Evelyne Gozal, PhD

Associate Professor of Pediatrics, Pediatric Research Institute

Academic Phone Number: 502-852-2213 • Email Address: evelyne.gozal@louisville.edu

Background

Evelyne Gozal received her B.Sc. in Biology, and a Pharm D. in Pharmacy from the Hebrew University of Jerusalem, Jerusalem, Israel. She then completed her Ph.D.in Toxicology at the University of Southern California, Los Angeles, CA.  She further trained as a post-doctoral fellow in lung biology at Tulane University, New Orleans, LA. She took a position as an Assistant Professor of Pediatrics at the University of Louisville and was later promoted to her current position as an Associate Professor of Pediatrics at the Pediatric Research Institute, with secondary appointments as Associate Professor in the Department of Pharmacology & Toxicology and the Department of Physiology.

Research Interests:

  • Neuroinflammation in developmental and neurodegenerative diseases
  • Endothelial injury
  • Neurovascular inflammation
  • Systemic and lung vascular inflammation in diabetes


 

Selected Publications and Manuscripts in Progress

Related to Neuroinflammation in developmental and neurodegenerative diseases:

  1. Li, Z., Jagadapillai, R., Gozal, E, Barnes, G. Deletion of Semaphorin 3F in Interneurons is Associated with Decreased GABAergic Neurons, Autism-Like Behavior, and Increased Oxidative Stress Cascades. Mol. Neurobiol. 2019; 56(8):5520-5538. https://doi.org/10.1007/s12035-018-1450-9 PMID 30635860
  2. Ohja, K., Gozal, E.., Cai, L., Cai, J., Fahnestock, M., Freedman, J., Switala, A., El-Baz, A., Barnes, G. Neuroimmunologic and Neurotrophic interactions in autism spectrum disorders: relationship to neuroinflammation. Neuromolecular Med. 2018; 20(2):161-173. doi: 10.1007/s12017-018-8488-8. PMID:29691724.
  3. Gozal, E*., Miller, C.J., Dematteis, M., Sachleben, Jr. L.R., Schurr, A., Rane, M.J.  PKA activity exacerbates hypoxia-induced ROS formation and hypoxic injury in PC-12 cells. Toxicology  Letters 2017; 5(279):107-114. doi: 10.1016/j.toxlet.2017.07.895. PMID:  279:107-114

