Publications produced from University of Louisville work

Current MD/PhD Students and Recent Graduates

Kritika Bajaj, Sarah A. Andres, Dillon T. Hofsommer, Aidan F. Greene, Oleksandr Heitsoi, Mark S. Mashuta, Theresa Weis, Levi J. Beverly, Paula J. Bates, Robert M. Buchanan, Craig A. Grapperhaus. Physical structure of constitutional isomers influences antiproliferation activity of thiosemicarbazone-alkyl thiocarbamate copper complexes. Journal of Inorganic Biochemistry, 246 (2023). https://doi.org/10.1016/j.jinorgbio.2023.112288

Eric Engelbrecht, Oscar L. Rodriguez, Kaitlyn Shields, Steven Schultze, David Tieri, Uddalok Jana, Gur Yaari, William D. Lees, Melissa L. Smith & Corey T. Watson: Resolving haplotype variation and complex genetic architecture in the human immunoglobulin kappa chain locus in individuals of diverse ancestry. doi:10.1038/s41435-024-00279-2

Brown TC, Crouse EC, Attaway CA, Oakes DK, Minton SW, Borghuis BG , McGee AW. Microglia are dispensable for experience-dependent refinement of visual circuitry. bioRxiv.  2023 Oct 17:2023.10.17.562708. Preprint. doi:10.1101/2023.10.17.562708

Gao Y, Wei GZ, Forston MD, Rood B, Hodges ER, Burke D, Addres K, Morehouse J, Armstrong Cm Glover C, Slomnicki LP, Ding J, Chariker JH, Rouchka EC, Saraswat Ohri S, Whittemore SR, Heman M. Opposite modulation of functional recovery following contusive spinal cord injury in mice with oligodendrocyte-selective deletions of Atf4 and Chop/Ddit3. Sci Rep. 2023 Jun 6;13(1):9193. doi: 10.1038/s41598-023-36258-2.

Keith Rj, Hom RH, Amraotkar AR, Bezold MM, Brick JM, Bushau-Sprinkle AM, Hamorsky KT, Kitterman KT, Palmer KE, Smith T, Yeager R, Bhatnagar A. Stratified Simple Random Sampling Versus Volunteer Community-Wide Sampling for Estimates of COVID-19 Prevalence. Am J Public Health. 2023 Jul;113(7). Epub 2023 May 18. doi: 10.2105/AJPH.2023.307303

Wang Y, Geller AE, Yan J. Spatial TIME landscape and its prognostic value in the lung and brain tumor: location matters. Signal Transduct Target Ther. 2023 May 8;8(1):192. doi: 10.1038/s41392-023-01473-w.

Woeste MR, Shrestha R, Geller AE, Li S, Montoya-Durango D, Ding C, Hu X, Li H, Puckett A, Mitchell  RA, Hayat T, Tan M, Li Y, McMasters KM , Martin RCG, Yan J. Irreversible electroporation augments beta-glucan induced trained innate immunity for the treatment of pancreatic ductal adenocarcinoma. J ImmunotherCancer. 2023 Apr;11(4):e006221.  doi: 10.1136/jitc-2022-006221

Ford EE, Tieri D, Rodriguez OL, Fancoeur NJ, Sota J, Kos JT, Peres A, Gibson WS, Silver CA, Deikus G, Hudson E, Woolley CR, Beckmann N, Charney A, Mitchell TC, Yaari G, Sebra RP, Watson CT, Smith ML. FLAIRR-Seq: A Method for Single-Molecule Resolution of Near Full-Length Antibody H Chain Repertoires. J Immunol.. 2023 May 15;210(10):1607-1619. doi: 10.4049/jimmunol.2200825.

