Marcin Wysoczynski, Ph.D.

Associate Professor of Medicine

502-852-6886 E-mail

Education and Training

M.S.: Jagiellonian University, Immunology and Microbiology
: Pomeranian Medical University, Hematology
Postdoctoral Research
: University of Louisville, Molecular Cardiology

Research Interests

The focus of my research is to understand how the immune system governs the pathophysiology of heart failure. Integrated themes of the ongoing projects in my laboratory include:

  • Immunomodulatory mechanisms of infarct healing after myocardial infarction;
  • Mechanisms controlling the initiation and resolution of inflammation in the heart;
  • The impact of heart failure on medullary and extramedullary hematopoiesis; and
  • The effects of cardiovascular risk factors on immune homeostasis.

Featured Publications

Find all papers and citations via ResearchGate

  • Tang XL, Nasr M, Zheng S, Zoubul T, Stephan JK, Uchida S, Singhal R, Khan A, Gumpert A, Bolli R, Wysoczynski M. Bone Marrow and Wharton's Jelly Mesenchymal Stromal Cells are Ineffective for Myocardial Repair in an Immunodeficient Rat Model of Chronic Ischemic Cardiomyopathy. Stem Cell Rev Rep. 2023 Jul 28. doi: 10.1007/s12015-023-10590-6. Epub ahead of print. PMID: 37500831.
  • Sansbury BE, Nystoriak MA, Uchida S, Wysoczynski M, Moore JB 4th. Rigor Me This: What Are the Basic Criteria for a Rigorous, Transparent, and Reproducible Scientific Study? Front Cardiovasc Med. 2022 Jul 1;9:913612. doi: 10.3389/fcvm.2022.913612. PMID: 35845053; PMCID: PMC9283916.
  • Sadri G, Fischer AG, Brittian KR, Elliott E, Nystoriak MA, Uchida S, Wysoczynski M, Leask A, Jones SP, Moore JB 4th. Collagen type XIX regulates cardiac extracellular matrix structure and ventricular function. Matrix Biol. 2022 May;109:49-69. doi: 10.1016/j.matbio.2022.03.007. Epub 2022 Mar 26. PMID: 35346795; PMCID: PMC9161575.
  • Wysoczynski M, Stephan J, Uchida S. Glucosamine regulates macrophage function in heart failure. Clin Transl Med. 2022 Apr;12(4):e819. doi: 10.1002/ctm2.819. PMID: 35452185; PMCID: PMC9028091.
  • Tang XL, Wysoczynski M, Gumpert AM, Li Y, Wu WJ, Li H, Stowers H, Bolli R. Effect of intravenous cell therapy in rats with old myocardial infarction. Mol Cell Biochem. 2022 Feb;477(2):431-444. doi: 10.1007/s11010-021-04283-2. Epub 2021 Nov 16. PMID: 34783963; PMCID: PMC8896398.
  • Petri BJ, Piell KM, South Whitt GC, Wilt AE, Poulton CC, Lehman NL, Clem BF, Nystoriak MA, Wysoczynski M, Klinge CM. HNRNPA2B1 regulates tamoxifen- and fulvestrant-sensitivity and hallmarks of endocrine resistance in breast cancer cells. Cancer Lett. 2021 Oct 10;518:152-168. doi: 10.1016/j.canlet.2021.07.015. Epub 2021 Jul 14. PMID: 34273466; PMCID: PMC8358706.
  • Solanki M, Dobson L, Alwair H, Ghafghazi S, Wysoczynski M, Slaughter MS, Trivedi JR. Association of temporal trends in neutrophil lymphocyte ratio on left ventricular assist device patient outcomes. Artif Organs. 2021 Jul;45(7):742-747. doi: 10.1111/aor.13911. Epub 2021 Feb 20. PMID: 33434359.
  • Nong Y, Guo Y, Tomlin A, Zhu X, Wysoczynski M, Li Q, Bolli R. Echocardiography-guided percutaneous left ventricular intracavitary injection as a cell delivery approach in infarcted mice. Mol Cell Biochem. 2021 May;476(5):2135-2148. doi: 10.1007/s11010-021-04077-6. Epub 2021 Feb 5. PMID: 33547546; PMCID: PMC8252912.
  • Moore JB, Wysoczynski M. Immunomodulatory Effects of Cell Therapy after Myocardial Infarction. J Cell Immunol. 2021;3(2):85-90. doi: 10.33696/immunology.3.082. PMID: 33959728; PMCID: PMC8098722.
  • Kang Y, Nasr M, Guo Y, Uchida S, Weirick T, Li H, Kim J, Moore JB 4th, Muthusamy S, Bolli R, Wysoczynski M. Administration of cardiac mesenchymal cells modulates innate immunity in the acute phase of myocardial infarction in mice. Sci Rep. 2020 Sep 8;10(1):14754. doi: 10.1038/s41598-020-71580-z. PMID: 32901075; PMCID: PMC7479609.