Related to Endothelial Injury

  1. Dixon, J.T., Gozal, E. and Roberts, A.M. Platelet-mediated vascular dysfunction during Acute Lung Injury. Arch. Physiol. Biochem. 2012; 118(2):72-82. PMID: 22439828
  2. Roberts, A.M., Jagadapillai, R., Vaishnav, R.A., Friedland, R.P., Drinovac, R., Xingyu Lin, X., Gozal, E*. Increased Pulmonary Arteriolar Tone Associated with Lung Oxidative Stress and Nitric Oxide in a Mouse Model of Alzheimer's Disease. Physiological Reports. 2016; 4(17): e12953. PMID:  27604401.
  3. Zheng, Z., Ma, T., Lian, X., Gao, J., Wang, W., Weng, W., Lu, X., Sun, W., Cheng, Y., Fu, Y., Rane, M., Gozal, E.*, Cai L*. Clopidogrel reduces fibronectin accumulation and improves diabetes-induced renal fibrosis. * Co-senior authors. International Journal of Biological Sciences 2019; 15(1): 239-252. PMID 30662363.
  4. Roberts, A.M., Moulana, N.Z., Jagadapillai, R., Cai, L., Gozal, E*. Intravital Assessment of Pre-capillary Pulmonary Arterioles of Type-1 Diabetic Mice Shows Oxidative Damage and Increased Tone in Response to L-NAME. J. Appl Physiol. 2021; September 30. doi:10.1152/japplphysiol.00395.2021. Online ahead of print. PMID:34590907.
Related to Neurovascular Inflammation
  1. Sedoris, K.C.,  Ovechkin, A.V.,  Gozal, E. and Roberts, A.M.: Differential effects of nitric  oxide synthesis on pulmonary vascular function during lung ischemia-reperfusion injury. Arch.  Physiol. Biochem. 2009; 115(1):34-46. PMID: 19267281.
  2. Mazzocco, J.C., Jagadapillai, R., Gozal, E., Kong, M., Xu, Q., Barnes, G.N., Freedman, J.H. Disruption of essential metal homeostasis in the brain by cadmium and high fat diet. Toxicology Reports 2020; 7:1164-1169. https://doi.org/10.1016/j.toxrep.2020.08.005 2020. PMID 32983904.
  3. Gozal, E.*, Jagadapillai, R., Cai, J., Potential Crosstalk between Sonic Hedgehog-Wingless-related Integration Site Signaling and Neurovascular Molecules: Implications for Blood Brain Barrier Integrity in Autism Spectrum Disorder. J. Neurochem. 2021; 159 (1): 15-28. doi: 10.1111/jnc.15460. PMID: 34169527.
  4. Jagadapillai, R.,Qiu, X., Ohja, K., Li, Z.,  El-Baz, A., Zhu, S., Gozal, E.*, Barnes, G*. Potential Cross Talk Between Autism Risk Genes and Neurovascular Molecules: A Pilot Study on Impact of Blood Brain Barrier Integrity. * Co-senior authors.  Cells. 2022 Jul 15;11(14):2211. doi: 10.3390/cells11142211. PMID: 35883654
Related to Systemic and Lung Vascular Inflammation in Diabetes
  1. Roberts, A.M., Jagadapillai, R., Vaishnav, R.A., Friedland, R.P., Drinovac, R., Xingyu Lin, X., Gozal, E*. Increased Pulmonary Arteriolar Tone Associated with Lung Oxidative Stress and Nitric Oxide in a Mouse Model of Alzheimer's Disease. Physiological Reports. 2016; 4(17): e12953. PMID:  27604401.
  2. Jagadapillai, R., Rane, M.J., Lin, X., Roberts, A.M., Hoyle, G.M., Cai, L., Gozal, E*. Diabetic Pulmonary Fibrosis: A role for platelets and pulmonary vascular injury. Int. J. Mol. Sci. 2016; 17, 1853; doi:10.3390/ijms17111853. PMID: 27834824.
  3. Lin, X., Jagadapilla,i R.,  Cai J, Cai, L., Shao, G., Gozal, E*. Metallothionein induction attenuates the progression of lung injury in mice exposed to long-term intermittent hypoxia. Inflamm Res. 2020; 69(1):15-26. doi: 10.1007/s00011-019-01287-z. PMID    31707449.
  4. Huang, S., Wang, J., Men, H., Tan, Y., Lin, Q., Gozal, E., Zheng, Y., Cai, L. Cardiac methallothionein overexpression rescues diabetic cardiomyopathy in Akt2-knockout mice. J. Cell. Mol. Med. 2021; 25(14): 6828-6840. PMID: 34053181https://doi.org/10.1111/jcmm.16687
  5. Roberts, A.M., Moulana, N.Z., Jagadapillai, R., Cai, L., Gozal, E*. Intravital Assessment of Pre-capillary Pulmonary Arterioles of Type-1 Diabetic Mice Shows Oxidative Damage and Increased Tone in Response to L-NAME. J. Appl Physiol. 2021; September 30. doi:10.1152/japplphysiol.00395.2021. Online ahead of print. PMID:34590907.

