Joseph B. Moore IV, Ph.D.

Associate Professor of Medicine

502-852-2036 E-Mail

Education and Training

Ph.D.: University of Louisville, Biochemistry and Molecular Biology
Postdoctoral Fellowship: Johns Hopkins University, Pediatric Oncology

Research Interests

Dr. Moore’s laboratory focuses on the use of biochemical and developmental programming strategies to investigate the genetic and molecular mechanisms modulating the survival and cardiac reparative properties of adult cardiac progenitor populations (CPCs) residing in the adult mammalian heart. The long term goal of such work is to identify molecular pathways that could be exploited, through genetic modification or pharmacological pretreatment, to enhance the therapeutic efficacy of various autologous cardiac progenitor populations in patients with ischemic cardiac injury.

Specific interests include:

  1. Pathophysiological and etiological mechanisms of heart failure
  2. Molecular mechanisms underlying cell therapy-mediated cardiac repair
  3. Methods to enhance the cardiac reparative capacity of donor cell populations for cell therapy
  4. Genetic and molecular signaling pathways directing cardiovascular cell lineage commitment and specification

Featured Publications

Find all papers and citations via ResearchGate

  • Sadri G, Fischer AG, Brittian KR, Elliott E, Nystoriak MA, Uchida S, Wysoczynski M, Leask A, Jones SP, Moore JB 4th. Collagen type XIX regulates cardiac extracellular matrix structure and ventricular function. Matrix Biol. 2022 May;109:49-69. doi: 10.1016/j.matbio.2022.03.007. Epub 2022 Mar 26. PMID: 35346795; PMCID: PMC9161575.
  • Dwenger MM, Raph SM, Reyzer ML, Lisa Manier M, Riggs DW, Wohl ZB, Ohanyan V, Mack G, Pucci T, Moore JB 4th, Hill BG, Chilian WM, Caprioli RM, Bhatnagar A, Nystoriak MA. Pyridine nucleotide redox potential in coronary smooth muscle couples myocardial blood flow to cardiac metabolism. Nat Commun. 2022 Apr 19;13(1):2051. doi: 10.1038/s41467-022-29745-z. PMID: 35440632; PMCID: PMC9018695.
  • Ohanyan V, Raph SM, Dwenger MM, Hu X, Pucci T, Mack G, Moore JB 4th, Chilian WM, Bhatnagar A, Nystoriak MA. Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvβ Proteins. Circ Res. 2021 Mar 19;128(6):738-751. doi: 10.1161/CIRCRESAHA.120.317715. Epub 2021 Jan 27. PMID: 33499656; PMCID: PMC8486354.
  • Moore JB, Wysoczynski M. Immunomodulatory Effects of Cell Therapy after Myocardial Infarction. J Cell Immunol. 2021;3(2):85-90. doi: 10.33696/immunology.3.082. PMID: 33959728; PMCID: PMC8098722.
  • Kang Y, Nasr M, Guo Y, Uchida S, Weirick T, Li H, Kim J, Moore JB 4th, Muthusamy S, Bolli R, Wysoczynski M. Administration of cardiac mesenchymal cells modulates innate immunity in the acute phase of myocardial infarction in mice. Sci Rep. 2020 Sep 8;10(1):14754. doi: 10.1038/s41598-020-71580-z. PMID: 32901075; PMCID: PMC7479609.
  • Moore JB 4th, Sadri G, Fischer AG, Weirick T, Militello G, Wysoczynski M, Gumpert AM, Braun T, Uchida S. The A-to-I RNA Editing Enzyme Adar1 Is Essential for Normal Embryonic Cardiac Growth and Development. Circ Res. 2020 Jul 31;127(4):550-552. doi: 10.1161/CIRCRESAHA.120.316932. Epub 2020 May 4. PMID: 32362246; PMCID: PMC7415551.
  • Wysoczynski M, Kim J, Moore JB 4th, Uchida S. Macrophage Long Non-Coding RNAs in Pathogenesis of Cardiovascular Disease. Noncoding RNA. 2020 Jul 11;6(3):28. doi: 10.3390/ncrna6030028. PMID: 32664594; PMCID: PMC7549353.
  • Moore JB 4th, Uchida S. Functional characterization of long noncoding RNAs. Curr Opin Cardiol. 2020 May;35(3):199-206. doi: 10.1097/HCO.0000000000000725. PMID: 32068613; PMCID: PMC7236552.
  • Heidel JS, Fischer AG, Tang XL, Sadri G, Wu WJ, Moisa CR, Stowers H, Sandella N, Wysoczynski M, Uchida S, Moore Iv JB. The Effect of Cardiogenic Factors on Cardiac Mesenchymal Cell Anti-Fibrogenic Paracrine Signaling and Therapeutic Performance. Theranostics. 2020 Jan 1;10(4):1514-1530. doi: 10.7150/thno.41000. PMID: 32042319; PMCID: PMC6993223.
  • Bonnet S, Boucherat O, Paulin R, Wu D, Hindmarch CCT, Archer SL, Song R, Moore JB 4th, Provencher S, Zhang L, Uchida S. Clinical value of non-coding RNAs in cardiovascular, pulmonary, and muscle diseases. Am J Physiol Cell Physiol. 2020 Jan 1;318(1):C1-C28. doi: 10.1152/ajpcell.00078.2019. Epub 2019 Sep 4. PMID: 31483703; PMCID: PMC6985837.