For refugees who have fled their home countries, resettling in a completely new culture can be overwhelming. Not only are they often unable to speak the language, they face bewildering systems of health care, money, transportation and more. Some have never even used electricity.

“One of the common things is how a microwave works because microwaves are freaky,” said Bethany Hodge, M.D., M.P.H., assistant professor and director of the Global Education Office of the University of Louisville School of Medicine. “If you are coming from a place where you didn’t have electricity, let alone microwaves where you put something in a box and push a button and it’s flaming hot and you burn yourself because you don’t see it coming, it can be frightening.”

Students in the School of Medicine were introduced to the struggles of resettling refugees and the agencies that assist them in Kentucky at “Refugees and Our Competencies,” a Compassion Rounds presentation hosted by the UofL chapter of the Gold Humanism Honor Society (GHHS) on Nov. 30. Hodge and Rahel Bosson, M.D., assistant professor in the UofL School of Medicine and director of the Refugee Health Program, familiarized the students with some of the health concerns of these individuals and issues confounding their introduction to the U.S. health-care system.

Refugees may have health problems related to trauma or injury experienced in their home countries, as well as health conditions that have been neglected during their transition from a life in peril to resettlement in the United States. Hodge coached the students on how to navigate these issues sensitively in conducting a health history and physical. To complicate matters further, the patients may have different naming or date customs, and missing or fragmented medical records.

According to the United Nations High Commissioner for Refugees (UNHCR), the international body governing refugee status, refugees are individuals who have been forced to flee their home country because of persecution, war or violence. Typically, they leave their home countries for refugee camps in neighboring nations. Fewer than 1 percent of refugees who apply to UNHCR are resettled in a third country such as the United States, Canada or a European country. Most of the approximately 2,500 refugees arriving in Kentucky annually in recent years have come from Cuba, the Democratic Republic of the Congo, Somalia and Iraq. Refugee resettlement in Kentucky is coordinated by Catholic Charities’ Kentucky Office for Refugees.

Through the UofL Refugee Health Program, part of the UofL Global Health Initiative of the Department of Medicine, individuals are provided health assessments, immunizations, school physicals and other services. Bosson said the program addresses health and other needs to enable refugees to become self-sufficient as quickly as possible.

“Refugee health is complex, and health is really more than just the absence of disease. We address the varied components of a person’s health through partnerships in community health, education, social services and economic empowerment,” Bosson said. “The idea is to help these refugees move from a mode of survival to a platform where they can thrive and succeed.”

MeNore Lake, a fourth-year medical student and co-chair of the UofL GHHS chapter, also founded the Kentucky Refugee Outreach Program in which medical students are collaborating with the Refugee Health Program, UofL School of Nursing and Kentucky Office for Refugees to reach the newly arrived refugees in Louisville. The group is designing a standardized orientation plan for familiarizing newly arrived refugees with the U.S. health-care system.

“We are working on a process for telling them:  What can you expect the first time you go to see the doctor here in the U.S.? What are the levels of care that we have? What happens if you call 911? What are other options?” Lake said. “These are things we may take for granted because we have grown up in this country, but something that helps them transition to life here in Louisville and America.”

The refugees’ acclimation to life in Kentucky is supported by Kentucky Refugee Ministries, Inc.,Migration and Refugee Services of Catholic Charities and the International Center in Bowling Green. These organizations help with setting up apartments for the new residents, language instruction and help in finding employment and transportation. The agencies try to help the refugees become self-sufficient within eight months of their arrival.

The Gold Humanism Honor Society recognizes students, residents and faculty who are exemplars of compassionate patient care and who serve as role models, mentors and leaders in medicine. GHHS members are nominated by their peers. The society is a nationwide program of the Gold Foundation.

December 21, 2016

Teddy bears, baby dolls, miniature cars and, of course, doctor play sets were among 886 toys collected by resident physicians at the University of Louisville School of Medicine this holiday season for underprivileged children in the Louisville area. For the second year, UofL’s House Staff Council, the representative body for resident and fellow physicians, led a collection for Toys for Tots, receiving donations from individual residents and fellows as well as School of Medicine faculty, staff and medical students.

In 2015, the first year of the drive, the group collected 570 toys in just six days. This year’s collection began early in December.

“It’s important to think about the kids in our community. They are our future,” said Mitesh Patel, M.D., a third-year resident in the Department of Psychiatry. “There is so much bad stuff in the world that it’s nice to see that kids can have a nice Christmas. It’s just a small thing that we can do as physicians to help support our community.”

To inject some friendly competition into the effort, Stock Yards Bank & Trust offered a luncheon and plaque to the three residency programs bringing in the highest ratio of toys. The winning program, Psychiatry, collected more than 300 toys, or 8.5 toys for each resident physician in the program. Radiology residents collected 5.6 toys per resident for second place. The Department of Obstetrics, Gynecology and Women’s Services was third with 3.8 toys per resident.

Patel spearheaded the drive for the Department of Psychiatry, which also won the competition last year, and plans to ensure his department continues their winning streak.

“We plan to win next year – if radiology lets us,” he said.

Erin Priddy, M.D., a radiology resident, is community engagement chair for the House Staff Council and helped organize this year’s drive. She already has ideas about how to increase overall participation next year.

“I hope that it will continue to grow. I think if we have an appointed delegate for each program that could help as far as communication,” Priddy said. “I would like to break a thousand.”

Staff members of the Office of Graduate Medical Education counted and packed the toys in 11 large donation boxes, which were picked up by a Toys for Tots coordinator on Dec. 15.

The U.S. Marine Corps Reserve Toys for Tots Program collects new, unwrapped toys during October, November and December each year, and distributes those toys as Christmas gifts to less fortunate children in the community in which the campaign is conducted.

