Israel D. Sithu, Ph.D.

Physiology Faculty

Israel D. Sithu, Ph.D.
israel.sithu@louisville.edu
Assistant Professor (term)
University of Lucknow, India, 1999

Research Interest:

The main goal of my research was to elucidate the molecular mechanisms underlying inflammatory diseases with the aim of impeding disease advancement. Over the past several years, my research scope has expanded to include study of environmental pollutants and their roles in endothelial dysfunction, cardiovascular injury, and atherogenesis. My lab is also managing biobanking operations and conducting clinical chemistry analysis for various studies.

Publications:

  1. Abouleisa RRE, Tang XL, Ou Q, Salama AM, Woolard A, Hammouri D, Abdelhafez H, Cayton S, Abdulwali SK, Arai M, Sithu ID, Conklin DJ, Bolli R, Mohamed TMA. Gene therapy encoding cell cycle factors to treat chronic ischemic heart failure in rats. Cardiovasc Res. 2024. 120(2):152-163. PMID: 38175760.
  2. McLeish AC, Smith T, Riggs DW, Hart JL, Walker KL, Keith RJ, Anderson L, Sithu I, Pinilla-Baquero J, Srivastava S, Bhatnagar A. Community-Based Evaluation of the Associations Between Well-Being and Cardiovascular Disease Risk. J Am Heart Assoc. 2022. 11(22):e027095. PMID: 36370026.
  3. Zelko IN, Taylor BS, Das TP, Watson WH, Sithu ID, Wahlang B, Malovichko MV, Cave MC, Srivastava S. Effect of vinyl chloride exposure on cardiometabolic toxicity. Environ Toxicol. 2022. 37(2):245-255. PMID: 34717031.
  4. Wahlang B, Gripshover TC, Gao H, Krivokhizhina T, Keith RJ, Sithu ID, Rai SN, Bhatnagar A, McClain CJ, Srivastava S, Cave MC. Associations Between Residential Exposure to Volatile Organic Compounds and Liver Injury Markers. Toxicol Sci. 2021 185(1):50-63. PMID: 34668566
  5. Malovichko MV, Abplanalp WT, McFall SA, Taylor BS, Wickramasinghe NS, Sithu ID, Zelko IN, Uchida S, Hill BG, Sutaria SR, Nantz MH, Bhatnagar A, Conklin DJ, O'Toole TE, Srivastava S. Subclinical markers of cardiovascular toxicity of benzene inhalation in mice. Toxicol Appl Pharmacol. 2021. 431:115742. PMID: 34624356.
  6. Orimoloye OA, Uddin SMI, Chen LC, Osei AD, Mirbolouk M, Malovichko MV, Sithu ID, Dzaye O, Conklin DJ, Srivastava S, Blaha MJ. Electronic cigarettes and insulin resistance in animals and humans: Results of a controlled animal study and the National Health and Nutrition Examination Survey (NHANES 2013-2016). PLoS One. 2019. 14(12):e0226744. PMID: 31891598.
  7. Brophy ML, Dong Y, Tao H, Yancey PG, Song K, Zhang K, Wen A, Wu H, Lee Y, Malovichko MV, Sithu SD, Wong S, Yu L, Kocher O, Bischoff J, Srivastava S, Linton MF, Ley K, Chen H. Myeloid-Specific Deletion of Epsins 1 and 2 Reduces Atherosclerosis by Preventing LRP-1 Downregulation. Circ Res. 2019. 124(4):e6-e19. PMID: 30595089.
  8. Abplanalp WT, Wickramasinghe NS, Sithu SD, Conklin DJ, Xie Z, Bhatnagar A, Srivastava S, O'Toole TE. Benzene Exposure Induces Insulin Resistance in Mice. Toxicol Sci. 2019. 167(2):426-437. PMID: 30346588.
  9. Malovichko MV, Zeller I, Krivokhizhina TV, Xie Z, Lorkiewicz P, Agarwal A, Wickramasinghe N, Sithu SD, Shah J, O'Toole T, Rai SN, Bhatnagar A, Conklin DJ, Srivastava S. Systemic Toxicity of Smokeless Tobacco Products in Mice. Nicotine Tob Res. 2019. 21(1):101-110. PMID: 30085294.
  10. Conklin DJ, Malovichko MV, Zeller I, Das TP, Krivokhizhina TV, Lynch BH, Lorkiewicz P, Agarwal A, Wickramasinghe N, Haberzettl P, Sithu SD, Shah J, O'Toole TE, Rai SN, Bhatnagar A, Srivastava S. Biomarkers of Chronic Acrolein Inhalation Exposure in Mice: Implications for Tobacco Product-Induced Toxicity. Toxicol Sci. 2017. 158(2):263-274. PMID: 28482051.
