Janice E. Sullivan, MD

Professor of Pediatrics

Vice Chair for Research, Department of Pediatrics
Divisions of Pediatric Clinical & Translational Research and Pediatric Critical Care
Assistant Chief Scientific Officer, Norton Children's Research Institute


Academic Phone Number: 502-852-8600 Email Address: sully@louisville.edu

Background

Dr. Sullivan joined the Department of Pediatrics in July 1995. She graduated from the University of Minnesota School of Medicine in 1988 and completed her Pediatric residency at Arkansas Children's Hospital in 1991. She completed a fellowship in Pediatric Critical Care and Clinical Pharmacology at Rainbow Babies and Children's Hospital in Cleveland, Ohio. She is board certified in Pediatrics, Pediatric Critical Care, and Clinical Pharmacology. She helped establish the Pediatric Clinical Research Unit in 2002 which has expanded from 4 to over 40 staff members.  Under her leadership, the unit's number of clinical trials and research grants funded through this entity has grown exponentially.  Currently she serves as the Vice Chair for Research in the Department of Pediatrics and the Assistant Chief Scientific Officer in the Norton Children’s Research Institute.


Research Interests:

  • Improving healthcare for children through clinical trials that involve medications to treat different disease entities in children who are inpatient or outpatient
  • Faculty education in clinical research
  • Mentoring the next generation of clinician scientists

Current Projects and Grants

  • I-ACT, Pediatric Improvement Collaborative for Clinical Trials & Research. 2021-2022. The goal of this proposal is to improve processes for study start-up to shorten the timeline for study initiation.
  • NIH, The Kentucky ECHO Pediatric IDeA Research Center. 2020-2027.  The goal is to provide medically underserved/rural populations access to clinical trials, applying findings from relevant pediatric cohort studies to children in IDeA state locations, and build pediatric research capacity at a national level.
  • NIH, Environmental Health Sciences Core Centers (EHSCC). 2020-2021. The goal of this award is to build a framework to integrate interactions of pollutants and lifestyle factors to better understand these interactions in human health and disease across life stages and improve the health of the Regional Community.
  • NIH (subaward--Duke University), Pediatric Trial Network Steering Committee. 2019-2022. The goal of this award is to help guide the development and implementation of sound scientific research to improve care for children.

Selected Publications and Manuscripts in Progress

Studies related to Improving healthcare for children through clinical trials that involves medications to treat different disease entities in children who are inpatient or outpatient:

  1. Maharaj AR; Wu H; Zimmerman KO; Muller WJ; Sullivan JE; Sherwin CMT; Autmizguine J; Rathore MH; Hornik CD; Al-Uzri A; Payne EH; Benjamin DK; Hornik CP, PhD. Pharmacokinetics of Ceftazidime in Children and Adolescents with Obesity. June 2021; Accepted for publication, Pediatric Drugs.description and list of publications
  2. Ganguly S, Edginton AN, Gerhart JG, Cohen-Wolkowiez M, Greenberg RG, Gonzalez D, and Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee (Sullivan JE is a member). Physiologically Based Pharmacokinetic Modeling of Meropenem in Preterm and Term Infants. Clin Pharmacokinet. 2021 Jun 22;. doi: 10.1007/s40262-021-01046-6. [Epub ahead of print] PubMed PMID: 34155614.
  3. Abdel-Rahman SM, Paul IM, Hornik C, Sullivan JE, Wade K, Delmore P, Sharma G, Benjamin DK, Zimmerman KO. Racial and Ethnic Diversity in Studies Funded Under the Best Pharmaceuticals for Children Act. Pediatrics. 2021 May;147(5). doi: 10.1542/peds.2020-042903. Epub 2021 Apr 12. PubMed PMID: 33846237.
  4. Ge S, Mendley SR, Gerhart JG, Melloni C, Hornik CP, Sullivan JE, Atz A, Delmore P, Tremoulet A, Harper B, Payne E, Lin S, Erinjeri J, Cohen-Wolkowiez M, Gonzalez D. Population Pharmacokinetics of Metoclopramide in Infants, Children, and Adolescents. Clin Transl Sci. 2020 Nov;13(6):1189-1198. doi: 10.1111/cts.12803. Epub 2020 May 27. PubMed PMID: 32324313; PubMed Central PMCID: PMC7719387.
  5. Shufan GE, Mendley SR, Gerhart JG, Melloni C, Hornik CP, Sullivan JE, Atz A, Delmore P, Tremoulet A, Harper B, Payne E, Lin S, Erinjeri J, Cohen-Wolkowieiz M, Gonzalez D, Best Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee. Population Pharmacokinetics of Metoclopramide in Infants, Children, and Adolescents. Clin Transl Sci. 2020 Apr 23. doi: 10.1111/cts.12803. Online ahead of print.

Studies related to Faculty education in clinical research and mentoring to train the next generation of clinician scientists:

  1. Knight L, Pahud BA, Scheffler M, Euteneuer JC, Allen C, Ross J, Ali W, Meyer M, Purohit PJ, Zimmerman KO, Sullivan JE. Capacity Building in a New Clinical Trials Network through Inter-Network Collaboration. J Pediatr. 2021 Apr 30;. doi: 10.1016/j.jpeds.2021.04.062. [Epub ahead of print] PubMed PMID: 33940019.
  2. Annett RD, Chervinskiy S, Chun TH, Cowen K, Foster K, Goodrich N, Hirschfeld M, Hsia DS, Jarvis JD, Kulbeth K, Madden C, Nesmith C, Raissy H, Ross J, Saul JP, Shiramizu, Smith P, Sullivan JE, Tucker L, Atz AM. IDeA States Pediatric Clinical Trials Network for Underserved and Rural Communities. Pediatrics. 2020 Oct;146(4):e20200290. doi: 10.1542/peds.2020-0290. Epub 2020 Sep 17.
  3. Zozus MN, Young LW, Simon AE, Garza M, Lawrence L, Ounpraseuth ST, Bledsoe M, Newman-Norlund S, Jarvis JD, McNally M, Harris KR, McCulloh R, Aikman R, Cox S, Malloch L, Walden A, Snowden J, Chedjieu IM, Wicker CA, Atkins L, Devlin LA. Training as an Intervention to Decrease Medical Record Abstraction Errors Multicenter Studies. Stud Health Technol Inform. 2019;257:526-539. PubMed PMID: 30741251; PubMed Central PMCID: PMC6692114.

Selected Conference Publications and Presentations

  1. Rahman S, Paul I, Sullivan JE, Hornik CD, Wade K, Delmore D, Zimmerman KO. Minority Representation in Pediatric Studies Funded under the Best Pharmaceuticals for Children’s Act (BPCA). ASCPT Virtual meeting; 3/13/2021.
  2. Sullivan JE representing ISPCTN POPS (POP01) Committee. Update on IDeA States Pediatric Network and the POP01 Protocol. NIH IDeA States Pediatric Network Meeting. Washington, DC. 5/1/2019.
  3. Sullivan JE. ISPCTN-PTN: Network to Network Support. Presented at DCRI Symposium, PAS, Baltimore, MD. 4/28/2019.
  4. Pettit N, Bryant K, Espinosa CM, Sullivan JE, Duong JT. Oral Gentamicin and Bloodstream Infections of Infants Hospitalized in a Neonatal Intensive Care Unit (NICU). PAS, April 2019, Baltimore, MD.
  5. Snowden J, Sullivan JE, Knight LM, Arnett RD, Cowan K. Pediatric Research Capacity Improvements in the IDeA States Pediatric Clinical Trial Network. PAS, April 2019, Baltimore, MD.