Zhong-bin Deng, Ph.D.

Education:

 B.S., Yangzhou University, Yangzhou, PR.China, Veterinary Medicine, 1994
M.S., Yangzhou University, Yangzhou, PR.China, Veterinary Medicine, 1997
Ph.D., Soochow University, Suzhou, PR.China, Immunology, 2003
Postdoctoral Fellowship, University of Alabama at Birmingham, 2007
Instructor, Department of Medicine, School of Medicine, University of Louisville, Louisville, KY, 2010

Curriculum Vitae

Current Positions:

Assistant Professor, Department of Medicine, School of Medicine, University of Louisville, Louisville, KY
Member, James Graham Brown Cancer Center, Louisville, KY

Contact Information:

Clinical Translational Research Building, Room 311
University of Louisville
505 South Hancock St
Louisville, KY 40202, USA
Phone 502-852-8621
Fax 502-852-2123

Email: z0deng01@louisville.edu

Research Description:

My research interest is in understanding the regulation of gut immune cells and microbiota in colitis and its related cancer development, especially colon cancer. IBD is strongly associated with inflammation accompanied by increased infiltration of leukocytes. We are investigating the mechanisms involved in maintaining balance between the good vs bad inflammatory conditions in gut. The complex nature of the human gut microbiota and its relevance to human health and disease is at a very early stage of investigation. It is becoming very clear that changes in the environment, diet and genetic factors greatly influence human microbiota contributing to the modulation of disease progression. Our research also focuses on the role that diet and nutrition play in the prevention and treatment of various cancers such as liver cancer and colon cancer. We put an emphasis on investigating the mechanisms of action of active dietary and nutritional nanoparticles. Our lab uses clinically relevant animal models and an integrated research system to identify effective dietary and nutritional nanoparticles for cancer prevention in vitro and in vivo, evaluate the efficacies of dietary and nutritional regimens, elucidate underlying cellular, molecular, and epigenetic mechanisms of action, identify novel anti-cancer components, and define risk factors of cancer development. We utilize several genetically altered transgenic/compound (knockout/conditional expression of interested genes) pre-clinical mouse models, cellular and molecular models and next generation sequencing methods to understand the IBD and colon cancer progression.

Representative Publications:

Myeloid cells in tumor

  1. Sun R, Gu X, Chen L, Lei C, Chu S, Xu G, Doll M, Feng W, Siskind L, McClain CJ, Deng Z. Neutral ceramidase-dependent regulation of macrophage metabolism directs intestinal immune homeostasis and controls enteric infection. Cell Reports 2022. March 29; 38 (13).
  2. Sun R, Lei C, Chen L, He L, Guo H, Zhang X, Feng W, Yan J, McClain CJ, Deng Z. Alcohol-driven metabolic reprogramming promotes development of RORγt-deficient thymic lymphoma. Oncogene 2022 Mar 4. Online ahead of print. PMID: 35246617
  3. Deng Z*, Rong Y, Teng Y, Zhuang X, Samykutty A , Mu J, Zhang L, Cao P, Yan J, Miller D, Zhang HG.  Exosomes miR-126a released from MDSCs induced by DOX treatment promotes lung metastasis.  Oncogene 2017 Feb 2;36(5):639-51. PMID: 27345402.(*: Corresponding author).
  4. Deng Z*,  Mu J, Tseng M, Wattenberg B, Zhuang X, Egilmez NK , Wang Q, Zhang L, Norris J, Guo H, Yan J , Bodduluri H, Miller D, Zhang HG*. Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis.  Nature Communications 2015 Apr 24;6:6928.PMID: 25907800.PMCID: PMC4410277.(*: Corresponding author).
  5. DengZ, Cheng Z, Xiang X, Yan J, Zhuang X, Liu C, Jiang H, Ju S, Zhang L, Grizzle W, Mobley J, Roman J, Miller D, Zhang HG.  Tumor cell cross talk with tumor-associated leukocytes leads to induction of tumor exosomal fibronectin and promotes tumor progression.  American Journal of Pathology 2012 Jan;180(1):390-8. PMID: 22067905.
  6. DengZ*, Pardi R, Cheadle W, Xiang X, Grizzle W, Miller D, Mountz J, Zhang HG*.  Plant homologue constitutive photomorphogenesis 9 (COP9) signalosome subunit CSN5 regulates innate immune responses in macrophages. Blood 2011 May 5;117(18):4796-804. PMID: 21403132.  (*: Corresponding author).
  7. Teng Y, Ren Y, Xu X, Mu J, Samykutty A, Zhuang X, Deng Z, Zhang L, Merchant M, Yan J, Miller D,  Kumar A, Zhang HG.  Major vault protein (MVP) dependent sorting tumor suppressor miR-193a into tumor exosomes promotes colon cancer progression.  Nature Communications 2017 Feb 17;8:14448. PMID: 28211508.
  8. Wang Q, Ren Y, Mu J, Egilmez NK, Zhuang X, Deng Z, Zhang L, Yan J, Miller D, Zhang HG. Grapefruit-derived nanovectors use an activated leukocyte trafficking pathway to deliver therapeutic agents to inflammatory tumor sites.  Cancer Research 2015 Apr 16;75(12):2520-9. [Epub ahead of print]. PMID: 25883092.

