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Portrait of Matthew Cave

Directory Entry For: Matthew Cave

Professor
HSC - Medicine Department - Liver Research
matt.cave@louisville.edu
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Academic Profile

Biography

Dr. Cave is Professor of Medicine, Distinguished University Scholar, and Vice Chair for Research in the Department of Medicine at the University of Louisville; and Staff Physician at the Robley Rex Veterans Affairs Medical Center (VAMC). He is a triple-boarded physician-scientist (Internal Medicine, Gastroenterology, and Transplant Hepatology) in the Division of Gastroenterology, Hepatology and Nutrition. Dr. Cave sees patients at and the UofL Health Outpatient Center, the Trager Transplant Center, and the VAMC. Dr. Cave has secondary appointments in UofL’s Departments of Biochemistry and Molecular Genetics, and Pharmacology and Toxicology.

Dr. Cave holds a prestigious R35 Merit Award on environmental liver disease, and he was ranked among the top 2% of most-cited researchers in his discipline worldwide according to a recent report from Stanford University/Elsevier. He is Deputy Director of the UofL Center for Integrative Environmental Health Sciences, UofL’s NIEHS-funded P30 environmental health science core center, and a co-investigator on numerous other program projects related to liver disease, environmental health, and clinical and translational research including clinical trials.

Dr. Cave has published over 110 peer-reviewed manuscripts and mast of these related to occupational and environmental liver diseases. His most important scientific accomplishment was the discovery of the new liver disease, ‘toxicant associated steatohepatitis’ (TASH) in highly exposed vinyl chloride workers from Louisville’s Rubbertown chemical manufacturing complex. Subsequently, the Cave laboratory spearheaded translational research in environmental hepatology through team science approaches with the support of major awards through the NIEHS (e.g., R35 RIVER and R01 ViCTER programs), Department of Defense, and others.

Research Interests

• Liver Disease

• Occupational and Environmental Health

• Military and Veterans Health

• Clinical Trials

• Nutrition

Degrees and Certifications

B.A., Biochemistry: B.S Chemical Engineering
Rice University, 1992-1997
M.D., with High Distinction
University of Kentucky College of Medicine, 1997-2001
Categorical Internal Medicine Internship and Residency
Washington University in St. Louis School of Medicine, 2001-2004
Gastroenterology and Hepatology Fellowship
University of Louisville, 2004-2007