Yongqing Liu, Ph.D.

Education:

B.S., Hunan Agricultural University, Changsha, Hunan Province, China; 1982
M.S., Hunan Agricultural University, Changsha, Hunan Province, China; 1987
Ph.D., Wageningen University, Wageningen, Netherlands; 1996
Postdoctoral Fellow, the Noble Foundation, Ardmore, Oklahoma; April 1998 - December 2000
Postdoctoral Fellow, Oak Ridge National Laboratory, Oak Ridge, Tennessee; January 2001 - December 2003

Curriculum Vitae

Current Positions:

Assistant Professor, Division of Medical Oncology, Department of Medicine
Member, Brown Cancer Center
Associated Member, Department of Ophthalmology and Visual Sciences

Contact Information:

Clinical & Translational Research Building
505 South Jackson Street
University of Louisville
Louisville, KY 40202

Phone:  (502) 852-8669
Email:  yongqing.liu@louisville.edu

Research Description:

In recent years, my research has been focused on the Zeb1-regulated corneal response to chemical insults and sphere-induced ocular cell reprogramming.  I published multiple Zeb1-related papers in high impact journals such as Nature Communications, Science Advances, Cell Stem Cell, Development, Stem Cells, eBioMedicine, Communications Biology, Cells, iScience and Stem Cell Research & Therapy.  In the past two years, I published two major papers on Zeb1-regulated corneal neovascularization and inflammation in Communications Biology and iScience.  In addition, I am also interested in uveal melanoma research.  My long-term goal is to study Zeb1-regulation of ocular diseases, to understand the underlying mechanisms and to formulate novel strategies for future clinical applications.

Literature Cited:

  1. Guo Y, Lu X, Chen Y, Clark G, Trent J, Cuatrecasas M, Emery D, Song ZH, Chariker J, Rouchka E, Postigo A, Liu Y, Dean DC. Opposing roles of ZEB1 in the cytoplasm and nucleus control cytoskeletal assembly and YAP1 activity.  CellReports 2022 Oct 4;41(1):111452.  doi: 10.1016/j.celrep.2022.111452.  PMID: 36198275.
  2. Chen Y, Lu X, Gao L, Dean DC, Liu Y.  Spheroid-induced heterogeneity and plasticity of uveal melanoma cells. CellularOncology(Dordrecht) 2022 Apr;45(2):309-321.  doi: 10.1007/s13402-022-00671-y.  Epub 2022 Apr 11.  PMID: 35404029.  PMCID: PMC9050762.
  3. Liang W, Zhang Y, Zhou L, Lu X, Finn ME, Wang W, Shao H, Dean DC, Zhang L, Liu Y.  Zeb1 regulation of wound healing-induced inflammation in alkali-damaged corneas.  iScience2022 Mar 8;25(4):104038.  doi: 10.1016/j.isci.2022.104038.  eCollection 2022 Apr 15.  PMID: 35340433.  PMCID: PMC8941209.
  4. Guo Y, Lu X, Chen Y, Rendon B, Mitchell RA, Cuatrecasas M, Cortés M, Postigo A, Liu Y, Dean DC.  Zeb1 induces immune checkpoints to form an immunosuppressive envelope around invading cancer cells.  ScienceAdvances2021 May 21;7(21):eabd7455.  doi: 10.1126/sciadv.abd7455.  PMID: 34020945.  PMCID: PMC8139582 .
  5. Wu J, Chen N, Liu Y, Godlewski G, Kaplan HJ, Shrader SH, Song ZH, Shao H.  Studies of involvement of G-protein coupled receptor-3 in cannabidiol effects on inflammatory responses of mouse primary astrocytes and microglia.  PLoSOne 2021 May 13;16(5):e0251677.  doi: 10.1371/journal.pone.0251677.  eCollection 2021.  PMID: 33984046.  PMCID: PMC8118243 .
  6. Zhang Y, Liu X, Liang W, Dean DC, Zhang L, Liu Y.  Expression and function of ZEB1 in the cornea.  Cells2021 Apr 16;10(4):925.  doi: 10.3390/cells10040925.  PMID: 33923743.  PMCID: PMC8074155 .
  7. Peng X, Gao L, Liu Y.  Cell-based therapies for age-related macular degeneration: cell replacement versus paracrine effects.  Neural Regeneration Research2021;16(6):1214-1215.  PMID: 33269782.  PMCID: PMC8224131 .
  8. Jin L, Zhang Y, Liang W, Lu X, Piri N, Wang W, Kaplan HJ, Dean DC, Zhang L, Liu Y.  Zeb1 promotes corneal neovascularization by regulation of vascular endothelial cell proliferation.  Communications Biology2020;3(1):349.  doi: 10.1038/s42003-020-1069-z.  PMID: 32620870.  PMCID: PMC7335040 .
  9. Chen F, Liu X, Chen Y, Lu H, Wang W, Lu X, Dean KC, Gao L, Kaplan HJ, Dean DC, Peng X, Liu Y. Sphere-induced reprogramming of RPE cells into dual-potential RPE stem-like cells.  EbioMedicine 2020 Feb;52:102618.  doi: 10.1016/j.ebiom.102618.  PMID: 31982829.  PMCID: PMC6994567 .
  10. Liu X, Chen F, Chen Y, Lu H, Lu X, Peng X, Kaplan HJ, Dean DC, Gao L, Liu Y. Paracrine effects of intraocularly implanted cells on degenerating retinas in mice. Stem Cell Research & Therapy. 2020 11(1):142. doi: 10.1186/s13287-020-01651-5. PMID: 32234075. PMCID: PMC7326149 .

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