Gut-liver Axis

  1. Gu X, Sun R, Chen L, Chu S, Liu M, Doll M, Li X, Feng W, Siskind L, McClain CJ, Deng Z. Neutral ceramidase mediates nonalcoholic steatohepatitis by regulating monounsaturated fatty acids and gut IgA+ B cells. Hepatology. 2021 Mar;73(3):901-919. PMID: 33185911.
  2. Chu S, Sun R, Gu X, Chen L, Liu M, Guo H, Ju S, Vatsalya V, Feng W, McClain CJ, Deng Z. Inhibition of sphingosine-1-phosphate-induced Th17 cells ameliorates alcoholic steatohepatitis in mice. Hepatology. 2020 May 17. doi: 10.1002/hep.31321. Online ahead of print. PMID: 32418220.
  3. Zhuang X, Deng ZB, Mu J, Zhang L, Yan J, Miller D, Feng W, McClain CJ, Zhang HG.  Ginger-derived nanoparticles protect against alcohol-induced liver damage.  J Extracell Vesicles 2015 Nov 25;4:28713. doi: 10.3402/jev.v4.28713. eCollection 2015. PMID: 26610593.
  4. DengZB*, Zhuang X, Ju S, Xiang X, Mu J, Wang Q, Hong J, Zhang L, Kronenberg M, Yan J, Miller D, Zhang HG*.  Intestinal mucus-derived nanoparticles mediate activation of Wnt/β-catenin signaling plays a role in induction of liver NKT cell anergy in mice.  Hepatology 2013 Mar;57(3):1250-61. PMID: 22991247PMCID: PMC4414328.(*: Corresponding author).
  5. DengZB*, Zhuang X, Ju S, Xiang X, Mu J, Liu Y, Jiang H, Zhang L, Mobley J, McClain C, Feng W, Grizzle W, Yan J, Miller D, Kronenberg M, Zhang HG*.  Exosome-like nanoparticles from intestinal mucosal cells carry prostaglandin E2 and suppress activation of liver NKT cells.  J Immunol 2013 Apr 1;190(7):3579-89. PMID: 23467936. PMCID: PMC4396634. (*: Corresponding author).
  6. DengZB, Poliakov A, Hardy RW, Clements R, Liu C, Liu Y, Wang J, Xiang X, Zhang S, Zhuang X, Shah SV, Sun D, Michalek S, Grizzle WE, Garvey T, Mobley J, Zhang HG.  Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin PMC2768161. resistance.  Diabetes 2009 Nov;58(11):2498-505. PMID: 19675137.
  7. DengZB, Liu Y, Liu C, Xiang X, Wang J, Cheng Z, Shah SV, Zhang S, Zhang L, Zhuang X, Michalek S, Grizzle WE, Zhang HG.  Immature myeloid cells induced by a high fat diet contribute to liver inflammation.  Hepatology, 2009 Nov; 50(5):1412-20. PMID: 19708080.PMCID: PMC2852608.

