Directory Entry For: Pawel Lorkiewicz

Biography

Helping other scientists solve problems by applying my skills and knowledge in mass spectrometry.
Keywords: Mass Spectrometry, LC-MS, Exposomics, Phase II metabolites, Stable Isotope Resolved Metabolomics, Biomarkers of Exposure, Xenobiotics, VOCs, Metabolites, Metabolite Profiling, Core Laboratory 

I am:
- an Associate Professor of (Analytical) Chemistry at the University of Louisville
- a Bionalytical Core Director & faculty at the Christina Lee Brown Envirome Institute
- a part of the Superfund Center at UofL (Met-Tox Core)
- a point person for the bioanalytical needs of UofL researchers.
- passionate about mass spectrometry-based methods for detecting small molecules
About me:
- For almost two decades I have worked with LC-MS, GC-MS, MALDI-MS, NanoESI-MS, ICRs, Orbitraps, QTOFs, QQQs etc.
- I have received S10 funding (shared instrumentation grants) for two LC-MS systems.
- I have purchased or influenced several LC-MS system purchases.
- In addition to directing a Core facility, I oversee a mass spectrometry lab with project-specific equipment (fully utilized, not shared)
- I am a Service track faculty. I help with analyses for large human cohort studies and animal studies. I am part of many projects and I know what over 20 PIs are working on (I take an active part in experimental design and proposal writing).
- I was a Guest Editor for 2 Special Issues of Metabolites (Stable Isotope Guided Metabolomics I and II)
- I have authored and co-authored over 50 peer-reviewed publications

Research Interests

Research Interests and Expertise:
- Phase II Metabolomics: Developed a comprehensive LC-MS-based platform for Phase II metabolomics, focusing on metabolites historically excluded from exposome-wide analyses. These metabolites serve as ideal markers for individual exposure to VOCs, xenobiotics, and endogenous metabolic products.
- Integrated Library-Guided Analysis: Our analytical approach for profiling Phase II metabolites.
- I have unique expertise in Stable Isotope Resolved Metabolomics (SIRM) - I have developed several workflows for analysis of labeled MS datasets.
- I also specialize in the analysis and discovery of biomarkers of exposure (to tobacco products, xenobiotics, and other environmental chemicals)
- I develop untargeted, targeted, and pseudo-targeted exposomics methods
- I leverage MS Excel, PowerQuery, and Pivot Tables to analyze and process complex data. And yes, I consider this an advanced skill.

Degrees and Certifications

Publications

All Scholarly and Creative Works