Aruni Bhatnagar, Ph.D., FAHA

Professor of Medicine
Smith and Lucille Gibson Professor of Medicine
Chief, Division of Environmental Medicine
Director, Christina Lee Brown Envirome Institute/
American Heart Association Tobacco Regulation Center

Distinguished University Scholar

502-852-5966 Email

Education and Training

Ph.D.: University of Kanpur, Chemistry
Postdoctoral Fellowship: University of Texas Medical Branch at Galveston

Research Interests

The major focus of our research is to elucidate the mechanisms by which oxidative stress affects cardiovascular function. In particular, we are interested in the role of lipid peroxidation as a contributor to myocardial ischemic injury and atherosclerosis. Although lipid peroxidation generates several reactive intermediates and end products, lipid-derived unsaturated aldehydes are believed to be a major source of oxidative stress and these toxicants appear to be critical mediators of tissue injury due to lipid peroxidation. In order to understand how the cardiovascular tissues protect themselves from the toxic products of lipid peroxidation, we are currently investigating the biochemical mechanisms by which unsaturated aldehydes are detoxified in the heart and blood vessels. We have learned that the enzymes - aldose reductase, glutathione S-transferases and aldehyde dehydrogenase are the major constituents of aldehyde metabolism in the heart, and vascular smooth muscle and endothelial cells, and that these enzymes function in tandem to protect cardiovascular tissues from the harmful effects of lipid peroxidation. Based on this understanding we are currently assessing in detail the role of aldose reductase and related aldo-keto reductases in the detoxification of lipid peroxidation products. We are investigating whether inhibition or upregulation of these enzymes affects the ability of the heart to withstand oxidative stress during ischemia and reperfusion. In a parallel series of experiments we are studying the role of aldose reductase in atherogenesis in an effort to ascertain whether changes in aldehyde metabolism alter plaque burden in atherosclerotic animals. We believe that this line of inquiry will lead to a better understanding of the mechanisms by which oxidative stress mediates or exacerbates cardiovascular disease, and how the untoward cardiovascular effects of lipid peroxidation could be prevented.

In addition to the metabolism and detoxification of endogenous aldehydes, our research interests also include cardiovascular toxicity of environmental aldehydes. Several ubiquitous pollutants such as gasoline vapor, car exhaust, smoke, and smog contain significant amounts of reactive aldehydes. Similar aldehydes are also generated during the metabolism of pollutants such as butadiene, vinyl chloride and allylamine and cardiotoxic drugs such as cylcophosphamide and adriamycin. These aldehydes are related, in structure and toxicity, to those generated endogenously during lipid peoxidation. Thus, our work on the lipid peroxidation-derived aldehydes bears significance for understanding the cardiovascular effects of environmental aldehydes. To examine this rigorously, we have recently initiated a series of studies to test whether environmental exposure to aldehydes exacerbates atherosclerosis and induces myocardial dysfunction, and whether aldehyde exposure is a risk factor for the development of heart disease.

Featured Publications

  • Bhatnagar A. Editorial Commentary: The cardiovascular cost of vaping. Trends Cardiovasc Med. 2020 Apr;30(3):141-142. doi: 10.1016/j.tcm.2019.05.011. Epub 2019 Jun 4. PubMed PMID: 31208811.
  • Yeager R, Riggs DW, DeJarnett N, Srivastava S, Lorkiewicz P, Xie Z, Krivokhizhina T, Keith RJ, Srivastava S, Browning MHEM, Zafar N, Krishnasamy S, DeFilippis A, Turner J, Rai SN, Bhatnagar A. Association between residential greenness and exposure to volatile organic compounds. Sci Total Environ. 2020 Mar 10;707:135435. doi: 10.1016/j.scitotenv.2019.135435. Epub 2019 Nov 23. PubMed PMID: 31865083.
  • Osei AD, Mirbolouk M, Orimoloye OA, Dzaye O, Uddin SMI, Benjamin EJ, Hall ME, DeFilippis AP, Bhatnagar A, Biswal SS, Blaha MJ. Association Between E-Cigarette Use and Chronic Obstructive Pulmonary Disease by Smoking Status: Behavioral Risk Factor Surveillance System 2016 and 2017. Am J Prev Med. 2020 Mar;58(3):336-342. doi: 10.1016/j.amepre.2019.10.014. Epub 2020 Jan 2. PubMed PMID: 31902685.
  • Konkle SL, Zierold KM, Taylor KC, Riggs DW, Bhatnagar A. National secular trends in ambient air volatile organic compound levels and biomarkers of exposure in the United States. Environ Res. 2020 Mar;182:108991. doi: 10.1016/j.envres.2019.108991. Epub 2019 Dec 2. PubMed PMID: 31835113.
  • Keith RJ, Fetterman JL, Orimoloye OA, Dardari Z, Lorkiewicz PK, Hamburg NM, DeFilippis AP, Blaha MJ, Bhatnagar A. Characterization of Volatile Organic Compound Metabolites in Cigarette Smokers, Electronic Nicotine Device Users, Dual Users, and Nonusers of Tobacco. Nicotine Tob Res. 2020 Feb 6;22(2):264-272. doi: 10.1093/ntr/ntz021. PubMed PMID: 30759242.
  • Eissenberg T, Bhatnagar A, Chapman S, Jordt SE, Shihadeh A, Soule EK. Invalidity of an Oft-Cited Estimate of the Relative Harms of Electronic Cigarettes. Am J Public Health. 2020 Feb;110(2):161-162. doi: 10.2105/AJPH.2019.305424. PubMed PMID: 31913680; PubMed Central PMCID: PMC6951374.
  • Riggs DW, Zafar N, Krishnasamy S, Yeager R, Rai SN, Bhatnagar A, O'Toole TE. Exposure to airborne fine particulate matter is associated with impaired endothelial function and biomarkers of oxidative stress and inflammation. Environ Res. 2020 Jan;180:108890. doi: 10.1016/j.envres.2019.108890. Epub 2019 Nov 5. PubMed PMID: 31718786; PubMed Central PMCID: PMC6899204.
  • Pope CA 3rd, Bhatnagar A. Does Air Pollution Increase Risk of Mortality After Cardiac Transplantation? J Am Coll Cardiol. 2019 Dec 17;74(24):3036-3038. doi: 10.1016/j.jacc.2019.07.091. Epub 2019 Dec 9. PubMed PMID: 31865971.
  • Obisesan OH, Mirbolouk M, Osei AD, Orimoloye OA, Uddin SMI, Dzaye O, El Shahawy O, Al Rifai M, Bhatnagar A, Stokes A, Benjamin EJ, DeFilippis AP, Blaha MJ. Association Between e-Cigarette Use and Depression in the Behavioral Risk Factor Surveillance System, 2016-2017. JAMA Netw Open. 2019 Dec 2;2(12):e1916800. doi: 10.1001/jamanetworkopen.2019.16800. PubMed PMID: 31800073; PubMed Central PMCID: PMC6902792.
  • Zheng JJ, Pena Calderin E, Hill BG, Bhatnagar A, Hellmann J. Exercise Promotes Resolution of Acute Inflammation by Catecholamine-Mediated Stimulation of Resolvin D1 Biosynthesis. J Immunol. 2019 Dec 1;203(11):3013-3022. doi: 10.4049/jimmunol.1900144. Epub 2019 Oct 25. PubMed PMID: 31653685; PubMed Central PMCID: PMC6864295.