Claudio Maldonado

Professor Updated 81924
CLAUDIO MALDONADO, Ph.D.
Claudio.Maldonado@louisville.edu
Professor
University of Louisville, 1994

My general research interests are in cardiovascular physiology, inflammation, reperfusion injury, and the development of anti-inflammatory therapies. My research focus has been to develop novel liposome-based therapies to attenuate alcohol-induced liver inflammation and therapies that protect the endothelial barrier from ischemia/reperfusion injury. Our group has developed novel technologies to attenuate reperfusion injury by decorating the surface of endothelial cells with therapeutic molecules to preserve the function of transplanted organs. Additionally, we have developed a rapid method to modify the lipid composition of plasma membranes of immune and endothelial cells to attenuate pro-inflammatory protein signaling. These therapies are designed to stabilize the microvascular endothelium in the area at risk, and attenuate microvascular dysfunction and the absence of microvascular blood flow. One application of this therapy is to reduce reperfusion-induced damage following myocardial infarction and stent placement.

  1. Auchampach JA, Rizvi A, Qiu Y, Tang XL, Maldonado C, Teschner S, Bolli R. Selective activation of A3 adenosine receptors with N6-(3-iodobenzyl)adenosine-5’-N-methyluronamide protects against myocardial stunning and infarction without hemodynamic changes in conscious rabbits. Circ Res 80:800-806, 1997.
  2. Maldonado C, Qiu Y, Tang XL, Cohen MV, Auchampach J, Bolli R. Role of adenosine receptors in late preconditioning against myocardial stunning in conscious rabbits. A J Physiol 273:H1324-1332, 1997.
  3. Ustuner ET, Zdichavsky M, Ren X, Edelstein J, Maldonado C, Ray M. Jevans AW, Breidenbach WC, Gruber SA, Barker JH, Jones JW.  Long-term composite tissue allograft survival in a porcine model with cyclosporine/mycophenalate mofetil therapy. Transplantation 66:1581-1587, 1998.
  4. Zdichavsky M, Jones J, Ustuner TE, Ren X, Edelstein J, Maldonado C, Breidenbach WC, Gruber SA, Ray M, Barker JH.  Scoring of skin rejection in a swine composite tissue allograft model. J Surg Res 85:1-8,1999.
  5. Francois C, Breidenbach WC, Maldonado C, Kakoulidis T, Dubernard J, Pei G, Ren X, Barker JH. Hand transplantation: comparisons and observations of the first four clinical cases. Microsurgery 20:360-371, 2000.
  6. Ren XP, Shirbacheh MV, Ustuner ET, Zdichavsky M, Edelstein J, Maldonado C, Breidenbach WC, Frank J, Jones J and Barker JH. Osteomyocutaneous flap as a pre-clinical composite tissue allograft: Swine model. Microsurgery 20:143-149, 2000.
  7. Gorantla, V, Perez-Abadia G, Prabhune K, Orhun H., Kakoulidis T, Majzoub R, Maldonado C, Anderson GL, Ogden L, Breidenbach WC, Ildstad S, Barker JH. Composite tissue allograft (CTA): tolerance induction without graft vs host disease (GvHD). Surg Forum, 51:578-580, 2000.
  8. Brouha P, Perez-Abadia G, Francois C, Gorantla V, Vossen M, Laurentin-Perez L, Maldonado C, Anderson G, Kon M, Barker J. “Prevention of graft-versus-host disease in chimeric hosts after limb allotransplantation”. Surg Forum 52:527-529, 2001.
  9. Bardoel JWJM, Stadelmann WK, Perez-Abadia GA, Galandiuk S, Zonnevijlle EDH, Maldonado C, Stremel RW, Tobin GR, Kon M, Barker JH. Dynamic rectus abdominis muscle sphincter for stoma continence: an acute functional study in a dog model. Plast Reconstr Surg 107: 478-484, 2001.