Selected Conference Publications and Presentations

  1. Jagadapillai R, Mellen N, Sachleben, Jr. LR., Gozal E. Increased susceptibility to excitotoxic injury in rat hippocampal slices exposed to intermittent hypoxia. Presented at: International Stroke Conference 2016, February 17 – 19, Los Angeles, CA, Abstracted in: Stroke, 2016.
  2. Drinovac R, Jagadapillai R, Gozal E, Lin X, Vaishnav R, Friedland RP, Roberts AM. Loss of bioavailable NO with enhanced iNOS expression and oxidative stress increase pulmonary arteriolar tone in aged mice. Presented at: Experimental Biology Meeting 2016, April 2 – 6, San Diego, CA, Abstracted in: FASEB J., 2016. Vol. 30(1)  Abstract # 728.5
  3.  Roberts AM, Jagadapillai R, Vaishnav R, Friedland RP, Drinovac R, Lin X, Gozal E. Altered nitric oxide signaling and oxidative stress increase pulmonary arteriolar tone and cause lung fibrosis in a mouse model of Alzheimer's disease. Presented at: Experimental Biology Meeting 2016, April 2 – 6, San Diego, CA, Abstracted in: FASEB J., 2016. Vol. 30 (1) Abstract # 960.3
  4. Friedland RP, Rane M, Gozal E, Jin S, Jagadapillai R, Roberts AM, Liu R, Adame A, Masliah E, Stribinskis V The influence of bacterial amyloid on Alpha synuclein (AS) misfolding in the rat. Presented at: American Academy of Neurology Annual Meeting, Vancouver BC, April 15-21, 2016, Abstracted in: Neurology April 5, 2016, 86:16 Supplement 1.003; 1526-632x.
  5. Barnes G, Gozal E, Jagadapillai R. The Association of ASD-like Behavior, Inflammatory Signaling, and Oxidative Stress Cascades in Semaphorin 3F KO Mice.       Presented at: International Meeting for Autism Research (IMFAR), San Francisco, CA, May 10 – 13, 2017. Abstract # 106.035.
  6. Jagadapillai R, Li Z, Gozal E, Barnes G. Deletion of semaphorin 3F in interneurons is associated with decreased GABAergic neurons, autism-like behavior, and increased inflammation and oxidative stress. Presented at: 46th Annual Meeting of the Society for Neuroscience, November 11-15, 2017, Washington, DC. Abstracted in: J. Neuroscience Vol. 42, Abstract # 651.07.
  7. Jagadapillai R, Li Z, Gozal E, Barnes G. Interneuron-specific Knockout of Semaphorin 3F Results in Increased Inflammation, Oxidative Stress and Autism-like Behavior. Presented at: INSAR 2018 Annual Meeting, Rotterdam, The Netherlands, May 9-12, 2018.
  8. Roberts AM, Jagadapillai R, Moulana N, Cai L, Gozal E. Increased Subpleural Pulmonary Arteriolar Tone Associated with Inhibition of Nitric Oxide Synthase in a Mouse Model of Type-1 Diabetes. Presented at: Experimental Biology Meeting 2018, April 21 – 25, San Diego, CA, Abstracted in: FASEB J., 2018. Vol. 32 (X) Abstract # LB276.
  9. Elnakieb Y, Dekhil O, Shalabi A, Ayinde B, Mahmoud A, Switala A, Elmaghraby A, Keynton R, Ghazal M, Gozal E, El-Baz A, Barnes G. An early-detection diagnostic framework for autism spectrum disorder using DTI and sMRI. Presented at: 47th Annual Meeting of the Society for Neuroscience, November 3-7, 2018, San Diego, CA. Abstracted in: J. Neuroscience Vol. 43, Abstract # 121.28.
  10. Moulana NZ, Jagadapillai R, Gozal E, Cai L, Roberts AM. Subpleural Microvascular Dysfunction in the Intact Mouse Lung in Conjunction with Increased Blood Glucose Levels, Oxidative Stress and Altered Nitric Oxide Signaling in a Model of Type-1 Diabetes. Presented at: Experimental Biology Meeting 2018, April 6 – 9, Orlando, FL, Abstracted in: FASEB J., 2019.Vol. 33 (1) supplement Abstract # 685.12.
  11. Jagadapillai, R, Li, Z., Gozal, E., Barnes, G. Interneuron-specific knockout of Semaphorin 3F induces neuroinflammation and endothelial injury with disruption of the blood brain barrier. Presented at: International Society for Autism Research (INSAR) 2020, Virtual event, June 3 2020. Abstract # 408.004.
  12. Barnes, G, Jagadapillai, R, Li, Z., Gozal, E. Semaphorin 3F Deletion in GABAergic Neurons of a Genetic Model of autism and Epilepsy induces Neuroinflammation and Endothelial Injury with Disruption of the Blood Brain Barrier. Selected for the Investigator Workshop/Basic Science Poster session. Presented at: American Epilepsy Society 2020, Virtual Event, December 4 – 8, 2020, Seattle, WA, Abstract ID: 913865
  13. Jagadapillai, R, Li, Z., Gozal, E., Barnes, G. Neuroinflammation and platelet-endothelial injury with disruption of the blood brain barrier in a genetic model of autism with GABAergic neuron-specific deletion of Semaphorin 3F.Presented at: Society for Neuroscience Global Connectome, virtual event, January 11-13, 2021. Abstracted in: J. Neuroscience Vol. 45, Abstract # 021.02
  14. Qiu, X, Ohja, K, Jagadapillai, R, Gozal, E, Shipu Zou, S, Barnes, G. Putative Relationships between Autism Risk Genes, Vascular Signaling, and Behavior in Autism Spectrum Disorder: A Pilot Study. Presented at: International Society for Autism Research (INSAR) 2021, May 5-8, Boston, MA, 
  15. Zeng, W., Chu, T., Gao, J., Gozal, E., Jagadapillai, R., Barnes, G.N., Cai, J. Genetic susceptibility and high fat diet-induced obesity underlie changes in neurobehavior, white matter microstructure, and hippocampal metabolites in C57Bl/6 mice. Presented at: Society for Neuroscience 2021, virtual event, November 8-11, 2021 and in person, November 13-16, Chicago, ILL. Abstracted in J. Neurosci, vol46, Abstract #
  16. Gozal, E., Jagadapillai, R., Chu, T., Cai, J., Barnes, G.N. Increased oxidative injury and blood brain barrier disruption in the brain of two murine models of autism spectrum disorder. Presented at: Society for Neuroscience 2021, virtual event, November 8-11, 2021 and in person, November 13-16, Chicago, ILL. Abstracted in J. Neurosci, vol46, Abstract # 043.03