Shahid P. Baba, Ph.D.

Assistant Professor of Medicine

502-852-5834 E-mail

Education and Training

  • Ph.D.: Aligarh Muslim University, Biochemistry
  • Postdoctoral Fellowship: Philip Morris External Research Program

Research Interests

Dr. Baba's main research is focused in examining the metabolic role of aldo-keto reductases (AKRs), in metabolizing different advanced glycation end products (AGEs) precursors and advanced lipoxidation products (ALEs). Oxidation of proteins and generation of AGEs is a normal process as tissues age, however, the generation of AGEs and ALEs are known to be involved in the etiology of hypertrophy, heart failure and secondary diabetic complications. He is also investigating the mechanisms of endogenously generated quenchers in quenching AGEs and ALEs. Recently, Dr. Baba was awarded a beginners grant from the American Heart Association to study the role of lipid peroxides in left ventricular remodeling.

Featured Publications

Find all papers and citations via ResearchGate

  • O'Toole TE, Li X, Riggs DW, Hoetker DJ, Baba SP, Bhatnagar A. Urinary Levels of the Acrolein Conjugates of Carnosine Are Associated with Cardiovascular Disease Risk. Int J Mol Sci. 2021 Jan 30;22(3):1383. doi: 10.3390/ijms22031383. PMID: 33573153; PMCID: PMC7866516.
  • O'Toole TE, Amraotkar AA, DeFilippis AP, Rai SN, Keith RJ, Baba SP, Lorkiewicz P, Crandell CE, Pariser GL, Wingard CJ, Pope Iii CA, Bhatnagar A. Protocol to assess the efficacy of carnosine supplementation in mitigating the adverse cardiovascular responses to particulate matter (PM) exposure: the Nucleophilic Defense Against PM Toxicity (NEAT) trial. BMJ Open. 2020 Dec 28;10(12):e039118. doi: 10.1136/bmjopen-2020-039118. PMID: 33372072; PMCID: PMC7772308.
  • O'Toole TE, Li X, Riggs DW, Hoetker DJ, Yeager R, Lorkiewicz P, Baba SP, Cooper NGF, Bhatnagar A. Urinary levels of the acrolein conjugates of carnosine are associated with inhaled toxicants. Inhal Toxicol. 2020 Nov-Dec;32(13-14):468-476. doi: 10.1080/08958378.2020.1845257. Epub 2020 Nov 12. PMID: 33179563; PMCID: PMC7875462.
  • Posa DK, Baba SP. Intracellular pH Regulation of Skeletal Muscle in the Milieu of Insulin Signaling. Nutrients. 2020 Sep 23;12(10):2910. doi: 10.3390/nu12102910. PMID: 32977552; PMCID: PMC7598285.
  • Baba S, Smith T, Hellmann J, Bhatnagar A, Carter K, Vanhoover A, Caruso J. Space Flight Diet-Induced Deficiency and Response to Gravity-Free Resistive Exercise. Nutrients. 2020 Aug 11;12(8):2400. doi: 10.3390/nu12082400. PMID: 32796546; PMCID: PMC7468946.
  • Zhao J, Conklin DJ, Guo Y, Zhang X, Obal D, Guo L, Jagatheesan G, Katragadda K, He L, Yin X, Prodhan MAI, Shah J, Hoetker D, Kumar A, Kumar V, Wempe MF, Bhatnagar A, Baba SP. Cardiospecific Overexpression of ATPGD1 (Carnosine Synthase) Increases Histidine Dipeptide Levels and Prevents Myocardial Ischemia Reperfusion Injury. J Am Heart Assoc. 2020 Jun 16;9(12):e015222. doi: 10.1161/JAHA.119.015222. Epub 2020 Jun 9. PMID: 32515247; PMCID: PMC7429021.
  • Everaert I, He J, Hanssens M, Stautemas J, Bakker K, Albrecht T, Zhang S, Van der Stede T, Vanhove K, Hoetker D, Howsam M, Tessier FJ, Yard B, Baba SP, Baelde HJ, Derave W. Carnosinase-1 overexpression, but not aerobic exercise training, affects the development of diabetic nephropathy in BTBRob/ob mice. Am J Physiol Renal Physiol. 2020 Apr 1;318(4):F1030-F1040. doi: 10.1152/ajprenal.00329.2019. Epub 2020 Mar 9. PMID: 32150446.
  • Zhang D, Bhatnagar A, Baba SP. Inhibition of aldose reductase activity stimulates starvation induced autophagy and clears aldehyde protein adducts. Chem Biol Interact. 2019 Jun 1;306:104-109. doi: 10.1016/j.cbi.2019.04.014. Epub 2019 Apr 15. PMID: 30998906.
  • Boakye AA, Zhang D, Guo L, Zheng Y, Hoetker D, Zhao J, Posa DK, Ng CK, Zheng H, Kumar A, Kumar V, Wempe MF, Bhatnagar A, Conklin DJ, Baba SP. Carnosine Supplementation Enhances Post Ischemic Hind Limb Revascularization. Front Physiol. 2019 Jul 2;10:751. doi: 10.3389/fphys.2019.00751. PMID: 31312142; PMCID: PMC6614208.
  • Derave W, De Courten B, Baba SP. Correction to: An update on carnosine and anserine research. Amino Acids. 2019 Jan;51(1):5. doi: 10.1007/s00726-019-02701-w. Erratum for: Amino Acids. 2019 Jan;51(1):1-4. PMID: 30694382.