Brian Clem, Ph.D.

Associate Professor 

Clinical & Translational Research Building, 505 South Hancock Street, Rm 422 (502) 852-8427

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Ph.D., 2005, Biochemistry and Molecular Biology, University of Louisville, Louisville, KY

      Research Interests

        • Regulation of tumor metabolism
        • Mechanism of action of pRB on controlling nutrient pathways
        • Development of novel anti-metabolic antagonists for cancer treatment
        • Define non-canonical functions for metabolic proteins

         Our lab aims to understand the mechanisms by which tumors can alter their nutrient metabolism to support their rapid and expansive growth. These changes are primarily promoted by genetic mutations that lead to oncogenic activation and/or loss of tumor suppressor function. We have previously demonstrated a direct role of the retinoblastoma protein, which was the first identified tumor suppressor, in controlling specific metabolic pathways that allow for enhanced cell proliferation as well as protection from cellular stress. From our research, we ultimately intend to identify specific differences within tumor cells that may be selective targets for new anti-cancer therapies.

          In collaboration with a computational biologist, biophysicist, and medicinal chemist, we are characterizing new inhibitors against metabolic targets that may have clinical activity in cancer patients. Using advanced compound screening methods, efficacy assays on human cancer in vitro and in vivo, and the ability to synthesize more potent molecules, we expect to generate unique anti-tumor chemotherapeutic strategies. 

          Laboratory Personnel

            • Rumeysa Biyik-Sit - PhD Candidate
            • Stephanie Metcalf - PhD Candidate
            • Lindsey Reynolds - PhD Candidate