Xiao-An (Sean) Fu



Curriculum Vitae

Current Positions:

Professor, Department of Chemical Engineering

Contact Information:

Department of Chemical Engineering
University of Louisville
Ernst Hall, Room 217
216 Eastern Parkway
Louisville, KY 40208
Phone 502-852-6349
Email Xiaoan.fu@louisville.edu

Research Description:

Dr. Fu’s current research interests include chemical microsensor array or electronic nose, microreactors, concentration and analytical methods for detection of trace volatile organic compounds (VOCs) in exhaled breath and biofluids, environmental air, aerosols of electronic cigarettes.  The analysis of metabolic VOCs in exhaled breath has led to identification of disease biomarkers.  He is developing  a noninvasive breath analysis tool for detection of early cancers, COVID-19 and other respiratory infectious diseases.

Literature Cited:

  1.  Fu XA, Li M, Knipp RJ, Nantz MH, Bousamra M.  Noninvasive detection of lung cancer using exhaled breath.  Cancer Medicine 2014 Feb;3(1):174-181.  doi: 20.2003/cam4.162.  Epub 2013 Nov 20.  PMID: 35503867.  PMCID: PMC3930402.
  2. Li MX, Yang D, Brock G, Knipp RJ, Bousamra M, Nantz MH, Fu XA.  Breath carbonyl compounds as biomarkers of lung cancer.  Lung Cancer 2015 Oct;90(1):92-97.  doi: 10.1016/j.lungcan.2015.07.005.  Epub 2015 Jul 19.  PMID: 26233567.
  3. Bousmra M 2nd, Schumer E, Li M, Knipp RJ, Nantz MH, van Berkel V, Fu XA.  Quantitative analysis of exhaled carbonyl compounds distinguishes benign from malignant pulmonary disease.  Journal of Thoracic & Cardiovascular Surgery 2014 Sep;148(3):1074-1080; discussion 1080-1081.  doi: 10.1016/j.jtcvs.2014.06.006.  Epub 2014 Jun 8.  PMID: 25129599.
  4. Schumer EM, Black M, Bousamra M 2nd, Trivedi JR, Li M, Fu XA, V. van Berkel V.  Normalization of exhaled carbonyl compounds after lung cancer resection.  Annals of Thoracic Surgery 2015 Oct;102(4):1095-1100, 2016.  doi: 10.1016/j.athoracsur.2016.04.068.  Epub 2016 Jun 9.  PMID: 27293148.  PMCID: PMC5042568.
  5. Schumer EM, Trivedi JR, van Berkel V, Black MC, Li M, Fu XA, Bousamra M 2nd.  High sensitivity for lung cancer detection using analysis of exhaled carbonyl compounds.  Journal of Thoracic & Cardiovascular Surgery 2015 Dec;150(6):1517-1522; discussion 1522-1523.  doi: 10.1016/j.jtcvs.2015.08.092.  Epub 2015 Aug 31.  PMID: 26412316.
  6. Shaffie A, Soliman A, Fu XA, Nantz M, Giridharan G, van Berkel V, Khalifeh HA, Elmaghraby A, El-Baz A.  A novel technology to integrate image and clinical markers for noninvasive diagnosis of lung cancer.  ScientificReport 2021 Feb 25;11(1):4597.  doi: 10.1038/s41598-021-83907-5.  PMID: 33633213.  PMCID: PMC7907202.
  7. Halder S, Xie Z, Nantz MH, Fu XA.  Integration of a micropreconcentrator with solid-phase microextraction for analysis of trace volatile organic compounds by gas chromatography-mass spectrometry.  Journal of Chromatography A 2022 Apr 22:1673:463083.  doi: 10.1016/j.chroma.2022.463083.  Epub ahead of print.  PMID: 35508097, 
  8. Li Q, Fu XA, Xu K, He H, Jiang N.  A stability study of carbonyl compounds in Tedlar bags by a fabricated MEMS microreactor approach.  Microchemical Journal 2021 Jan 1;160(Part A):105611.  https://doi.org.10.1016.j.microc.2020.105611
