Members of the University of Louisville Division of Gastroenterology, Hepatology & Nutrition and their collaborators presented the following abstracts at the 38th annual Research Society on Alcoholism Scientific Meeting held June 20-24, 2015:

• PDE4B Inhibition Significantly Attenuates Alcohol-Induced Hepatic Lipid Peroxidation and Prevent Inactivation of AmpK - Diana Avila

• Oral Administration of Tributyrin Targets The "Gut-Liver" Axis and Attenuates Alcoholic Liver Disease (ALD) - Shirish Barve, Hridgandh Donde

• Embryonic Exposure to Ethanol Increases The Susceptibility of Larval Zebrafish to Chemically Induced Seizures - Shao-Yu Chen, Keling Wang

• Sulforaphane Protects Against Ethanol-Induced Apoptosis in Neural Crest Cells by Epigenetic Modulation of BCL2 Gene Expression - Shao-Yu Chen, Xiaopan Chen

• Up-Regulation of Siah1 by Ethanol Triggers Apoptosis in Neural Crest Cells Through P38 MapK-Mediated Activation of P53 Signaling Pathway - Shao-Yu Chen, Fuqiang Yuan

• Lipid-Derived Aldehyde, Acrolein, is a Critical Mediator of Alcohol-Induced Gut-Liver Injury in Alcoholic Liver Disease - Wei-Yang Chen, Swati Joshi-Barve

• FGF21 Mediates Alcohol-Induced Adipose Tissue Lipolysis by Activation of Systemic Release of Catecholamine in Mice - Wenke Feng

• Ethanol Inhibits Transcriptionally Permissive Promoter Histone Modifications and Decreases Il-2 Expression in Activated Human CD4+ T Lymphocytes

• Alcohol-Induced Neuro-Inflammation is Critically Regulated by Phosphodiesterase 4B (PDE4B) - Leila Gobejishvili

• Lipoxygenase Inhibition Ameliorates Alcohol-Induced Liver Injury and Inflammation in a Mouse Model of Alcoholic Liver Disease - Huillin Liu, Irina A Kirpich

• Improvement of Inflammatory Biomarkers, Liver Fibrosis & Clinical Parameters With 3 Months Zinc Sulfate For Alcoholic Cirrhosis-Zac Clinical Trial - Mohammad Mohammad

• Role of Drinking History and Sex-Differences in Metabolites Involved in Inflammation in Alcohol Dependents - Vatsalya Vatsalya

• Role of Family History of Alcoholism and Recent Drinking on Subjective & Objective Responses to Acute IV Alcohol: Clamp and Biphasic Exposure Profiles - Vatsalya Vatsalya

• Association of Liver Injury Exacerbation and Fatty Acids of W-6 and W-3 Inflammatory Pathways in Early-Stage HIV-Diagnosed Alcoholic Patients - Vatsalya Vatsalya

• Mixed Lineage Protein Kinase 3 Contributes to Ethanol-Induced Liver Injury - Sanjoy Roychowdhury, Megan R. McMullen, Laura E. Nagy

• Specific-Sized Hyaluronan Fragments Differentially Regulate LPS Signal Transduction in Kupffer Cells After Ethanol Feeding to Rats - Paramananda Saikia, Katherine A. Pollard, Megan R. McMullen, Laura E. Nagy

• Factor D Contributes to Hepatoprotection from Chronic Ethanol-Induced Liver Injury in Mice - R.L. Smathers McCullough, S. Roychowdhury, M.R. McMullen, Laura E. Nagy