December 20, 2016

The University of Louisville (UofL), University Medical Center (UMC) and KentuckyOne Health today (Dec. 13) announced they have agreed to redesign their partnership with a vision to better support the future of health and wellness in Louisville and across Kentucky. UofL and KentuckyOne Health will continue their academic affiliation, which includes decades-long Academic Affiliation Agreements with Jewish Hospital and Frazier Rehab Institute. The Joint Operating Agreement established in 2012 will be revised, bringing management of University of Louisville Hospital (ULH) and the James Graham Brown Cancer Center (JGBCC) to UMC. This decision was agreed upon by all parties as the most effective way to collaborate in care for the community, moving direct operations of the academic medical center to UMC and ensuring continuation of innovative and high-quality patient care and clinical training via KentuckyOne Health facilities.

“The dynamic nature of the health care landscape requires organizations to explore innovative approaches and relationships for the delivery of care,” said Gregory C. Postel, M.D., interim executive vice president of health affairs at UofL. “Today, we are presented with a very different environment than when we signed the joint operating agreement and revised the academic affiliation agreement in 2012. We are pleased with our shared accomplishments yet understand that changes were necessary to address ongoing challenges and ensure we are able to respond nimbly to the unique needs of our care facilities, particularly the academic medical center.”

“We are pleased to move into the next phase of our relationship with University of Louisville. Our longstanding partnership at Jewish Hospital dates back several decades prior to KentuckyOne Health. Since the formation of KentuckyOne Health, we have partnered in many areas and will continue to do so for many years to come, including working together on our innovations to meet the health needs of our community,” said Ruth W. Brinkley, president and CEO of KentuckyOne Health. “During the past four years of our partnership, we have implemented significant improvements to enhance the health of our patients and the communities we serve. This includes the installation of an electronic health record system, and many other updates and enhancements to the University of Louisville Hospital.”

“It is important to emphasize that the transition of care will be seamless for our patients, physicians, employees and community partners,” said Joan Coleman, interim CEO of University Medical Center. “We are committed to continuing the facility improvements and staffing initiatives that began during our partnership and look forward to seeing them through to completion. We will be active with focused transition teams working closely with current leaders, physicians and employees across the Downtown Louisville campus to ensure continued high-quality care, support our employees and shape the future of health and wellness.”

The agreement, effective Dec. 14, 2016, establishes the framework for future partnerships between the organizations and resolves all disputes previously raised. Key aspects of the agreement include the following:  KentuckyOne Health, UMC, and UofL, working together, will continue to implement projects involving up to $44.8 million in capital investments at ULH by July 1, 2017; KentuckyOne Health has agreed to complete the funding of the joint investment proposals as set forth in the Academic Affiliation Agreement; The University of Louisville will release its rights to three seats on the KentuckyOne Health Board of Directors; and the University Medical Center is expected to take over the management of the University of Louisville Hospital on July 1, 2017.

The University Medical Center, University of Louisville and KentuckyOne Health will work together over the next six months to facilitate a successful transition for both the management of ULH and JGBCC, and the Academic Affiliation Agreement between the organizations for programs at other locations. Ongoing information and details on the transition will be provided to patients, community partners, employees and physicians as the process evolves. Transition teams focused on key areas of patient care, employee engagement and infrastructure are being assembled, drawing from the shared expertise currently in place at ULH, JGBCC, KentuckyOne Health, UMC and UofL. These teams will guide the continuation of initiatives underway, including patient care quality and safety programs and recruitment and retention of top nursing talent, while also shaping the future operations and leadership structure.

Partner Profiles:

University Medical Center (UMC): Comprised of the University of Louisville Hospital (ULH), the James Graham Brown Cancer Center (JGBCC), and the Center for Women and Infants (CWI) is an integral part of the University of Louisville’s academic health center. Its first priority and concern is the welfare of patients and therefore provides, without regard to economic status, the highest quality patient and family centered inpatient and outpatient hospital-based services; supports the educational and research missions of the University of Louisville’s Health Sciences Center; and initiates outreach to meet community needs.

The University of Louisville Health Sciences Center is the city’s only academic medical center. Approximately 1,000 faculty members are involved in education, research and clinical care. The UofL HSC is home to more than 650 medical and dental residents, 3,000 students pursuing degrees in health-related fields within the Schools of Dentistry, Medicine, Nursing and Public Health and Information Sciences, as well as 14 interdisciplinary centers and institutes. Approximately $140 million in extramural funding enables researchers to uncover the causes of disease and better ways to prevent, treat and cure those diseases. Patients are seen at the Ambulatory Care Building, The James Graham Brown Cancer Center, the UofL Health Care Outpatient Center and University Hospital, which is the primary adult teaching hospital for the School of Medicine. University Hospital’s public mission is steeped in history and now is most clearly visible through its provision of nearly $90 million of health care to the uninsured annually.

KentuckyOne Health,the largest and most comprehensive health system in the Commonwealth, has more than 200 locations, including hospitals, physician groups, clinics, primary care centers, specialty institutes and home health agencies in Kentucky and southern Indiana. KentuckyOne Health is dedicated to bringing wellness, healing and hope to all, including the underserved.  The system is made up of the former Jewish Hospital & St. Mary’s HealthCare and Saint Joseph Health System, along with the University of Louisville Hospital and James Graham Brown Cancer Center. KentuckyOne Health is proud of and strengthened by its Catholic, Jewish and academic heritages.

Three area organizations are teaming up to sponsor a free legal clinic for people facing cancer and their families and caregivers on Dec. 5.

The Kentucky Cancer Program at the University of Louisville, Louisville Bar Association and Louisville Pro Bono Consortium are sponsoring the clinic, which will be held 6-7:30 p.m., Monday, Dec. 5, at Gilda’s Club of Louisville, 633 Baxter Ave. Free parking is available behind the building and across the street from the club.

