Irving G. Joshua, Ph.D.

Irving G. Joshua, Ph.D.
Professor and Chairman
The Pennsylvania State University, 1976


In general, I am involved in small animal research investigating the mechanisms associated with the control of microvascular function during normal and disease states.  Specifically, I am investigating alterations in the vasoconstrictor responses of several vessel levels of the microcirculation during the development of several cardiovascular diseases using established animal models.  Current studies involving hypertension development have focused on the role of endothelial derived dilator and constrictor factors in the observed increases in peripheral resistance and blood pressure.  In the area of diabetes mellitus, we are investigating the potential vascular effects of both insulin and C-peptide, two agents released from the endocrine pancreas and deficient in individuals suffering from Type 1 diabetes mellitus. Recently, we have begun investigations into the  microvascular mechanisms that may be altered in several vascular beds (muscle, kidney and intestine) with aging, using in vivo and in vitro microcirculatory techniques and procedures.

Recent Publications:

  1. Joshua, I.G., Q. Zhang, J.C. Falcone, A.P. Bratcher, W. Rodriguez, and S.C. Tyagi.  Mechanisms of endothelial dysfunction with development of type 1 diabetes mellitus:  role of insulin and C-peptide.  Journal of Cellular Biochemistry 15;96 (6):1149-1156, 2005.
  2. Passmore, J.C., P.P. Rowell, I.G. Joshua, J.P. Porter, D.H. Patel, and J.C. Falcone.  Alpha 1 adrenergic receptor control of renal blood vessels during aging.  Canadian Journal of Physiology & Pharmacology 83:335-342, 2005.
  3. Passmore, J.C.,  I.G. Joshua, P.P. Rowell, S.C. Tyagi, and J.C. Falcone.  Reduced alpha adrenergic mediated contraction of renal preglomerular blood vessels as a function of gender and aging.  Journal Cellular Biochemistry 96 (4):672-681, 2005.
  4. Tyagi, N., K.S. Moshal, A.V. Ovechkin, W. Rodriguez, M. Steed, B. Henderson, A.M. Roberts, I.G. Joshua, and S.C. Tyagi.  Mitochondrial mechanism of oxidative stress and systemic hypertension in hyperhomocysteinemia.  Journal of Cellular Biochemistry 96 (4):665-671, 2005.
  5. Tyagi, S.C., W. Rodriguez, A.M. Patel, A.M. Roberts, J.C. Falcone, J.C. Passmore, J.T. Fleming, and I.G. Joshua. Hyperhomocysteinemic diabetic cardiomyopathy: oxidative stress, remodeling, and endothelial-myocyte uncoupling. Journal of Cardiovascular Pharmacology and Therapeutics 10 (1):1-10, 2005.
  6. Reddy, H.K., S.G. Koshy, S. Wasson, E.E. Quan, S. Pagni, A.M. Roberts, I.G. Joshua, and S.C. Tyagi.  Adaptive-outward and maladaptive-inward arterial remodeling measured by intracoronary ultrasound in homocysteinemia and diabetes.  Journal Cardiovascular Pharmacology & Therapeutics 11:65-76, 2006.
  7. Rodriguez, W.E., I.G. Joshua, J.C. Passmore, and S.C. Tyagi.  Piogiltazone mitigates renal glomerular vascular changes in high-fat high-calorie induced type 2 diabetes mellitus.  American Journal of Physiology 291(3):F694-701, 2006.
  8. Rodriguez, W.E., I.G. Joshua, J.C. Falcone, and S.C. Tyagi. Pioglitazone prevents cardiac remodeling in high-fat high-calorie induced type 2 diabetes mellitus.  American Journal of Physiology (Heart & Circulatory Physiol) 291 (1):H81-7, 2006.
  9. Sen U., N. Tyagi, K.S. Moshal, G.K. Kartha, D. Rosenberger, B.C. Henderson, I.G. Joshua, and S.C. Tyagi. Cardiac Synchronous and  Dys-synchronous Remodeling in Diabetes Mellitus.  Antioxid Redox Signal. 9(7):971-8, 2007.
  10. Kartha G.K., K.S. Moshal, U. Sen, I.G. Joshua, N. Tyagi, M.M. Steed, and S.C. Tyagi. Renal mitochondrial damage and protein modification in type-2 diabetes. Acta Diabetol. 2008 Feb 22 [Epub ahead of print] Links.
  11. Rodriguez, W.E., N. Tyagi, A.Y. Deng, A.S. Adeagbo, I.G. Joshua, and S.C. Tyagi.  Congenic expression of tissue inhibitor of metalloproteinase in Dahl-salt sensitive hypertensive rats is associated with reduced LV hypertrophy. Arch Physiol Biochem. 2008 Nov 10:1-9. [Epub ahead of print]  PMID: 19003589 [PubMed - as supplied by publisher]
  12. Motaz Qadan, B.Sc. (Hons) MBChB MRCS (Ed); Sarah A. Gardner, B.S.; David S. Vitale, BS; David Lominadze, PhD; Irving G. Joshua, PhD; Hiram C. Polk, M.D. "Hypothermia and Surgery: Immunologic Mechanisms for Current Practice. Annals of Surgery 2009, IN PRESS.