Craig J. McClain, M.D., AGAF, FACG, FAASLD, FACN

Craig J. McClain, M.D.

Craig J. McClain, M.D., AGAF, FACG, FAASLD, FACN

  • Professor of Medicine and Pharmacology & Toxicology
  • Chief of Research Affairs, Division of Gastroenterology, Hepatology and Nutrition
  • Associate Vice President for Health Affairs/Research
  • Associate Vice President for Translational Research
  • Director, Clinical Trials Unit / Liver Research Program
  • Distinguished University Scholar
UofL Physicians Outpatient Center
401 East Chestnut Street, Ste. 310
Louisville, KY 40202

502-852-6991 - Academic Office
502-588-4600 - Patient Appointments


Clinical Expertise
Alcoholic Liver Disease; Non-Alcoholic Steatohepatitis; Nutrition


Board Certifications

  • American Board of Internal Medicine -
    Internal Medicine / Gastroenterology
  • Certification Board for Nutrition Specialists
  • American Board of Physician Nutrition Specialists

Education and Training

  • Medical School: University of Tennessee
  • Residency: University of Pittsburgh Hospitals
  • Fellowship: University of Minnesota Hospitals

Get To Know Dr. McClain


Featured Publications

  • McClain CJ, Rios CD, Condon S, Marsano LS. Malnutrition and Alcohol-Associated Hepatitis. Clin Liver Dis. 2021 Aug;25(3):557-570. doi: 10.1016/j.cld.2021.03.002. Epub 2021 May 26. PMID: 34229839.
  • Guardiola JJ, Hardesty JE, Beier JI, Prough RA, McClain CJ, Cave MC. Plasma Metabolomics Analysis of Polyvinyl Chloride Workers Identifies Altered Processes and Candidate Biomarkers for Hepatic Hemangiosarcoma and Its Development. Int J Mol Sci. 2021 May 11;22(10):5093. doi: 10.3390/ijms22105093. PMID: 34065028; PMCID: PMC8150673.
  • Teng Y, Xu F, Zhang X, Mu J, Sayed M, Hu X, Lei C, Sriwastva M, Kumar A, Sundaram K, Zhang L, Park JW, Chen SY, Zhang S, Yan J, Merchant ML, Zhang X, McClain CJ, Wolfe JK, Adcock RS, Chung D, Palmer KE, Zhang HG. Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12. Mol Ther. 2021 May 11:S1525-0016(21)00257-4. doi: 10.1016/j.ymthe.2021.05.005. Epub ahead of print. PMID: 33984520; PMCID: PMC8110335.
  • Eisa M, Kennedy R, Teferra R, Heckroth M, Eiswerth M, McClain C. SARS-COV-2 Infection in Patients With Alcohol-Associated Hepatitis: Metabolic Similarities and Treatment Challenges. Am J Gastroenterol. 2021 Apr;116(4):847-848. doi: 10.14309/ajg.0000000000001002. PMID: 33982972.
  • Chu S, Sun R, Gu X, Chen L, Liu M, Guo H, Ju S, Vatsalya V, Feng W, McClain CJ, Deng Z. Inhibition of Sphingosine-1-Phosphate-Induced Th17 Cells Ameliorates Alcohol-Associated Steatohepatitis in Mice. Hepatology. 2021 Mar;73(3):952-967. doi: 10.1002/hep.31321. PMID: 32418220; PMCID: PMC8009334.
  • Miyata T, Wu X, Fan X, Huang E, Sanz-Garcia C, Ross CKC, Roychowdhury S, Bellar A, McMullen MR, Dasarathy J, Allende DS, Caballeria J, Sancho-Bru P, McClain CJ, Mitchell M, McCullough AJ, Radaeva S, Barton B, Szabo G, Dasarathy S, Nagy LE. Differential role of MLKL in alcohol-associated and non-alcohol-associated fatty liver diseases in mice and humans. JCI Insight. 2021 Feb 22;6(4):e140180. doi: 10.1172/jci.insight.140180. PMID: 33616081; PMCID: PMC7934930.
  • Gu X, Sun R, Chen L, Chu S, Doll MA, Li X, Feng W, Siskind L, McClain CJ, Deng Z. Neutral Ceramidase Mediates Nonalcoholic Steatohepatitis by Regulating Monounsaturated Fatty Acids and Gut IgA+ B Cells. Hepatology. 2021 Mar;73(3):901-919. doi: 10.1002/hep.31628. Epub 2021 Feb 18. PMID: 33185911.
  • Warner D, Vatsalya V, Zirnheld KH, Warner JB, Hardesty JE, Umhau JC, McClain CJ, Maddipati K, Kirpich IA. Linoleic Acid-Derived Oxylipins Differentiate Early Stage Alcoholic Hepatitis From Mild Alcohol-Associated Liver Injury. Hepatol Commun. 2021 Feb 9;5(6):947-960. doi: 10.1002/hep4.1686. PMID: 34141982; PMCID: PMC8183177.
  • Gu Z, Li F, Liu Y, Jiang M, Zhang L, He L, Wilkey DW, Merchant M, Zhang X, Deng ZB, Chen SY, Barve S, McClain CJ, Feng W. Exosome-Like Nanoparticles From Lactobacillus rhamnosusGG Protect Against Alcohol-Associated Liver Disease Through Intestinal Aryl Hydrocarbon Receptor in Mice. Hepatol Commun. 2021 Feb 5;5(5):846-864. doi: 10.1002/hep4.1679. PMID: 34027273; PMCID: PMC8122379.
  • Hardesty JE, Warner JB, Song YL, Rouchka EC, McClain CJ, Warner DR, Kirpich IA. Ileum Gene Expression in Response to Acute Systemic Inflammation in Mice Chronically Fed Ethanol: Beneficial Effects of Elevated Tissue n-3 PUFAs. Int J Mol Sci. 2021 Feb 4;22(4):1582. doi: 10.3390/ijms22041582. PMID: 33557303; PMCID: PMC7914826.