Exosomal miRNA and Delivery 

  1. Sriwastva M#, Deng Z#, Wang B, Teng Y, Kumar A, Sundaram K, Mu J, Lei C, Dryden GW, Xu F, Zhang L, Yan J, Zhang X, Park JW, Merchant M, Egilmez NK, Zhang HG. Mulberry exosomes-like nanoparticles prevent DSS-induced colitis via AhR/COPS8 signalling pathway. EMBO Reports. 2022 Jan 7: e53365. Online ahead of print. PMID: 34994476. #: Co-First Author.
  2. Deng Z, Rong Y, Teng Y, Mu J, Zhuang X,Tseng M, Samykutty A, Zhang L, Yan J, Miller D, Suttles J,and Zhang HG.  Broccoli-derived nanoparticle inhibits mouse colitis by activating dendritic cell AMP-activated protein kinase.  Molecular Therapy2017 Jul 5;25(7):1641-1654. PMID:28274798.
  3. Zhuang X, Teng Y, Samykutty A, Mu J, Deng Z, Zhang L, Cao P, Rong Y, Yan J, Miller D, Zhang HG.  Grapefruit-derived nanovectors delivering therapeutic miR17 through an Intranasal route inhibit brain tumor progression.  Molecular Therapy 2016 Feb;24(1):96-105. doi: 10.1038/mt.2015.188. [Epub 2015 Oct 7] PMID: 26444082. PMCID: PMC4754550
  4. Teng Y, Mu J, Hu X, Samykutty A, Zhuang X, Deng Z, Zhang L, Cao P, Yan J, Miller D, Zhang HG. Grapefruit-derived nanovectors deliver miR-18a for treatment of liver metastasis of colon cancer by induction of M1 macrophages.  Oncotarget 2016 May 3;7(18):25683-97. doi: 10.18632/oncotarget.8361. [Epub 2016 Mar 25] PMID: 27028860. PMCID:  PMC5041936.
  5. Wang B, Zhuang X, DengZB, Jiang H, Mu J, Wang Q, Xiang X, Guo H, Zhang L, Dryden G, Yan J, Miller D, Zhang HG. Targeted drug delivery to intestinal macrophages by bioactive nanovesicles released from grapefruit. Molecular Therapy 2014 Mar; 22(3):522-34. PMID: 23939022. PMCID: PMC3944329
  6. Jiang H, Wang P, Li X, Wang Q, Deng ZB, Zhuang X, Mu J, Zhang L, Wang B, Yan J, Miller D, Zhang HG.  Restoration of miR17/20a in solid tumor cells enhances the natural killer cell antitumor activity by targeting Mekk2.  Cancer Immunol Res 2014 Aug; 2(8):789-99. PMID: 24801835. PMCID: PMC4396632.
  7. Wang Q, Zhuang X, Mu J, DengZB, Jiang H, Xiang X, Wang B, Yan J, Miller D, Zhang HG.  Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids.  Nature Communications 2013;4:1867. PMID: 23695661. PMCID: PMC4396627.
  8. Ju S, Mu J, Dokland T, Zhuang X, Wang Q, Jiang H, Xiang X, Deng ZB, Wang B, Zhang L, Roth M, Welti R, Mobley J, Jun Y, Miller D, Zhang HG. Grape exosome-like nanoparticles induce intestinal stem cells and protect mice from DSS-induced colitis.  Molecular Therapy 2013 Jul;21(7):1345-57. PMID: 23752315. PMCID: PMC3702113.

PubMed Information