Shirish S. Barve, Ph.D.

Shirish S. Barve, Ph.D.

Shirish S. Barve, Ph.D.

  • Professor of Medicine
  • Distinguished University Scholar

502-852-6991 - Academic Office


  • B.Sc.: University of Bombay

  • M.Sc.: University of Bombay

  • Ph.D.: University of Kentucky


Featured Publications

  • Wahlang B, McClain C, Barve S, Gobejishvili L. Role of cAMP and phosphodiesterase signaling in liver health and disease. Cell Signal. 2018 Jun 11. pii: S0898-6568(18)30125-6. doi: 10.1016/j.cellsig.2018.06.005. [Epub ahead of print] PubMed PMID: 29902522.
  • Shao T, Zhao C, Li F, Gu Z, Liu L, Zhang L, Wang Y, He L, Liu Y, Liu Q, Chen Y, Donde H, Wang R, Jala VR, Barve S, Chen SY, Zhang X, Chen Y, McClain CJ, Feng W. Intestinal HIF-1α Deletion Exacerbates Alcoholic Liver Disease through Inducing Intestinal Dysbiosis and Barrier Dysfunction. J Hepatol. 2018 May 24. pii: S0168-8278(18)32067-1. doi: 10.1016/j.jhep.2018.05.021. [Epub ahead of print] PubMed PMID: 29803899.
  • Jones DZ, Schmidt ML, Suman S, Hobbing KR, Barve SS, Gobejishvili L, Brock G, Klinge CM, Rai SN, Park J, Clark GJ, Agarwal R, Kidd LR. Micro-RNA-186-5p inhibition attenuates proliferation, anchorage independent growth and invasion in metastatic prostate cancer cells. BMC Cancer. 2018 Apr 13;18(1):421. doi: 10.1186/s12885-018-4258-0. PubMed PMID: 29653561; PubMed Central PMCID: PMC5899400.
  • Moghe A, Barve SS, McClain CJ, Joshi-Barve S. Jumonji: Welcome to the World of Interferon Signaling in Alcohol and HCV. Cell Mol Gastroenterol Hepatol. 2017 Dec 9;5(2):163-164. doi: 10.1016/j.jcmgh.2017.11.009. eCollection 2018. PubMed PMID: 29693044; PubMed Central PMCID: PMC5904047.
  • Chen WY, Wang M, Zhang J, Barve SS, McClain CJ, Joshi-Barve S. Acrolein Disrupts Tight Junction Proteins and Causes Endoplasmic Reticulum Stress-Mediated Epithelial Cell Death Leading to Intestinal Barrier Dysfunction and Permeability. Am J Pathol. 2017 Dec;187(12):2686-2697. doi: 10.1016/j.ajpath.2017.08.015. Epub 2017 Sep 19. PubMed PMID: 28935573; PubMed Central PMCID: PMC5818631.
  • Avila DV, Myers SA, Zhang J, Kharebava G, McClain CJ, Kim HY, Whittemore SR, Gobejishvili L, Barve S. Phosphodiesterase 4b expression plays a major role in alcohol-induced neuro-inflammation. Neuropharmacology. 2017 Oct;125:376-385. doi: 10.1016/j.neuropharm.2017.08.011. Epub 2017 Aug 12. PubMed PMID: 28807677; PubMed Central PMCID: PMC5797427.
  • Barve S, Chen SY, Kirpich I, Watson WH, Mcclain C. Development, Prevention, and Treatment of Alcohol-Induced Organ Injury: The Role of Nutrition. Alcohol Res. 2017;38(2):289-302. Review. PubMed PMID: 28988580; PubMed Central PMCID: PMC5513692.
  • Vatsalya V, Pandey A, Schwandt ML, Cave MC, Barve SS, Ramchandani VA, McClain CJ. Safety Assessment of Liver Injury with Quetiapine Fumarate XR Management in Very Heavy Drinking Alcohol-Dependent Patients. Clin Drug Investig. 2016 Nov;36(11):935-944. PubMed PMID: 27503091; PubMed Central PMCID: PMC5095696.
  • Vatsalya V, Song M, Schwandt ML, Cave MC, Barve SS, George DT, Ramchandani VA, McClain CJ. Effects of Sex, Drinking History, and Omega-3 and Omega-6 Fatty Acids Dysregulation on the Onset of Liver Injury in Very Heavy Drinking Alcohol-Dependent Patients. Alcohol Clin Exp Res. 2016 Oct;40(10):2085-2093. doi: 10.1111/acer.13197. Epub 2016 Sep 2. PubMed PMID: 27589090; PubMed Central PMCID: PMC5367046.
  • Avila DV, Barker DF, Zhang J, McClain CJ, Barve S, Gobejishvili L. Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol-induced steatosis. J Pathol. 2016 Sep;240(1):96-107. doi: 10.1002/path.4760. PubMed PMID: 27287961; PubMed Central PMCID: PMC4993672.