  11. Sithu SD, Malovichko MV, Riggs KA, Wickramasinghe NS, Winner MG, Agarwal A, Hamed-Berair RE, Kalani A, Riggs DW, Bhatnagar A, Srivastava S. Atherogenesis and metabolic dysregulation in LDL receptor-knockout rats. JCI Insight. 2017. 2(9):e86442. PMID: 28469073.
  12. Ma X, Conklin DJ, Li F, Dai Z, Hua X, Li Y, Xu-Monette ZY, Young KH, Xiong W, Wysoczynski M, Sithu SD, Srivastava S, Bhatnagar A, Li Y. The oncogenic microRNA miR-21 promotes regulated necrosis in mice. Nat Commun. 2015. 6:7151. PMID: 25990308.
  13. Bartoli CR, Dassanayaka S, Brittian KR, Luckett A, Sithu S, Siess T, Raess DH, Spence PA, Koenig SC, Dowling RD, D'Souza SE. Insights into the mechanism(s) of von Willebrand factor degradation during mechanical circulatory support. J Thorac Cardiovasc Surg. 2014. 147(5):1634-43. PMID: 24139617.
  14. Barski OA, Xie Z, Baba SP, Sithu SD, Agarwal A, Cai J, Bhatnagar A, Srivastava S. Dietary carnosine prevents early atherosclerotic lesion formation in apolipoprotein E-null mice. Arterioscler Thromb Vasc Biol. 2013. 33(6):1162-70. PMID: 23559625.
  15. Vladykovskaya E, Sithu SD, Haberzettl P, Wickramasinghe NS, Merchant ML, Hill BG, McCracken J, Agarwal A, Dougherty S, Gordon SA, Schuschke DA, Barski OA, O'Toole T, D'Souza SE, Bhatnagar A, Srivastava S. Lipid peroxidation product 4-hydroxy-trans-2-nonenal causes endothelial activation by inducing endoplasmic reticulum stress. J Biol Chem. 2012. 30;287(14):11398-409. PMID: 22228760.
  16. Srivastava S, Sithu SD, Vladykovskaya E, Haberzettl P, Hoetker DJ, Siddiqui MA, Conklin DJ, D'Souza SE, Bhatnagar A. Oral exposure to acrolein exacerbates atherosclerosis in apoE-null mice. Atherosclerosis. 2011. 215(2):301-8. PMID: 21371710.
  17. Sithu SD, Srivastava S, Siddiqui MA, Vladykovskaya E, Riggs DW, Conklin DJ, Haberzettl P, O'Toole TE, Bhatnagar A, D'Souza SE. Exposure to acrolein by inhalation causes platelet activation. Toxicol Appl Pharmacol. 2010. 248(2):100-10. PMID: 20678513.
  18. Han S, Arnold SA, Sithu SD, Mahoney ET, Geralds JT, Tran P, Benton RL, Maddie MA, D'Souza SE, Whittemore SR, Hagg T. Rescuing vasculature with intravenous angiopoietin-1 and alpha v beta 3 integrin peptide is protective after spinal cord injury. Brain. 2010. 133(Pt 4):1026-42. PMID: 20375135.
  19. Srivastava S, Vladykovskaya EN, Haberzettl P, Sithu SD, D'Souza SE, States JC. Arsenic exacerbates atherosclerotic lesion formation and inflammation in ApoE-/- mice. Toxicol Appl Pharmacol. 2009. 241(1):90-100. 19682479.
  20. Nakashima S, Arnold SA, Mahoney ET, Sithu SD, Zhang YP, D'Souza SE, Shields CB, Hagg T. Small-molecule protein tyrosine phosphatase inhibition as a neuroprotective treatment after spinal cord injury in adult rats. J Neurosci. 2008. 16;28(29):7293-303. PMID: 18632933.
  21. Sithu SD, English WR, Olson P, Krubasik D, Baker AH, Murphy G, D'Souza SE. Membrane-type 1-matrix metalloproteinase regulates intracellular adhesion molecule-1 (ICAM-1)-mediated monocyte transmigration. J Biol Chem. 2007. 282(34):25010-9. PMID: 17591781.
  22. Tsakadze NL, Sithu SD, Sen U, English WR, Murphy G, D'Souza SE. Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM-17) mediates the ectodomain cleavage of intercellular adhesion molecule-1 (ICAM-1). J Biol Chem. 2006. 281(6):3157-64. PMID: 16332693.
  23. Tsakadze NL, Sen U, Zhao Z, Sithu SD, English WR, D'Souza SE. Signals mediating cleavage of intercellular adhesion molecule-1. Am J Physiol Cell Physiol. 2004. 287(1):C55-63.PMID: 14973144.