At the clinic, attorneys will be available to offer help with life-planning documents under Medicare Part D, including wills, powers of attorney, health care surrogacy and living wills. They also will provide guidance on employee benefits during illness and government assistance that is available such as Medicaid, Medicare and Social Security disability insurance.

Although admission is free, RSVPs in advance are needed at 502-852-6318. For additional information, contact the Kentucky Cancer Program at pam.templejennings@louisville.edu or 502-852-6318.

Two brothers are working together to ensure that patients at the University of Louisville James Graham Brown Cancer Center have a happy Thanksgiving.

Alex and Tommy Gift lost their mother to a 20-plus year battle with cancer in 2010. In her memory, they established the Mary Jane Gift Quality of Life Fund at the cancer center in 2013.

Cancer treatment can be costly and leave many families with little resources during the holidays. The fund helps patients and their families enjoy life while facing a cancer diagnosis.

On Wednesday, Nov. 23, the brothers will distribute turkeys to more than 100 patients at the cancer center in memory of their mother. This will be the fourth annual turkey distribution sponsored by the Gift brothers.

“We experienced how cancer treatment can impact a family throughout my mother’s illness,” said Alex Gift. “Establishing this fund in her memory is our way of giving back to those who supported us and helping improve the lives of others battling cancer.”

As they have every year for the past 11 years, future providers throughout health care disciplines dedicated a day to improving their ability to provide health care to all patients – especially those with perhaps different backgrounds and experiences than their own. At the 2016 Culturally Effective Care Symposium, nearly 550 students learned about working with colleagues from different disciplines to improve health equity for patients and populations and participated in discussions on LGBT health and barriers to health care faced by immigrants and refugees. The day-long event, “Health Equity through Interprofessional Practice,” was coordinated by the University of Louisville Health Sciences Center Office of Diversity and Inclusion.

Previously known as Cultural Competency Day, the event was renamed this year to more accurately reflect its mission.

“Through one day events no one becomes ‘fully competent’ about any culture, including their own, so the name did not reflect the true purpose of the program,” said Ryan Simpson, assistant director of the UofL HSC Office of Diversity and Inclusion. “In these symposiums we are trying to provide participants foundational experiences in culturally effective care to equip future health professionals in achieving optimal patient care. Our planning committee renamed it the ‘Culturally Effective Care Symposium’ to better represent what we are there to achieve.”

Students from all four UofL Health Sciences Center schools, as well as the Sullivan University College of Pharmacy, and UofL Kent School of Social Work participated in the symposium, held at the Kentucky Center for African American Heritage (KCAAH) in Louisville. Participants included students and residents in nursing, dentistry, dental hygiene, speech pathology, pharmacy, social work, public health and medicine.

UofL’s Patricia Allen Cultural Competency Day was first held in 2006, the result of efforts by V. Faye Jones, M.D., Ph.D., assistant vice president for health affairs – diversity initiatives, and Patricia Allen, administrative associate for the Area Health Education Center (AHEC) program office at UofL, to improve cultural understanding of UofL Health Sciences Center students. The event is named for Allen, who helped lay the groundwork and planning for the event.

Nov. 17, 2016

• For women age 40 and over
• No cost to women without insurance
• Advance appointments required by calling 502-776-1177

• Take-home stool test (FIT Kits)
• For all men and women age 50 and over
• For African-American men and women age 45 and over
• No appointment needed

Blood pressure checks, health insurance information and free gifts

For additional information, contact Janikaa Sherrod, Kentucky Cancer Program, 502-852-6318, janikaa.sherrod@louisville.edu.

For patients with severe heart failure, a heart transplant or permanent artificial heart assist device have been considered the only permanent therapy as severe heart failure was not known to be reversible. However, a new study, led by Emma J. Birks, M.B.B.S., Ph.D., professor at the University of Louisville School of Medicine, is showing that an artificial heart assist device along with medications may actually help heal the heart, avoiding the need for a heart transplant and allowing for the removal of the device.

Birks presented preliminary results of the study at the American Heart Association’s Scientific Sessions this weekend in New Orleans, showing more than 40 percent of advanced heart failure patients treated with a combination of an artificial heart assist device, called a left ventricular assist device (LVAD), and intensive drug therapy have recovered their heart function enough to allow removal of the LVAD device.

The multicenter trial called RESTAGE, includes 40 patients at six different centers (including Jewish Hospital, a part of KentuckyOne Health) with very advanced or end stage heart failure implanted with an LVAD (HeartMate II) pump, 36 of whom were considered evaluable, and prescribed an aggressive combination of drugs (Lisinopril 40 mg, spironolactone 25 mg, digoxin 125 mic, losartan 150 mg daily and coreg 25 mg bid). All of the patients were so disabled from heart failure that the initial intent with the LVAD was to use it until they could receive a heart transplant or to leave the device in for the rest of their lives.

“This suggests that even very advanced heart failure can be reversed using these heart pumps, particularly when combined with additional drug therapy, avoiding the need for heart transplantation for these patients and making the donor heart available for another needy individual,” Birks said.

Researchers tested the 36 patients’ heart function to determine if their heart function had improved enough from the therapy to have the pumps removed, or if their heart function remained poor and needed a heart transplant or to remain on the pump. Sixteen patients receiving the combination therapy had recovered enough heart function (after an average of 330 days) to have the pump removed.

“The fact that this could be done in several centers suggests that using the device with this drug combination to reverse heart failure is possible on a larger scale. It has previously been thought that these devices rarely recover heart function enough to allow them to be removed, but this study suggests that this can occur in a much bigger number than originally thought, particularly if combined with drug therapy,” Birks said.

“The next step, we hope, is for more centers to start doing this and then to see if we can potentially add other drugs to further optimize recovery and create a good platform to recover heart function.”

