Shirish S. Barve, Ph.D.

Professor of Medicine
Distinguished University Scholar


502-852-5245 E-mail

Education and Training

B.Sc.: University of Bombay
M.Sc.: University of Bombay
Ph.D.: University of Kentucky


Research Interests

  • Alcohol and Immune Function
  • Epigenetics and Immune Function
  • HIV

Featured Publications

  • Jiang M, Li F, Liu Y, Gu Z, Zhang L, Lee J, He L, Vatsalya V, Zhang HG, Deng Z, Zhang X, Chen SY, Guo GL, Barve S, McClain CJ, Feng W. Probiotic-derived Nanoparticles Inhibit ALD through Intestinal miR194 Suppression and Subsequent FXR Activation. Hepatology. 2022 Jun 11. doi: 10.1002/hep.32608. Epub ahead of print. PMID: 35689610.
  • Gobejishvili L, Rodriguez WE, Bauer P, Wang Y, Soni C, Lydic T, Barve S, McClain C, Maldonado C. Novel Liposomal Rolipram Formulation for Clinical Application to Reduce Emesis. Drug Des Devel Ther. 2022 May 3;16:1301-1309. doi: 10.2147/DDDT.S355796. PMID: 35535222; PMCID: PMC9078351.
  • Ghare S, Singhal R, Bryant V, Gautam S, Tirumala CC, Srisailam PK, Reyes-Vega A, Ghooray D, McClain CJ, Hoffman K, Petrosino J, Bryant K, Govind V, Cohen R, Cook RL, Barve S. Age-Associated Gut Dysbiosis, Marked by Loss of Butyrogenic Potential, Correlates With Altered Plasma Tryptophan Metabolites in Older People Living With HIV. J Acquir Immune Defic Syndr. 2022 Feb 1;89(Suppl 1):S56-S64. doi: 10.1097/QAI.0000000000002866. PMID: 35015746; PMCID: PMC8751293.
  • Hamorsky KT, Bushau-Sprinkle AM, Kitterman K, Corman JM, DeMarco J, Keith RJ, Bhatnagar A, Fuqua JL, Lasnik A, Joh J, Chung D, Klein J, Flynn J, Gardner M, Barve S, Ghare SS, Palmer KE. Serological assessment of SARS-CoV-2 infection during the first wave of the pandemic in Louisville Kentucky. Sci Rep. 2021 Sep 14;11(1):18285. doi: 10.1038/s41598-021-97423-z. PMID: 34521900; PMCID: PMC8440627.
  • Chichetto NE, Kundu S, Freiberg MS, Koethe JR, Butt AA, Crystal S, So-Armah KA, Cook RL, Braithwaite RS, Justice AC, Fiellin DA, Khan M, Bryant KJ, Gaither JR, Barve SS, Crothers K, Bedimo RJ, Warner A, Tindle HA; Veterans Aging Cohort Study. Association of Syndemic Unhealthy Alcohol Use, Smoking, and Depressive Symptoms on Incident Cardiovascular Disease among Veterans With and Without HIV-Infection. AIDS Behav. 2021 Sep;25(9):2852-2862. doi: 10.1007/s10461-021-03327-4. Epub 2021 Jun 8. PMID: 34101074; PMCID: PMC8376776.
  • Morrissey SM, Geller AE, Hu X, Tieri D, Ding C, Klaes CK, Cooke EA, Woeste MR, Martin ZC, Chen O, Bush SE, Zhang HG, Cavallazzi R, Clifford SP, Chen J, Ghare S, Barve SS, Cai L, Kong M, Rouchka EC, McLeish KR, Uriarte SM, Watson CT, Huang J, Yan J. A specific low-density neutrophil population correlates with hypercoagulation and disease severity in hospitalized COVID-19 patients. JCI Insight. 2021 May 10;6(9):e148435. doi: 10.1172/jci.insight.148435. PMID: 33986193; PMCID: PMC8262329.
  • Gu Z, Li F, Liu Y, Jiang M, Zhang L, He L, Wilkey DW, Merchant M, Zhang X, Deng ZB, Chen SY, Barve S, McClain CJ, Feng W. Exosome-Like Nanoparticles From Lactobacillus rhamnosusGG Protect Against Alcohol-Associated Liver Disease Through Intestinal Aryl Hydrocarbon Receptor in Mice. Hepatol Commun. 2021 Feb 5;5(5):846-864. doi: 10.1002/hep4.1679. PMID: 34027273; PMCID: PMC8122379.
  • Singhal R, Donde H, Ghare S, Stocke K, Zhang J, Vadhanam M, Reddy S, Gobejishvili L, Chilton P, Joshi-Barve S, Feng W, McClain C, Hoffman K, Petrosino J, Vital M, Barve S. Decrease in acetyl-CoA pathway utilizing butyrate-producing bacteria is a key pathogenic feature of alcohol-induced functional gut microbial dysbiosis and development of liver disease in mice. Gut Microbes. 2021 Jan-Dec;13(1):1946367. doi: 10.1080/19490976.2021.1946367. PMID: 34369304; PMCID: PMC8354657.
  • Ghare SS, Chilton PM, Rao AV, Joshi-Barve S, Peyrani P, Reyes Vega A, McClain CJ, Bryant K, Cook RL, Freiberg M, Barve S. Epigenetic Mechanisms Underlying HIV-Infection Induced Susceptibility of CD4+ T Cells to Enhanced Activation-Induced FasL Expression and Cell Death. J Acquir Immune Defic Syndr. 2021 Jan 1;86(1):128-137. doi: 10.1097/QAI.0000000000002526. PMID: 33093334; PMCID: PMC8384352.
  • Li F, Zhao C, Shao T, Liu Y, Gu Z, Jiang M, Li H, Zhang L, Gillevet PM, Puri P, Deng ZB, Chen SY, Barve S, Gobejishvili L, Vatsalya V, McClain CJ, Feng W. Cathelicidin-related antimicrobial peptide alleviates alcoholic liver disease through inhibiting inflammasome activation. J Pathol. 2020 Dec;252(4):371-383. doi: 10.1002/path.5531. Epub 2020 Sep 26. PMID: 33245573; PMCID: PMC8006217.