Noe JT, Ding C, Geller AE, Rendon BE, Yan J, Mitchell RA. A Tumor-admixture Model to Interrogate Immune Cell-dependent Tumorigenesis. Bio Protoc. 2023 Mar 5;13(5):e4630. eCollection 2023 Mar 5. doi: 10.21769/BioProtoc.4630

Engelbrecht E, Kooistra T, Knipe RS. The Vasculature in Pulmonary Fibrosis. Cur Tissue Microenviron Rep. 2022 Dec;3(4):83-97. Epub 2022 Jul 13. doi:10.1007/s43152-022-00040-9. (Available 2023-12-01)

Ding C, Shrestha R, Zhu X, Geller AE, Wu S, Woeste MR, Li W, Wang H, Yuan F, Xu R, Chariker JH, Hu X, Li H, Tieri D, Zhang HG , Rouchka EC, Mitchell R, Siskind LJ, Zhang X, Xu XG, McMasters KM, Yu Y, Yan J. Inducing trained immunity in pro-metastatic macrophages to control tumor metastasis. Nat Immunol. 2023 Feb;24(2):239-254. Epub 2023 Jan 5. doi: 10.1038/s41590-022-01288-8

Whittemore SR, Saraswat Ohri S, Forston MD, Wei GZ, Heman M. The Proteostasis Network: A Global Therapeutic Target for Neuroprotection after Spinal Cord Injury. Cells. 2022 Oct 22;11(21):3339. doi: 10.3390/cells11213339

Wang Y, Geller AE, Yan J. Unexpected Breg-NK crosstalk in STING agonist therapy. Cell Mol Immunol. 2022 Dec;19(12):1330-1332. Epub 2022 Nov 10.    doi:1038/s41423-022-00952-4

Woolley CR, Chariker JH, Rouchka EC, Ford EE, Hudson EA, Waigel SJ, Smith ML, Mitchell TC. Reference long-read isoform-aware transcriptomes of 4 human peripheral blood lumphocyte subsets. G3 (Bethesda). 2022 Nov 4:12(11):jkac253. doi: 10.1093/g3journa/jkac253.

Rowe G, Heng DS, Beare JE, Hodges NA, Tracy EP, Murfee WL, Le Blan AJ. Enhanced beta-1 adrenergic receptor responsiveness in coronary arterioles following intravenous stromal vascular fraction therapy in aged rats. J Vasc Res. 2022;59(6):343-357. Epub 2022 Sep 8. doi: 10.1159/000526002.

Tracy EP, Nair R, Roe G, Beare JE, Beyer A, LeBlanc AJ. Adipose Stromal Vascular Fraction Reverses Mitochondrial Dysfunction and Hyperfission in Aging-Induced Coronary Microvascular Disease. Am J Physiol Heart Circ Physiol. 2022 Aug 26. doi:10.1152/ajpheart.00311.2022.

Tracy EP, Dukes M, Rowe G, Beare JE, Nair R, LeBlanc AJ. Stromal Vascular Fraction Restores Vasodilatory Function by Reducing Oxidative Stress in Aging-Induced Coronary Microvascular Disease. Antioxid Redox Signal. 2022 Aug 11. Epub 2022 Jul 13. doi: 10.1089/ars.2021.0249

Engelbrecht E, Metzler MA, Sandell LL. Retinoid signaling regulates angiogenesis and blood-retinal barrier integrity in neonatal mouse retina. Microcirculation. 2022 Apr; 29(3):e12752. doi 10.1111/micc.12752. Epub 2022 Mar 5.

Tracy EP, Stielberg V, Rowe G, Benson D, Nunes SS, Hoying JB, Murfee WL, LeBlanc AJ. State of the field: cellular and exosomal therapeutic approaches in vascular regeneration. Am J Physiol Heart Circ Physiol. 2022 Apr 1: 322(4): H647-H680. doi 10.1152/ajpheart.00674.2021. Epub 2022 Feb 18.