Aaron W. McGee, Ph.D., assistant professor at the University of Louisville School of Medicine, has received the Disney Award for Amblyopia Research in the amount of $100,000 from Research to Prevent Blindness (RPB). McGee will use the award to investigate approaches for improving recovery from amblyopia, or “lazy eye.”

Established in 2002, the RPB Walt and Lilly Disney Award for Amblyopia Research is intended to stimulate, strengthen and promote research to improve the diagnosis and treatment of amblyopia. The grant is offered to exceptional ophthalmic scientists – M.D.s or Ph.D.s – with research pursuits of potential significance and promise. McGee is one of two scientists to receive the award in 2016.

“Dr. McGee’s funding from RPB addresses a major cause of blindness in children – namely, amblyopia. The potential to reverse ‘lazy eye’ through medical therapy would be a major advance in curing childhood visual disabilities and improve the quality of life for those affected. His research is exciting and has major potential translational clinical impact,” said Henry Kaplan, M.D., chair of the UofL Department of Ophthalmology and Visual Sciences.

Amblyopia occurs in 2-3 percent of children and presents with a number of impairments in spatial vision including stereopsis, or depth perception. Permanent visual deficits may result if amblyopia is not treated during a ‘critical period’ for development of the visual system that ends in early adolescence. The funded research builds on McGee’s previous work investigating how the timing and duration of critical periods in the visual system are determined. McGee will test methods for reversing the loss of depth perception resulting from amblyopia by ‘re-opening’ the critical period in adulthood to enhance the flexibility, or ‘plasticity,’ of brain circuitry.

“Previously, we discovered that a gene encoding a neuronal receptor is essential for closing the critical period for visual plasticity,” McGee said. “This award from RPB will enable my lab to explore whether neutralizing this receptor will improve depth perception in the murine model of amblyopia.”

McGee moved from the University of Southern California to join the UofL Department of Ophthalmology and Visual Sciences and Department of Anatomical Sciences and Neurobiology in September 2016. The goals of his research program are to identify treatments for low vision and aberrant eye dominance by understanding critical periods for neural plasticity and how experience drives changes in brain function.

The Disney Award for Amblyopia Research is a two-year award to help the awardee pursue promising scientific leads and take opportunities for which other funds are not readily available. RPB is the world’s leading voluntary organization supporting eye research. Since it was founded in 1960, RPB has provided hundreds of millions of dollars to support research into blinding eye diseases by medical institutions throughout the United States. For information on RPB, RPB-funded research, eye disorders and the RPB Grants Program, go to www.rpbusa.org.

November 14, 2016

University of Louisville School of Medicine faculty and staff will deliver four presentations at the annual meeting of the Association of American Medical Colleges (AAMC) beginning today in Seattle. At Learn Serve Lead 2016, UofL faculty and staff will share with other educators from medical schools around the nation their research conducted as part of developing medical education curricula.

The 2016 conference, which runs Nov. 11-15, brings deans, faculty, researchers, administrators, residents and students from medical schools across the United States and Canada together to network and share insights on academic medicine.

“Presentation of these scholarly educational works at the AAMC meeting affirms the knowledge and talent of our outstanding faculty and staff in developing curriculum,” said Toni Ganzel, M.D., M.B.A., dean of the UofL School of Medicine. “The innovations presented here will help advance medical education in institutions across the nation.”

Three of the four research presentations selected for the conference stem from the eQuality Project at UofL, which is developing and incorporating curriculum related to health care for individuals who are lesbian, gay, bisexual, transgender (LGBT), gender nonconforming or born with differences of sex development (DSD). UofL is serving as the nation’s pilot for implementing competencies for LGBT-DSD care published by the AAMC in 2014.

An oral presentation, “Baseline Bias:  Implicit Attitudes of First Year Medical Students Prior to a Health Equity Curriculum Intervention,” is co-authored by Katie Leslie, Ph.D., V. Faye Jones, M.D., Ph.D., Ryan Simpson, M.D.A., Susan Sawning, M.S.S.W., Leslee Martin, M.A., M. Ann Shaw, M.D., M.A., vice dean for undergraduate medical education, and Stacie Steinbock, M.Ed., director of the LGBT Center HSC Satellite Office. The presentation, scheduled for Saturday, Nov. 12 beginning at 10:30 a.m., assesses attitudes toward sexuality, race and weight among first and second-year medical students before and after debriefing sessions on mitigating implicit bias.

A related poster presentation addresses undergraduate medical students’ attitudes and knowledge about LGBT patient care. The poster was selected for a special presentation session on Monday, Nov. 14 at 6 p.m. Sawning, Martin, Steinbock, Amy Holthouser, M.D., Emily Noonan, M.A., Jones, Leslie and Shaw will present the poster.

A third poster presentation resulting from the eQuality Project describes initiatives to engage the transgender community to inform curriculum and prioritize initiatives via a community forum on transgender care. The work is presented by Noonan, Sawning, Ryan Combs, Ph.D., Steinbock, Holthouser, Martin and Shaw.

The fourth presentation examines challenges and opportunities in developing and assessing emotional intelligence in medical education and training. The presenting team includes medical educators from Vanderbilt University, Withrop University in N.Y., Florida International University, along with Sawning, UofL’s director of undergraduate medical education research.

The four presentations for this year’s conference double the number of presentations accepted in 2015. UofL faculty had two oral presentations accepted in 2015.

In addition to the scholarly presentations, UofL faculty will assume leadership roles with the AAMC. Karen Hughes Miller, Ph.D., associate professor of graduate medical education, is incoming chair for the AAMC Research in Medical Education (RIME) Program Planning Committee. Miller also is chair elect for 2017 of the Southern Group on Educational Affairs (SGEA), a regional subgroup of the AAMC. Miller and Sara Petruska, M.D., assistant professor at UofL, will host roundtable luncheon discussions on Saturday, Nov. 12 on preparing residents for scholarly activity and interprofessional education in core clerkships.

