Background

Dr. Sullivan joined the Department of Pediatrics in July 1995. She graduated from the University of Minnesota School of Medicine in 1988 and completed her Pediatric residency at Arkansas Children's Hospital in 1991. She completed a fellowship in Pediatric Critical Care and Clinical Pharmacology at Rainbow Babies and Children's Hospital in Cleveland, Ohio. She is board certified in Pediatrics, Pediatric Critical Care, and Clinical Pharmacology. She helped establish the Pediatric Clinical Research Unit in 2002 which has expanded from 4 to over 70 staff members.  Under her leadership, the unit's number of clinical trials and research grants funded through this entity has grown exponentially.  Currently she serves as the Vice Chair for Research in the Department of Pediatrics and the Assistant Chief Scientific Officer in the Norton Children’s Research Institute.

Research Interests:

• Improving healthcare for children through clinical trials that involve medications to treat different disease entities in children who are inpatient or outpatient
• Faculty education in clinical research
• Mentoring the next generation of clinician scientists

Current Projects and Grants

• NIH, The Kentucky ECHO Pediatric IDeA Research Center. 2020-2027.  The goal is to provide medically underserved/rural populations access to clinical trials, applying findings from relevant pediatric cohort studies to children in IDeA state locations, and build pediatric research capacity at a national level.
• NIH, Environmental Health Sciences Core Centers (EHSCC). 2020-2024. The goal of this award is to build a framework to integrate interactions of pollutants and lifestyle factors to better understand these interactions in human health and disease across life stages and improve the health of the Regional Community.
• NIH (subaward--Duke University), Pediatric Trial Network Steering Committee. 2019-2024. The goal of this award is to help guide the development and implementation of sound scientific research to improve care for children.

Selected Publications and Manuscripts in Progress

Publications including guidelines:

1. Smith HAB, Besunder J, Betters K, Johnson P, Srinivasan V, Stormorken A, Farrington E, Golianu B, Godshall A, Acinelli L, Almgren C, C Bailey, Boyd J, Cisco M, Damian M, deAlmeida M, Fehr J, Fenton K, Gilliland F, Grant MJC, Howell J, Ruggles C, Simone S, Su F, Sullivan JE, Tegtmeyer K, Traube C, Williams S, and Berkenbosch JW. 2022 Society of Critical Care Medicine Clinical Practice Guidelines on Prevention and Management of Pain, Agitation, Neuromuscular Blockade, and Delirium in Critically Ill Pediatric Patients with Consideration of the ICU Environment and Early Mobility. Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2022
2. Shaw JL, Semmens E, Okihiro M, Lewis JL, Hirschfeld M, VanWagoner TM, Stephens L, Easa D, Ross JL, Graham N, Watson SE, Szyld EG, Dillard DA, Pyles LA, Darden PM, Carlson JC, Smith PG, McCulloh RJ, Snowden JN, Adeky SH, Singleton R. (ISPCTN: member Sullivan JE). Best Practices for Conducting Clinical Trials with Indigenous Children in the United States. Am J Public Health. 2021 Sep;111(9):1645-1653. doi: 10.2105/AJPH.2021.306372. Epub 2021 Aug 26. PubMed PMID: 34436921; PubMed Central PMCID: PMC8494399.
3. LaRovere KL, Riggs BJ, Poussaint TY, Young CC, Newhams MM, Maamari M, Walker TC, Singh AR, Dapul H, Hobbs CV, McLaughlin GE, Son MBF, Maddux AB, Clouser KN, Rowan CM, McGuire JK, Fitzgerald JC, Gertz SJ, Shein SL, Munoz AC, Thomas NJ, Irby K, Levy ER, Staat MA, Tenforde MW, Feldstein LR, Halasa NB, Giuliano JS Jr, Hall MW, Kong M, Carroll CL, Schuster JE, Doymaz S, Loftis LL, Tarquinio KM, Babbitt CJ, Nofziger RA, Kleinman LC, Keenaghan MA, Cvijanovich NZ, Spinella PC, Hume JR, Wellnitz K, Mack EH, Michelson KN, Flori HR, Patel MM, Randolph AG. Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome. JAMA Neurol. 2021 May 1;78(5):536-547. doi: 10.1001/jamaneurol.2021.0504. PubMed PMID: 33666649; PubMed Central PMCID: PMC7936352.
4. Payne AB, Gilani Z, Godfred-Cato S, et al. Incidence of Multisystem Inflammatory Syndrome in Children Among US Persons Infected With SARS-CoV-2. JAMA Netw Open. 2021;4(6):e2116420. doi:10.1001/jamanetworkopen.2021.16420.
5. Feldstein LR, Tenforde MW, Friedman KG, et al for the Overcoming COVID-19 Investigators/ for PALISI PICFLU Network (member: Sullivan JE). Characteristics and Outcomes of US Children and Adolescents with Multisystem Inflammatory Syndrome in Children (MIS-C) Compared with Severe Acute COVID-19. JAMA. 2021;325(11):1074-1087. doi:10.1001/jama.2021.2091.

