Guidance Documents
What proposal submissions does Cayuse Proposals (S2S) handle? 
Office of Research and Innovation
University of Louisville
Louisville, Ky. 40202
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Proposals (S2S)
Cayuse is a cloud-based, electronic research administration system designed to support the full research project lifecycle. The Proposals (S2S) application is UofL’s institutional system-to-system solution for the submission of federal grant applications to Grants.gov. Using Proposals (S2S) you can:
- Download and apply for hundreds of Grants.gov opportunities posted by the National Institutes of Health (NIH), National Science Foundation (NSF), Department of Defense (DoD), and other federal agencies.
- Streamline the development of grant proposals using pre-populated institutional and personnel data and autofill capabilities.
- Track errors, warnings, and informational items with real-time error validations.
- Compile, submit, and store your completed proposal document for future reference.
Guidance Documentation and Training Materials
- Understanding and navigating the Cayuse Platform (Home) and My Tasks
- Reviewing and updating your User Profile (aka My Profile)
- Proposals (S2S) end user instructions – This guidance document includes UofL instructions on downloading funding opportunities, creating a new proposal, completing a proposal using S2S functionality, final proposal routing and approval, and more.
- Cayuse Proposals (S2S) Help Center – Access additional help articles for Proposals (S2S), including guidance documents on budget development, personnel management, managing subawards, and more. Note: As UofL’s Cayuse instance is the newest application release, some older help articles may not be applicable (in part or in whole) to UofL’s use of Proposals (S2S).
- Proposals (S2S) training opportunities via MS Teams are posted here and to the UofL events calendar (Search: Cayuse)
- Proposals (S2S) Training Video– This training includes the following topics which can be individually accessed using the ‘Chapters’ links in the video:
- Downloading and Viewing Opportunities in Proposals (S2S)
- Starting a New Proposal in S2S
- Proposal and Application Icons
- Managing People
- And more…
Join the UofL Cayuse team on MS Teams – Ask questions using the Proposals (S2S) channel chat function.
Frequently Asked Questions (FAQs)
Proposals (S2S) handles grant applications to federal agencies. The Cayuse system connects directly with Grants.gov and submits to the federal agencies that use Grants.gov. (Proposals (S2S) does not handle applications to private nonprofit or industry entities.)
No, Cayuse Proposals (S2S) provides a turnkey environment for the development, institutional review and approval, and submission of proposals to Grants.gov. It can even incorporate subawards to or from other Cayuse customers into the primary submission to Grants.gov.
Departmental use of Proposals (S2S) is optional, and researchers may continue to apply for federal award opportunities through Grants.gov Workspace, NIH ASSIST, and other federal portals.
Please complete the subrecipient entity request form here. The Research Systems team will add the new subrecipient to Cayuse S2S.
