Gerald W. Dryden, M.D., Ph.D., MSPH, M.Sc.

• Professor of Medicine
• Director, Inflammatory Bowel Disease Program

UofL Physicians Outpatient Center
401 East Chestnut Street, Ste. 310
Louisville, KY 40202

502-852-6991 - Academic Office
502-588-4600 - Patient Appointments

Featured Publications

• Sundaram K, Teng Y, Mu J, Xu Q, Xu F, Sriwastva MK, Zhang L, Park JW, Zhang X, Yan J, Zhang SQ, Merchant ML, Chen SY, McClain CJ, Dryden GW, Zhang HG. Outer Membrane Vesicles Released from Garlic Exosome-like Nanoparticles (GaELNs) Train Gut Bacteria that Reverses Type 2 Diabetes via the Gut-Brain Axis. Small. 2024 May;20(20):e2308680. doi: 10.1002/smll.202308680. Epub 2024 Jan 15. PMID: 38225709; PMCID: PMC11102339.
• Cash E, Deitz K, Potts KL, Nabeta HW, Zahin M, Rai SN, Dryden GW, Palmer KE. Development and validation of a product acceptability questionnaire for intranasal Q-Griffithsin COVID-19 prophylaxis (SPRAY PAL). BMJ Open. 2023 Sep 12;13(9):e073735. doi: 10.1136/bmjopen-2023-073735. PMID: 37699630; PMCID: PMC10503384.
• Liu L, Li F, Shao T, Zhang L, Lee J, Dryden G, McClain CJ, Zhao C, Feng W. FGF21 Depletion Attenuates Colitis through Intestinal Epithelial IL-22-STAT3 Activation in Mice. Nutrients. 2023 Apr 26;15(9):2086. doi: 10.3390/nu15092086. PMID: 37432218; PMCID: PMC10181108.
• Sriwastva MK, Teng Y, Mu J, Xu F, Kumar A, Sundaram K, Malhotra RK, Xu Q, Hood JL, Zhang L, Yan J, Merchant ML, Park JW, Dryden GW, Egilmez NK, Zhang HG. An extracellular vesicular mutant KRAS-associated protein complex promotes lung inflammation and tumor growth. J Extracell Vesicles. 2023 Feb;12(2):e12307. doi: 10.1002/jev2.12307. PMID: 36754903; PMCID: PMC9908562.
• Sriwastva MK, Deng ZB, Wang B, Teng Y, Kumar A, Sundaram K, Mu J, Lei C, Dryden GW, Xu F, Zhang L, Yan J, Zhang X, Park JW, Merchant ML, Egilmez NK, Zhang HG. Exosome-like nanoparticles from Mulberry bark prevent DSS-induced colitis via the AhR/COPS8 pathway. EMBO Rep. 2022 Feb 3;23(3):e53365. doi: 10.15252/embr.202153365. Epub 2022 Jan 7. PMID: 34994476; PMCID: PMC8892346.
• Sundaram K, Mu J, Kumar A, Behera J, Lei C, Sriwastva MK, Xu F, Dryden GW, Zhang L, Chen S, Yan J, Zhang X, Park JW, Merchant ML, Tyagi N, Teng Y, Zhang HG. Garlic exosome-like nanoparticles reverse high-fat diet induced obesity via the gut/brain axis. Theranostics. 2022 Jan 1;12(3):1220-1246. doi: 10.7150/thno.65427. PMID: 35154484; PMCID: PMC8771565.
• Dadlani A, Gala K, Rai J, Rai S, Dryden G. P027 Brain Fog in Patients With Inflammatory Bowel Disease, and Association With Use of Probiotics. Am J Gastroenterol. 2021 Dec 1;116(Suppl 1):S7. doi: 10.14309/01.ajg.0000798708.22025.c0. PMID: 37461946.
• Somineni HK, Nagpal S, Venkateswaran S, Cutler DJ, Okou DT, Haritunians T, Simpson CL, Begum F, Datta LW, Quiros AJ, Seminerio J, Mengesha E, Alexander JS, Baldassano RN, Dudley-Brown S, Cross RK, Dassopoulos T, Denson LA, Dhere TA, Iskandar H, Dryden GW, Hou JK, Hussain SZ, Hyams JS, Isaacs KL, Kader H, Kappelman MD, Katz J, Kellermayer R, Kuemmerle JF, Lazarev M, Li E, Mannon P, Moulton DE, Newberry RD, Patel AS, Pekow J, Saeed SA, Valentine JF, Wang MH, McCauley JL, Abreu MT, Jester T, Molle-Rios Z, Palle S, Scherl EJ, Kwon J, Rioux JD, Duerr RH, Silverberg MS, Zwick ME, Stevens C, Daly MJ, Cho JH, Gibson G, McGovern DPB, Brant SR, Kugathasan S. Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease. Am J Hum Genet. 2021 Mar 4;108(3):431-445. doi: 10.1016/j.ajhg.2021.02.001. Epub 2021 Feb 17. PMID: 33600772; PMCID: PMC8008495.
• Kumar A, Ren Y, Sundaram K, Mu J, Sriwastva MK, Dryden GW, Lei C, Zhang L, Yan J, Zhang X, Park JW, Merchant ML, Teng Y, Zhang HG. miR-375 prevents high-fat diet-induced insulin resistance and obesity by targeting the aryl hydrocarbon receptor and bacterial tryptophanase (tnaA) gene. Theranostics. 2021 Feb 19;11(9):4061-4077. doi: 10.7150/thno.52558. PMID: 33754048; PMCID: PMC7977461.
• Kumar A, Sundaram K, Mu J, Dryden GW, Sriwastva MK, Lei C, Zhang L, Qiu X, Xu F, Yan J, Zhang X, Park JW, Merchant ML, Bohler HCL, Wang B, Zhang S, Qin C, Xu Z, Han X, McClain CJ, Teng Y, Zhang HG. High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance. Nat Commun. 2021 Jan 11;12(1):213. doi: 10.1038/s41467-020-20500-w. PMID: 33431899; PMCID: PMC7801461.