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Since 2013, members of the ToTOL Research Group have produced nearly 50 peer-reviewed publications.

Those articles include:

• Ubiquilin proteins regulate EGFR levels and activity in lung adenocarcinoma cells
  Kurlawala Z, Saurabh K, Dunaway R, Shah PP, Siskind LJ, Beverly LJ. J Cell Biochem. 2020 Jul 28. doi: 10.1002/jcb.29830. Online ahead of print. PMID: 32720736
• Perturbation of Methionine/S-adenosylmethionine Metabolism as a Novel Vulnerability in MLL Rearranged Leukemia
  Barve A, Vega A, Shah PP, Ghare S, Casson L, Wunderlich M, Siskind LJ, Beverly LJ. Cells. 2019 Oct 25;8(11):1322. doi: 10.3390/cells8111322. PMID: 31717699
• Computational/experimental evaluation of liver metastasis post hepatic injury: interactions with macrophages and transitional ECM
  Hudson SV, Miller HA, Mahlbacher GE, Saforo D, Beverly LJ, Arteel GE, Frieboes HB. Sci Rep. 2019 Oct 21;9(1):15077. doi: 10.1038/s41598-019-51249-y. PMID: 31636296
• De novo synthesis of serine and glycine fuels purine nucleotide biosynthesis in human lung cancer tissues
  Fan TWM, Bruntz RC, Yang Y, Song H, Chernyavskaya Y, Deng P, Zhang Y, Shah PP, Beverly LJ, Qi Z, Mahan AL, Higashi RM, Dang CV, Lane AN. J Biol Chem. 2019 Jul 23. pii: jbc.RA119.008743. doi: 10.1074/jbc.RA119.008743. [Epub ahead of print] PMID: 31337706
• Solution structure and functional investigation of human guanylate kinase reveals allosteric networking and a crucial role for the enzyme in cancer
  Khan N, Shah PP, Ban D, Trigo-Mouriño P, Carneiro MG, DeLeeuw L, Dean WL, Trent JO, Beverly LJ, Konrad M, Lee D, Sabo TM. J Biol Chem. 2019 Aug 2;294(31):11920-11933. doi: 10.1074/jbc.RA119.009251. Epub 2019 Jun 14. PMID: 31201273
• Loss of the Na+/H+ Exchange Regulatory Factor 1 Increases Susceptibility to Cisplatin-Induced Acute Kidney Injury
  Bushau-Sprinkle A, Barati M, Conklin C, Dupre T, Gagnon KB, Khundmiri SJ, Clark B, Siskind L, Doll MA, Rane M, Brier M, Coventry S, Lederer ED. Am J Pathol. 2019 Jun;189(6):1190-1200. doi: 10.1016/j.ajpath.2019.02.010. Epub 2019 Mar 27. PMID: 30926337
• Primary lung cancer samples cultured under microenvironment-mimetic conditions enrich for mesenchymal stem-like cells that promote metastasis
  Saforo D, Omer L, Smolenkov A, Barve A, Casson L, Boyd N, Clark G, Siskind L, Beverly L. Sci Rep. 2019 Mar 12;9(1):4177. doi: 10.1038/s41598-019-40519-4. PMID: 30862796 Free PMC Article
• Integrative Genomic Analyses Identifies GGA2 as a Cooperative Driver of EGFR-Mediated Lung Tumorigenesis
  O'Farrell H, Harbourne B, Kurlawala Z, Inoue Y, Nagelberg AL, Martinez VD, Lu D, Oh MH, Coe BP, Thu KL, Somwar R, Lam S, Lam WL, Unni AM, Beverly L, Lockwood WW. J Thorac Oncol. 2019 Apr;14(4):656-671. doi: 10.1016/j.jtho.2018.12.004. Epub 2018 Dec 19. PMID: 30578931
• Moderate aging does not exacerbate cisplatin-induced kidney injury or fibrosis despite altered inflammatory cytokine expression and immune cell infiltration
  Sharp CN, Doll M, Dupre TV, Beverly LJ, Siskind LJ. Am J Physiol Renal Physiol. 2019 Jan 1;316(1):F162-F172. doi: 10.1152/ajprenal.00463.2018. Epub 2018 Nov 28. PMID: 30484347
• The role of sphingolipids in acute kidney injury
  Dupre TV, Siskind LJ. Adv Biol Regul. 2018 Dec;70:31-39. doi: 10.1016/j.jbior.2018.11.003. Epub 2018 Nov 13. Review. PMID: 30455062
• Comparative utility of NRG and NRGS mice for the study of normal hematopoiesis, leukemogenesis, and therapeutic response
