Matthew C. Cave, M.D., FAASLD

• Professor of Medicine, Biochemistry and Molecular Genetics, and Pharmacology and Toxicology
• Vice Chair for Research
• Distinguished University Scholar

UofL Physicians Outpatient Center
401 East Chestnut Street, Ste. 310
Louisville, KY 40202

502-852-6991 - Academic Office
502-588-4600 - Patient Appointments

Get To Know Dr. Cave

Featured Publications

• Thakurdesai A, Rivera-Matos L, Nagra N, Busch B, Mais DD, Cave MC. Severe Drug-Induced Liver Injury Due to Self-administration of the Veterinary Anthelmintic Medication, Fenbendazole. ACG Case Rep J. 2024 May 2;11(5):e01354. doi: 10.14309/crj.0000000000001354. PMID: 38706451; PMCID: PMC11068125.
• Condon S, Hu H, Kong M, Cave MC, McClain CJ. ALT poorly predicts Nonalcoholic Fatty Liver Disease (NAFLD) and liver fibrosis as determined by vibration-controlled transient elastography in adult National Health and Nutrition Examination Survey 2017-2018. Am J Med Sci. 2024 May;367(5):310-322. doi: 10.1016/j.amjms.2024.01.022. Epub 2024 Feb 1. PMID: 38307172.
• Gripshover TC, Wahlang B, Head KZ, Luo J, Bolatimi OE, Smith ML, Rouchka EC, Chariker JH, Xu J, Cai L, Cummins TD, Merchant ML, Zheng H, Kong M, Cave MC. Multiomics Analysis of PCB126's Effect on a Mouse Chronic-Binge Alcohol Feeding Model. Environ Health Perspect. 2024 Apr;132(4):47007. doi: 10.1289/EHP14132. Epub 2024 Apr 15. PMID: 38619879; PMCID: PMC11018247.
• Piell KM, Petri BJ, Xu J, Cai L, Rai SN, Li M, Wilkey DW, Merchant ML, Cave MC, Klinge CM. Chronic Aroclor 1260 exposure alters the mouse liver proteome, selenoproteins, and metals in steatotic liver disease. Environ Toxicol Pharmacol. 2024 Apr;107:104430. doi: 10.1016/j.etap.2024.104430. Epub 2024 Mar 27. PMID: 38552755; PMCID: PMC11044900.
• Zhao J, Adiele N, Gomes D, Malovichko M, Conklin DJ, Ekuban A, Luo J, Gripshover T, Watson WH, Banerjee M, Smith ML, Rouchka EC, Xu R, Zhang X, Gondim DD, Cave MC, O'Toole TE. Obesogenic polystyrene microplastic exposures disrupt the gut-liver-adipose axis. Toxicol Sci. 2024 Mar 26;198(2):210-220. doi: 10.1093/toxsci/kfae013. PMID: 38291899; PMCID: PMC10964747.
• Hopkins CD, Wessel C, Chen O, El-Kersh K, Cathey D, Cave MC, Cai L, Huang J. A hypothesis: Potential contributions of metals to the pathogenesis of pulmonary artery hypertension. Life Sci. 2024 Jan 1;336:122289. doi: 10.1016/j.lfs.2023.122289. Epub 2023 Nov 24. PMID: 38007143; PMCID: PMC10872724.
• Hassanein T, McClain CJ, Vatsalya V, Stein LL, Flamm SL, Martin P, Cave MC, Mitchell M Jr, Barton B, Nagy L, Szabo G, McCullough A, Dasarathy S, Shah J, Blevins C, Scott D, Krebs W, Brown JE, Lin W. Safety, Pharmacokinetics, and Efficacy Signals of Larsucosterol (DUR-928) in Alcohol-Associated Hepatitis. Am J Gastroenterol. 2024 Jan 1;119(1):107-115. doi: 10.14309/ajg.0000000000002275. Epub 2023 Apr 3. PMID: 37011138; PMCID: PMC10758349.
• Petri BJ, Piell KM, Wahlang B, Head KZ, Rouchka EC, Park JW, Hwang JY, Banerjee M, Cave MC, Klinge CM. Altered splicing factor and alternative splicing events in a mouse model of diet- and polychlorinated biphenyl-induced liver disease. Environ Toxicol Pharmacol. 2023 Oct;103:104260. doi: 10.1016/j.etap.2023.104260. Epub 2023 Sep 7. PMID: 37683712; PMCID: PMC10591945.
• Hopkins CD, Wessel C, Chen O, El-Kersh K, Cave MC, Cai L, Huang J. Potential Roles of Metals in the Pathogenesis of Pulmonary and Systemic Hypertension. Int J Biol Sci. 2023 Sep 25;19(16):5036-5054. doi: 10.7150/ijbs.85590. PMID: 37928257; PMCID: PMC10620830.
• Petri BJ, Cave MC, Klinge CM. Changes in m6A in Steatotic Liver Disease. Genes (Basel). 2023 Aug 19;14(8):1653. doi: 10.3390/genes14081653. PMID: 37628704; PMCID: PMC10454815.