Geller AE, Shrestha R, Woeste MR, Guo H, Hu X, Ding C, Andreeva K, Chariker JH, Zhou M, Tieri D, Watson CT, Mitchell RA, Zhang HG, Li Y, Martin RCG, Rouchka EC, Yan J. The induction of peripheral trained immunity in the pancreas incites anti-tumor activity to control pancreatic cancer progression Nat Commun. 2022 Feb 9;13(1):759. doi: 10.1038/s41467-022-28407-4

Knipe RS, Spinney JJ, Abe EA, Probst CK, Franklin A, Logue A, Giacona F, Drummond M, Griffith J, Brazee PL, Hariri LP, Montesi SB, Black KE, Hla T, Kuo A, Cartier A, Engelbrecht E, Christoffersen C, Shea BS, Tager AM, Medoff BD. Am J Respir Cell Mol Biol. 2022 Jan:66(1):38-52. doi: 10.1165/rcmb.2020-0408OC.

Rowe G, Tracy E, Beare JE, LeBlanc AJ. Cell Therapy rescues aging-induced beta-1 adrenergic receptor and GRK2 dysfunction in the coronary microcirculation. Geroscience. 2022 Feb; 44(1):329-348. doi: 10.1007/s11357-021-00455-6. Epub 2021 Oct 4.

Woolley CR, Brinkman NC, Cash ED, Chandran SK, Mitchell TC. An Unexpected Role for Cell Density Rather than IgM in Cell-Surface Display of the Fc Receptor for IgM in Cell-Surface Display of the Fc Receptor for IgM on Human Lymphocytes. Immunohorizons. 2022 Jan 18: 6(1):47-63. doi: 10.4049/immunohorizons.2100094.

Slomnicki LP, Wei G, Burke DA, Hodges ER, Myers SA, Yarberry CD, Morehouse JR, Whittemore SR, Saraswat Ohri S, Hetman M. Limited Changes in locomotor recovery and unaffected white matter sparing after spinal cord contusion at different times of day. PLoS One. 2021 Nov 23; 16(11):e0249981. doi:10.137/journal.pone.0249981. eCollection 2021.

Noe JT, Rendon BE, Geller AE, Conroy LR, Morrissey SM, Young LEA, Buntz RC, Kim EJ, Wise-Mitchell A, Barbosa deSouza Rizzo M, Relich ER, Baby BV, Johnson LA,Affronti HC, McMaster KM,Clem BF, Gentry MS, Yan J, Wellen KE, Sun RC, Mitcehll RA. Lactate supports a metabolic-epigenetic link in macrophage polarization. Sci Adv. 2021 Nov 12; 7(46):eabi8602. doi 10.1126/sciadv.abi8602. Epub 2021 Nov 12

Morrissey SM, Zhang F, Ding C, Montoya-Durango DE, Hu X, Yang C, Wang Z, Yuan F, Fox M, Zhang HG, Guo H, Tieri D, Kong M, Watson CT, Mitchell RA, Zhang X, McMasters KM, Huang J, Yan J. Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic nich through glycolytic dominant metabolic reprogramming. Cell Matab. 2021 Oct 5; 33(10):2040-2058.e10. doi: 10.1016/j.cmet.2021.09.002. Epub 2021 Sep 23.

Tracy EP, Hushes W, Beare JE, Rowe G, Beyer A, LeBlanc AJ. Aging-Induced Impairment of Vascular Function: Mitochondrial Redox Contributions and Physiological/Clinical Implications. Antioxid Redox Signal. 2021 Oct 20; 35(12):974-1015. doi:10.1089/ars.2021.0031. Epub 2021 Sep 17.

Donninger H, Harrell-Stewart D, Clark GJ. Detection of Endogenous RASSF1A Interacting Proteins. Methods Mol Biol. 2021; 2262:303-310. doi: 10.1007/978-1-0716-1190-6_18.

