Kenneth R. McLeish, M.D., FACP

Kenneth R. McLeish, M.D.

Kenneth R. McLeish, M.D., FACP

  • Professor of Medicine
VA Medical Center
800 Zorn Avenue
Louisville, KY 40206

502-852-5757- Academic Office
502-287-4000 - VAMC


Clinical Expertise
Nephrology; Lupus Nephritis; Glomerulonephritis


Board Certifications

  • American Board of Internal Medicine -
    Internal Medicine / Nephrology

Education and Training

  • Medical School: Indiana University
  • Residency: Indiana University Medical Center
  • Fellowship: Indiana University Medical Center

Featured Publications

  • Morrissey SM, Geller AE, Hu X, Tieri D, Ding C, Klaes CK, Cooke EA, Woeste MR, Martin ZC, Chen O, Bush SE, Zhang HG, Cavallazzi R, Clifford SP, Chen J, Ghare S, Barve SS, Cai L, Kong M, Rouchka EC, McLeish KR, Uriarte SM, Watson CT, Huang J, Yan J. A specific low-density neutrophil population correlates with hypercoagulation and disease severity in hospitalized COVID-19 patients. JCI Insight. 2021 May 10;6(9):148435. doi: 10.1172/jci.insight.148435. PMID: 33986193.
  • Caster DJ, Korte EA, Merchant ML, Klein JB, Barati MT, Joglekar A, Wilkey DW, Coventry S, Hata J, Rovin BH, Harley JB, Namjou-Khales B, McLeish KR, Powell DW. Patients with Proliferative Lupus Nephritis Have Autoantibodies That React to Moesin and Demonstrate Increased Glomerular Moesin Expression. J Clin Med. 2021 Feb 16;10(4):793. doi: 10.3390/jcm10040793. PMID: 33669337; PMCID: PMC7920286.
  • Paré G, Vitry J, Merchant ML, Vaillancourt M, Murru A, Shen Y, Elowe S, Lahoud MH, Naccache PH, McLeish KR, Fernandes MJ. The Inhibitory Receptor CLEC12A Regulates PI3K-Akt Signaling to Inhibit Neutrophil Activation and Cytokine Release. Front Immunol. 2021 Jun 21;12:650808. doi: 10.3389/fimmu.2021.650808. PMID: 34234773; PMCID: PMC8256872.
  • Kolonics F, Kajdácsi E, Farkas VJ, Veres DS, Khamari D, Kittel Á, Merchant ML, McLeish KR, Lőrincz ÁM, Ligeti E. Neutrophils produce proinflammatory or anti-inflammatory extracellular vesicles depending on the environmental conditions. J Leukoc Biol. 2021 Apr;109(4):793-806. doi: 10.1002/JLB.3A0320-210R. Epub 2020 Sep 18. PMID: 32946637.
  • Merchant ML, Barati MT, Caster DJ, Hata JL, Hobeika L, Coventry S, Brier ME, Wilkey DW, Li M, Rood IM, Deegens JK, Wetzels JF, Larsen CP, Troost JP, Hodgin JB, Mariani LH, Kretzler M, Klein JB, McLeish KR. Proteomic Analysis Identifies Distinct Glomerular Extracellular Matrix in Collapsing Focal Segmental Glomerulosclerosis. J Am Soc Nephrol. 2020 Aug;31(8):1883-1904. doi: 10.1681/ASN.2019070696. Epub 2020 Jun 19. PMID: 32561683; PMCID: PMC7460901.
  • Catz SD, McLeish KR. Therapeutic targeting of neutrophil exocytosis. J Leukoc Biol. 2020 Mar;107(3):393-408. doi: 10.1002/JLB.3RI0120-645R. Epub 2020 Jan 28. PMID: 31990103; PMCID: PMC7044074.
  • Singel KL, Emmons TR, Khan ANH, Mayor PC, Shen S, Wong JT, Morrell K, Eng KH, Mark J, Bankert RB, Matsuzaki J, Koya RC, Blom AM, McLeish KR, Qu J, Ram S, Moysich KB, Abrams SI, Odunsi K, Zsiros E, Segal BH. Mature neutrophils suppress T cell immunity in ovarian cancer microenvironment. JCI Insight. 2019 Mar 7;4(5):e122311. doi: 10.1172/jci.insight.122311. PMID: 30730851; PMCID: PMC6483507.
  • Kartha V, Franco L, Coventry S, McLeish K, Caster DJ, Schadt CR. Hepatitis C mixed cryoglobulinemia with undetectable viral load: A case series. JAAD Case Rep. 2018 Aug 15;4(7):684-687. doi: 10.1016/j.jdcr.2018.04.004. PMID: 30128338; PMCID: PMC6098195.
  • Caster DJ, Korte EA, Tan M, Barati MT, Tandon S, Creed TM, Salant DJ, Hata JL, Epstein PN, Huang H, Powell DW, McLeish KR. Neutrophil exocytosis induces podocyte cytoskeletal reorganization and proteinuria in experimental glomerulonephritis. Am J Physiol Renal Physiol. 2018 Sep 1;315(3):F595-F606. doi: 10.1152/ajprenal.00039.2018. Epub 2018 May 23. PMID: 29790391; PMCID: PMC6172569.
  • Merchant ML, Brier ME, Slaughter MS, Klein JB, McLeish KR. Biomarker enhanced risk prediction for development of AKI after cardiac surgery. BMC Nephrol. 2018 May 2;19(1):102. doi: 10.1186/s12882-018-0902-9. PMID: 29720115; PMCID: PMC5930948.