Matthew C. Cave, M.D., FAASLD

Matthew C. Cave, M.D.

Matthew C. Cave, M.D., FAASLD

  • Professor of Medicine, Biochemistry and Molecular Genetics, and Pharmacology and Toxicology
  • Vice Chair for Research
  • Distinguished University Scholar
UofL Physicians Outpatient Center
401 East Chestnut Street, Ste. 310
Louisville, KY 40202

502-852-6991 - Academic Office
502-588-4600 - Patient Appointments

Clinical Expertise
Mechanisms of Toxin-induced Hepatotoxicity; Hepatology; Liver Transplantation; Nutrition

Board Certifications

  • American Board of Internal Medicine -
    Gastroenterology / Transplant Hepatology

Education and Training

  • Medical School: University of Kentucky
  • Residency: Washington University Barnes-Jewish Hospital
  • Fellowship: University of Louisville

Get To Know Dr. Cave

Featured Publications

  • Piell KM, Petri BJ, Head KZ, Wahlang B, Xu R, Zhang X, Pan J, Rai SN, de Silva K, Chariker JH, Rouchka EC, Tan M, Li Y, Cave MC, Klinge CM. Disruption of the mouse liver epitranscriptome by long-term aroclor 1260 exposure. Environ Toxicol Pharmacol. 2023 Jun;100:104138. doi: 10.1016/j.etap.2023.104138. Epub 2023 May 1. PMID: 37137421.
  • Liu S, He L, Bannister OB, Li J, Schnegelberger RD, Vanderpuye CM, Althouse AD, Schopfer FJ, Wahlang B, Cave MC, Monga SP, Zhang X, Arteel GE, Beier JI. Western diet unmasks transient low-level vinyl chloride-induced tumorigenesis; potential role of the (epi-)transcriptome. Toxicol Appl Pharmacol. 2023 Jun 1;468:116514. doi: 10.1016/j.taap.2023.116514. Epub 2023 Apr 14. PMID: 37061008; PMCID: PMC10164119.
  • Heindel JJ, Alvarez JA, Atlas E, Cave MC, Chatzi VL, Collier D, Corkey B, Fischer D, Goran MI, Howard S, Kahan S, Kayhoe M, Koliwad S, Kotz CM, La Merrill M, Lobstein T, Lumeng C, Ludwig DS, Lustig RH, Myers P, Nadal A, Trasande L, Redman LM, Rodeheffer MS, Sargis RM, Stephens JM, Ziegler TR, Blumberg B. Obesogens and Obesity: State-of-the-Science and Future Directions Summary from a Healthy Environment and Endocrine Disruptors Strategies Workshop. Am J Clin Nutr. 2023 May 23:S0002-9165(23)63923-1. doi: 10.1016/j.ajcnut.2023.05.024. Epub ahead of print. PMID: 37230178.
  • Ge Y, Bruno M, Nash MS, Coates NH, Chorley BN, Cave MC, Beier JI. Vinyl chloride enhances high-fat diet-induced proteome alterations in the mouse pancreas related to metabolic dysfunction. Toxicol Sci. 2023 May 12;193(1):103-114. doi: 10.1093/toxsci/kfad024. PMID: 36892438; PMCID: PMC10176240.
  • Hassanein T, McClain CJ, Vatsalya V, Stein LL, Flamm SL, Martin P, Cave MC, Mitchell M Jr, Barton B, Nagy L, Szabo G, McCullough A, Dasarathy S, Shah J, Blevins C, Scott D, Krebs W, Brown JE, Lin W. Safety, Pharmacokinetics, and Efficacy Signals of Larsucosterol (DUR-928) in Alcohol-Associated Hepatitis. Am J Gastroenterol. 2023 May 8. doi: 10.14309/ajg.0000000000002275. Epub ahead of print. PMID: 37011138.
  • El-Kersh K, Hopkins CD, Wu X, Rai SN, Cave MC, Smith MR, Go YM, Jones DP, Cai L, Huang J. Metallomics in pulmonary arterial hypertension patients. Pulm Circ. 2023 Feb 21;13(1):e12202. doi: 10.1002/pul2.12202. PMID: 36824690; PMCID: PMC9941844.
  • Bolatimi OE, Head KZ, Luo J, Gripshover TC, Lin Q, Adiele NV, Watson WH, Wilkerson C, Cai L, Cave MC, Young JL. Can Zinc Supplementation Attenuate High Fat Diet-Induced Non-Alcoholic Fatty Liver Disease? Int J Mol Sci. 2023 Jan 16;24(2):1763. doi: 10.3390/ijms24021763. PMID: 36675277; PMCID: PMC9864360.
  • Gripshover TC, Wahlang B, Head KZ, Young JL, Luo J, Mustafa MT, Kirpich IA, Cave MC. The environmental pollutant, polychlorinated biphenyl 126, alters liver function in a rodent model of alcohol-associated liver disease. Alcohol Clin Exp Res. 2023 Jan;47(1):60-75. doi: 10.1111/acer.14976. Epub 2022 Dec 1. PMID: 36377258; PMCID: PMC9974797.
  • Petri BJ, Piell KM, Wahlang B, Head KZ, Andreeva K, Rouchka EC, Cave MC, Klinge CM. Polychlorinated biphenyls alter hepatic m6A mRNA methylation in a mouse model of environmental liver disease. Environ Res. 2023 Jan 1;216(Pt 3):114686. doi: 10.1016/j.envres.2022.114686. Epub 2022 Oct 28. PMID: 36341798; PMCID: PMC10120843.
  • He L, Vatsalya V, Ma X, Klinge CM, Cave MC, Feng W, McClain CJ, Zhang X. Metabolic Analysis of Nucleosides/Bases in the Urine and Serum of Patients with Alcohol-Associated Liver Disease. Metabolites. 2022 Nov 28;12(12):1187. doi: 10.3390/metabo12121187. PMID: 36557225; PMCID: PMC9783452.