Shahid P. Baba, Ph.D.

Assistant Professor of Medicine

502-852-5834 E-mail

Education and Training

  • Ph.D.: Aligarh Muslim University, Biochemistry
  • Postdoctoral Fellowship: Philip Morris External Research Program

Research Interests

Dr. Baba's main research is focused in examining the metabolic role of aldo-keto reductases (AKRs), in metabolizing different advanced glycation end products (AGEs) precursors and advanced lipoxidation products (ALEs). Oxidation of proteins and generation of AGEs is a normal process as tissues age, however, the generation of AGEs and ALEs are known to be involved in the etiology of hypertrophy, heart failure and secondary diabetic complications. He is also investigating the mechanisms of endogenously generated quenchers in quenching AGEs and ALEs. Recently, Dr. Baba was awarded a beginners grant from the American Heart Association to study the role of lipid peroxides in left ventricular remodeling.

Featured Publications

Find all papers and citations via ResearchGate

  • Posa DK, Miller J, Hoetker D, Ramage MI, Gao H, Zhao J, Doelling B, Bhatnagar A, Wigmore SJ, Skipworth RJE, Baba SP. Skeletal muscle analysis of cancer patients reveals a potential role for carnosine in muscle wasting. J Cachexia Sarcopenia Muscle. 2023 Aug;14(4):1802-1814. doi: 10.1002/jcsm.13258. Epub 2023 May 18. PMID: 37199284; PMCID: PMC10401540.
  • Feehan J, Hariharan R, Buckenham T, Handley C, Bhatnagar A, Baba SP, de Courten B. Carnosine as a potential therapeutic for the management of peripheral vascular disease. Nutr Metab Cardiovasc Dis. 2022 Oct;32(10):2289-2296. doi: 10.1016/j.numecd.2022.07.006. Epub 2022 Jul 16. PMID: 35973888.
  • Dwenger MM, Raph SM, Baba SP, Moore JB 4th, Nystoriak MA. Diversification of Potassium Currents in Excitable Cells via Kvβ Proteins. Cells. 2022 Jul 18;11(14):2230. doi: 10.3390/cells11142230. PMID: 35883673; PMCID: PMC9317154.
  • Yan K, Mei Z, Zhao J, Prodhan MAI, Obal D, Katragadda K, Doelling B, Hoetker D, Posa DK, He L, Yin X, Shah J, Pan J, Rai S, Lorkiewicz PK, Zhang X, Liu S, Bhatnagar A, Baba SP. Integrated Multilayer Omics Reveals the Genomic, Proteomic, and Metabolic Influences of Histidyl Dipeptides on the Heart. J Am Heart Assoc. 2022 Jul 5;11(13):e023868. doi: 10.1161/JAHA.121.023868. Epub 2022 Jun 22. PMID: 35730646; PMCID: PMC9333374.
  • Spaas J, Franssen WMA, Keytsman C, Blancquaert L, Vanmierlo T, Bogie J, Broux B, Hellings N, van Horssen J, Posa DK, Hoetker D, Baba SP, Derave W, Eijnde BO. Carnosine quenches the reactive carbonyl acrolein in the central nervous system and attenuates autoimmune neuroinflammation. J Neuroinflammation. 2021 Nov 5;18(1):255. doi: 10.1186/s12974-021-02306-9. PMID: 34740381; PMCID: PMC8571880.
  • O'Toole TE, Li X, Riggs DW, Hoetker DJ, Baba SP, Bhatnagar A. Urinary Levels of the Acrolein Conjugates of Carnosine Are Associated with Cardiovascular Disease Risk. Int J Mol Sci. 2021 Jan 30;22(3):1383. doi: 10.3390/ijms22031383. PMID: 33573153; PMCID: PMC7866516.
  • O'Toole TE, Amraotkar AA, DeFilippis AP, Rai SN, Keith RJ, Baba SP, Lorkiewicz P, Crandell CE, Pariser GL, Wingard CJ, Pope Iii CA, Bhatnagar A. Protocol to assess the efficacy of carnosine supplementation in mitigating the adverse cardiovascular responses to particulate matter (PM) exposure: the Nucleophilic Defense Against PM Toxicity (NEAT) trial. BMJ Open. 2020 Dec 28;10(12):e039118. doi: 10.1136/bmjopen-2020-039118. PMID: 33372072; PMCID: PMC7772308.
  • O'Toole TE, Li X, Riggs DW, Hoetker DJ, Yeager R, Lorkiewicz P, Baba SP, Cooper NGF, Bhatnagar A. Urinary levels of the acrolein conjugates of carnosine are associated with inhaled toxicants. Inhal Toxicol. 2020 Nov-Dec;32(13-14):468-476. doi: 10.1080/08958378.2020.1845257. Epub 2020 Nov 12. PMID: 33179563; PMCID: PMC7875462.
  • Posa DK, Baba SP. Intracellular pH Regulation of Skeletal Muscle in the Milieu of Insulin Signaling. Nutrients. 2020 Sep 23;12(10):2910. doi: 10.3390/nu12102910. PMID: 32977552; PMCID: PMC7598285.
  • Baba S, Smith T, Hellmann J, Bhatnagar A, Carter K, Vanhoover A, Caruso J. Space Flight Diet-Induced Deficiency and Response to Gravity-Free Resistive Exercise. Nutrients. 2020 Aug 11;12(8):2400. doi: 10.3390/nu12082400. PMID: 32796546; PMCID: PMC7468946.