Bradford G. Hill, Ph.D., FAHA

Professor of Medicine
University Scholar

502-852-1015 E-mail

Education and Training

Ph.D.: University of Louisville, Biochemistry
Postdoctoral Fellowship: University of Alabama at Birmingham, Mitochondrial Biology

Research Interests

The broad theme of my research entails understanding how changes in metabolism contribute to cardio-metabolic health and disease. This involves the critical examination of glycolysis, mitochondria, and other pathways of intermediary metabolism and the development of causal relationships between metabolic defects or signatures and (patho)physiology.

Featured Publications

Find all papers and citations via My NCBI

  • Fulghum K, Collins HE, Jones SP, Hill BG. Influence of biological sex and exercise on murine cardiac metabolism. J Sport Health Sci. 2022 Jun 7:S2095-2546(22)00059-X. doi: 10.1016/j.jshs.2022.06.001. Epub ahead of print. PMID: 35688382.
  • Fulghum KL, Smith JB, Chariker J, Garrett LF, Brittian KR, Lorkiewicz P, McNally LA, Uchida S, Jones SP, Hill BG, Collins HE. Metabolic Signatures of Pregnancy-Induced Cardiac Growth. Am J Physiol Heart Circ Physiol. 2022 May 27. doi: 10.1152/ajpheart.00105.2022. Epub ahead of print. PMID: 35622533.
  • Mohamed TMA, Abouleisa R, Hill BG. Metabolic Determinants of Cardiomyocyte Proliferation. Stem Cells. 2022 May 27;40(5):458-467. doi: 10.1093/stmcls/sxac016. PMID: 35263763; PMCID: PMC9156555.
  • Gibb AA, Murray EK, Huynh AT, Gaspar RB, Ploesch TL, Bedi K, Lombardi AA, Lorkiewicz PK, Roy R, Arany Z, Kelly DP, Margulies KB, Hill BG, Elrod JW. Glutaminolysis is Essential for Myofibroblast Persistence and In Vivo Targeting Reverses Fibrosis and Cardiac Dysfunction in Heart Failure. Circulation. 2022 May 24;145(21):1625-1628. doi: 10.1161/CIRCULATIONAHA.121.057879. Epub 2022 May 23. PMID: 35605036; PMCID: PMC9179236.
  • Abouleisa RRE, Salama ABM, Ou Q, Tang XL, Solanki M, Guo Y, Nong Y, McNally L, Lorkiewicz PK, Kassem KM, Ahern BM, Choudhary K, Thomas R, Huang Y, Juhardeen HR, Siddique A, Ifthikar Z, Hammad SK, Elbaz AS, Ivey KN, Conklin DJ, Satin J, Hill BG, Srivastava D, Bolli R, Mohamed TMA. Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure. Circulation. 2022 Apr 26;145(17):1339-1355. doi: 10.1161/CIRCULATIONAHA.121.057641. Epub 2022 Jan 21. PMID: 35061545; PMCID: PMC9038650.
  • Dwenger MM, Raph SM, Reyzer ML, Lisa Manier M, Riggs DW, Wohl ZB, Ohanyan V, Mack G, Pucci T, Moore JB 4th, Hill BG, Chilian WM, Caprioli RM, Bhatnagar A, Nystoriak MA. Pyridine nucleotide redox potential in coronary smooth muscle couples myocardial blood flow to cardiac metabolism. Nat Commun. 2022 Apr 19;13(1):2051. doi: 10.1038/s41467-022-29745-z. PMID: 35440632; PMCID: PMC9018695.
  • Fulghum KL, Audam TN, Lorkiewicz PK, Zheng Y, Merchant M, Cummins TD, Dean WL, Cassel TA, Fan TWM, Hill BG. In vivo deep network tracing reveals phosphofructokinase-mediated coordination of biosynthetic pathway activity in the myocardium. J Mol Cell Cardiol. 2022 Jan;162:32-42. doi: 10.1016/j.yjmcc.2021.08.013. Epub 2021 Sep 3. PMID: 34487754; PMCID: PMC8766935.
  • Malovichko MV, Abplanalp WT, McFall SA, Taylor BS, Wickramasinghe NS, Sithu ID, Zelko IN, Uchida S, Hill BG, Sutaria SR, Nantz MH, Bhatnagar A, Conklin DJ, O'Toole TE, Srivastava S. Subclinical markers of cardiovascular toxicity of benzene inhalation in mice. Toxicol Appl Pharmacol. 2021 Nov 15;431:115742. doi: 10.1016/j.taap.2021.115742. Epub 2021 Oct 5. PMID: 34624356; PMCID: PMC8647905.
  • Audam TN, Howard CM, Garrett LF, Zheng YW, Bradley JA, Brittian KR, Frank MW, Fulghum KL, Pólos M, Herczeg S, Merkely B, Radovits T, Uchida S, Hill BG, Dassanayaka S, Jackowski S, Jones SP. Cardiac PANK1 deletion exacerbates ventricular dysfunction during pressure overload. Am J Physiol Heart Circ Physiol. 2021 Oct 1;321(4):H784-H797. doi: 10.1152/ajpheart.00411.2021. Epub 2021 Sep 17. PMID: 34533403; PMCID: PMC8794231.
