Education and Training

Ph.D.: University of Louisville, Biochemistry and Molecular Biology
Postdoctoral Fellowship: Johns Hopkins University, Pediatric Oncology

Research Interests

Dr. Moore's laboratory focuses on comprehending the fundamental biology of the cardiac extracellular matrix (ECM) and its intricate involvement in cardiovascular health and disease. The cardiac ECM not only supports the heart's three-dimensional structure and orchestrates the precise arrangement of its multifarious cellular constituents but also serves as a pivotal signaling nexus, facilitating recursive communication between the cardiac stroma and parenchyma.

Despite its critical role, our understanding of the nature of this communication and its significance in cardiac development and disease processes remains limited. This knowledge gap highlights the laboratory's central pursuits: elucidating novel ECM-mediated biological processes, unraveling the intricate signaling networks underpinning cardiac development, injury-stress responses, and heart failure pathophysiology, and understanding how alterations in ECM architecture impact cardiac structure and function.

In the long term, the goal is to identify novel ECM-centric processes that can be targeted for therapeutic intervention in heart failure patients, potentially transforming treatment paradigms and improving patient outcomes.

Featured Publications

Find all papers and citations via ResearchGate

• Hosen MR, Goody PR, Zietzer A, Xiang X, Niepmann ST, Sedaghat A, Tiyerili V, Chennupati R, Moore JB 4th, Boon RA, Uchida S, Sinning JM, Zimmer S, Latz E, Werner N, Nickenig G, Jansen F. Circulating MicroRNA-122-5p Is Associated With a Lack of Improvement in Left Ventricular Function After Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracellular Vesicles. Circulation. 2022 Dec 13;146(24):1836-1854. doi: 10.1161/CIRCULATIONAHA.122.060258. Epub 2022 Jul 8. PMID: 35862223.
• Smith T, Holm RH, Yeager R, Moore JB 4th, Rouchka EC, Sokoloski KJ, Elliott EM, Talley D, Arora V, Moyer S, Bhatnagar A. Combining Community Wastewater Genomic Surveillance with State Clinical Surveillance: A Framework for SARS-CoV-2 Public Health Practice. Food Environ Virol. 2022 Dec;14(4):410-416. doi: 10.1007/s12560-022-09531-2. Epub 2022 Aug 18. PMID: 35982363; PMCID: PMC9387882.
• Westcott CE, Sokoloski KJ, Rouchka EC, Chariker JH, Holm RH, Yeager RA, Moore JB 4th, Elliott EM, Talley D, Bhatnagar A, Smith T. The Detection of Periodic Reemergence Events of SARS-CoV-2 Delta Strain in Communities Dominated by Omicron. Pathogens. 2022 Oct 28;11(11):1249. doi: 10.3390/pathogens11111249. PMID: 36365000; PMCID: PMC9697103.
• Dwenger MM, Raph SM, Baba SP, Moore JB 4th, Nystoriak MA. Diversification of Potassium Currents in Excitable Cells via Kvβ Proteins. Cells. 2022 Jul 18;11(14):2230. doi: 10.3390/cells11142230. PMID: 35883673; PMCID: PMC9317154.
• Sansbury BE, Nystoriak MA, Uchida S, Wysoczynski M, Moore JB 4th. Rigor Me This: What Are the Basic Criteria for a Rigorous, Transparent, and Reproducible Scientific Study? Front Cardiovasc Med. 2022 Jul 1;9:913612. doi: 10.3389/fcvm.2022.913612. PMID: 35845053; PMCID: PMC9283916.
• Sadri G, Fischer AG, Brittian KR, Elliott E, Nystoriak MA, Uchida S, Wysoczynski M, Leask A, Jones SP, Moore JB 4th. Collagen type XIX regulates cardiac extracellular matrix structure and ventricular function. Matrix Biol. 2022 May;109:49-69. doi: 10.1016/j.matbio.2022.03.007. Epub 2022 Mar 26. PMID: 35346795; PMCID: PMC9161575.
• Dwenger MM, Raph SM, Reyzer ML, Lisa Manier M, Riggs DW, Wohl ZB, Ohanyan V, Mack G, Pucci T, Moore JB 4th, Hill BG, Chilian WM, Caprioli RM, Bhatnagar A, Nystoriak MA. Pyridine nucleotide redox potential in coronary smooth muscle couples myocardial blood flow to cardiac metabolism. Nat Commun. 2022 Apr 19;13(1):2051. doi: 10.1038/s41467-022-29745-z. PMID: 35440632; PMCID: PMC9018695.
• Ohanyan V, Raph SM, Dwenger MM, Hu X, Pucci T, Mack G, Moore JB 4th, Chilian WM, Bhatnagar A, Nystoriak MA. Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvβ Proteins. Circ Res. 2021 Mar 19;128(6):738-751. doi: 10.1161/CIRCRESAHA.120.317715. Epub 2021 Jan 27. PMID: 33499656; PMCID: PMC8486354.
• Moore JB, Wysoczynski M. Immunomodulatory Effects of Cell Therapy after Myocardial Infarction. J Cell Immunol. 2021;3(2):85-90. doi: 10.33696/immunology.3.082. PMID: 33959728; PMCID: PMC8098722.
• Kang Y, Nasr M, Guo Y, Uchida S, Weirick T, Li H, Kim J, Moore JB 4th, Muthusamy S, Bolli R, Wysoczynski M. Administration of cardiac mesenchymal cells modulates innate immunity in the acute phase of myocardial infarction in mice. Sci Rep. 2020 Sep 8;10(1):14754. doi: 10.1038/s41598-020-71580-z. PMID: 32901075; PMCID: PMC7479609.