  10. Barker JH, Francois C, Frank J, Maldonado C. Composite Tissue Allotransplantation.  Transplantation 73:832-835, 2002.
  11. Majzoub RK, Bardoel J, Maldonado C, Barker JH, Stadelmann WK.  Analysis of fiber type transformation and histology in chronic electrically stimulated canine rectus abdominis muscle island-flap stomal sphincters. Plast Reconstr Surg  111:189-98, 2003.
  12. Gorantla VS, Prabhune KA, Perez-Abadia G, Ildstad ST, Maldonado C, Orhun H, Majzoub RK, Francois C, Kakoulidis TP, Brouha P, Anderson GL, Pidwell DJ, Breidenbach WC, Barker JH. Composite tissue allotransplantation in chimeric hosts part I.  Prevention of graft-versus-host disease.  Transplantation 75:922-932, 2003.
  13. Prabhune KA, Gorantla VS, Perez-Abadia G, Francois C, Vossen M, Laurentin-Perez LA, Breidenbach WC, Anderson GL, Pidwell DJ, Barker JH, Maldonado C. Composite tissue allotransplantation in chimeric hosts Part II. A clinically feasible protocol to induce Tolerance in a rat model.  Transplantation 76(11):1548-1555, 2003.
  14. Wiggins OP, Barker JH,Martinez S, Vossen M, Maldonado C, Grossi F, Francois CG, Cunningham M, Perez-Abadia G, Kon M, and Banis JC.  Response to Selected Commentaries on the AJOB Target Article “On the Ethics of Facial Transplantation Research.” Am J Bioeth  4:W1-W9, 2004.
  15. Francois CG, Brouha P, Laurentin-Perez LA, Perez-Abadia G, Grossi FV, Barker JH, Hewitt CW, Pidwell DJ, Kon M, Ramsamooj R, Maldonado C. Vascularized Lymph Node Transplantation induced Graft-Versus-Host Disease in Chimeric Hosts. Transplantation 81: 1435-1441, 2006.
  16. Barker J H, Furr A, Cunningham M, Grossi FV, Vasilic D; Storey B, Wiggins O, Brouha P, Vossen M, Majzoub R, Martinez S, Maldonado C, Reynolds CC; Francois C, Perez-Abadia G, Frank JM, Kon M, Banis JC. Investigation of Risk Acceptance in Facial Transplantation. Plast Reconstruc Surg 118(3):663-670, 2006.
  17. Vasilic D, Reynolds CC, Cunningham M, Furr A, Storey B, Banis JC, Wiggins O, Maldonado C, Alloway RR, Kon M, Barker JH. Plastic Surgeon’s Risk Acceptance in Facial transplantation. Plast Reconstr Surg 28:387-9, 2008.
  18. Maldonado C, Soni CV, Todnem ND, Pushpakumar S, Rosenberger D, Givvimani S, Villafane J, Tyagi SC. Hyperhomocysteinemia and Sudden Cardiac Death: Potential Arrhythmogenic Mechanisms. Current Vasc Pharm 8:64-74, 2010.
  19. Goga L, Pushpakumar SB, Perez-Abadia G, Olson P, Anderson G, Soni CV, Barker JH, Maldonado C. A novel liposome-based therapy to reduce complement-mediated injury in revascularized tissues. J Surg Res. 165:e51-57, 2011.
  20. Pushpakumar SB, Perez-Abadia G, Soni C, Wan R, Todnem N, Patibandla PK, Fensterer T, Zhang Q, Barker JH, Maldonado C. Enhancing complement control on endothelial barrier reduces renal post-ischemia dysfunction. J Surg Res. 170:e263-70, 2011.
  21. Maldonado C, Pushpakumar SB, Perez-Abadia G, Arumugam S, Lane AN.Administration of Exogenous ATP to Ischemic Skeletal Muscle Induces an Energy Sparing Effect: Role of Adenosine Receptors.J Surg. Res 181:e15-22, 2013.
