Matthew C. Cave, M.D.

Matthew C. Cave, M.D.

Matthew C. Cave, M.D.

  • Professor of Medicine
UofL Physicians Outpatient Center
401 East Chestnut Street, Ste. 310
Louisville, KY 40202

502-852-6991 - Academic Office
502-588-4600 - Patient Appointments


Clinical Expertise
Hepatology; Nutrition; Liver Transplantation


Board Certifications

  • American Board of Internal Medicine -
    Gastroenterology / Transplant Hepatology

Education and Training

  • Medical School: University of Kentucky
  • Residency: Washington University Barnes-Jewish Hospital
  • Fellowship: University of Louisville

Featured Publications

  • Wahlang B, Hardesty JE, Head KZ, Jin J, Falkner KC, Prough RA, Cave MC, Beier JI. Hepatic Injury Caused by the Environmental Toxicant Vinyl Chloride is Sex-Dependent in Mice. Toxicol Sci. 2020 Mar 1;174(1):79-91. doi: 10.1093/toxsci/kfz236. PubMed PMID: 31774537; PubMed Central PMCID: PMC7043220.
  • Vatsalya V, Gala KS, Mishra M, Schwandt ML, Umhau J, Cave MC, Parajuli D, Ramchandani VA, McClain CJ. Lower Serum Magnesium Concentrations are associated With Specific Heavy Drinking Markers, Pro-Inflammatory Response and Early-Stage Alcohol-associated Liver Injury§. Alcohol Alcohol. 2020 Feb 12. pii: agaa001. doi: 10.1093/alcalc/agaa001. [Epub ahead of print] PubMed PMID: 32047901.
  • Wahlang B, Appana S, Falkner KC, McClain CJ, Brock G, Cave MC. Insecticide and metal exposures are associated with a surrogate biomarker for non-alcoholic fatty liver disease in the National Health and Nutrition Examination Survey 2003-2004. Environ Sci Pollut Res Int. 2020 Feb;27(6):6476-6487. doi: 10.1007/s11356-019-07066-x. Epub 2019 Dec 23. PubMed PMID: 31873887; PubMed Central PMCID: PMC7047555.
  • Vatsalya V, Cave MC, Kong M, Gobejishvili L, Falkner KC, Craycroft J, Mitchell M, Szabo G, McCullough A, Dasarathy S, Radaeva S, Barton B, McClain CJ. Keratin 18 is a Diagnostic and Prognostic Factor for Acute Alcoholic Hepatitis. Clin Gastroenterol Hepatol. 2019 Dec 4. pii: S1542-3565(19)31390-4. doi: 10.1016/j.cgh.2019.11.050. [Epub ahead of print] PubMed PMID: 31811953.
  • Shi H, Hardesty JE, Jin J, Head KZ, Falkner KC, Cave MC, Prough RA. Concentration dependence of human and mouse aryl hydrocarbon receptor responsiveness to polychlorinated biphenyl exposures: Implications for aroclor mixtures. Xenobiotica. 2019 Dec;49(12):1414-1422. doi: 10.1080/00498254.2019.1566582. Epub 2019 Apr 16. PubMed PMID: 30991879; PubMed Central PMCID: PMC6764862.
  • Wahlang B, Jin J, Beier JI, Hardesty JE, Daly EF, Schnegelberger RD, Falkner KC, Prough RA, Kirpich IA, Cave MC. Mechanisms of Environmental Contributions to Fatty Liver Disease. Curr Environ Health Rep. 2019 Sep;6(3):80-94. doi: 10.1007/s40572-019-00232-w. Review. PubMed PMID: 31134516; PubMed Central PMCID: PMC6698418.
  • Wahlang B, Jin J, Hardesty JE, Head KZ, Shi H, Falkner KC, Prough RA, Klinge CM, Cave MC. Identifying sex differences arising from polychlorinated biphenyl exposures in toxicant-associated liver disease. Food Chem Toxicol. 2019 Jul;129:64-76. doi: 10.1016/j.fct.2019.04.007. Epub 2019 Apr 23. PubMed PMID: 31026535; PubMed Central PMCID: PMC6555661.
  • Hardesty JE, Wahlang B, Falkner KC, Shi H, Jin J, Zhou Y, Wilkey DW, Merchant ML, Watson CT, Feng W, Morris AJ, Hennig B, Prough RA, Cave MC. Proteomic Analysis Reveals Novel Mechanisms by Which Polychlorinated Biphenyls Compromise the Liver Promoting Diet-Induced Steatohepatitis. J Proteome Res. 2019 Apr 5;18(4):1582-1594. doi: 10.1021/acs.jproteome.8b00886. Epub 2019 Mar 15. PubMed PMID: 30807179; PubMed Central PMCID: PMC7059562.
  • Bassler J, Ducatman A, Elliott M, Wen S, Wahlang B, Barnett J, Cave MC. Environmental perfluoroalkyl acid exposures are associated with liver disease characterized by apoptosis and altered serum adipocytokines. Environ Pollut. 2019 Apr;247:1055-1063. doi: 10.1016/j.envpol.2019.01.064. Epub 2019 Jan 18. PubMed PMID: 30823334; PubMed Central PMCID: PMC6404528.
  • Shi H, Jan J, Hardesty JE, Falkner KC, Prough RA, Balamurugan AN, Mokshagundam SP, Chari ST, Cave MC. Polychlorinated biphenyl exposures differentially regulate hepatic metabolism and pancreatic function: Implications for nonalcoholic steatohepatitis and diabetes. Toxicol Appl Pharmacol. 2019 Jan 15;363:22-33. doi: 10.1016/j.taap.2018.10.011. Epub 2018 Oct 9. PubMed PMID: 30312631; PubMed Central PMCID: PMC7059560.