Studies related to Improving healthcare for children through clinical trials that involves medications to treat different disease entities in children who are inpatient or outpatient:

1. Bekelman TA, Dabelea D, Ganiban JM, Law A, McGovern Reilly A, Althoff KN, Mueller N, Camargo CA Jr, Duarte CS, Dunlop AL, Elliott AJ, Ferrara A, Gold DR, Hertz-Picciotto I, Hartert T, Hipwell AE, Huddleston K, Johnson CC, Karagas MR, Karr CJ, Hershey GKK, Leve L, Mahabir S, McEvoy CT, Neiderhiser J, Oken E, Rundle A, Sathyanarayana S, Turley C, Tylavsky FA, Watson SE, Wright R, Zhang M, Zoratti E. (ISPCTN: member Sullivan JE) Regional and sociodemographic differences in average BMI among US children in the ECHO program. Obesity (Silver Spring). 2021 Dec;29(12):2089-2099. doi: 10.1002/oby.23235. Epub 2021 Aug 31. PubMed PMID: 34467678; PubMed Central PMCID: PMC9088705.Maharaj AR; Wu H; Zimmerman KO; Muller WJ; Sullivan JE; Sherwin CMT; Autmizguine J; Rathore MH; Hornik CD; Al-Uzri A; Payne EH; Benjamin DK; Hornik CP, PhD. Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee. Pharmacokinetics of Ceftazidime in Children and Adolescents with Obesity. Paediatr Drugs. 2021 Jul 23. doi: 10.1007/s40272-021-00460-4. Online ahead of print. PMID: 34302290
2. Maharaj AR; Wu H; Zimmerman KO; Muller WJ; Sullivan JE; Sherwin CMT; Autmizguine J; Rathore MH; Hornik CD; Al-Uzri A; Payne EH; Benjamin DK; Hornik CP, PhD. Pharmacokinetics of Ceftazidime in Children and Adolescents with Obesity. June 2021; Accepted for publication, Pediatric Drugs.description and list of publications
3. Ganguly S, Edginton AN, Gerhart JG, Cohen-Wolkowiez M, Greenberg RG, Gonzalez D, and Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee (Sullivan JE is a member). Physiologically Based Pharmacokinetic Modeling of Meropenem in Preterm and Term Infants. Clin Pharmacokinet. 2021 Jun 22;. doi: 10.1007/s40262-021-01046-6. [Epub ahead of print] PubMed PMID: 34155614.
4. Ge S, Mendley SR, Gerhart JG, Melloni C, Hornik CP, Sullivan JE, Atz A, Delmore P, Tremoulet A, Harper B, Payne E, Lin S, Erinjeri J, Cohen-Wolkowiez M, Gonzalez D. Population Pharmacokinetics of Metoclopramide in Infants, Children, and Adolescents. Clin Transl Sci. 2020 Nov;13(6):1189-1198. doi: 10.1111/cts.12803. Epub 2020 May 27. PubMed PMID: 32324313; PubMed Central PMCID: PMC7719387.
5. Shufan GE, Mendley SR, Gerhart JG, Melloni C, Hornik CP, Sullivan JE, Atz A, Delmore P, Tremoulet A, Harper B, Payne E, Lin S, Erinjeri J, Cohen-Wolkowieiz M, Gonzalez D, Best Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee. Population Pharmacokinetics of Metoclopramide in Infants, Children, and Adolescents. Clin Transl Sci. 2020 Apr 23. doi: 10.1111/cts.12803. Online ahead of print.