Morrissey SM, Geller AE, Hu X, Tieri D, Ding C, Klaes CK, Cooke EA, Woeste MR, Martin ZC, Chen  O, Bush SE, Zhang HG, Cavallazzi R, Clifford SP, Chen J, Ghare S, Barve SS, Cai L, Kong M, Rouchka EC, McLeish KR, Uriarte SM, Watson CT, Huang J, Yan J. A specific low-density neutrophil population correlates with hypercoagulation and disease severity in hospitalized COVID-19 patients. JCI Insight. 2021 May 10;6(9):e 148435. doi: 10.1172/jci.insight.148435 

Wei GZ, Saraswat OS, Khattar NK, Listerman AW, Doyle CH, Andres KR, Karuppagounder SS, Ratan RR, Whittemore SR, Hetman M. Hypoxia-inducible factor prolyl hydroxylase domain (PHD) inhibition after contusive spinal cord injury does not improve locomotor recovery. PLoS One. 2021 Apr 5;16(4):e0249591. doi: 10.1371/journal.pone.0249591. Collection 2021.

Cash E, Sephton S, Woolley C, Elbehi AM, RIA, Ekine-Afolabi B, Kok VC. The role of circadian clock in cancer hallmark acquisition and immune-based cancer therapeutics. J Exp Clin Cancer Res. 2021 Apr 1;40(1):119. doi: 10.1186/s13046-021-01919-5.

Woeste MR, Geller AE, Martin RCG 2nd, Polk HC Jr. Optimizing the Combination of Immunotherapy and Trans-Arterial Locoregional Therapy for Stages B and C Hepatocellular Cancer. Ann Surg Oncol. 2021 Mar;28(3):1499-1510. doi: 10.1245/s10434-020-09414-5. Epub 2021 Jan 3.

Noe JT, Mitchell RA. MIF-Dependent Control of Tumor Immunity. Front Immunol. 2020 Nov 25;11:609948. doi: 10.3389/fimmu.2020.609948. eCollection 2020.

Govindaiah G, Campbell PW, Guido W. Differential Distribution of Ca2+ Channel Subtypes at Retinofugal Synapses. eNeuro. 2020 Nov 5; 7(6):ENEURO.0293-20.2020 doi:10.1523/ENEURO.0293-20.2020 Print 2020 Nov/Dec.

Tracy EP, Gettler BC, Zakhari JS, Schwartz RJ , Williams SK, Birla RK. 3D Bioprinting the Cardiac Purkinje System Using Human Adipogenic Mesenchymal Stem Cell Derived Purkinje Cells. Cardiovasc Eng Technol. 2020 Oct;11(5):587-604. doi: 10.1007/s13239-020-00478-8. Epub 2020 Jul 24.

Bridgwater C, Geller A, Hu X, Burlison JA, Zhang HG, Yan J, Guo H. ⁸⁹Zr-Labeled Anti-PD-L1 Antibody Fragment for Evaluating In Vivo PD-L1 Levels in Melanoma Mouse Model. Cancer Biother Radiopharm. 2020 Oct;35(8):549-557. doi: 10.1089/cbr.2019.3056. Epub 2020 Apr 21.

Campbell PW, Govindaiah G, Masterson SP, Bickford ME, Guido W. Synaptic properties of the feedback connections from the thalamic reticular nucleus to the dorsal lateral geniculate nucleus. J Neurophysiol. 2020 Aug 1: 124(2):404-417. doi: 10.1152/jn.00757.2019. Epub 2020 Jul 1.

Geller A., Yan J. Could the Induction of Trained Immunity by Beta-Glucan Serve as a Defense Against COVID-19? Front Immunol. 2020 Jul 14;11:1782. doi: 10.3389/fimmu.2020.01782. eCollection 2020

Morrissey SM, Yan J. Exosomal PD-L1: Roles in Tumor Progression and Immunotherapy. Trends Cancer. 2020 Jul;6(7):550-558.                                                doi: 10.1016/j.trecan.2020.03.002 Epub 2020 Mar 29.

