Education:

M.B.B.S., The First Military Medicial University (now Southern Medical University), Guangzhou, Guangdong, China; June 2003
Master of Medicine, Department of Immunology, Southern Medical University, Guangzhou, Guangdong, China; June 2007
Ph.D., Department of Pediatrics & Adolescent Medicine, University of Hong Kong, Hong Kong, China; August 2011
Postdoctoral Fellow, Department of Pediatrics & Adolescent Medicine, University of Hong Kong, Hong Kong, China; January 2012-January 2015
Postdoctoral Research Scholar, Department of Microbiology & Immunology, University of Iowa, Iowa City, Iowa; December 2016-January 2021

Current Positions:

Assistant Professor, Department of Microbiology & Immunology
Member, Center for Predictive Medicine
Member, Brown Cancer Center

Contact Information:

Jian.zheng.1@louisville.edu

Research Description:

My research interest includes the anti-tumor immunology and the development of novel therapy against tumor or cancer diseases.  My lab is now running some tumor-related projects and I am seeking collaborative opportunities with current members in the Brown Cancer Center.

Recent/Notable Publications:

1. Shi J, Wang G, Zheng J, Verma AK, Guan X, Malisheni MM, Geng Q, Li F, Perlman S, Du L.  Effective vaccination strategy using SARS-CoV-2 spike cocktail against Omicron and other variants of concern.  NPJ Vaccines 2022 Dec 19;7(1):169.  doi: 10.1038/s41541-022-00580-z.  PMID: 36535987.  PMCID: PMC9762654.
2. Dampalla CS, Zheng J, Perera KD, Wong LR, Meyerholz DK, Nguyen HN, Kashipathy MM, Battaile KP, Lovell S, Kim Y, Perlman S, Groutas WC, Chang KO.  Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection.  Proceedings of the National Academy of Sciences USA 2021 Jul 20;118(29):e2101555118.  doi: 10.1073/pnas.2101555118.  PMID: 34210738.  PMCID: PMC8307543.
3. Wong LR, Zheng J, Wilhelmsen K, Li K, Ortiz ME, Schnicker NJ, Thurman A, Pezzulo AA, Szachowicz PJ, Li P, Pan R, Klumpp K, Aswad F, Rebo J, Narumiya S, Murakami M, Zuniga S, Sola I, Enjuanes L, Meyerholz DK, Fortney K, McCray PB Jr, Perlman S. (co-first author) Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19.  Nature 2022 May;605(7908):146-151.  doi: 10.1038/s41586-022-04630-3.  Epub 2022 Mar 21.  PMID: 35314834.  PMCID: PMC9783543.
4. Zheng J, Meyerholz D, Wong LR, Gelb M, Murakami M, Perlman S.  Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D.  Journal of Clinical Investigation 2021 Jun 1;131(11):e147201.  doi: 10.1172/JCI147201.  PMID: 34060490.  PMCID: PMC8266207.
5. Zheng J, Wen L, Yen HL, Liu M, Liu Y, Teng O, Wu WF, Ni K, Lam KT, Huang C, Yang J, Lau YL, Perlman S, Peiris M, Tu W.  Phenotypic and functional characteristics of a novel influenza virus hemagglutinin-specific memory NK cell.  Journal of Virology 2021 May 24;95(12):e00165-21.  doi: 10.1128/JVI.00165-21.  PMID: 33827945.  PMCID: PMC8316001.
6. Zheng J, Wang Y, Li K, Meyerholz DK, Allamargot C, Perlman S.  Severe Acute Respiratory Syndrome Coronavirus-2-induced immune activation and death of monocyte-derived human macrophages and dendritic cells.  Journal of Infectious Diseases 2021 Mar 1;223(5):785-795.  Epub 2020 Dec 3.  doi: 10.1093;infdis/jaaa753.  PMID: 33277988.   PMCID: PMC7799009
7. Zheng J, Wong LYR, Li K, Verma AK, Ortiz ME, Wohlford-Lenane C, Leidinger MR, Knudson CM, Meyerholz DK, McCray PB Jr., Perlman S.  COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice.  Nature 2021 Jan;589(7843):603-607.  doi: 10.1038/s41586-020-2943-z.  Epub 2020 Nov 9.  PMID: 33166988.  PMCID: PMC7855185.
8. Zheng J, Sariol A, Meyerholz DK, Zhang Q, Abrahante Lloréns JE, Narumiya S, Perlman S.  Prostaglandin D2 signaling in dendritic cells is critical for the development of EAE.  Journal of  Autoimmunity 2020 Nov;114:102508.  doi: 10.1016/j.jaut.2020.102508.  Epub 2020 Jul 2.  PMID: 32624353.  PMCID: PMC7332282.

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