Lori Wagner, M.D., M.A., has been elected to the national steering committee for the AAMC Group on Women in Medicine and Science (G-WIMS). Wagner founded the Louisville Women in Medicine and Science (L-WIMS) Chapter in 2015.

November 11, 2016

Thanks to a donation from the Institute for Sustainable Health & Optimal Aging at the University of Louisville, the $25 application fee for an “End Alz” license plate will be waived for the remaining applications needed to reach the required 900 for issuance of plates. This limited opportunity is available on a first-come, first-serve basis to constituents throughout Kentucky.

“The Institute for Sustainable Health & Optimal Aging is honored to be able to support the Alzheimer’s Association and all Kentuckians who have been touched by Alzheimer’s disease. We believe that this license is a powerful symbol of our enduring love for those affected by Alzheimer’s, our unwavering support for their family members, and our commitment to working with our communities and the Alzheimer’s Association to end Alzheimer’s,” said Dr. Anna Faul, Executive Director of the Institute.  

The Alzheimer’s Kentucky specialty license plate features a “forget-me-not” flower on a purple background with the words: “Honor. Remember. Care. End Alzheimer’s.” It is an eye-catching design and phrase capturing both the hope and devastation of this disease.  “The Alzheimer’s Association is grateful to the Institute for Sustainable Health & Optimal Aging for understanding the value of helping to finalize this stage of the initiative.  Getting the End Alz plate on the roads of Kentucky has been a labor of love for the Association.  This awareness will shine an even brighter light on the impact of this disease for affected individuals and families as well as the vital need to find effective prevention, treatment and cure,” said Bari Lewis, Director of Community Outreach for the Association. 

Alzheimer’s affects 70,000 Kentuckians and over 5 million people nationwide.  There are over 270,000 Alzheimer’s family caregivers in Kentucky.  Every 67 seconds, someone in America develops Alzheimer’s and the number of people with Alzheimer’s is projected to triple by 2050.

Alzheimer’s is the sixth leading cause of death in the United States, the fifth for people over 65.  Research has not yet found a way to stop or reverse this disease. As many as half of people with dementia have never received a diagnosis, yet they could benefit from a variety of available medical and support services.

It is a disease that touches virtually everyone – including Faul. Her own father, the Rev. Japie Vermeulen of Ceres, South Africa, recently died after a 16-year battle with the disease.

“My education and training as a social worker specializing in older adults gave me knowledge about the hardship families endure when caring for a loved one with Alzheimer’s,” Faul said. “It was caring for my own father, however, that showed me the emotional burden this dreaded disease takes on both caregivers and the patients themselves.”

In order to receive a plate, constituents should fill out the application form located on alz.org/kyin and return to Alzheimer’s Association, 6100 Dutchman’s Lane, Suite 401, Louisville, KY 40205 or email to infoky-in@alz.org. Applicants will be notified by their local county clerk when plates are ready to be picked up. Plates will be available approximately three months after the 900 commitments are secured.

About the Alzheimer’s Association

The Alzheimer’s Association is the world’s leading voluntary health organization in Alzheimer’s research, care and support. Our mission is to eliminate Alzheimer’s disease through advancement of research, to provide and enhance care and support for all affected, and to reduce the risk of dementia through the promotion of brain health. For more information, visit www.alz.org/kyin.

The National Heart, Lung and Blood Institute (NHLBI) of the National Institutes of Health (NIH) recently announced a strategic vision of eight objectives that provide the framework for the institute’s research priorities for the coming decade.

Gary H. Gibbons, M.D., director of the NHLBI, will discuss that vision in the 24^th Leonard Leight Lecture at the University of Louisville on Friday, Nov. 4, at noon in the HSC Auditorium. In his talk, “Charting our future together:  Setting an agenda for the NHLBI,” Gibbons will outline the priorities set out in the vision, which support the NHLBI’s goals to understand and promote health, stimulate discoveries in the causes of disease, enable the translation of those discoveries into clinical practice and foster the next generation of scientists and physicians.

“The convergence of innovations in areas such as computational biology, data science, bioengineering and high-throughput ‘omics’ technologies is paving the way for a new appreciation of human health and disease,” Gibbons said as the institute published the NHLBI’s Strategic Vision in August. “We now have unprecedented opportunities to better understand the complex interplay of environmental, behavioral and molecular factors that promote health; a clearer picture of the earliest point of disease development; and the ability to repair damaged tissues with stem cell and tissue engineering techniques.”

The NHLBI provides global leadership for research, training and education programs to promote the prevention and treatment of heart, lung and blood diseases and enhance the health of all individuals so that they can live longer and more fulfilling lives.

The 24^th Leonard Leight Lecture is scheduled for Friday, Nov. 4, 2016, noon - 1 p.m. in the HSC Auditorium in Kornhauser Library on the UofL Health Sciences Center Campus.

The Leonard Leight Lecture is presented by the Division of Cardiovascular Medicine in the Department of Medicine at the UofL School of Medicine. For 30 years until 1996, Leight was a practicing cardiologist in Louisville and played a major role in developing cardiology services and bringing innovative treatment modalities in heart disease to Louisville. The Leonard Leight Lecture series was established in 1994 and is made possible by gifts from Dr. and Mrs. Kurt Ackermann and Medical Center Cardiologists to the Jewish Hospital & St. Mary’s Foundation.

Gibbons is the second director of a National Institute to speak at UofL in three weeks. On Oct. 14, Linda S. Birnbaum, Ph.D., director of the National Institute of Environmental Health Sciences and the National Toxicology Program, discussed environmental research and the role of the NIEHS in human health at UofL as the keynote speaker of Research!Louisville.

