Education and Training

• Ph.D.: University of Louisville, Physiology and Biophysics
• Postdoctoral Fellowships: University of Louisville; Brigham and Women's Hospital/Harvard Medical School

Research Interests

• Jason Hellmann Lab

We aim to identify basic cellular mechanisms that intrinsically regulate inflammatory tone and duration to garner new knowledge for the better treatment of chronic diseases with an inflammatory etiology. Our research is focused on uncovering novel mechanisms that control bioactive lipid mediator biosynthesis and inflammation resolution.

Featured Publications

Find all papers and citations via ResearchGate

• Brady A, Sheneman KR, Pulsifer AR, Price SL, Garrison TM, Maddipati KR, Bodduluri SR, Pan J, Boyd NL, Zheng JJ, Rai SN, Hellmann J, Haribabu B, Uriarte SM, Lawrenz MB. Type 3 secretion system induced leukotriene B4 synthesis by leukocytes is actively inhibited by Yersinia pestis to evade early immune recognition. PLoS Pathog. 2024 Jan 25;20(1):e1011280. doi: 10.1371/journal.ppat.1011280. PMID: 38271464; PMCID: PMC10846697.
• McGowan NG, Zhong JH, Trasande L, Hellmann J, Heffron SP. A randomized, placebo-controlled crossover trial to assess the influence of body weight on aspirin-triggered specialized pro-resolving mediators: Protocol for the DISCOVER Study. Int J Clin Trials. 2024 Jan-Mar;11(1):53-60. doi: 10.18203/2349-3259.ijct20240043. Epub 2024 Jan 24. PMID: 38585621; PMCID: PMC10997378.
• Ribble A, Hellmann J, Conklin DJ, Bhatnagar A, Haberzettl P. Fine particulate matter (PM_2.5)-induced pulmonary oxidative stress contributes to increases in glucose intolerance and insulin resistance in a mouse model of circadian dyssynchrony. Sci Total Environ. 2023 Jun 15;877:162934. doi: 10.1016/j.scitotenv.2023.162934. Epub 2023 Mar 18. PMID: 36934930; PMCID: PMC10164116.
• Calderin EP, Zheng JJ, Boyd NL, McNally L, Audam TN, Lorkiewicz P, Hill BG, Hellmann J. Exercise-induced specialized proresolving mediators stimulate AMPK phosphorylation to promote mitochondrial respiration in macrophages. Mol Metab. 2022 Dec;66:101637. doi: 10.1016/j.molmet.2022.101637. Epub 2022 Nov 15. PMID: 36400404; PMCID: PMC9719872.
• Farley G, Riggs DW, Bhatnagar A, Hellmann J. Omega-3 polyunsaturated fatty acids modify the inverse association between systemic inflammation and cardiovascular fitness. Clin Nutr. 2021 Jun;40(6):4097-4105. doi: 10.1016/j.clnu.2021.02.006. Epub 2021 Feb 11. PMID: 33618966; PMCID: PMC8243787.
• Baba S, Smith T, Hellmann J, Bhatnagar A, Carter K, Vanhoover A, Caruso J. Space Flight Diet-Induced Deficiency and Response to Gravity-Free Resistive Exercise. Nutrients. 2020 Aug 11;12(8):2400. doi: 10.3390/nu12082400. PMID: 32796546; PMCID: PMC7468946.
• Zheng JJ, Pena Calderin E, Hill BG, Bhatnagar A, Hellmann J. Exercise Promotes Resolution of Acute Inflammation by Catecholamine-Mediated Stimulation of Resolvin D1 Biosynthesis. J Immunol. 2019 Dec 1;203(11):3013-3022. doi: 10.4049/jimmunol.1900144. Epub 2019 Oct 25. PMID: 31653685; PMCID: PMC6864295.
• Chuong P, Wysoczynski M, Hellmann J. Do Changes in Innate Immunity Underlie the Cardiovascular Benefits of Exercise? Front Cardiovasc Med. 2019 May 29;6:70. doi: 10.3389/fcvm.2019.00070. PMID: 31192231; PMCID: PMC6549037.
• Hellmann J, Sansbury BE, Wong B, Li X, Singh M, Nuutila K, Chiang N, Eriksson E, Serhan CN, Spite M. Biosynthesis of D-Series Resolvins in Skin Provides Insights into their Role in Tissue Repair. J Invest Dermatol. 2018 Sep;138(9):2051-2060. doi: 10.1016/j.jid.2018.03.1498. Epub 2018 Mar 17. PMID: 29559341; PMCID: PMC6109422.
• Fredman G, Hellmann J, Proto JD, Kuriakose G, Colas RA, Dorweiler B, Connolly ES, Solomon R, Jones DM, Heyer EJ, Spite M, Tabas I. An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques. Nat Commun. 2016 Sep 23;7:12859. doi: 10.1038/ncomms12859. PMID: 27659679; PMCID: PMC5036151.