Jason A. Chesney, M.D., Ph.D.

Jason A. Chesney, M.D., Ph.D.

Jason A. Chesney, M.D., Ph.D.

UofL Health - Brown Cancer Center
529 South Jackson Street
Louisville, KY 40202

502-562-4585 - Academic Office
502-562-4370 - Patient Appointments


Clinical Expertise
Metastatic Melanoma; Refractory Solid Tumors; Clinical Trial Testing of Immunotherapeutics; Development of Anti-Metabolites as Targeted Chemotherapies


Education and Training

  • Medical School: University of Minnesota
  • Residency: Memorial Sloan-Kettering Cancer Center
  • Fellowship: Cornell University Medical College
  • Ph.D.: University of Minnesota

Get To Know Dr. Chesney


Featured Publications

  • Sarnaik AA, Hamid O, Khushalani NI, Lewis KD, Medina T, Kluger HM, Thomas SS, Domingo-Musibay E, Pavlick AC, Whitman ED, Martin-Algarra S, Corrie P, Curti BD, Oláh J, Lutzky J, Weber JS, Larkin JMG, Shi W, Takamura T, Jagasia M, Qin H, Wu X, Chartier C, Graf Finckenstein F, Fardis M, Kirkwood JM, Chesney JA. Lifileucel, a Tumor-Infiltrating Lymphocyte Therapy, in Metastatic Melanoma. J Clin Oncol. 2021 May 12:JCO2100612. doi: 10.1200/JCO.21.00612. Epub ahead of print. PMID: 33979178.
  • Linder MW, Egger ME, Van Meter T, Rai SN, Valdes R Jr, Hall MB, Wu X, Alghamdi N, Chesney JA. Longitudinal Relationship between Idylla Plasma ctBRAF V600 Mutation Detection and Tumor Burden in Patients with Metastatic Melanoma. Mol Diagn Ther. 2021 May;25(3):361-371. doi: 10.1007/s40291-021-00528-4. Epub 2021 May 10. PMID: 33970440.
  • Lanceta L, Lypova N, O'Neill C, Li X, Rouchka E, Chesney J, Imbert-Fernandez Y. Differential gene expression analysis of palbociclib-resistant TNBC via RNA-seq. Breast Cancer Res Treat. 2021 Apr;186(3):677-686. doi: 10.1007/s10549-021-06127-5. Epub 2021 Feb 18. PMID: 33599863; PMCID: PMC8019424.
  • Harrington KJ, Kong A, Mach N, Chesney JA, Fernandez BC, Rischin D, Cohen EEW, Radcliffe HS, Gumuscu B, Cheng J, Snyder W, Siu LL. Talimogene Laherparepvec and Pembrolizumab in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (MASTERKEY-232): A Multicenter, Phase 1b Study. Clin Cancer Res. 2020 Oct 1;26(19):5153-5161. doi: 10.1158/1078-0432.CCR-20-1170. Epub 2020 Jul 15. PMID: 32669371.
  • Ozcan SC, Sarioglu A, Altunok TH, Akkoc A, Guzel S, Guler S, Imbert-Fernandez Y, Muchut RJ, Iglesias AA, Gurpinar Y, Clem AL, Chesney JA, Yalcin A. PFKFB2 regulates glycolysis and proliferation in pancreatic cancer cells. Mol Cell Biochem. 2020 Jul;470(1-2):115-129. doi: 10.1007/s11010-020-03751-5. Epub 2020 May 15. PMID: 32415418.
  • Lanceta L, O'Neill C, Lypova N, Li X, Rouchka E, Waigel S, Gomez-Gutierrez JG, Chesney J, Imbert-Fernandez Y. Transcriptomic Profiling Identifies Differentially Expressed Genes in Palbociclib-Resistant ER+ MCF7 Breast Cancer Cells. Genes (Basel). 2020 Apr 24;11(4):467. doi: 10.3390/genes11040467. PMID: 32344635; PMCID: PMC7230561.
  • Andtbacka RHI, Amatruda T, Nemunaitis J, Zager JS, Walker J, Chesney JA, Liu K, Hsu CP, Pickett CA, Mehnert JM. Biodistribution, shedding, and transmissibility of the oncolytic virus talimogene laherparepvec in patients with melanoma. EBioMedicine. 2019 Sep;47:89-97. doi: 10.1016/j.ebiom.2019.07.066. Epub 2019 Aug 10. PMID: 31409575; PMCID: PMC6796514.
  • Chesney J, Puzanov I, Collichio F, Milhem MM, Hauschild A, Chen L, Sharma A, Garbe C, Singh P, Mehnert JM. Patterns of response with talimogene laherparepvec in combination with ipilimumab or ipilimumab alone in metastatic unresectable melanoma. Br J Cancer. 2019 Aug;121(5):417-420. doi: 10.1038/s41416-019-0530-6. Epub 2019 Jul 29. PMID: 31353364; PMCID: PMC6738060.
  • Chesney J, Puzanov I, Ross M. The Importance of Outcome and Precise Evaluation in Economic Analysis of Cancer Drugs. JAMA Dermatol. 2019 Jul 1;155(7):862-863. doi: 10.1001/jamadermatol.2019.0594. PMID: 31066868.
  • Lypova N, Telang S, Chesney J, Imbert-Fernandez Y. Increased 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 activity in response to EGFR signaling contributes to non-small cell lung cancer cell survival. J Biol Chem. 2019 Jul 5;294(27):10530-10543. doi: 10.1074/jbc.RA119.007784. Epub 2019 May 24. PMID: 31126985; PMCID: PMC6615683.