Azariyas A. Challa, M.D., Ph.D.
Azariyas A. Challa, M.D., Ph.D.
- Assistant Professor of Medicine
401 East Chestnut Street, Ste. 310
Louisville, KY 40202
502-852-9505 - Academic Office
502-588-7010 - Patient Appointments
Clinical Expertise
Atrial Fibrillation; Coronary Artery Disease; Heart Failure; Valvular Heart Disease
Board Certifications
- American Board of Internal Medicine -
Internal Medicine
Education and Training
- Medical School: Gondar College of Medical and Health Sciences
- Residencies: University of Pittsburgh Medical Center
- Fellowships: The Ohio State University
Featured Publications
Challa AA, Vidal P, Maurya SK, Maurya CK, Baer LA, Wang Y, James NM, Pardeshi PJ, Fasano M, Carley AN, Stanford KI, Lewandowski ED. UCP1-dependent brown adipose activation accelerates cardiac metabolic remodeling and reduces initial hypertrophic and fibrotic responses to pathological stress. FASEB J. 2024 Jun 15;38(11):e23709. doi: 10.1096/fj.202400922R. PMID: 38809700; PMCID: PMC11163965.Challa AA, Lewandowski ED. Short-Chain Carbon Sources: Exploiting Pleiotropic Effects for Heart Failure Therapy. JACC Basic Transl Sci. 2022 Mar 30;7(7):730-742. doi: 10.1016/j.jacbts.2021.12.010. PMID: 35958686; PMCID: PMC9357564.
- Erqou S, Adler AI, Challa AA, Fonarow GC, Echouffo-Tcheugui JB. Insulin resistance and incident heart failure: a meta-analysis. Eur J Heart Fail. 2022 Jun;24(6):1139-1141. doi: 10.1002/ejhf.2531. Epub 2022 May 16. PMID: 35502564; PMCID: PMC9262840.
- Challa AA, Calaway AC, Cullen J, Garcia J, Desai N, Weintraub NL, Deswal A, Kutty S, Vallakati A, Addison D, Baliga R, Campbell CM, Guha A. Cardiovascular Toxicities of Androgen Deprivation Therapy. Curr Treat Options Oncol. 2021 Apr 17;22(6):47. doi: 10.1007/s11864-021-00846-z. PMID: 33866442; PMCID: PMC8053026.
- Jung JJ, Razavian M, Challa AA, Nie L, Golestani R, Zhang J, Ye Y, Russell KS, Robinson SP, Heistad DD, Sadeghi MM. Multimodality and molecular imaging of matrix metalloproteinase activation in calcific aortic valve disease. J Nucl Med. 2015 Jun;56(6):933-8. doi: 10.2967/jnumed.114.152355. Epub 2015 Apr 23. PMID: 25908827; PMCID: PMC4454445.
- Razavian M, Nie L, Challa A, Zhang J, Golestani R, Jung JJ, Robinson S, Sadeghi MM. Lipid lowering and imaging protease activation in atherosclerosis. J Nucl Cardiol. 2014 Apr;21(2):319-328. doi: 10.1007/s12350-013-9843-7. Epub 2013 Dec 25. PMID: 24368425; PMCID: PMC3991560.
- Challa AA, Vukmirovic M, Blackmon J, Stefanovic B. Withaferin-A reduces type I collagen expression in vitro and inhibits development of myocardial fibrosis in vivo. PLoS One. 2012;7(8):e42989. doi: 10.1371/journal.pone.0042989. Epub 2012 Aug 10. PMID: 22900077; PMCID: PMC3416765.
- Challa AA, Stefanovic B. A novel role of vimentin filaments: binding and stabilization of collagen mRNAs. Mol Cell Biol. 2011 Sep;31(18):3773-89. doi: 10.1128/MCB.05263-11. Epub 2011 Jul 11. PMID: 21746880; PMCID: PMC3165730.
