Steven P. Jones, Ph.D., FAHA

Professor of Medicine
University Scholar
Director, Diabetes and Obesity Center

502-852-2460 Email Twitter logo@StevenPJones

Education and Training

Ph.D.: Louisiana State University, Cardiovascular Physiology
Postdoctoral Fellowship: Johns Hopkins University, Mitochondrial Biology

Research Goal

My goal is to understand why myocytes die during acute myocardial infarction and heart failure and to develop strategies to prevent cell death.

Research Interests

  • Understanding the mechanisms of cardiac muscle damage during a heart attack and developing novel therapeutics to preserve the heart
  • Elucidating the molecular regulation of cardiac hypertrophy and the transition to heart failure
  • Investigating the confounding influence of risk factors (such as diabetes) on the development of heart disease

In all such endeavors, the laboratory group invokes a multidisciplinary approach to answer important questions in a variety of in vivo and in vitro models. My laboratory is also dedicated to providing a fertile environment for students and fellows to gain the necessary experience and guidance to become independent investigators.

Featured Publications

For a complete list, please visit Publons

  • Alcaide P, Jones SP. The Sweet Smell of Progress With Hyaluronan and Heart Failure. Hypertension. 2021 Jun;77(6):1928-1930. doi: 10.1161/HYPERTENSIONAHA.121.17211. Epub 2021 May 12. PMID: 33979180.
  • Audam TN, Nong Y, Tomlin A, Jurkovic A, Li H, Zhu X, Long BW, Zheng YW, Weirick T, Brittian KR, Riggs DW, Gumpert A, Uchida S, Guo Y, Wysoczynski M, Jones SP. Cardiac mesenchymal cells from failing and nonfailing hearts limit ventricular dilation when administered late after infarction. Am J Physiol Heart Circ Physiol. 2020 Jul 1;319(1):H109-H122. doi: 10.1152/ajpheart.00114.2020. Epub 2020 May 22. PMID: 32442025; PMCID: PMC7474443.
  • Dassanayaka S, Brittian KR, Long BW, Higgins LA, Bradley JA, Audam TN, Jurkovic A, Gumpert AM, Harrison LT, Hartyánszky I, Perge P, Merkely B, Radovits T, Hanover JA, Jones SP. Cardiomyocyte Oga haploinsufficiency increases O-GlcNAcylation but hastens ventricular dysfunction following myocardial infarction. PLoS One. 2020 Nov 30;15(11):e0242250. doi: 10.1371/journal.pone.0242250. PMID: 33253217; PMCID: PMC7703924.
  • Kilfoil PJ, Chapalamadugu KC, Hu X, Zhang D, Raucci FJ Jr, Tur J, Brittian KR, Jones SP, Bhatnagar A, Tipparaju SM, Nystoriak MA. Metabolic regulation of Kv channels and cardiac repolarization by Kvβ2 subunits. J Mol Cell Cardiol. 2019 Dec;137:93-106. doi: 10.1016/j.yjmcc.2019.09.013. Epub 2019 Oct 19. PMID: 31639389; PMCID: PMC7344177.
  • Ou Q, Jacobson Z, Abouleisa RRE, Tang XL, Hindi SM, Kumar A, Ivey KN, Giridharan G, El-Baz A, Brittian K, Rood B, Lin YH, Watson SA, Perbellini F, McKinsey TA, Hill BG, Jones SP, Terracciano CM, Bolli R, Mohamed TMA. Physiological Biomimetic Culture System for Pig and Human Heart Slices. Circ Res. 2019 Aug 30;125(6):628-642. doi: 10.1161/CIRCRESAHA.119.314996. Epub 2019 Jul 16. PMID: 31310161; PMCID: PMC6715512.
  • Friedl RM, Raja S, Metzler MA, Patel ND, Brittian KR, Jones SP, Sandell LL. RDH10 function is necessary for spontaneous fetal mouth movement that facilitates palate shelf elevation. Dis Model Mech. 2019 Jul 3;12(7):dmm039073. doi: 10.1242/dmm.039073. PMID: 31300413; PMCID: PMC6679383.
  • Dassanayaka S, Brittian KR, Jurkovic A, Higgins LA, Audam TN, Long BW, Harrison LT, Militello G, Riggs DW, Chitre MG, Uchida S, Muthusamy S, Gumpert AM, Jones SP. E2f1 deletion attenuates infarct-induced ventricular remodeling without affecting O-GlcNAcylation. Basic Res Cardiol. 2019 May 31;114(4):28. doi: 10.1007/s00395-019-0737-y. PMID: 31152247; PMCID: PMC7278029.
  • Dassanayaka S, Zheng Y, Gibb AA, Cummins TD, McNally LA, Brittian KR, Jagatheesan G, Audam TN, Long BW, Brainard RE, Jones SP, Hill BG. Cardiac-specific overexpression of aldehyde dehydrogenase 2 exacerbates cardiac remodeling in response to pressure overload. Redox Biol. 2018 Jul;17:440-449. doi: 10.1016/j.redox.2018.05.016. Epub 2018 Jun 1. PMID: 29885625; PMCID: PMC5991908.
  • Baba SP, Zhang D, Singh M, Dassanayaka S, Xie Z, Jagatheesan G, Zhao J, Schmidtke VK, Brittian KR, Merchant ML, Conklin DJ, Jones SP, Bhatnagar A. Deficiency of aldose reductase exacerbates early pressure overload-induced cardiac dysfunction and autophagy in mice. J Mol Cell Cardiol. 2018 May;118:183-192. doi: 10.1016/j.yjmcc.2018.04.002. Epub 2018 Apr 5. PMID: 29627295; PMCID: PMC6205513.
  • Hosen MR, Militello G, Weirick T, Ponomareva Y, Dassanayaka S, Moore JB 4th, Döring C, Wysoczynski M, Jones SP, Dimmeler S, Uchida S.Airn Regulates Igf2bp2 Translation in Cardiomyocytes. Circ Res. 2018 May 11;122(10):1347-1353. doi: 10.1161/CIRCRESAHA.117.312215. Epub 2018 Feb 26. PMID: 29483092; PMCID: PMC5948151.