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Studies related to Faculty education in clinical research and mentoring to train the next generation of clinician scientists:

1. Abdel-Rahman SM, Paul IM, Hornik C, Sullivan JE, Wade K, Delmore P, Sharma G, Benjamin DK, Zimmerman KO. Racial and Ethnic Diversity in Studies Funded Under the Best Pharmaceuticals for Children Act. Pediatrics. 2021 May;147(5). doi: 10.1542/peds.2020-042903. Epub 2021 Apr 12. PubMed PMID: 33846237.
2. Knight L, Pahud BA, Scheffler M, Euteneuer JC, Allen C, Ross J, Ali W, Meyer M, Purohit PJ, Zimmerman KO, Sullivan JE. Capacity Building in a New Clinical Trials Network through Inter-Network Collaboration. J Pediatr. 2021 Apr 30;. doi: 10.1016/j.jpeds.2021.04.062. [Epub ahead of print] PubMed PMID: 33940019.
3. Annett RD, Chervinskiy S, Chun TH, Cowen K, Foster K, Goodrich N, Hirschfeld M, Hsia DS, Jarvis JD, Kulbeth K, Madden C, Nesmith C, Raissy H, Ross J, Saul JP, Shiramizu, Smith P, Sullivan JE, Tucker L, Atz AM. IDeA States Pediatric Clinical Trials Network for Underserved and Rural Communities. Pediatrics. 2020 Oct;146(4):e20200290. doi: 10.1542/peds.2020-0290. Epub 2020 Sep 17.
4. Zozus MN, Young LW, Simon AE, Garza M, Lawrence L, Ounpraseuth ST, Bledsoe M, Newman-Norlund S, Jarvis JD, McNally M, Harris KR, McCulloh R, Aikman R, Cox S, Malloch L, Walden A, Snowden J, Chedjieu IM, Wicker CA, Atkins L, Devlin LA. Training as an Intervention to Decrease Medical Record Abstraction Errors Multicenter Studies. Stud Health Technol Inform. 2019;257:526-539. PubMed PMID: 30741251; PubMed Central PMCID: PMC6692114.

Selected Conference Publications and Presentations

1. Sullivan JE.  Moderator "Junior Faculty and Senior Faculty Development Leader's" Collaborative session.  ECHO ISPCTN Spring Meeting, Washington, DC.
2. Rahman S, Paul I, Sullivan JE, Hornik CD, Wade K, Delmore D, Zimmerman KO. Minority Representation in Pediatric Studies Funded under the Best Pharmaceuticals for Children’s Act (BPCA). ASCPT Virtual meeting; 3/13/2021.
3. Sullivan JE representing ISPCTN POPS (POP01) Committee. Update on IDeA States Pediatric Network and the POP01 Protocol. NIH IDeA States Pediatric Network Meeting. Washington, DC. 5/1/2019.
4. Sullivan JE. ISPCTN-PTN: Network to Network Support. Presented at DCRI Symposium, PAS, Baltimore, MD. 4/28/2019.
5. Snowden J, Sullivan JE, Knight LM, Arnett RD, Cowan K. Pediatric Research Capacity Improvements in the IDeA States Pediatric Clinical Trial Network. PAS, April 2019, Baltimore, MD.