Craig J. McClain, M.D., AGAF, FACG, FAASLD, FACN

Craig J. McClain, M.D.

Craig J. McClain, M.D., AGAF, FACG, FAASLD, FACN

  • Professor of Medicine and Pharmacology & Toxicology
  • Chief of Research Affairs, Division of Gastroenterology, Hepatology and Nutrition
  • Associate Vice President for Health Affairs/Research
  • Associate Vice President for Translational Research
  • Director, Clinical Trials Unit / Liver Research Program
  • Distinguished University Scholar
UofL Physicians Outpatient Center
401 East Chestnut Street, Ste. 310
Louisville, KY 40202

502-852-6991 - Academic Office
502-588-4600 - Patient Appointments


Clinical Expertise
Alcohol Associated Liver Disease; Non-Alcoholic Steatohepatitis; Nutrition


Board Certifications

  • American Board of Internal Medicine -
    Internal Medicine / Gastroenterology
  • Certification Board for Nutrition Specialists
  • American Board of Physician Nutrition Specialists

Education and Training

  • Medical School: University of Tennessee
  • Residency: University of Pittsburgh Hospitals
  • Fellowship: University of Minnesota Hospitals

Get To Know Dr. McClain


Featured Publications

  • Gobejishvili L, Rodriguez WE, Bauer P, Wang Y, Soni C, Lydic T, Barve S, McClain C, Maldonado C. Novel Liposomal Rolipram Formulation for Clinical Application to Reduce Emesis. Drug Des Devel Ther. 2022 May 3;16:1301-1309. doi: 10.2147/DDDT.S355796. PMID: 35535222; PMCID: PMC9078351.
  • Hardesty J, Day L, Warner J, Warner D, Gritsenko M, Asghar A, Stolz A, Morgan T, McClain C, Jacobs J, Kirpich I. Hepatic Protein and Phosphoprotein Signatures of Alcohol-Associated Cirrhosis and Hepatitis. Am J Pathol. 2022 Apr 28:S0002-9440(22)00121-3. doi: 10.1016/j.ajpath.2022.04.004. Epub ahead of print. PMID: 35490715.
  • Sun R, Lei C, Chen L, He L, Guo H, Zhang X, Feng W, Yan J, McClain CJ, Deng Z. Alcohol-driven metabolic reprogramming promotes development of RORγt-deficient thymic lymphoma. Oncogene. 2022 Apr;41(16):2287-2302. doi: 10.1038/s41388-022-02257-2. Epub 2022 Mar 4. PMID: 35246617; PMCID: PMC9018612.
  • Faulkner CS, White CM, Manatsathit W, Lamb B, Vatsalya V, McClain CJ, Jophlin LL. Positive blood phosphatidylethanol concentration is associated with unfavorable waitlist-related outcomes for patients medically appropriate for liver transplantation. Alcohol Clin Exp Res. 2022 Apr;46(4):581-588. doi: 10.1111/acer.14786. Epub 2022 Mar 15. PMID: 35102553; PMCID: PMC9150771.
  • Singal AK, Kwo P, Kwong A, Liangpunsakul S, Louvet A, Mandrekar P, McClain C, Mellinger J, Szabo G, Terrault N, Thursz M, Winder GS, Kim WR, Shah VH. Research methodologies to address clinical unmet needs and challenges in alcohol-associated liver disease. Hepatology. 2022 Apr;75(4):1026-1037. doi: 10.1002/hep.32143. Epub 2021 Nov 27. PMID: 34496071.
  • Sun R, Gu X, Lei C, Chen L, Chu S, Xu G, Doll MA, Tan Y, Feng W, Siskind L, McClain CJ, Deng Z. Neutral ceramidase-dependent regulation of macrophage metabolism directs intestinal immune homeostasis and controls enteric infection. Cell Rep. 2022 Mar 29;38(13):110560. doi: 10.1016/j.celrep.2022.110560. PMID: 35354041; PMCID: PMC9007044.
  • Szabo G, Mitchell M, McClain CJ, Dasarathy S, Barton B, McCullough AJ, Nagy LE, Kroll-Desrosiers A, Tornai D, Min HA, Radaeva S, Holbein MEB, Casey L, Cuthbert J. IL-1 receptor antagonist plus pentoxifylline and zinc for severe alcohol-associated hepatitis. Hepatology. 2022 Mar 27. doi: 10.1002/hep.32478. Epub ahead of print. PMID: 35340032.
  • Ghare S, Singhal R, Bryant V, Gautam S, Tirumala CC, Srisailam PK, Reyes-Vega A, Ghooray D, McClain CJ, Hoffman K, Petrosino J, Bryant K, Govind V, Cohen R, Cook RL, Barve S. Age-Associated Gut Dysbiosis, Marked by Loss of Butyrogenic Potential, Correlates With Altered Plasma Tryptophan Metabolites in Older People Living With HIV. J Acquir Immune Defic Syndr. 2022 Feb 1;89(Suppl 1):S56-S64. doi: 10.1097/QAI.0000000000002866. PMID: 35015746; PMCID: PMC8751293.
  • Xu F, Mu J, Teng Y, Zhang X, Sundaram K, Sriwastva MK, Kumar A, Lei C, Zhang L, Liu QM, Yan J, McClain CJ, Merchant ML, Zhang HG. Restoring Oat Nanoparticles Mediated Brain Memory Function of Mice Fed Alcohol by Sorting Inflammatory Dectin-1 Complex Into Microglial Exosomes. Small. 2022 Feb;18(6):e2105385. doi: 10.1002/smll.202105385. Epub 2021 Dec 13. PMID: 34897972; PMCID: PMC8858573.
  • Warner JB, Larsen IS, Hardesty JE, Song YL, Warner DR, McClain CJ, Sun R, Deng Z, Jensen BAH, Kirpich IA. Human Beta Defensin 2 Ameliorated Alcohol-Associated Liver Disease in Mice. Front Physiol. 2022 Jan 27;12:812882. doi: 10.3389/fphys.2021.812882. PMID: 35153819; PMCID: PMC8829467.