Steven P. Jones, Ph.D., FAHA, FISHR

Professor of Medicine
Director, Center for Cardiometabolic Science
University Scholar

502-852-2460 Email Twitter logo@StevenPJones

Education and Training

Ph.D.: Louisiana State University, Cardiovascular Physiology
Postdoctoral Fellowship: The Johns Hopkins University, Mitochondrial Biology

Research Goal

We endeavor to know the cellular and metabolic composition of the heart. We will apply such information to elucidating the causes and consequences of cardiac health and disease.

Research Interests

  • Heart failure
    • How does metabolism regulate cardiac structure and function?
    • What regulates fibroblast activation?
    • How do cells in the heart interact?
  • Physical activity
    • What are the structural consequences of physical activity on the heart?
    • How does physical activity alter cell function in the heart?
    • How can insights from physical activity be applied to the failing heart?
  • Cardiovascular aging
  • Cardiohepatic interactions
  • Risk factors (such as diabetes) in the development of disease

In all such endeavors, the laboratory group invokes a multidisciplinary approach to answer important questions in a variety of in vivo and in vitro models. Our group is also dedicated to providing a fertile environment for trainees to gain the necessary experience and guidance to become independent investigators.

Featured Publications

For a complete list, please visit MyNCBI.

  • Head KZ, Bolatimi OE, Gripshover TC, Tan M, Li Y, Audam TN, Jones SP, Klinge CM, Cave MC, Wahlang B. Investigating the effects of long-term Aroclor 1260 exposure on fatty liver disease in a diet-induced obesity mouse model. Front Gastroenterol (Lausanne). 2023;2:1180712. doi: 10.3389/fgstr.2023.1180712. Epub 2023 May 12. PMID: 37426695; PMCID: PMC10327714.
  • Fulghum K, Collins HE, Jones SP, Hill BG. Influence of biological sex and exercise on murine cardiac metabolism. J Sport Health Sci. 2022 Jul;11(4):479-494. doi: 10.1016/j.jshs.2022.06.001. Epub 2022 Jun 7. PMID: 35688382; PMCID: PMC9338340.
  • Fulghum KL, Smith JB, Chariker J, Garrett LF, Brittian KR, Lorkiewicz PK, McNally LA, Uchida S, Jones SP, Hill BG, Collins HE. Metabolic signatures of pregnancy-induced cardiac growth. Am J Physiol Heart Circ Physiol. 2022 Jul 1;323(1):H146-H164. doi: 10.1152/ajpheart.00105.2022. Epub 2022 May 27. PMID: 35622533; PMCID: PMC9236881.
  • Sadri G, Fischer AG, Brittian KR, Elliott E, Nystoriak MA, Uchida S, Wysoczynski M, Leask A, Jones SP, Moore JB 4th. Collagen type XIX regulates cardiac extracellular matrix structure and ventricular function. Matrix Biol. 2022 May;109:49-69. doi: 10.1016/j.matbio.2022.03.007. Epub 2022 Mar 26. PMID: 35346795; PMCID: PMC9161575.
  • Zelko IN, Dassanayaka S, Malovichko MV, Howard CM, Garrett LF, Uchida S, Brittian KR, Conklin DJ, Jones SP, Srivastava S. Chronic Benzene Exposure Aggravates Pressure Overload-Induced Cardiac Dysfunction. Toxicol Sci. 2021 Dec 28;185(1):64-76. doi: 10.1093/toxsci/kfab125. PMID: 34718823; PMCID: PMC8714365.
  • Lindsey ML, Brunt KR, Kirk JA, Kleinbongard P, Calvert JW, de Castro Brás LE, DeLeon-Pennell KY, Del Re DP, Frangogiannis NG, Frantz S, Gumina RJ, Halade GV, Jones SP, Ritchie RH, Spinale FG, Thorp EB, Ripplinger CM, Kassiri Z. Guidelines for in vivo mouse models of myocardial infarction. Am J Physiol Heart Circ Physiol. 2021 Dec 1;321(6):H1056-H1073. doi: 10.1152/ajpheart.00459.2021. Epub 2021 Oct 8. PMID: 34623181; PMCID: PMC8834230.
  • Audam TN, Howard CM, Garrett LF, Zheng YW, Bradley JA, Brittian KR, Frank MW, Fulghum KL, Pólos M, Herczeg S, Merkely B, Radovits T, Uchida S, Hill BG, Dassanayaka S, Jackowski S, Jones SP. Cardiac PANK1 deletion exacerbates ventricular dysfunction during pressure overload. Am J Physiol Heart Circ Physiol. 2021 Oct 1;321(4):H784-H797. doi: 10.1152/ajpheart.00411.2021. Epub 2021 Sep 17. PMID: 34533403; PMCID: PMC8794231.
  • Jones SP. Angiotensinogen Takes Some of the Spotlight From Angiotensin II in the Cardiohepatic Axis. Circ Res. 2021 Aug 20;129(5):565-567. doi: 10.1161/CIRCRESAHA.121.319784. Epub 2021 Aug 19. PMID: 34410822; PMCID: PMC8384130.
  • Alcaide P, Jones SP. The Sweet Smell of Progress With Hyaluronan and Heart Failure. Hypertension. 2021 Jun;77(6):1928-1930. doi: 10.1161/HYPERTENSIONAHA.121.17211. Epub 2021 May 12. PMID: 33979180; PMCID: PMC8415039.
  • Dassanayaka S, Brittian KR, Long BW, Higgins LA, Bradley JA, Audam TN, Jurkovic A, Gumpert AM, Harrison LT, Hartyánszky I, Perge P, Merkely B, Radovits T, Hanover JA, Jones SP. Cardiomyocyte Oga haploinsufficiency increases O-GlcNAcylation but hastens ventricular dysfunction following myocardial infarction. PLoS One. 2020 Nov 30;15(11):e0242250. doi: 10.1371/journal.pone.0242250. PMID: 33253217; PMCID: PMC7703924.