Jon B. Klein, M.D., Ph.D.

Jon B. Klein, M.D., Ph.D.

Jon B. Klein, M.D., Ph.D., FASN

UofL Physicians Outpatient Center
401 East Chestnut Street, Ste. 690
Louisville, KY 40202

502-852-5757- Academic Office
502-588-4714 - Patient Appointments


Clinical Expertise
Diabetic Nephropathy


Board Certifications

  • American Board of Internal Medicine -
    Internal Medicine / Nephrology

Education and Training

  • Medical School: University of Texas Medical Branch (Galveston)
  • Residency: University of Kansas Medical Center (Kansas City)
  • Fellowship: University of Louisville
  • Ph.D.: University of Louisville

Featured Publications

  • Caster DJ, Korte EA, Merchant ML, Klein JB, Barati MT, Joglekar A, Wilkey DW, Coventry S, Hata J, Rovin BH, Harley JB, Namjou-Khales B, McLeish KR, Powell DW. Patients with Proliferative Lupus Nephritis Have Autoantibodies That React to Moesin and Demonstrate Increased Glomerular Moesin Expression. J Clin Med. 2021 Feb 16;10(4):793. doi: 10.3390/jcm10040793. PMID: 33669337; PMCID: PMC7920286.
  • Brier ME, Gooding JR, Harrington JM, Burgess JP, McRitchie SL, Zhang X, Rovin BH, Klein JB, Himmelfarb J, Sumner SJ, Merchant ML. Serum trace metal association with response to erythropoiesis stimulating agents in incident and prevalent hemodialysis patients. Sci Rep. 2020 Nov 19;10(1):20202. doi: 10.1038/s41598-020-77311-8. PMID: 33214633; PMCID: PMC7677396.
  • Satoskar AA, Shapiro JP, Jones M, Bott C, Parikh SV, Brodsky SV, Yu L, Nagaraja HN, Wilkey DW, Merchant ML, Klein JB, Nadasdy T, Rovin BH. Differentiating Staphylococcus infection-associated glomerulonephritis and primary IgA nephropathy: a mass spectrometry-based exploratory study. Sci Rep. 2020 Oct 14;10(1):17179. doi: 10.1038/s41598-020-73847-x. PMID: 33057112; PMCID: PMC7560901.
  • Samuel G, Crow J, Klein JB, Merchant ML, Nissen E, Koestler DC, Laurence K, Liang X, Neville K, Staggs V, Ahmed A, Atay S, Godwin AK. Ewing sarcoma family of tumors-derived small extracellular vesicle proteomics identify potential clinical biomarkers. Oncotarget. 2020 Aug 4;11(31):2995-3012. doi: 10.18632/oncotarget.27678. PMID: 32821345; PMCID: PMC7415402.
  • Merchant ML, Barati MT, Caster DJ, Hata JL, Hobeika L, Coventry S, Brier ME, Wilkey DW, Li M, Rood IM, Deegens JK, Wetzels JF, Larsen CP, Troost JP, Hodgin JB, Mariani LH, Kretzler M, Klein JB, McLeish KR. Proteomic Analysis Identifies Distinct Glomerular Extracellular Matrix in Collapsing Focal Segmental Glomerulosclerosis. J Am Soc Nephrol. 2020 Aug;31(8):1883-1904. doi: 10.1681/ASN.2019070696. Epub 2020 Jun 19. PMID: 32561683; PMCID: PMC7460901.
  • Gooding JR, Agrawal S, McRitchie S, Acuff Z, Merchant ML, Klein JB, Smoyer WE, Sumner SJ; Midwest Pediatric Nephrology Consortium. Predicting and Defining Steroid Resistance in Pediatric Nephrotic Syndrome Using Plasma Metabolomics. Kidney Int Rep. 2019 Sep 19;5(1):81-93. doi: 10.1016/j.ekir.2019.09.010. PMID: 31922063; PMCID: PMC6943762.
  • Agrawal S, Merchant ML, Kino J, Li M, Wilkey DW, Gaweda AE, Brier ME, Chanley MA, Gooding JR, Sumner SJ, Klein JB, Smoyer WE; Midwest Pediatric Nephrology Consortium. Predicting and Defining Steroid Resistance in Pediatric Nephrotic Syndrome Using Plasma Proteomics. Kidney Int Rep. 2019 Sep 19;5(1):66-80. doi: 10.1016/j.ekir.2019.09.009. PMID: 31922062; PMCID: PMC6943770.
  • Weingartner LA, Sawning S, Shaw MA, Klein JB. Compassion cultivation training promotes medical student wellness and enhanced clinical care. BMC Med Educ. 2019 May 10;19(1):139. doi: 10.1186/s12909-019-1546-6. PMID: 31077192; PMCID: PMC6511143.
  • Mariani LH, Bomback AS, Canetta PA, Flessner MF, Helmuth M, Hladunewich MA, Hogan JJ, Kiryluk K, Nachman PH, Nast CC, Rheault MN, Rizk DV, Trachtman H, Wenderfer SE, Bowers C, Hill-Callahan P, Marasa M, Poulton CJ, Revell A, Vento S, Barisoni L, Cattran D, D'Agati V, Jennette JC, Klein JB, Laurin LP, Twombley K, Falk RJ, Gharavi AG, Gillespie BW, Gipson DS, Greenbaum LA, Holzman LB, Kretzler M, Robinson B, Smoyer WE, Guay-Woodford LM; CureGN Consortium. CureGN Study Rationale, Design, and Methods: Establishing a Large Prospective Observational Study of Glomerular Disease. Am J Kidney Dis. 2019 Feb;73(2):218-229. doi: 10.1053/j.ajkd.2018.07.020. Epub 2018 Nov 9. PMID: 30420158; PMCID: PMC6348011.
  • Looker HC, Merchant ML, Rane MJ, Nelson RG, Kimmel PL, Rovin BH, Klein JB, Mauer M; CKD Biomarkers Consortium. Urine inositol pentakisphosphate 2-kinase and changes in kidney structure in early diabetic kidney disease in type 1 diabetes. Am J Physiol Renal Physiol. 2018 Nov 1;315(5):F1484-F1492. doi: 10.1152/ajprenal.00183.2018. Epub 2018 Aug 22. PMID: 30132343; PMCID: PMC6293310.