  22. Fensterer TF, Keeling WB, Patibandla PK, Pushpakumar S, Perez-Abadia G, Bauer P, Soni CV, Anderson GL, Maldonado C. Stabilizing endothelium of donor hearts with fusogenic liposomes reduces myocardial injury and dysfunction.  J Surg. Res 182:331-38, 2013.
  23. Carlson E, Perez-Abadia G, Adams S, Zhang JZ, Kang KA, Maldonado C. A Novel Technique for Visualizing the Intralymphatic Primo Vascular System by Using Hollow Gold Nanospheres. Journal of Acupuncture and Meridian Studies 8(6):294-300, 2015.
  24. Soni CV, Tyagi SC, Todnem ND, Givvimani S, Pushpakumar SB, Villafane J, Maldonado C.  Hyperhomocysteinemia alters sinoatrial and atrioventricular nodal function: Role of Magnesium in attenuating these effects. Cell Biochemistry and Biophysics 74:59-65, 2016.
  25. Kalani A, Chaturvedi P, Kamat PK, Maldonado C, Bauer P, Joshua IG, Tyagi SC, Tyagi N. Curcumin-loaded embryonic stem cell exosomes restored neurovascular unit following ischemia-reperfusion injury. Int J Biochem Cell Biol. 79:360-369, 2016.
  26. Kalani A, Chaturvedi P, Kamat PK, Maldonado C, Bauer P, Joshua IG, Tyagi SC, Tyagi N. Dementia-like pathology in type-2 diabetes: A novel microRNA mechanism. Mol Cell Neurosci Biol. 80:58-65, 2017.
  27. Rodriguez WE, Wahlang B, Wang Y, Zhang J, VadhanamMV, Joshi-Barve S, Bauer P, Cannon R, Ahmadi AR, Sun Z, Cameron A, Barve S, Maldonado C, McClain C and Gobejishvili L. Phosphodiesterase 4 inhibition as a therapeutic target for alcoholic liver disease: from bedside to bench. Hepatology 70:1958-1971, 2019.
  28. Maldonado C, Nguyen MD, Bauer P, Nakamura S, Khundmiri SJ, Perez-Abadia G, Stowers HL, Wu WJ, and Tang XL. Rapid Lipid Modification of Endothelial Cell Membranes in Cardiac Ischemia/Reperfusion Injury: A Novel Therapeutic Strategy to Reduce Infarct Size. Cardiovascular Drugs and Therapy 35:113-123, 2021.
  29. Gobejishvili L, Rodriguez W, Wang Y, Zhang JW, Bauer P, Soni C, Lydic T, Barve S, McClain C, and Maldonado C. Novel Liposomal Rolipram Formulation for Clinical Application to Reduce Emesis. Drug Des Devel Ther 16:1301-1309, 2022
  30. Elnagdy M, Wang Y, Rodriguez W, Zhang JW, Bauer P, Wilkey DW, Merchant M, Pan J, Farooqui Z, Cannon R, Rai S, Maldonado C, Barve S, McClain C, and Gobejishvili L. Increased expression of phosphodiesterase 4 in activated hepatic stellate cells promotes cytoskeleton remodeling and cell migration. J Pathol. 261:361-371, 2023.
  31. Montoya-Durango D, Walter MN, Rodriguez W, Wang Y, Chariker J, Rouchka EC, Maldonado C, Barve S, McClain C, and Gobejishvili L. Dysregulated Cyclic Nucleotide Metabolism in Alcohol-Associated Steatohepatitis: Implications for Novel Targeted Therapies. Biology (Basel) 12:1321, 2023.
  32. Walter MN, Montoya-Durango D, Rodriguez W, Wang Y, Zhang JW, Chariker J, Rouchka EC, Maldonado C, Bennett A,McClain C, Barve S, and Gobejishvili L. Hepatocyte-specific mitogen-activated protein kinase phosphatase 1 in sexual dimorphism and susceptibility to alcohol induced liver injury.