  9. Xie Z, Raju MV, Adhihetty PK, Fu XA, Nantz MH.  Effect of thiol molecular structure on the sensitivity of gold nanoparticle-based chemiresistors toward carbonyl compounds.  Sensors (Basil) 2020 Dec 8;20(24):7024.  doi: 10.3390/s20247024.  PMID: 33302491.  PMCID: PMC7763667.
  10. Ando T, Fu XA.  Materials: silicon and beyond.  Sensors & Actuators A: Physical 2019;296:340-351.  Epub: July 10, 2019.
  11. Ogunwale MA, Knipp RJ, Evrard CN, Thompson LM, Nantz MH, Fu XA.  The influence of β-ammonium substitution on the reaction kinetics of aminooxy condensations with aldehydes and ketones.  ChemPhysChem 2019 Mar 18;20(6):815-822.  doi: 10.1002/cphc.201801143.  Epub 2019 Mar 5.  PMID: 30725495.  PCID: PMC7382545.
  12. Chen Y, Li Q, Xie Z, Fu XA.  Characterization of DNPH-coated microreactor chip for analysis of trace carbonyls with application for breath analysis.  Journal of Chromatography B: Analytical Technologies in Biomedical & Life Sciences. 2019 Feb 1:1106-1107:58-63.  doi: 10.1016/j.jchromb.2018.12.030.  Epub 2019 Jan 6.  PMID: 30641269.  
  13. Xie Z, Ramakrishnam Raju MV, Stewart AC, Nantz MH, Fu XA.  Imparting sensitivity and selectivity to a gold nanoparticle chemiresistor through thiol monolayer functionalization.  RSC Advances 2018 Oct 21;8(62):35618-35624.  doi: 10.1039/c8ra06137h.  Epub 2018 Oct 18.  PMID: 30555687.  PMCID: PMC6238108. 
  14. Conklin DJ, Ogunwale MA, Chen Y, Theis WS, Nantz MH, Fu XA, Chen LC, Riggs DW, Lorkiewicz P, Bhatnagar A, Srivastava S.  Electronic cigarette-generated aldehydes: The contribution of e-liquid components to their formation and the use of urinary aldehyde metabolites as biomarkers of exposure.  Aerosol Science & Technology 2018;52(11):1219-1232.  doi: 10.1080/02786826.2018.1500013.  Epub 2018 Aug 23.  PMID: 31456604.  PMCID: PMC6711607.
  15. Li M, Li Q, Nantz MH, Fu XA.  Analysis of carbonyl compounds in ambient air by a microreactor approach.  ACS Omega 2018 Jun 30;3(6):6764-6769.  doi: 10.1021/acsomega.8b00503.  Epub 2018 Jun 21.  PMID: 29978147.  PMCID: PMC6026843.
  16. Ogunwale MA, Li MX, Ramakrishnam Raju MV, Chen Y, Nantz MH, Conklin DJ, Fu XA.  Aldehyde detection in electronic cigarette aerosols.  ACS Omega 2017 Mar 31;2(3):1207-1214.  doi: 10.1021/acsomega.6b00489.  Epub 2017 Mar 29.  PMID: 28393137.  PMCID: PMC5377270.
  17. Ogunwale MA, Chen Y, Theis WS, Nantz MH, Conklin DJ, Fu XA.  A novel method of nicotine quantification in electronic cigarette liquids and aerosols.  Analytical Methods 2017 Aug 7;9(2):4261-4266.  doi: 10.1039/C7AY00501F.  Epub 2017 Jun 19.  PMID: 29187865.  PMCID: PMC5303602.
  18. Salgaeva U, Zhao R, Mushinsky S, Jasinski J, Fu XA, Henner V, Dharmasena R, Sumanasekera G.  Photoluminescence in functionalized/doped graphene quantum dots, role of surface states.  Journal of Nanomaterials & Molecular Nanotechnology 2017;6(2).  doi:10.4172/2324-8777.1000215.
  19. Li M, Biswas S, Nantz MH, Higashi RM, Fu XA.  A microfabricated preconcentration device for breath analysis.  Sensors & Actuators B:Chemical 2013 April;180:130-136.
  20. Li M, Biswas S, Nantz MH, Higashi RM, Fu XA.  Preconcentration and analysis of trace volatile carbonyl compounds.  Analytical Chemistry 2012 Feb 7;84(3):1288-1293.  doi: 10.1021/ac2021757.  Epub 2012 Jan 20.  PMID: 22145792.