  Barve A, Casson L, Krem M, Wunderlich M, Mulloy JC, Beverly LJ. Exp Hematol. 2018 Nov;67:18-31. doi: 10.1016/j.exphem.2018.08.004. Epub 2018 Aug 17. PMID: 30125602
• The Antiarrhythmic Drug, Amiodarone, Decreases AKT Activity and Sensitizes Human Acute Myeloid Leukemia Cells to Apoptosis by ABT-263
  Ketchem CJ, Kucera C, Barve A, Beverly LJ. Am J Med Sci. 2018 May;355(5):488-496. doi: 10.1016/j.amjms.2018.01.011. Epub 2018 Feb 6. PMID: 29753379 Free Article
• Teaching Old Drugs New Tricks: Repositioning Pharmaceuticals for Bench to Bedside Success
  Beverly LJ, Krem MM. Am J Med Sci. 2018 Mar;355(3):205-206. doi: 10.1016/j.amjms.2017.12.007. Epub 2017 Dec 26. No abstract available. PMID: 29549920
• Subclinical kidney injury induced by repeated cisplatin administration results in progressive chronic kidney disease
  Sharp CN, Doll MA, Megyesi J, Oropilla GB, Beverly LJ, Siskind LJ. Am J Physiol Renal Physiol. 2018 Jul 1;315(1):F161-F172. doi: 10.1152/ajprenal.00636.2017. Epub 2018 Jan 31. PMID: 29384415 Free PMC Article
• Neuraminidase activity mediates IL-6 production by activated lupus-prone mesangial cells
  Sundararaj K, Rodgers JI, Marimuthu S, Siskind LJ, Bruner E, Nowling TK. Am J Physiol Renal Physiol. 2018 Apr 1;314(4):F630-F642. doi: 10.1152/ajprenal.00421.2017. Epub 2017 Dec 20. PMID: 29357434 Free PMC Article
• Regulation of insulin-like growth factor receptors by Ubiquilin1
  Kurlawala Z, Dunaway R, Shah PP, Gosney JA, Siskind LJ, Ceresa BP, Beverly LJ. Biochem J. 2017 Dec 6;474(24):4105-4118. doi: 10.1042/BCJ20170620. PMID: 29054976 Free PMC Article
• Developing better mouse models to study cisplatin-induced kidney injury
  Sharp CN, Siskind LJ. Am J Physiol Renal Physiol. 2017 Oct 1;313(4):F835-F841. doi: 10.1152/ajprenal.00285.2017. Epub 2017 Jul 19. Review. PMID: 28724610 Free PMC Article
• Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury
  Dupre TV, Doll MA, Shah PP, Sharp CN, Siow D, Megyesi J, Shayman J, Bielawska A, Bielawski J, Beverly LJ, Hernandez-Corbacho M, Clarke CJ, Snider AJ, Schnellmann RG, Obeid LM, Hannun YA, Siskind LJ. J Lipid Res. 2017 Jul;58(7):1439-1452. doi: 10.1194/jlr.M076745. Epub 2017 May 10. PMID: 28490444 Free PMC Article
• MIR155 Regulation of Ubiquilin1 and Ubiquilin2: Implications in Cellular Protection and Tumorigenesis
  Yadav S, Singh N, Shah PP, Rowbotham DA, Malik D, Srivastav A, Shankar J, Lam WL, Lockwood WW, Beverly LJ. Neoplasia. 2017 Apr;19(4):321-332. doi: 10.1016/j.neo.2017.02.001. Epub 2017 Mar 16. PMID: 28315615 Free PMC Article
• Common cytotoxic chemotherapeutics induce epithelial-mesenchymal transition (EMT) downstream of ER stress
  Shah PP, Dupre TV, Siskind LJ, Beverly LJ. Oncotarget. 2017 Apr 4;8(14):22625-22639. doi: 10.18632/oncotarget.15150. PMID: 28186986 Free PMC Article
• The STI and UBA Domains of UBQLN1 Are Critical Determinants of Substrate Interaction and Proteostasis
  Kurlawala Z, Shah PP, Shah C, Beverly LJ. J Cell Biochem. 2017 Aug;118(8):2261-2270. doi: 10.1002/jcb.25880. Epub 2017 Apr 25. PMID: 28075048 Free PMC Article
• Bridging translation for acute kidney injury with better preclinical modeling of human disease
  Skrypnyk NI, Siskind LJ, Faubel S, de Caestecker MP. Am J Physiol Renal Physiol. 2016 May 15;310(10):F972-84. doi: 10.1152/ajprenal.00552.2015. Epub 2016 Mar 9. Review. PMID: 26962107 Free PMC Article
