Matthew C. Cave, M.D.

Matthew C. Cave, M.D.

Matthew C. Cave, M.D.

  • Professor of Medicine, Pharmacology and Toxicology, Biochemistry and Molecular Genetics
  • Distinguished University Scholar
UofL Physicians Outpatient Center
401 East Chestnut Street, Ste. 310
Louisville, KY 40202

502-852-6991 - Academic Office
502-588-4600 - Patient Appointments


Clinical Expertise
Hepatology; Nutrition; Liver Transplantation


Board Certifications

  • American Board of Internal Medicine -
    Gastroenterology / Transplant Hepatology

Education and Training

  • Medical School: University of Kentucky
  • Residency: Washington University Barnes-Jewish Hospital
  • Fellowship: University of Louisville

Get To Know Dr. Cave


Featured Publications

  • Guardiola JJ, Hardesty JE, Beier JI, Prough RA, McClain CJ, Cave MC. Plasma Metabolomics Analysis of Polyvinyl Chloride Workers Identifies Altered Processes and Candidate Biomarkers for Hepatic Hemangiosarcoma and Its Development. Int J Mol Sci. 2021 May 11;22(10):5093. doi: 10.3390/ijms22105093. PMID: 34065028; PMCID: PMC8150673.
  • Hardesty JE, Wahlang B, Prough RA, Head KZ, Wilkey D, Merchant M, Shi H, Jin J, Cave MC. Effect of Epidermal Growth Factor Treatment and Polychlorinated Biphenyl Exposure in a Dietary-Exposure Mouse Model of Steatohepatitis. Environ Health Perspect. 2021 Mar;129(3):37010. doi: 10.1289/EHP8222. Epub 2021 Mar 31. PMID: 33788613; PMCID: PMC8011667.
  • Wahlang B, Alexander NC 2nd, Li X, Rouchka EC, Kirpich IA, Cave MC. Polychlorinated biphenyls altered gut microbiome in CAR and PXR knockout mice exhibiting toxicant-associated steatohepatitis. Toxicol Rep. 2021 Mar 10;8:536-547. doi: 10.1016/j.toxrep.2021.03.010. PMID: 33777700; PMCID: PMC7985695.
  • Cave MC. Environmental Pollution and the Developmental Origins of Childhood Liver Disease. Hepatology. 2020 Nov;72(5):1518-1521. doi: 10.1002/hep.31549. PMID: 32910501.
  • Shi H, Jin J, Hardesty JE, Falkner KC, Prough RA, Balamurugan AN, Mokshagundam SP, Chari ST, Cave MC. Corrigendum to "Polychlorinated biphenyl exposures differentially regulate hepatic metabolism and pancreatic function: Implications for nonalcoholic steatohepatitis and diabetes" [Toxicology & Applied Pharmacology, 363 (2018) 22-33]. Toxicol Appl Pharmacol. 2020 Oct 1;404:115149. doi: 10.1016/j.taap.2020.115149. Epub 2020 Jul 20. Erratum for: Toxicol Appl Pharmacol. 2019 Jan 15;363:22-33. PMID: 32702359.
  • Jin J, Wahlang B, Shi H, Hardesty JE, Falkner KC, Head KZ, Srivastava S, Merchant ML, Rai SN, Cave MC, Prough RA. Dioxin-like and non-dioxin-like PCBs differentially regulate the hepatic proteome and modify diet-induced nonalcoholic fatty liver disease severity. Med Chem Res. 2020 Jul;29:1247-1263. doi: 10.1007/s00044-020-02581-w. Epub 2020 Jun 7. PMID: 32831531; PMCID: PMC7440142.
  • Werder EJ, Beier JI, Sandler DP, Falkner KC, Gripshover T, Wahlang B, Engel LS, Cave MC. Blood BTEXS and heavy metal levels are associated with liver injury and systemic inflammation in Gulf states residents. Food Chem Toxicol. 2020 May;139:111242. doi: 10.1016/j.fct.2020.111242. Epub 2020 Mar 20. PMID: 32205228; PMCID: PMC7368391.
  • Vatsalya V, Gala KS, Mishra M, Schwandt ML, Umhau J, Cave MC, Parajuli D, Ramchandani VA, McClain CJ. Lower Serum Magnesium Concentrations are associated With Specific Heavy Drinking Markers, Pro-Inflammatory Response and Early-Stage Alcohol-associated Liver Injury§. Alcohol Alcohol. 2020 Mar 19;55(2):164-170. doi: 10.1093/alcalc/agaa001. PMID: 32047901; PMCID: PMC7082490.
  • Wahlang B, Hardesty JE, Head KZ, Jin J, Falkner KC, Prough RA, Cave MC, Beier JI. Hepatic Injury Caused by the Environmental Toxicant Vinyl Chloride is Sex-Dependent in Mice. Toxicol Sci. 2020 Mar 1;174(1):79-91. doi: 10.1093/toxsci/kfz236. PMID: 31774537; PMCID: PMC7043220.
  • Rai SN, Qian C, Pan J, Rai JP, Song M, Bagaitkar J, Merchant M, Cave M, Egilmez NK, McClain CJ. Microbiome data analysis with applications to pre-clinical studies using QIIME2: Statistical considerations. Genes Dis. 2019 Dec 24;8(2):215-223. doi: 10.1016/j.gendis.2019.12.005. PMID: 33997168; PMCID: PMC8099687.