Craig J. McClain, M.D., AGAF, FACG, FAASLD, FACN

• Professor of Medicine and Pharmacology & Toxicology
• Chief of Research Affairs, Division of Gastroenterology, Hepatology and Nutrition
• Associate Vice President for Health Affairs/Research
• Associate Vice President for Translational Research
• Director, Clinical Trials Unit / Liver Research Program
• Distinguished University Scholar

UofL Physicians Outpatient Center
401 East Chestnut Street, Ste. 310
Louisville, KY 40202

502-852-6991 - Academic Office
502-588-4600 - Patient Appointments

Get To Know Dr. McClain

Featured Publications

• Gawrieh S, Dasarathy S, Tu W, Kamath PS, Chalasani NP, McClain CJ, Bataller R, Szabo G, Tang Q, Radaeva S, Barton B, Nagy LE, Shah VH, Sanyal AJ, Mitchell MC; AlcHepNet Investigators. Randomized trial of anakinra plus zinc vs. prednisone for severe alcohol-associated hepatitis. J Hepatol. 2024 May;80(5):684-693. doi: 10.1016/j.jhep.2024.01.031. Epub 2024 Feb 10. PMID: 38342441.
• Condon S, Hu H, Kong M, Cave MC, McClain CJ. ALT poorly predicts Nonalcoholic Fatty Liver Disease (NAFLD) and liver fibrosis as determined by vibration-controlled transient elastography in adult National Health and Nutrition Examination Survey 2017-2018. Am J Med Sci. 2024 May;367(5):310-322. doi: 10.1016/j.amjms.2024.01.022. Epub 2024 Feb 1. PMID: 38307172.
• Sundaram K, Teng Y, Mu J, Xu Q, Xu F, Sriwastva MK, Zhang L, Park JW, Zhang X, Yan J, Zhang SQ, Merchant ML, Chen SY, McClain CJ, Dryden GW, Zhang HG. Outer Membrane Vesicles Released from Garlic Exosome-like Nanoparticles (GaELNs) Train Gut Bacteria that Reverses Type 2 Diabetes via the Gut-Brain Axis. Small. 2024 May;20(20):e2308680. doi: 10.1002/smll.202308680. Epub 2024 Jan 15. PMID: 38225709; PMCID: PMC11102339.
• Ghooray DT, Xu M, Shi H, McClain CJ, Song M. Hepatocyte-Specific Fads1 Overexpression Attenuates Western Diet-Induced Metabolic Phenotypes in a Rat Model. Int J Mol Sci. 2024 Apr 29;25(9):4836. doi: 10.3390/ijms25094836. PMID: 38732052; PMCID: PMC11084797.
• Xu R, Liu H, Yuan F, Kim S, Kirpich I, McClain CJ, Zhang X. Lipid Wizard: Analysis Software for Comprehensive Two-Dimensional Liquid Chromatography-Mass Spectrometry-Based Lipid Profiling. Anal Chem. 2024 Apr 9;96(14):5375-5383. doi: 10.1021/acs.analchem.3c04419. Epub 2024 Mar 24. PMID: 38523323.
• Taiwo M, Huang E, Pathak V, Bellar A, Welch N, Dasarathy J, Streem D, McClain CJ, Mitchell MC, Barton BA, Szabo G, Dasarathy S; Alcohol Hepatitis Network (AlcHepNet) Consortium; Schaefer EA, Luther J, Day LZ, Ouyang X, Suyavaran A, Mehal WZ, Jacobs JM, Goodman RP, Rotroff DM, Nagy LE. Proteomics identifies complement protein signatures in patients with alcohol-associated hepatitis. JCI Insight. 2024 Apr 4;9(9):e174127. doi: 10.1172/jci.insight.174127. PMID: 38573776; PMCID: PMC11141929.
• Hardesty J, Hawthorne M, Day L, Warner J, Warner D, Gritsenko M, Asghar A, Stolz A, Morgan T, McClain C, Jacobs J, Kirpich IA. Steroid responsiveness in alcohol-associated hepatitis is linked to glucocorticoid metabolism, mitochondrial repair, and heat shock proteins. Hepatol Commun. 2024 Mar 4;8(3):e0393. doi: 10.1097/HC9.0000000000000393. PMID: 38437061; PMCID: PMC10914234.
• Jophlin L, Liu TY, McClain CJ. Nutritional deficiencies in alcohol use disorder/alcohol-associated liver disease. Curr Opin Gastroenterol. 2024 Mar 1;40(2):112-117. doi: 10.1097/MOG.0000000000000999. Epub 2024 Jan 2. PMID: 38193343.
• Cai J, Song M, Li M, Merchant M, Benz F, McClain C, Klein J. Site-Specific Identification of Protein S-Acylation by IodoTMT0 Labeling and Immobilized Anti-TMT Antibody Resin Enrichment. J Proteome Res. 2024 Feb 2;23(2):673-683. doi: 10.1021/acs.jproteome.3c00525. Epub 2023 Dec 29. PMID: 38157263.
• Walter MN, Montoya-Durango D, Rodriguez W, Wang Y, Zhang J, Chariker JH, Rouchka EC, Maldonado C, Bennett A, McClain CJ, Barve S, Gobejishvili L. Hepatocyte-specific mitogen-activated protein kinase phosphatase 1 in sexual dimorphism and susceptibility to alcohol induced liver injury. Front Immunol. 2024 Feb 1;15:1316228. doi: 10.3389/fimmu.2024.1316228. PMID: 38370409; PMCID: PMC10871047.