Joseph B. Moore IV, Ph.D.

Associate Professor of Medicine

502-852-2036 E-Mail

Education and Training

Ph.D.: University of Louisville, Biochemistry and Molecular Biology
Postdoctoral Fellowship: Johns Hopkins University, Pediatric Oncology

Research Interests

Dr. Moore’s laboratory focuses on the use of biochemical and developmental programming strategies to investigate the genetic and molecular mechanisms modulating the survival and cardiac reparative properties of adult cardiac progenitor populations (CPCs) residing in the adult mammalian heart. The long term goal of such work is to identify molecular pathways that could be exploited, through genetic modification or pharmacological pretreatment, to enhance the therapeutic efficacy of various autologous cardiac progenitor populations in patients with ischemic cardiac injury.

Specific interests include:

  1. Pathophysiological and etiological mechanisms of heart failure
  2. Molecular mechanisms underlying cell therapy-mediated cardiac repair
  3. Methods to enhance the cardiac reparative capacity of donor cell populations for cell therapy
  4. Genetic and molecular signaling pathways directing cardiovascular cell lineage commitment and specification

Featured Publications

Find all papers and citations via ResearchGate

  • Hosen MR, Goody PR, Zietzer A, Xiang X, Niepmann ST, Sedaghat A, Tiyerili V, Chennupati R, Moore JB 4th, Boon RA, Uchida S, Sinning JM, Zimmer S, Latz E, Werner N, Nickenig G, Jansen F. Circulating MicroRNA-122-5p Is Associated With a Lack of Improvement in Left Ventricular Function After Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracellular Vesicles. Circulation. 2022 Dec 13;146(24):1836-1854. doi: 10.1161/CIRCULATIONAHA.122.060258. Epub 2022 Jul 8. PMID: 35862223.
  • Smith T, Holm RH, Yeager R, Moore JB 4th, Rouchka EC, Sokoloski KJ, Elliott EM, Talley D, Arora V, Moyer S, Bhatnagar A. Combining Community Wastewater Genomic Surveillance with State Clinical Surveillance: A Framework for SARS-CoV-2 Public Health Practice. Food Environ Virol. 2022 Dec;14(4):410-416. doi: 10.1007/s12560-022-09531-2. Epub 2022 Aug 18. PMID: 35982363; PMCID: PMC9387882.
  • Westcott CE, Sokoloski KJ, Rouchka EC, Chariker JH, Holm RH, Yeager RA, Moore JB 4th, Elliott EM, Talley D, Bhatnagar A, Smith T. The Detection of Periodic Reemergence Events of SARS-CoV-2 Delta Strain in Communities Dominated by Omicron. Pathogens. 2022 Oct 28;11(11):1249. doi: 10.3390/pathogens11111249. PMID: 36365000; PMCID: PMC9697103.
  • Dwenger MM, Raph SM, Baba SP, Moore JB 4th, Nystoriak MA. Diversification of Potassium Currents in Excitable Cells via Kvβ Proteins. Cells. 2022 Jul 18;11(14):2230. doi: 10.3390/cells11142230. PMID: 35883673; PMCID: PMC9317154.
  • Sansbury BE, Nystoriak MA, Uchida S, Wysoczynski M, Moore JB 4th. Rigor Me This: What Are the Basic Criteria for a Rigorous, Transparent, and Reproducible Scientific Study? Front Cardiovasc Med. 2022 Jul 1;9:913612. doi: 10.3389/fcvm.2022.913612. PMID: 35845053; PMCID: PMC9283916.
  • Dwenger MM, Raph SM, Reyzer ML, Lisa Manier M, Riggs DW, Wohl ZB, Ohanyan V, Mack G, Pucci T, Moore JB 4th, Hill BG, Chilian WM, Caprioli RM, Bhatnagar A, Nystoriak MA. Pyridine nucleotide redox potential in coronary smooth muscle couples myocardial blood flow to cardiac metabolism. Nat Commun. 2022 Apr 19;13(1):2051. doi: 10.1038/s41467-022-29745-z. PMID: 35440632; PMCID: PMC9018695.
  • Ohanyan V, Raph SM, Dwenger MM, Hu X, Pucci T, Mack G, Moore JB 4th, Chilian WM, Bhatnagar A, Nystoriak MA. Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvβ Proteins. Circ Res. 2021 Mar 19;128(6):738-751. doi: 10.1161/CIRCRESAHA.120.317715. Epub 2021 Jan 27. PMID: 33499656; PMCID: PMC8486354.
  • Moore JB, Wysoczynski M. Immunomodulatory Effects of Cell Therapy after Myocardial Infarction. J Cell Immunol. 2021;3(2):85-90. doi: 10.33696/immunology.3.082. PMID: 33959728; PMCID: PMC8098722.
  • Kang Y, Nasr M, Guo Y, Uchida S, Weirick T, Li H, Kim J, Moore JB 4th, Muthusamy S, Bolli R, Wysoczynski M. Administration of cardiac mesenchymal cells modulates innate immunity in the acute phase of myocardial infarction in mice. Sci Rep. 2020 Sep 8;10(1):14754. doi: 10.1038/s41598-020-71580-z. PMID: 32901075; PMCID: PMC7479609.
  • Moore JB 4th, Sadri G, Fischer AG, Weirick T, Militello G, Wysoczynski M, Gumpert AM, Braun T, Uchida S. The A-to-I RNA Editing Enzyme Adar1 Is Essential for Normal Embryonic Cardiac Growth and Development. Circ Res. 2020 Jul 31;127(4):550-552. doi: 10.1161/CIRCRESAHA.120.316932. Epub 2020 May 4. PMID: 32362246; PMCID: PMC7415551.