Andrew A. Gibb, Ph.D.

Assistant Professor of Medicine

502-852-9699 • E-Mail • Twitter logo@AndrewGibbPhD

Education and Training

Ph.D.: University of Louisville, Physiology and Biophysics
Postdoctoral Fellowship: Temple University, Mitochondrial Biology and Cardiovascular Physiology

Research Goals

The overall goal of the lab is to elucidate the causes and consequences of cardiac health and disease through the mechanistic interrogation of novel molecular and metabolic pathways. Our team utilizes a wide-range of techniques from discovery-based screen, in vitro mechanistic approaches, in vivo models of exercise and heart failure, and the generation of novel mutant animal models with a goal of discovering new therapies for the treatment and prevention of heart disease.

Research Interests

As multiple comorbidities and cell types contribute to the development and progression of cardiovascular disease and eventual heart failure, the lab has developed a diverse yet targeted research portfolio to address these issues.

Current Interests:

  1. Understanding the mechanisms contributing to and distinguishing between heart failure with reduced (HFrEF) and preserved (HFpEF) ejection fraction.
  2. Identification of novel metabolic pathways which can be therapeutically manipulated to enhance cardiac energetics and mitigate maladaptive remodeling in HF.
  3. Defining novel pathways by which cardiac fibroblasts are activated and contribute to tissue fibrosis in.

Additional Interests:

  1. The effects of exercise on cardiac health and whether these pathways can be beneficially applied to HF.
  2. The interplay between metabolism and the epigenome in cell fate decisions and overall responses to stress.
  3. Metabolic regulation of striated muscle responses in health and disease.

Featured Publications

For a complete list, please visit MyNCBI

  • Gibb AA, Murray EK, Huynh AT, Gaspar RB, Ploesch TL, Bedi K, Lombardi AA, Lorkiewicz PK, Roy R, Arany Z, Kelly DP, Margulies KB, Hill BG, Elrod JW. Glutaminolysis is Essential for Myofibroblast Persistence and In Vivo Targeting Reverses Fibrosis and Cardiac Dysfunction in Heart Failure. Circulation. 2022 May 24;145(21):1625-1628. doi: 10.1161/CIRCULATIONAHA.121.057879. Epub 2022 May 23. PubMed PMID: 35605036; PubMed Central PMCID: PMC9179236.
  • Gibb AA, Huynh AT, Gaspar RB, Ploesch TL, Lombardi AA, Lorkiewicz PK, Lazaropoulos MP, Bedi K, Arany Z, Margulies KB, Hill BG, Elrod JW. Glutamine uptake and catabolism is required for myofibroblast formation and persistence. J Mol Cell Cardiol. 2022 Nov;172:78-89. doi: 10.1016/j.yjmcc.2022.08.002. Epub 2022 Aug 18. PubMed PMID: 35988357; PubMed Central PMCID: PMC10486318.
  • Gibb AA, Murray EK, Eaton DM, Huynh AT, Tomar D, Garbincius JF, Kolmetzky DW, Berretta RM, Wallner M, Houser SR, Elrod JW. Molecular Signature of HFpEF: Systems Biology in a Cardiac-Centric Large Animal Model. JACC Basic Transl Sci. 2021 Aug;6(8):650-672. doi: 10.1016/j.jacbts.2021.07.004. eCollection 2021 Aug. PubMed PMID: 34466752; PubMed Central PMCID: PMC8385567.
  • Gross P, Johnson J, Romero CM, Eaton DM, Poulet C, Sanchez-Alonso J, Lucarelli C, Ross J, Gibb AA, Garbincius JF, Lambert J, Varol E, Yang Y, Wallner M, Feldsott EA, Kubo H, Berretta RM, Yu D, Rizzo V, Elrod J, Sabri A, Gorelik J, Chen X, Houser SR. Interaction of the Joining Region in Junctophilin-2 With the L-Type Ca(2+) Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca(2+) Dynamics. Circ Res. 2021 Jan 8;128(1):92-114. doi: 10.1161/CIRCRESAHA.119.315715. Epub 2020 Oct 23. PubMed PMID: 33092464; PubMed Central PMCID: PMC7790862.
  • Gibb AA, Lazaropoulos MP, Elrod JW. Myofibroblasts and Fibrosis: Mitochondrial and Metabolic Control of Cellular Differentiation. Circ Res. 2020 Jul 17;127(3):427-447. doi: 10.1161/CIRCRESAHA.120.316958. Epub 2020 Jul 16. Review. PubMed PMID: 32673537; PubMed Central PMCID: PMC7982967.
  • Lombardi AA, Gibb AA, Arif E, Kolmetzky DW, Tomar D, Luongo TS, Jadiya P, Murray EK, Lorkiewicz PK, Hajnóczky G, Murphy E, Arany ZP, Kelly DP, Margulies KB, Hill BG, Elrod JW. Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation. Nat Commun. 2019 Oct 4;10(1):4509. doi: 10.1038/s41467-019-12103-x. PubMed PMID: 31586055; PubMed Central PMCID: PMC6778142.
  • Gibb AA, Hill BG. Metabolic Coordination of Physiological and Pathological Cardiac Remodeling. Circ Res. 2018 Jun 22;123(1):107-128. doi: 10.1161/CIRCRESAHA.118.312017. Review. PubMed PMID: 29929976; PubMed Central PMCID: PMC6023588.
  • Gibb AA, Epstein PN, Uchida S, Zheng Y, McNally LA, Obal D, Katragadda K, Trainor P, Conklin DJ, Brittian KR, Tseng MT, Wang J, Jones SP, Bhatnagar A, Hill BG. Exercise-Induced Changes in Glucose Metabolism Promote Physiological Cardiac Growth. Circulation. 2017 Nov 28;136(22):2144-2157. doi: 10.1161/CIRCULATIONAHA.117.028274. Epub 2017 Aug 31. PubMed PMID: 28860122; PubMed Central PMCID: PMC5704654.
  • Gibb AA, Lorkiewicz PK, Zheng YT, Zhang X, Bhatnagar A, Jones SP, Hill BG. Integration of flux measurements to resolve changes in anabolic and catabolic metabolism in cardiac myocytes. Biochem J. 2017 Aug 7;474(16):2785-2801. doi: 10.1042/BCJ20170474. PubMed PMID: 28706006; PubMed Central PMCID: PMC5545928.
  • Gibb AA, McNally LA, Riggs DW, Conklin DJ, Bhatnagar A, Hill BG. FVB/NJ Mice Are a Useful Model for Examining Cardiac Adaptations to Treadmill Exercise. Front Physiol. 2016;7:636. doi: 10.3389/fphys.2016.00636. eCollection 2016. PubMed PMID: 28066267; PubMed Central PMCID: PMC5174104.