Andrew N. Bankston, Ph.D., a postdoctoral fellow at the University of Louisville, has been elected to the board of directors for the National Postdoctoral Association (NPA). His three-year term of service begins Jan. 1, 2017.

The NPA is a national educational association created to advance research and serve as a national voice for postdoctoral scholars. Founded in 2003, the NPA serves more than 3,400 individual members and 200 institutional members of the postdoctoral community. A “postdoc” is an individual who has received a doctoral (Ph.D.) degree and is employed in a temporary research position for the purpose of gaining additional experience that will lead to an independent academic research or faculty position.

Bankston is a postdoctoral research fellow in the lab of Scott Whittemore, Ph.D., scientific director of the Kentucky Spinal Cord Injury Research Center at UofL. Bankston’s research at UofL focuses on the role of autophagy, or selective degradation of cell components, in developmental myelination and myelin repair after injury. Myelin is the insulating material surrounding nerve fibers. Bankston earned his doctorate in biochemistry, cell and developmental biology from Emory University in 2013.

Bankston, one of four newly elected board members for NPA, served as chair of the NPA Outreach Committee beginning in February 2015. At UofL, he is a member of the postdoctoral advisory board and a member of the planning committee for the Career Research Advancement Focused Training (CRAFT) seminar series, which hosts speakers to provide information on potential career options for postdoctoral fellows and graduate students. In addition, Bankston is a volunteer leader and member of event planning committees within the local chapter of the National Multiple Sclerosis Society.

October 31, 2016

From bees to birds to bats, species around the world are threatened at unprecedented rates. Many people feel powerless to help preserve local species because they think “real” nature can only be sustained in parks and reserves, but local urban park systems cannot do the job of maintaining native biodiversity alone.

About 120 square miles of plantable land in Jefferson County is residential property. However, much of this green space is planted in lawn, which is a food desert for many species of wildlife.

At the next Beer with a Scientist, Margaret Carreiro, Ph.D., will explain how residents in cities and suburbs can protect native species by weaving local nature into the very places where they live and work. She will describe Reconciliation Ecology, a concept in which habitats for wildlife are created within urban and suburban areas.

“I want people to know they can make a large difference in conservation of local species through their plantings at home,” Carreiro said. “They can use native plants to create food webs and friendly habitat for desired species, especially pollinators and birds. It's about keeping our common species common.”

Carreiro is associate professor in the Department of Biology at the University of Louisville. Her work focuses on understanding how urban environments interact with natural components of cities and suburbs. This includes studying the effects of atmospheric nitrogen from fossil fuel combustion and other sources, invasive species, habitat fragmentation, restoration management and socio-cultural legacies in affecting plant and soil communities and ecosystem processes.

The event begins at 8 p.m. onWednesday, Nov. 16, at Against the Grain Brewery, 401 E. Main St. in Louisville. A 30-minute presentation will be followed by an informal Q&A session.

The Beer with a Scientist program began in 2014, the brainchild of UofL cancer researcher Levi Beverly, Ph.D., who hoped to make science accessible to the public in an informal setting. Once a month, the public is invited to enjoy exactly what the title promises:  beer and science.

Admission is free. Purchase of beer, other beverages or menu items is not required but is encouraged.

Organizers add that they also encourage Beer with a Scientist patrons to drink responsibly.

For more information and to suggest future Beer with a Scientist topics, follow Louisville Underground Science on Facebook.

November 7, 2016

For the final Optimal Aging Lecture for the fall semester, the Institute for Sustainable Health & Optimal Aging and the UofL Alumni Association present a panel discussion entitled “Expanded Medicare: A Single Payer Alternative.” This lecture will unpack the myths and realities of developing a national health insurance program. The lecture will be held on Nov. 9 from 11:30 a.m. – 1 p.m. at the University Club, 200 E. Brandeis Ave.

The panel presenters for this exploration of available health care options are Syed Quadri, M.D., Kay Tillow and Edgar Lopez, M.D., all from the national organization Physicians for a National Health Program. The PNHP is a non-profit research and education organization consisting of 20,000 physicians, medial students and other health professionals who support single-payer national health insurance.

The panelists will discuss their common belief that too many working individuals are unable to afford health care. In addition to their roles with PNHP, the speakers are Kentucky-based professionals with expertise and experience in the state’s health system. Quadri is the co-medical director of the Hardin County Free Clinic in Elizabethtown. Tillow is the coordinator of the All Unions Committee for Single Payer Health Care, a Kentucky advocacy organization. Lopez is a Louisville-based plastic and reconstructive surgeon. 

Admission is $30 per person and includes lunch. Reservations are required online. Click here to register. For information, call 502-852-5629 or email OptimalAging@louisville.edu.

Thanks to advances in medical science and a highly developed network of specialized pediatric health care services, people with intellectual and developmental disabilities (IDD) are much more likely to live into adulthood than they were several decades ago. However, once they reach age 18, they may find a limited number of providers available to address their unique and specialized health care needs.

To improve access to quality health care for adults with IDD, the University of Louisville School of Medicine, UofL School of Dentistry and the Lee Specialty Clinic are sponsoring the Second Annual Caring for Adults with Intellectual and Developmental Disabilities Conference on Saturday, Nov. 12 at UofL. The conference will inform physical, occupational and speech therapists, physicians, dentists, social workers, patients and their caregivers about best current practices and future treatment directions for adults with IDD and address the multidisciplinary approach needed for their care.

“These are individuals with neurologically based conditions who require interdisciplinary care from a variety of health care providers, including primary care, dentistry, cardiology, pulmonary, neurology, psychiatry and psychology, as well as physical therapy, speech therapy and occupational therapy,” said Michael Sowell, M.D., professor in the Department of Neurology at UofL and co-director of the conference.

