Bradford G. Hill, Ph.D., FAHA

Professor of Medicine
Associate Director, Center for Cardiometabolic Science
University Scholar

502-852-1015 E-mail

Education and Training

Ph.D.: University of Louisville, Biochemistry
Postdoctoral Fellowship: University of Alabama at Birmingham, Mitochondrial Biology

Research Interests

The broad theme of my research entails understanding how changes in metabolism contribute to cardio-metabolic health and disease. This involves the critical examination of glycolysis, mitochondria, and other pathways of intermediary metabolism and the development of causal relationships between metabolic defects or signatures and (patho)physiology.

Featured Publications

Find all papers and citations via My NCBI

  • Schulman-Geltzer EB, Collins HE, Hill BG, Fulghum KL. Coordinated Metabolic Responses Facilitate Cardiac Growth in Pregnancy and Exercise. Curr Heart Fail Rep. 2023 Aug 15. doi: 10.1007/s11897-023-00622-0. Epub ahead of print. PMID: 37581772.
  • Zheng Y, Gibb AA, Xu H, Liu S, Hill BG. The metabolic state of the heart regulates mitochondrial supercomplex abundance in mice. Redox Biol. 2023 Jul;63:102740. doi: 10.1016/j.redox.2023.102740. Epub 2023 May 15. PMID: 37210780; PMCID: PMC10209883.
  • Kurlawala Z, Singh P, Hill BG, Haberzettl P. Fine Particulate Matter (PM2.5)-Induced Pulmonary Oxidative Stress Contributes to Changes in the Plasma Lipidome and Liver Transcriptome in Mice. Toxicol Sci. 2023 Mar 1;192(2):209–22. doi: 10.1093/toxsci/kfad020. Epub ahead of print. PMID: 36857595; PMCID: PMC10109534.
  • Calderin EP, Zheng JJ, Boyd NL, McNally L, Audam TN, Lorkiewicz P, Hill BG, Hellmann J. Exercise-induced specialized proresolving mediators stimulate AMPK phosphorylation to promote mitochondrial respiration in macrophages. Mol Metab. 2022 Dec;66:101637. doi: 10.1016/j.molmet.2022.101637. Epub 2022 Nov 15. PMID: 36400404; PMCID: PMC9719872.
  • Gibb AA, Huynh AT, Gaspar RB, Ploesch TL, Lombardi AA, Lorkiewicz PK, Lazaropoulos MP, Bedi K, Arany Z, Margulies KB, Hill BG, Elrod JW. Glutamine uptake and catabolism is required for myofibroblast formation and persistence. J Mol Cell Cardiol. 2022 Nov;172:78-89. doi: 10.1016/j.yjmcc.2022.08.002. Epub 2022 Aug 18. PMID: 35988357.
  • Whitt AG, Meng S, Jin JZ, Conroy LR, McNally LA, Burlison JA, Hill BG, Clem BF, White C, Li C. PON2 mediates mitochondrial dysfunction in tracheal epithelial cells in response to a quorum sensing molecule N-(-3-oxododecanoyl)-l-homoserine lactone. Biochem J. 2022 Oct 14;479(19):2013-2034. doi: 10.1042/BCJ20220100. PMID: 36094147.
  • Miller JM, Meki MH, Elnakib A, Ou Q, Abouleisa RRE, Tang XL, Salama ABM, Gebreil A, Lin C, Abdeltawab H, Khalifa F, Hill BG, Abi-Gerges N, Bolli R, El-Baz AS, Giridharan GA, Mohamed TMA. Biomimetic cardiac tissue culture model (CTCM) to emulate cardiac physiology and pathophysiology ex vivo. Commun Biol. 2022 Sep 9;5(1):934. doi: 10.1038/s42003-022-03919-3. PMID: 36085302; PMCID: PMC9463130.
  • Fulghum K, Collins HE, Jones SP, Hill BG. Influence of biological sex and exercise on murine cardiac metabolism. J Sport Health Sci. 2022 Jul;11(4):479-494. doi: 10.1016/j.jshs.2022.06.001. Epub 2022 Jun 7. PMID: 35688382; PMCID: PMC9338340.
  • Fulghum KL, Smith JB, Chariker J, Garrett LF, Brittian KR, Lorkiewicz PK, McNally LA, Uchida S, Jones SP, Hill BG, Collins HE. Metabolic signatures of pregnancy-induced cardiac growth. Am J Physiol Heart Circ Physiol. 2022 Jul 1;323(1):H146-H164. doi: 10.1152/ajpheart.00105.2022. Epub 2022 May 27. PMID: 35622533; PMCID: PMC9236881.
  • Hill BG. Cardiac GRK2 and the Communicative Axis Between Heart and Fat. JACC Basic Transl Sci. 2022 Jun 27;7(6):580-581. doi: 10.1016/j.jacbts.2022.02.020. PMID: 35818507; PMCID: PMC9270589.