Hongying Hao, MD, PhD

Education:Hongying Hao, MD, PhD

M.D., Department of Medicine, The Third Military Medical College, China, 1989
Ph.D., Hematology, Health Sciences Center, Beijing University, China, 2001

Curriculum Vitae

Current Positions:

Assistant Professor, Department of Surgery, University of Louisville

Contact Information:

Clinical Translational Research Building, Room 407
University of Louisville
505 Hancock St.
Louisville, KY 40202, USA
Phone 502-852-8404
Fax 502-852-3661

Email:

Research Description:

Dr. Hao has a longstanding interest in cancer research, spanning from basic studies to translational explorations. Her current studies include investigations on the mechanisms of tumor-derived exosomes in promoting melanoma progression and the use of tumor-derived exosomes and sentinel lymph node biomarkers as a prognostic approach for melanoma. She is also investigating the signal pathways that are involved in melanoma immune surveillance.

Representative Publications:

 1. Hao H, Dong Y, Bowling MT, Gomez-Gutierrez JG, Zhou HS and McMasters KM. E2F-1 induces melanoma cell apoptosis via PUMA up-regulation and Bax translocation. BMC Cancer, 2007 Jan 30; 7: 24

2. Zheng X, Rao X, Gomez-Gutierrez JG, Hao H, McMasters KM and Zhou HS. Adenovirus E1B55K region is required to enhance cyclin E expression for efficient viral DNA replication. J Virology 2008, 82(7): 3415-27

3. Gomez-Gutierrez JG, Rao X, Garcia-Gracia A, Hao H, McMasters KM and Zhou HS. Developing adenoviral vectors for encoding therapeutic genes toxic to host cells: comparing binary and single inducible vectors expressing truncated E2F-1. Virology 2010, 397(2): 337-45

4.  Gomez-Gutierrez JG, Garcia-Gracia A, Hao H, Rao XM, Montes de Oca-Luna R, Zhou HS, McMasters KM. Adenovirus-mediated expression of truncated E2F-1 suppresses tumor growth in vitro and in vivo. Cancer 2010; 116 (18): 4420-32

5.  Hao H, Chen C, Rao XM, Gomez-Gutierrez JG, Zhou HS, McMasters KM. E2F-1- and E2Ftr-mediated apoptosis: the role of DREAM and HRK. J Cell Mol Med. 2012; 16(3):605-15. doi: 10.1111/j.1582-4934.2011.01338.x.

6. Gomez-Gutierrez JG, Egger ME, Hao H, Zhou HS, McMasters KM. Adenovirus-mediated expression of mutated forkhead human transcription like-1 suppresses tumor growth in a mouse melanoma xenograft model. Cancer Biol Ther. 2012; 13(12):1195-204. doi: 10.4161/cbt.21349. PMID: 22892845

7. Xiao D, Ohlendorf J, Chen Y, Taylor DD, Rai SN, Waigel S, Zacharias W, Hao H*, McMasters KM*. Identifying mRNA, microRNA and protein profiles of melanoma exosome. PLoS One. 2012; 7(10):e46874. doi: 10.1371/journal.pone.0046874. (* corresponding author)

8. Xiao D, Barry S, Kmetz D, Egger M, Pan J, Rai S, Qu J, McMasters KM and Hao H. Melanoma cell-derived exosomes promote epithelial-mesenchymal transition in primary melanocytes through paracrine/autocrine signaling in the tumor environment. Cancer Letters. 2016; 376(2): 318-27.doi:10.1016/j.canlet.2016.03.050 PMC 27063098

9. Hao H, Xiao D, Pan J, Qu J, Egger ME, Waigel S, Sanders MAG, Zacharias W, Rai S, McMasters KM. Sentinel lymph node genes to predict prognosis in node-positive melanoma patients. Ann Surg Oncol. 2017; 24 (1): 108-116. doi: 10.1245/s10434-016-5575-7. PMID: 27663566

10. Egger ME, Xiao D, Hao H, Kimbrough CW, Pan J, Rai SN, Cambon AC, Waigel SJ, Zacharias W, McMasters KM. Unique Genes in Tumor-Positive Sentinel Lymph Nodes Associated with Nonsentinel Lymph Node Metastases in Melanoma. Ann Surg Oncol. 2018 25(5): 1296-1303. doi: 10.1245/s10434-018-6377-x.

11. Xiao J, Egger ME, McMasters KM, and Hao H. Differential expression of ABCB5 in BRAF inhibitor-resistant melanoma cell lines. BMC Cancer. 2018; 18(1):675. doi: 10.1186/s12885-018-4583-3.

PubMed Information