Marcin Wysoczynski, Ph.D.

Associate Professor of Medicine


502-852-6886 E-mail

Education and Training

M.S.: Jagiellonian University, Immunology and Microbiology
Ph.D.
: Pomeranian Medical University, Hematology
Postdoctoral Research
: University of Louisville, Molecular Cardiology


Research Interests

The focus of my research is to understand how the immune system governs the pathophysiology of heart failure. Integrated themes of the ongoing projects in my laboratory include:

  • Immunomodulatory mechanisms of infarct healing after myocardial infarction;
  • Mechanisms controlling the initiation and resolution of inflammation in the heart;
  • The impact of heart failure on medullary and extramedullary hematopoiesis; and
  • The effects of cardiovascular risk factors on immune homeostasis.

Featured Publications

Find all papers and citations via ResearchGate

  • Solanki M, Dobson L, Alwair H, Ghafghazi S, Wysoczynski M, Slaughter MS, Trivedi JR. Association of temporal trends in neutrophil lymphocyte ratio on left ventricular assist device patient outcomes. Artif Organs. 2021 Jul;45(7):742-747. doi: 10.1111/aor.13911. Epub 2021 Feb 20. PMID: 33434359.
  • Nong Y, Guo Y, Tomlin A, Zhu X, Wysoczynski M, Li Q, Bolli R. Echocardiography-guided percutaneous left ventricular intracavitary injection as a cell delivery approach in infarcted mice. Mol Cell Biochem. 2021 May;476(5):2135-2148. doi: 10.1007/s11010-021-04077-6. Epub 2021 Feb 5. PMID: 33547546; PMCID: PMC8252912.
  • Moore JB, Wysoczynski M. Immunomodulatory Effects of Cell Therapy after Myocardial Infarction. J Cell Immunol. 2021;3(2):85-90. doi: 10.33696/immunology.3.082. PMID: 33959728; PMCID: PMC8098722.
  • Kang Y, Nasr M, Guo Y, Uchida S, Weirick T, Li H, Kim J, Moore JB 4th, Muthusamy S, Bolli R, Wysoczynski M. Administration of cardiac mesenchymal cells modulates innate immunity in the acute phase of myocardial infarction in mice. Sci Rep. 2020 Sep 8;10(1):14754. doi: 10.1038/s41598-020-71580-z. PMID: 32901075; PMCID: PMC7479609.
  • Wysoczynski M, Kim J, Moore JB 4th, Uchida S. Macrophage Long Non-Coding RNAs in Pathogenesis of Cardiovascular Disease. Noncoding RNA. 2020 Jul 11;6(3):28. doi: 10.3390/ncrna6030028. PMID: 32664594; PMCID: PMC7549353.
  • Wysoczynski M, Bolli R. A realistic appraisal of the use of embryonic stem cell-based therapies for cardiac repair. Eur Heart J. 2020 Jul 1;41(25):2397-2404. doi: 10.1093/eurheartj/ehz787. PMID: 31778154; PMCID: PMC7327535.
  • Audam TN, Nong Y, Tomlin A, Jurkovic A, Li H, Zhu X, Long BW, Zheng YW, Weirick T, Brittian KR, Riggs DW, Gumpert A, Uchida S, Guo Y, Wysoczynski M, Jones SP. Cardiac mesenchymal cells from failing and nonfailing hearts limit ventricular dilation when administered late after infarction. Am J Physiol Heart Circ Physiol. 2020 Jul 1;319(1):H109-H122. doi: 10.1152/ajpheart.00114.2020. Epub 2020 May 22. PMID: 32442025; PMCID: PMC7474443.
  • Moore JB 4th, Sadri G, Fischer AG, Weirick T, Militello G, Wysoczynski M, Gumpert AM, Braun T, Uchida S. The A-to-I RNA Editing Enzyme Adar1 Is Essential for Normal Embryonic Cardiac Growth and Development. Circ Res. 2020 Jul 31;127(4):550-552. doi: 10.1161/CIRCRESAHA.120.316932. Epub 2020 May 4. PMID: 32362246; PMCID: PMC7415551.
  • Heidel JS, Fischer AG, Tang XL, Sadri G, Wu WJ, Moisa CR, Stowers H, Sandella N, Wysoczynski M, Uchida S, Moore Iv JB. The Effect of Cardiogenic Factors on Cardiac Mesenchymal Cell Anti-Fibrogenic Paracrine Signaling and Therapeutic Performance. Theranostics. 2020 Jan 1;10(4):1514-1530. doi: 10.7150/thno.41000. PMID: 32042319; PMCID: PMC6993223.
  • Wysoczynski M, Pathan A, Moore JB 4th, Farid T, Kim J, Nasr M, Kang Y, Li H, Bolli R. Pro-Angiogenic Actions of CMC-Derived Extracellular Vesicles Rely on Selective Packaging of Angiopoietin 1 and 2, but Not FGF-2 and VEGF. Stem Cell Rev Rep. 2019 Aug;15(4):530-542. doi: 10.1007/s12015-019-09891-6. PMID: 31102187; PMCID: PMC6941436.