Education:

Ph.D., the Institute of Microbiology, Czech Acad. Sci., Prague, Czech Republic

Curriculum Vitae

Current Positions:

Professor, Department of Pathology, School of Medicine, University of Louisville
Member, Immuno-Oncology Program, James Graham Brown Cancer Center

Contact Information:

Vaclav.vetvicka@louisville.edu

Website Link:

www.glucan.us

Research Description:

Cancer research; natural immunomodulators.

Representative Publications:

 Muto S, Vetvicka V, Ross GD.  CR3 (CD11b/CD18) expressed by cytotoxic T cells and NK cells is upregulated in a manner similar to neutrophil CR3 following stimulation with various activating agents.  Journal of Clinical Immunology 1993 May;13(3):175-84. PMID: 8100571. Subsection 1- Pull from Section A – Overall representative publications Biosketch

 Vetvicka V, Vetvickova J, Fusek M.  Effect of human procathepsin D on proliferation of human cell lines.  Cancer Letters 1994 May 16;79(2):131-5. PMID: 8019970. Subsection 2-  Pull from Section C – Contribution to Science from Biosketch

 Vetvicka V, Thornton BP, Ross GD.  Soluble b-glucan polysaccharide binding to the lectin site of neutrophil or NK cell complement receptor type 3 (CD11b/CD18) generates a primed state of the receptor capable of mediating cytotoxicity of iC3B-opsonized target cells.  Journal of Clinical Investigation 1996 Jul 1;98(1):50-61. PMID: 8690804. PMCID: PMC507400.  Subsection 3-  Pull from Section C – Contribution to Science from Biosketch   

 Benes P, Vashishta A, Saraswat-Ohri S, Fusek M, Pospisilova S, Tichy B, Vetvicka V.  Effects of procathepsin D on gene expression in breast cancer cells.  Cancer Letters 2006 Jul 28;239(1):46-54. PMID: 16168559.  Subsection 4-  Pull from Section C – Contribution to Science from Biosketch

 Ferry A, Malik G, Guinchard X, Vetvicka V, Crich D.  Synthesis and evaluation of di- and trimeric hydroxylamine-based b-(1-3)-glucan mimetics.  Journal of the American Chemical Society 2014 Oct 2;136(42):14852-7. PMID: 25247738.  Subsection 5-  Pull from Section C – Contribution to Science from Biosketch

 Vetvicka V, Vetvickova J.  Glucan supplementation has strong anti-melanoma effects: role of NK cells.  Anticancer Research 2015 Feb;35(2):5287-92. PMID: 25738142. PMCID: PMC4322159.  Subsection 6- Pull from Section C – Contribution to Science from Biosketch

PubMed Information