One such individual is Steven Haburne, described by his mother as, “a 41-year-old man with a pleasant personality who was born with spastic quadriplegic cerebral palsy and developmental disability.” He moves in a wheelchair, is non-verbal and has a seizure disorder. Haburne’s mother, Shirley Haburne, said they have met with physicians over the years who did not speak to Steven directly or who made assumptions about his condition without listening to Shirley’s description of his individual needs. When Haburne was very young, his family’s dentist told Shirley he was not comfortable treating Steven.

“It did hurt my feelings, but I understand. He is not the same as other patients,” Shirley said. “It has taken a lifetime of finding doctors. It takes time to find a doctor who will listen to you and trust what you say.”

Steven now receives dental care at Lee Specialty Clinic in Louisville, which offers medical, dental, psychiatric and general health care services for patients with IDD, and he receives medical care from several specialists at University of Louisville Physicians. Shirley hopes the conference will help make optimal health care available for her son and others with IDD.

The conference will cover autism outreach, mobility and assistive technology, cognitive decline, advocacy for adults with IDD, and understanding the barriers in transitioning a child with neurodevelopmental disabilities into the adult provider network. Afternoon breakout sessions include topics in medicine, dentistry, developmental psychiatry and psychology, therapeutics and social work and are designed to stimulate discussions among health care providers, patients and their families that will lead to an improved standard of care in the region.

The event also is designed to support the physician specialty of adult developmental medicine.

“Developmental medicine as an emerging specialty pulls together a formal curriculum and training pathway to prepare physicians to provide the comprehensive care that these individuals need,” Sowell said. Learn more about this specialty at the American Academy of Developmental Medicine and Dentistry.

CONFERENCE DETAILS:  The Second Annual Caring for Adults with Intellectual and Developmental Disabilities (IDD) Conference is scheduled for Saturday, Nov. 12, from 8 a.m. to 3 p.m. at the UofL School of Medicine, Instructional Building B - Room 115, 500 S. Preston St., Louisville, Ky. Continuing education credit is available. Register for the conference at http://louisville.edu/medicine/cme/events/IDD16 or call 502-852-5329.

REMOTE ATTENDANCE: This conference also is available via a LIVE interactive video conference for all persons interested in caring for adult individuals with a diagnosis of an intellectual or a developmental disability. Register in advance of the conference at http://bit.ly/disabilities16.

November 1, 2016

Fine particulate matter air pollution may be associated with blood vessel damage and inflammation among young, healthy adults, according to new research in CirculationResearch, anAmerican Heart Association journal.

“These results substantially expand our understanding about how air pollutioncontributes to cardiovascular disease by showing that exposure is associated with a cascade of adverse effects,” said C. Arden Pope, Ph.D., study lead author and Mary Lou Fulton Professor of Economics at Brigham Young University in Provo, Utah.

“These findings suggest that living in a polluted environment could promote the development of high blood pressure, heart disease and stroke more pervasively and at an earlier stage than previously thought,” said Aruni Bhatnagar, Ph.D., study co-author and the Smith and Lucille Gibson Chair in Medicine at the University of Louisville. “Although we have known for some time that air pollution can trigger heart attacks or strokes in susceptible, high-risk individuals, the finding that it could also affect even seemingly healthy individuals suggests that increased levels of air pollution are of concern to all of us, not just the sick or the elderly.”

Air pollution is known to contribute to cardiovascular disease and related deaths. In 2004, the American Heart Association released a scientific statement, updated in 2010, warning of the risk and recommending that people talk to their doctor about avoiding exposure to air pollution specific to their area. What remained unclear, however, was how air pollution actually affects the blood vessels to increase the risk of disease.

For this study, investigators analyzed the component of air pollution known as fine particulate matter (PM_2.5) — the tiny pieces of solid or liquid pollution emitted from motor vehicles, factories, power plants, fires and smoking. They found that periodic exposure to fine particulate matter was associated with several abnormal changes in the blood that are markers for cardiovascular disease. As air pollution rose, they found:

• small, micro-particles indicating cell injury and death significantly increased in number;

• levels of proteins that inhibit blood vessel growth increased; and

• proteins that signify blood-vessel inflammation also showed significant increases.

Study participants included 72 healthy, nonsmoking, adults in Provo, Utah. Their average age was 23, most were white and more than half were male. During the winters of 2013, 2014 and 2015, participants provided blood samples, which researchers then tested for markers of cardiovascular disease. Due to the unique weather and geographical features of Provo, they were able to evaluate these informative blood markers with various levels of air pollution.

However, researchers noted that the third study year, 2015, was relatively unpolluted, which could have affected the results.

Other co-authors are James P. McCracken, Ph.D.; Wesley Abplanalp, Ph.D.; Daniel J. Conklin, Ph.D.; and Timothy O’Toole, Ph.D., all of UofL. The National Institutes of Health funded the study.

Additional Resources:

• Household air pollution linked to higher risk of heart attacks, death
• High blood pressure linked to short-, long-term exposure to some air pollutants
• Follow AHA/ASA news on Twitter @HeartNews
• For updates and new science from the Circulation: Research journal follow @CircRES

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Spinal cord injury researchers at the University of Louisville pioneered activity-based interventions that have helped individuals with spinal cord injury (SCI) improve mobility. The addition of epidural stimulation to the lumbosacral spinal cord has allowed individuals with SCI to stand without assistance. Susan Harkema, Ph.D., who leads this research at UofL, Claudia Angeli, Ph.D., Enrico Rejc, Ph.D., and Sunil Agrawal, Ph.D., an engineer at Columbia University, have won a $5 million grant to develop a robotic device that will aid individuals with SCI further by helping them regain balance. The Tethered Pelvic Assist Device (TPAD) will provide stimulation and feedback to aid in the recovery of balance, and will be integrated with activity-based training and epidural stimulation research at UofL.

