disease.
“Given the increasing prevalence of alcohol consumption and the widespread presence of PFAS in the environment, many individuals who drink alcohol may be inevitably exposed to these persistent pollutants. This makes it critically important to study how combined exposures to alcohol and environmental chemicals like PFOS might influence liver health,” said Matthew Cave, UofL professor of medicine and publication co-author.
Although it is well known that both alcohol and PFOS cause liver damage individually, little has been understood about their combined effects until now. Recent studies have shown that only about 35% of heavy drinkers develop severe forms of liver disease, indicating that additional factors such as genetics, sex, microbiome and environmental exposures may contribute to individual susceptibility.
"This work helps explain why two people with similar alcohol consumption may experience very different liver outcomes," said Frederick Ekuban, assistant professor of medicine at UofL and first author of the study. "Environmental exposures like PFOS may be the missing link."
Using animal models, the researchers simulated real-world exposures to both alcohol and PFOS. The study showed that co-exposure to alcohol and PFOS significantly increased fat accumulation and markers of liver damage, as well as clear signs of disrupted metabolism and activation of genes and pathways predicted to be associated with oxidative stress and cancer development.
In short, the study demonstrates that PFOS exposure can significantly worsen liver damage when combined with alcohol consumption. While this research used high levels of alcohol to understand the underlying mechanisms, the findings reveal important biological pathways that warrant further investigation across different drinking patterns.
The research team also found that PFOS interferes with the liver's ability to manage fats, disrupts its natural protective and repair systems and activates pathways that promote liver injury.
“While the liver typically has a remarkable capacity to recover from alcohol-induced stress, PFOS appears to push that resilience beyond its limits, resulting in compounded and more severe damage,” said Jennifer Schlezinger professor of environmental health at Boston University and co-author of the publication.
Perhaps most concerning, the team discovered that 60% of all PFOS exposure ended up concentrated in the liver, exactly where alcohol damage occurs.
Ongoing research at UofL is examining how other PFAS compounds may interact with alcohol, whether males and females respond differently to these exposures and what the long-term consequences of combined exposures might be. The team is also exploring whether targeted therapies can be developed to prevent or mitigate this type of liver damage.
Although more studies are needed, people can take practical steps now to limit their exposure to PFAS. These include:
- Choose stainless steel or cast-iron cookware instead of non-stick pans
- Use water filters, especially in areas near industrial zones
- Avoid stain-resistant treatments on furniture and carpets
- Reduce consumption of packaged fast foods and microwave popcorn.
- Select household products with PFAS-free labels
Given that liver disease affects millions of Americans and is becoming more prevalent worldwide, the findings of this research support growing calls for stronger regulation and oversight of persistent chemical contaminants. By better understanding the hidden interactions between environmental toxicants and lifestyle behaviors, scientists and policymakers may be better equipped to prevent and treat liver disease.