• Methods to Study Metastasis in Genetically Modified Mice
  Kabeer F, Beverly LJ, Darrasse-Jèze G, Podsypanina K. Cold Spring Harb Protoc. 2016 Feb 1;2016(2):pdb.top069948. doi: 10.1101/pdb.top069948. PMID: 26832689
• Murine Stem Cell-Based Retrovirus Production for Marking Primary Mouse Mammary Cells for Metastasis Studies
  Beverly LJ, Podsypanina K. Cold Spring Harb Protoc. 2016 Feb 1;2016(2):pdb.prot078337. doi: 10.1101/pdb.prot078337. PMID: 26832680
• Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death
  Sundaram K, Mather AR, Marimuthu S, Shah PP, Snider AJ, Obeid LM, Hannun YA, Beverly LJ, Siskind LJ. Biochem J. 2016 Mar 15;473(6):743-55. doi: 10.1042/BJ20150586. Epub 2016 Jan 8. PMID: 26747710 Free PMC Article
• Repeated administration of low-dose cisplatin in mice induces fibrosis
  Sharp CN, Doll MA, Dupre TV, Shah PP, Subathra M, Siow D, Arteel GE, Megyesi J, Beverly LJ, Siskind LJ. Am J Physiol Renal Physiol. 2016 Mar 15;310(6):F560-8. doi: 10.1152/ajprenal.00512.2015. Epub 2016 Jan 6. PMID: 26739893 Free PMC Article
• Suramin protects from cisplatin-induced acute kidney injury
  Dupre TV, Doll MA, Shah PP, Sharp CN, Kiefer A, Scherzer MT, Saurabh K, Saforo D, Siow D, Casson L, Arteel GE, Jenson AB, Megyesi J, Schnellmann RG, Beverly LJ, Siskind LJ. Am J Physiol Renal Physiol. 2016 Feb 1;310(3):F248-58. doi: 10.1152/ajprenal.00433.2015. Epub 2015 Dec 9. PMID: 26661653 Free PMC Article
• Ceramide channel: Structural basis for selective membrane targeting
  Perera MN, Ganesan V, Siskind LJ, Szulc ZM, Bielawska A, Bittman R, Colombini M. Chem Phys Lipids. 2016 Jan;194:110-116. doi: 10.1016/j.chemphyslip.2015.09.007. Epub 2015 Sep 25. PMID: 26408265 Free PMC Article
• Fibroblast-Derived Extracellular Matrices: An Alternative Cell Culture System That Increases Metastatic Cellular Properties
  Scherzer MT, Waigel S, Donninger H, Arumugam V, Zacharias W, Clark G, Siskind LJ, Soucy P, Beverly L. PLoS One. 2015 Sep 15;10(9):e0138065. doi: 10.1371/journal.pone.0138065. eCollection 2015. PMID: 26371754 Free PMC Article
• Ceramide channels: destabilization by Bcl-xL and role in apoptosis
  Chang KT, Anishkin A, Patwardhan GA, Beverly LJ, Siskind LJ, Colombini M. Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):2374-84. doi: 10.1016/j.bbamem.2015.07.013. Epub 2015 Jul 26. PMID: 26215742 Free PMC Article
• Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells
  Subathra M, Korrapati M, Howell LA, Arthur JM, Shayman JA, Schnellmann RG, Siskind LJ. Am J Physiol Renal Physiol. 2015 Aug 1;309(3):F204-15. doi: 10.1152/ajprenal.00150.2015. Epub 2015 Jun 3. PMID: 26041445 Free PMC Article
• Regulation of VCP/p97 demonstrates the critical balance between cell death and epithelial-mesenchymal transition (EMT) downstream of ER stress
  Shah PP, Beverly LJ. Oncotarget. 2015 Jul 10;6(19):17725-37. PMID: 25970786 Free PMC Article
• Sphingolipids and mitochondrial apoptosis
  Patwardhan GA, Beverly LJ, Siskind LJ. J Bioenerg Biomembr. 2016 Apr;48(2):153-68. doi: 10.1007/s10863-015-9602-3. Review. PMID: 25620271 Free PMC Article<
• Renal glycosphingolipid metabolism is dysfunctional in lupus nephritis
  Nowling TK, Mather AR, Thiyagarajan T, Hernández-Corbacho MJ, Powers TW, Jones EE, Snider AJ, Oates JC, Drake RR, Siskind LJ. J Am Soc Nephrol. 2015 Jun;26(6):1402-13. doi: 10.1681/ASN.2014050508. Epub 2014 Sep 30. PMID: 25270066 Free PMC Article