Tracy E, Rowe G, LeBlanc AJ. "Cardiac tissue remodeling in health aging: the road to pathology." Am J Physiol Cell Physiol. 2020 Jul 1;319(1):C166-C182.            doi: 10.1152/ajpcell.00021.2020. Epub 2020 May 20.

Woeste MR, Bhutiani N, Geller AE, Eldridge-Hindy H, McMasters KM, Ajkay N. "Identifying Factors Predicting Prolonged Opioid Use After Mastectomy." Ann Surg Oncol. 2020 Apr;27(4):993-1001. doi: 10.1245/s10434-019-08171-4. Epub 2020 Jan 21.

Harrell Stewart DR, Clark Gj. Pumping the brakes on RAS - negative regulators and death effectors of RAS. J Cell Sci. 2020 Feb 10; 133(3)jcs238865.                doi: 10.1242/jcs.238865.

Chen X, Morrissey S, Chen F, Yan J. "Novel Insight into the Molecular and Metabolic Mechanisms Orchestrating IL-17 Production in yS T Cells." Front Immunol. 2019 Dec 3;10:2828. doi: 10.3389/fimmu.2019.02828 eCollection 2019.

SenGupta S, Rane MJ, Uriarte SM, Woolley C, Mitchell TC. "Human neutrophils depend on extrinsic factors produced by monocytes for their survival response to TLR4 stimulation." Innate Immun. 2019 Nov;25(8)473-486. doi: 10.1177/1753425919871994. Epub 2019 Sep 3.

Noe JT, Mitchell RA. "Tricarboxylic acid cycle metabolites in the control of macrophage activation and effector phenotypes." J Leukoc Biol. 2019 Aug;106(2):359-367. doi: 10.1002/JLB.3RU1218-496R. Epub 2019 Feb 15.

Geller A, Shrestha R, Yan J. "Yeast-Derived Betta-Glucan in Cancer: Novel Uses of a Traditional Therapeutic." Int J Mol Sci. 2019 Jul 24;20(15):3618.                doi: 10.3390/ijms20153618.

Rowe G, Kelm NQ, Beare JE, Tracy E, Yuan F, LeBlanc AJ. "Enhanced beta-1 adrenergic receptor responsiveness in coronary arterioles following intravenous stromal vascular fraction therapy in aged rats." Aging (Albany NY). 2019 Jul 11;11(13):4561-4578. doi: 10.18632/aging.102069.

Geller, A, Yan J. "The Role of Membrane Bound Complement Regulatory Proteins in Tumor Development and Cancer Immunotherapy." Front Immunol. 2019 May 21:10:1074. doi: 10.3389/fimmu.2019.01074. eCollection 2019

Charalambakis NE, Govindaiah G, Campbell PW, Guido W. Developmental Remodeling of Thalamic Interneurons Requires Retinal Signaling. J Neurosci. 2019 May 15; 39(20):3856-3866. doi: 10.1523/JNEUOSCI.2224-18.2019. Epub 2019 Mar 6.

Harrell Stewart D, Hobbing K, Schmidt ML, Donninger H, Clark GJ. The role of RASSF proteins in modulating RAS driven lung tumors in vivo. J. Thorac Dis. 2019 May; 11(Suppl 9):S1436-S1437. doi: 10.21037/jtd.2019.03.60.

Sokhadze G, Campbell PW, Guido W. Postnatal development of cholinergic input to the thalamic reticular nucleus of the mouse. Eur J Neurosci. 2019 Apr; 49(8):978-989. doi:10.1111/ejn.13942. Epub 2018 Jul 21.

Dwenger M, Kowalski WJ, Ye F, Yuan F, Tinney JP, Setozaki S, Nakane T, Masumoto H, Campbell P, Guido W, Keller BB. Chronic optical pacing conditioning of H-iPSC engineered cardiac tissues. J Tissue Eng. 2019 Apr 17; 10:2041731419841748. doi: 10.1177.2041731419841748. ecollection 2019 Jan-Dec.