COVID-19


Our Role

Over the course of the pandemic the Infectious Diseases Laboratory has adapted and grown to support the needs our community. In 2020, our biorepository expanded to include high quality human specimens and data support for investigator research in the development of novel diagnostic and therapeutics for COVID-19.

The COVID-19 Biorepository offers prospective and retrospective specimen selection from the bank of whole blood, serum, plasma, urine, sputum, bronchioalveolar, and tissue samples from subjects hospitalized and tested positive for COVID-19.


Projects and Publications

Research Projects

ProjectSample QuantitySample Type(s)
Surveillance with CPM (BR has only positive samples)893NP Swabs, Sputum
Norton HCW pilot85NP Swabs, Blood, plasma, serum, urine
Norton Healthcare patients (BR has only positive samples)406NP Swabs, Sputum
3D swab project44NP Swabs
COVID-19 retrospective waste specimen1182Whole blood/ plasma/ serum, urine, NP Swabs
UAD 2 (Positive COVID-19)91Urine
Prospective sample collection project (ACRC)51Urine, Sputum, Blood/ Plasma
Post COVID-19 Research Clinic (CRC)113Grey top plasma, purple top blood, Tiger top serum, and gold top serum

 

Sample Sharing

CollaboratorSample QuantitySample Type(s)Date Transferred
Dr. Gabino Fernandez Botran: UofL30PlasmaAugust 2020
Dr. Gabino Fernandez Botran: UofL40PlasmaAugust 2021
Dr. Gabino Fernandez Botran: UofL40PlasmaSeptember 2021
Dr. Colleen Jonsson: UT HSC Regional Biocontainment Lab45NP SwabsOctober 2020
Dr. Colleen Jonsson: UT HSC Regional Biocontainment Lab45NP SwabsSeptember 2020
Dr. Christina Kaufman: UofL21Whole Blood & PlasmaJune 2021
Dr. Haribabu Bodduluri60NP SwabsFebruary 2020
Dr. Haribabu Bodduluri60NP SwabsMarch 2021
Dr. Donghoon Chung45NP SwabsOctober 2020

 

Publications

January 2022
Impact of Pooling Samples on Analytic Sensitivity of a Real-Time Reverse Transcriptase PCR Assay for SARS CoV-2
Subathra Marimuthu, Stephen P Furmanek, Holly Aliesky, Leslie A Wolf

April 2021
Development of a real-time Reverse-Transcription PCR for SARS CoV-2 on the Luminex ARIES® Platform
Subathra Marimuthu, Holly Aliesky, Brigid Connelly, Danial Arsalan Malik, Leslie A Wolf

August 2021
Induction of interferon response by high viral loads at early stage infection may protect against severe outcomes in COVID-19 patients
Eric C. Rouchka, Julia H. Chariker, Brian Alejandro, Robert S. Adcock, Richa Singhal, Julio Ramirez, Kenneth E. Palmer, Amanda B. Lasnik, Ruth Carrico, Forest W. Arnold, Stephen Furmanek, Mei Zhang, Leslie A. Wolf, Sabine Waigel, Wolfgang Zacharias, Jose Bordon & Donghoon Chung

March 2020 - White Paper
Development and Evaluation of Two SARS-CoV-2 RT-PCR Laboratory Developed Tests on the ARIES® Automated, Sample-to-Answer, Real-Time PCR System
Arundhati Rao, DY Goldstein, Donna M. Wolk, Leslie A Wolf


Resources

January 2021: Lessons from the Frontlines: How a Louisville Lab Used the ARIES® System to Respond to the COVID‑19 Pandemic

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