• The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets
  Saurabh K, Scherzer MT, Shah PP, Mims AS, Lockwood WW, Kraft AS, Beverly LJ. Oncotarget. 2014 Sep 30;5(18):8503-14. PMID: 25238262 Free PMC Article
• Glucose availability and glycolytic metabolism dictate glycosphingolipid levels
  Stathem M, Marimuthu S, O'Neal J, Rathmell JC, Chesney JA, Beverly LJ, Siskind LJ. J Cell Biochem. 2015 Jan;116(1):67-80. doi: 10.1002/jcb.24943. PMID: 25145677 Free PMC Article
• Defining a role for acid sphingomyelinase in the p38/interleukin-6 pathway
  Perry DM, Newcomb B, Adada M, Wu BX, Roddy P, Kitatani K, Siskind L, Obeid LM, Hannun YA. J Biol Chem. 2014 Aug 8;289(32):22401-12. doi: 10.1074/jbc.M114.589648. Epub 2014 Jun 20. PMID: 24951586 Free PMC Article
• IRAK1: oncotarget in MDS and AML
  Beverly LJ, Starczynowski DT. Oncotarget. 2014 Apr 15;5(7):1699-700. No abstract available. PMID: 24880611 Free PMC Article
• Ubiquilin1 represses migration and epithelial-to-mesenchymal transition of human non-small cell lung cancer cells
  Shah PP, Lockwood WW, Saurabh K, Kurlawala Z, Shannon SP, Waigel S, Zacharias W, Beverly LJ. Oncogene. 2015 Mar 26;34(13):1709-17. doi: 10.1038/onc.2014.97. Epub 2014 Apr 21. PMID: 24747970 Free PMC Article
• Dissecting the in vivo leukemogenic potency of BCLxl
  Saurabh K, Scherzer MT, Song A, Yip KW, Reed JC, Li C, Beverly LJ. J Leuk (Los Angel). 2014;2(5):158. Epub 2014 Sep 24. PMID: 26636115 Free PMC Article
• Reducing FLI1 levels in the MRL/lpr lupus mouse model impacts T cell function by modulating glycosphingolipid metabolism
  Richard EM, Thiyagarajan T, Bunni MA, Basher F, Roddy PO, Siskind LJ, Nietert PJ, Nowling TK. PLoS One. 2013 Sep 10;8(9):e75175. doi: 10.1371/journal.pone.0075175. eCollection 2013. PMID: 24040398 Free PMC Article
• Suramin: a potential therapy for diabetic nephropathy
  Korrapati MC, Howell LA, Shaner BE, Megyesi JK, Siskind LJ, Schnellmann RG. PLoS One. 2013 Sep 9;8(9):e73655. doi: 10.1371/journal.pone.0073655. eCollection 2013. Erratum in: PLoS One. 2014;9(1):e114426. Howell, Lauren H [corrected to Howell, Lauren A]. PMID: 24040012 Free PMC Article
• Targeting IRAK1 as a therapeutic approach for myelodysplastic syndrome
  Rhyasen GW, Bolanos L, Fang J, Jerez A, Wunderlich M, Rigolino C, Mathews L, Ferrer M, Southall N, Guha R, Keller J, Thomas C, Beverly LJ, Cortelezzi A, Oliva EN, Cuzzola M, Maciejewski JP, Mulloy JC, Starczynowski DT. Cancer Cell. 2013 Jul 8;24(1):90-104. doi: 10.1016/j.ccr.2013.05.006. PMID: 23845443 Free PMC Article
• The novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers
  Lockwood WW, Chandel SK, Stewart GL, Erdjument-Bromage H, Beverly LJ. PLoS One. 2013 May 2;8(5):e63610. doi: 10.1371/journal.pone.0063610. Print 2013. PMID: 23658844 Free PMC Article
• BAK activation is necessary and sufficient to drive ceramide synthase-dependent ceramide accumulation following inhibition of BCL2-like proteins
  Beverly LJ, Howell LA, Hernandez-Corbacho M, Casson L, Chipuk JE, Siskind LJ. Biochem J. 2013 May 15;452(1):111-9. doi: 10.1042/BJ20130147. PMID: 23480852 Free PMC Article
• Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteins
  Casson L, Howell L, Mathews LA, Ferrer M, Southall N, Guha R, Keller JM, Thomas C, Siskind LJ, Beverly LJ. PLoS One. 2013;8(1):e54525. doi: 10.1371/journal.pone.0054525. Epub 2013 Jan 16. PMID: 23342165 Free PMC Article