Jason L. Hellmann, Ph.D.

Associate Professor of Medicine

502-852-8071 E-mail

Education and Training

  • Ph.D.: University of Louisville, Physiology and Biophysics
  • Postdoctoral Fellowships: University of Louisville; Brigham and Women's Hospital/Harvard Medical School

Research Interests

We aim to identify basic cellular mechanisms that intrinsically regulate inflammatory tone and duration to garner new knowledge for the better treatment of chronic diseases with an inflammatory etiology. Our research is focused on uncovering novel mechanisms that control bioactive lipid mediator biosynthesis and inflammation resolution.

Featured Publications

Find all papers and citations via ResearchGate

  • Ribble A, Hellmann J, Conklin DJ, Bhatnagar A, Haberzettl P. Fine particulate matter (PM2.5)-induced pulmonary oxidative stress contributes to increases in glucose intolerance and insulin resistance in a mouse model of circadian dyssynchrony. Sci Total Environ. 2023 Jun 15;877:162934. doi: 10.1016/j.scitotenv.2023.162934. Epub 2023 Mar 18. PMID: 36934930; PMCID: PMC10164116.
  • Calderin EP, Zheng JJ, Boyd NL, McNally L, Audam TN, Lorkiewicz P, Hill BG, Hellmann J. Exercise-induced specialized proresolving mediators stimulate AMPK phosphorylation to promote mitochondrial respiration in macrophages. Mol Metab. 2022 Dec;66:101637. doi: 10.1016/j.molmet.2022.101637. Epub 2022 Nov 15. PMID: 36400404; PMCID: PMC9719872.
  • Farley G, Riggs DW, Bhatnagar A, Hellmann J. Omega-3 polyunsaturated fatty acids modify the inverse association between systemic inflammation and cardiovascular fitness. Clin Nutr. 2021 Jun;40(6):4097-4105. doi: 10.1016/j.clnu.2021.02.006. Epub 2021 Feb 11. PMID: 33618966; PMCID: PMC8243787.
  • Baba S, Smith T, Hellmann J, Bhatnagar A, Carter K, Vanhoover A, Caruso J. Space Flight Diet-Induced Deficiency and Response to Gravity-Free Resistive Exercise. Nutrients. 2020 Aug 11;12(8):2400. doi: 10.3390/nu12082400. PMID: 32796546; PMCID: PMC7468946.
  • Zheng JJ, Pena Calderin E, Hill BG, Bhatnagar A, Hellmann J. Exercise Promotes Resolution of Acute Inflammation by Catecholamine-Mediated Stimulation of Resolvin D1 Biosynthesis. J Immunol. 2019 Dec 1;203(11):3013-3022. doi: 10.4049/jimmunol.1900144. Epub 2019 Oct 25. PMID: 31653685; PMCID: PMC6864295.
  • Chuong P, Wysoczynski M, Hellmann J. Do Changes in Innate Immunity Underlie the Cardiovascular Benefits of Exercise? Front Cardiovasc Med. 2019 May 29;6:70. doi: 10.3389/fcvm.2019.00070. PMID: 31192231; PMCID: PMC6549037.
  • Hellmann J, Sansbury BE, Wong B, Li X, Singh M, Nuutila K, Chiang N, Eriksson E, Serhan CN, Spite M. Biosynthesis of D-Series Resolvins in Skin Provides Insights into their Role in Tissue Repair. J Invest Dermatol. 2018 Sep;138(9):2051-2060. doi: 10.1016/j.jid.2018.03.1498. Epub 2018 Mar 17. PMID: 29559341; PMCID: PMC6109422.
  • Fredman G, Hellmann J, Proto JD, Kuriakose G, Colas RA, Dorweiler B, Connolly ES, Solomon R, Jones DM, Heyer EJ, Spite M, Tabas I. An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques. Nat Commun. 2016 Sep 23;7:12859. doi: 10.1038/ncomms12859. PMID: 27659679; PMCID: PMC5036151.
  • Zhang MJ, Sansbury BE, Hellmann J, Baker JF, Guo L, Parmer CM, Prenner JC, Conklin DJ, Bhatnagar A, Creager MA, Spite M. Resolvin D2 Enhances Postischemic Revascularization While Resolving Inflammation. Circulation. 2016 Aug 30;134(9):666-680. doi: 10.1161/CIRCULATIONAHA.116.021894. Epub 2016 Aug 9. PMID: 27507404; PMCID: PMC5214591.
  • Hellmann J, Sansbury BE, Holden CR, Tang Y, Wong B, Wysoczynski M, Rodriguez J, Bhatnagar A, Hill BG, Spite M. CCR7 Maintains Nonresolving Lymph Node and Adipose Inflammation in Obesity. Diabetes. 2016 Aug;65(8):2268-81. doi: 10.2337/db15-1689. Epub 2016 May 3. PMID: 27207557; PMCID: PMC4955992.