Harkema, Angeli and Rejc, faculty members in the Department of Neurological Surgery at UofL, are working with Agrawal, professor of mechanical engineering and of rehabilitation and regenerative medicine at Columbia Engineering, to develop TPAD. Agrawal specializes in the development of novel robotic devices and interfaces that help patients retrain their movements.

The project has won a five-year, $5 million grant from the New York State Spinal Cord Injury Board. The project also includes Joel Stein, chair of the Department of Rehabilitation and Regenerative Medicine, and Ferne Pomerantz, M.D., assistant professor in that department at Columbia University Medical Center.

TPAD is a wearable, light-weight cable-driven device that can be programmed to provide motion cues to the pelvis and corrective forces to stabilize it. It consists of a pelvic belt with multiple cables connected to motors, a real-time motion capture system, and a real-time controller to regulate the tensions in the cables. The UofL researchers will incorporate the device into the training of SCI patients during standing.

“Our stand and step training, combined with epidural stimulation, have shown success in enabling individuals with SCI regain the ability to stand. We hope the integration of the TPAD device will help these individuals with balance, further improving their functional ability and quality of life,” said Harkema, who also is Director of Research at Frazier Rehab Institute, part of KentuckyOne Health.

In their work with the Kentucky Spinal Cord Injury Research Center (KSCIRC), the UofL researchers have studied the effects of stand and step training along with epidural stimulation in adults with spinal cord injury. Epidural stimulation involves surgically implanting an electrode array over the lower spinal cord to activate the neural circuits.

October 24, 2016

A Jeffersonville, Ind., woman has become the first female hand transplant recipient in Kentucky and the 10th patient to receive a hand transplant from the Louisville Vascularized Composite Allograft (VCA) program, a partnership of physicians, researchers and health care providers from the University of Louisville, Jewish Hospital, part of KentuckyOne Health, the Christine M. Kleinert Institute for Hand and Microsurgery (CMKI) and the Kleinert Kutz Hand Care Center.

During a 17-hour procedure on Sept. 17, Louella Aker underwent a double hand transplant at Jewish Hospital. The 69-year-old acquired an infection while involved in the cleanup of Henryville, Ind., after an EF4 tornado hit the area on March 2, 2012. Aker was later diagnosed with septicemia and underwent a bilateral, below-the-knee amputation on her legs, left forearm amputation, and right partial hand amputation. Aker was added to the organ donor registry in September 2015.

“There are so many things you cannot do without your hands. This will change my life and allow me to do the things I miss, like holding my granddaughter’s hand,” Aker said at a news conference on Oct. 19. “I spent many days praying for a donor, but also crying for the donor’s family for their loss. This is such a huge and exquisite gift they have given me and I thank and bless them for their sacrifice. I also want to thank the surgeons, my family and my church for their support.”

Twenty surgeons from UofL, CMKI and Kleinert Kutz performed the procedure. Fourteen staff members and six anesthesiologists also assisted with the surgery.

“Although a little slow, we are pleased with the progress that Louella has been making,” said Tuna Ozyurekoglu, M.D., lead surgeon on the procedure and assistant clinical professor of orthopedic surgery at UofL. “She is truly a fighter who has continued to grow stronger each day following this surgery. We look forward to watching her return to her normal activities, as she shows the world how successful transplantation can be.”

“Operations such as this help demonstrate the enormous importance of organ and tissue donation,” said Christopher Jones, M.D., associate professor of surgery at UofL and director of abdominal transplantation at Jewish Hospital. “If it were not for the donor family graciously agreeing to limb donation, the efforts of Kentucky Organ Donor Affiliates and neighboring organ procurement organizations, this certainly would not have been possible.”

Aker was placed on immunosuppressive medications to prevent rejection of the new hand.

“She is tolerating her medications, and to date, has no signs of clinical rejection,” said Jones, who is overseeing the patient’s immunosuppressive therapy by closely monitoring her for signs of rejection and adverse reaction to medications.

“It is amazing to be part of an extraordinary team, performing procedures such as this double hand transplant,” said Stuart K. Williams, II, PhD, director, Bioficial Organs Program, Cardiovascular Innovation Institute. “New innovations developed by investigators at the Cardiovascular Innovation Institute are being translated to help patients recover more quickly from transplant surgery.”

The Louisville team developed the pioneering hand transplant procedure and has performed hand transplants on 10 patients since 1999. The clinical trial is led by Ozyurekoglu with research at the CMKI and the Cardiovascular Innovation Institute, a partnership of UofL and the Jewish Heritage Fund for Excellence.

Funding for the surgical procedure was provided by the Jewish Hospital & St. Mary’s Foundation, part of KentuckyOne Health.

The success of the Louisville VCA program has led to additional funding for ongoing transplantation and research. Early funding for research on composite tissue allotransplantation and immunotherapy from the Jewish Hospital & St. Mary’s Foundation helped bring about the nation’s first hand transplant. Other hand transplants were funded by the Department of Defense.

In late 2012, the Jewish Hospital & St. Mary’s Foundation allocated $1.5 million for the Louisville VCA program to bring potential hand transplant recipients to Louisville for screening, hand transplantation surgery and patient therapy and rehabilitation after surgery.

In 2013, the Louisville VCA program was awarded $850,000 to fund a clinical trial of a new treatment that will help prevent rejection of hand transplants as part of the Armed Forces Institute of Regenerative Medicine (AFIRM) research program. AFIRM II is a five-year, $75 million federally funded project that will focus on applying regenerative medicine to battlefield injuries. Results of this trial will be far-reaching and benefit not only military patients, but all hand transplant recipients.

The AFIRM II funding enables Louisville VCA researchers to explore the potential for a cell-based therapy to help control the immune system’s response to a hand transplant, with a goal to lessen or eliminate the need for immune-suppressant drugs.