  • Abouleisa RRE, McNally L, Salama ABM, Hammad SK, Ou Q, Wells C, Lorkiewicz PK, Bolli R, Mohamed TMA, Hill BG. Cell cycle induction in human cardiomyocytes is dependent on biosynthetic pathway activation. Redox Biol. 2021 Oct;46:102094. doi: 10.1016/j.redox.2021.102094. Epub 2021 Aug 5. PMID: 34418597; PMCID: PMC8379496.
  • Hill BG, Rood B, Ribble A, Haberzettl P. Fine particulate matter (PM2.5) inhalation-induced alterations in the plasma lipidome as promoters of vascular inflammation and insulin resistance. Am J Physiol Heart Circ Physiol. 2021 May 1;320(5):H1836-H1850. doi: 10.1152/ajpheart.00881.2020. Epub 2021 Mar 5. PMID: 33666505; PMCID: PMC8163652.
  • Singh P, O'Toole TE, Conklin DJ, Hill BG, Haberzettl P. Endothelial progenitor cells as critical mediators of environmental air pollution-induced cardiovascular toxicity. Am J Physiol Heart Circ Physiol. 2021 Apr 1;320(4):H1440-H1455. doi: 10.1152/ajpheart.00804.2020. Epub 2021 Feb 19. PMID: 33606580; PMCID: PMC8260385.
  • McNally LA, Altamimi TR, Fulghum K, Hill BG. Considerations for using isolated cell systems to understand cardiac metabolism and biology. J Mol Cell Cardiol. 2021 Apr;153:26-41. doi: 10.1016/j.yjmcc.2020.12.007. Epub 2020 Dec 21. PMID: 33359038; PMCID: PMC8026511.
  • Miller JM, Meki MH, Ou Q, George SA, Gams A, Abouleisa RRE, Tang XL, Ahern BM, Giridharan GA, El-Baz A, Hill BG, Satin J, Conklin DJ, Moslehi J, Bolli R, Ribeiro AJS, Efimov IR, Mohamed TMA. Heart slice culture system reliably demonstrates clinical drug-related cardiotoxicity. Toxicol Appl Pharmacol. 2020 Nov 1;406:115213. doi: 10.1016/j.taap.2020.115213. Epub 2020 Aug 30. PMID: 32877659; PMCID: PMC7554180.
  • Bushau-Sprinkle A, Barati MT, Gagnon KB, Khundmiri SJ, Kitterman K, Hill BG, Sherwood A, Merchant M, Rai SN, Srivastava S, Clark B, Siskind L, Brier M, Hata J, Lederer E. NHERF1 Loss Upregulates Enzymes of the Pentose Phosphate Pathway in Kidney Cortex. Antioxidants (Basel). 2020 Sep 14;9(9):862. doi: 10.3390/antiox9090862. PMID: 32937931; PMCID: PMC7554817.
  • Liu M, Tong Z, Ding C, Luo F, Wu S, Wu C, Albeituni S, He L, Hu X, Tieri D, Rouchka EC, Hamada M, Takahashi S, Gibb AA, Kloecker G, Zhang HG, Bousamra M 2nd, Hill BG, Zhang X, Yan J. Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer. J Clin Invest. 2020 Apr 1;130(4):2081-2096. doi: 10.1172/JCI131335. PMID: 31945018; PMCID: PMC7108920.
  • Hill BG, Shiva S, Ballinger S, Zhang J, Darley-Usmar VM. Bioenergetics and translational metabolism: implications for genetics, physiology and precision medicine. Biol Chem. 2019 Dec 18;401(1):3-29. doi: 10.1515/hsz-2019-0268. PMID: 31815377; PMCID: PMC6944318.
  • Zheng JJ, Pena Calderin E, Hill BG, Bhatnagar A, Hellmann J. Exercise Promotes Resolution of Acute Inflammation by Catecholamine-Mediated Stimulation of Resolvin D1 Biosynthesis. J Immunol. 2019 Dec 1;203(11):3013-3022. doi: 10.4049/jimmunol.1900144. Epub 2019 Oct 25. PMID: 31653685; PMCID: PMC6864295.
  • Haus JM, Hill BG. Editorial: Mechanisms by Which Acute and Chronic Exercise Promote Cardiometabolic Health. Front Cardiovasc Med. 2019 Nov 6;6:159. doi: 10.3389/fcvm.2019.00159. PMID: 31781575; PMCID: PMC6851014.
  • Lombardi AA, Gibb AA, Arif E, Kolmetzky DW, Tomar D, Luongo TS, Jadiya P, Murray EK, Lorkiewicz PK, Hajnóczky G, Murphy E, Arany ZP, Kelly DP, Margulies KB, Hill BG, Elrod JW. Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation. Nat Commun. 2019 Oct 4;10(1):4509. doi: 10.1038/s41467-019-12103-x. PMID: 31586055; PMCID: PMC6778142.