Norman L. Lehman, M.D., Ph.D.

Education:

B.S., Biological Science, University of Southern California; June 1986
M.S., Pharmaceutical Science, University of Southern California; June 1994
M.D., University of Southern California Keck School of Medicine; May 1994
Ph.D., Pharmaceutical Science, Emphasis on Molecular Pharmacology, University of Southern California; December 1998

Curriculum Vitae

Current Position:

Professor, Department of Pathology & Laboratory Medicine
Vice-Chair for Research, Department of Pathology & Laboratory Medicine
Member, Experimental Therapeutics & Diagnostics Program, Brown Cancer Center

Contact Information:

Department of Pathology & Laboratory Medicine
University of Louisville
Clinical & Translational Research Building, #307
505 South Hancock Street
Louisville, KY 40202

Phone: (502)852-1414
Email:  norm.lehman@louisville.edu

Recent/Notable Publications:

  1. Sak M, Williams BJ, Zumbar CT, Teer L, Al-Kawaaz MNG, Kakar A, Hey AJ, Wilson MJ, Schier LM, Chen J, Lehman NL.  The CNS-penetrating taxane drug TPI 287 potentiates antiglioma activity of the AURKA inhibitor alisertib in vivo.  Cancer Chemotherapy & Pharmacology 2023 Feb;91(2):191-201.  doi: 10.1007/s00280-023-04503-0.  Epub 2023 Jan 25.  PMID: 36694044.
  2. Terry M, WakemanK, WilliamsBJ, Miller DM, Sak M Abdullaev Z, Pacheco MC, Aldape K, Lehman NL.  Malignant melanotic nerve sheath tumor with PRKAR1A, KMT2C and GNAQ mutations.  Free Neuropathology 2022 3:21.  doi: https://doi.org/10.17879/freeneuropathology-2022-3864 .
  3. Lehman NL.  Early ependymal tumor with MN1-BEND2 fusion: a mostly cerebral tumor of female children with a good prognosis that is distinct from classical astroblastoma.  Journal of Neurooncology 2023 Feb;161(3):425-439.  doi: 10.1007/s11060-022-04222-1.  Epub 2023 Jan 6.  PMID: 36604386.  PMCID: PMC9992034.
  4. Lehman NL, Spassky N, Sak M, Webb A, Zumbar CT, Usubalieva A, Alkhateeb KJ, McElroy JP, Maclean KH, Fadda P, Liu T, Gangalapudi V, Carver J, Abdullaev Z, Timmers C, Parker JR, Pierson CR, Mobley BC, Gokden M, Hattab EM, Parrett T, Cooke RX, Lehman TD, Costinean S, Parwani A, Williams BJ, Jensen RL, Aldape K, Mistry AM.  Astroblastomas exhibit radial glia stem cell lineages and differential expression of imprinted and X-inactivation escape genes.  Nature Communications 2022 Apr 19;13(1):2083. doi: 10.1038/s41467-022-29302-8.  Erratum in: NatureCommunications 2023 Jan 31;14(1):507.  PMID: 35440587.  PMCID: PMC9018799.
  5. Alkhateeb KJ, Crane JE, Sak M, Jorgensen CJ, O'Donnell JP, Zumbar CT, Wozniak JA, Salazar CR, Parwani AV, Lehman NL.  Aurora-A kinase is differentially expressed in the nucleus and cytoplasm in normal Müllerian epithelium and benign, borderline and malignant serous ovarian neoplasms.  DiagnosticPathology 2021 Oct 27;16(1):98.  doi: 10.1186/s13000-021-01158-4.  PMID: 34706741.  PMCID: PMC8549328.
  6. Petri BJ, Piell KM, South Whitt GC, Wilt AE, Poulton CC, Lehman NL, Clem BF, Nystoriak MA, Wysoczynski M, Klinge CM.  HNRNPA2B1 regulates tamoxifen- and fulvestrant-sensitivity and hallmarks of endocrine resistance in breast cancer cells. Cancer Letters 2021 Oct 10;518:152-168.  doi: 10.1016/j.canlet.2021.07.015.  Epub 2021 Jul 14.  PMID: 34273466.  PMCID: PMC8358706.
  7. Sak M, Zumbar CT, King PD, Li X, Mifsud CS, Usubalieva A, Anderson CD, Chesnick HM, McElroy JP, Chakravarti A, Burton EC, Lehman NL.  Cytotoxic synergy between alisertib and carboplatin versus alisertib and irinotecan are inversely dependent on MGMT levels in glioblastoma cells.  Journal of Neurooncology 2019 Jun;143(2):231-240.  doi: 10.1007/s11060-019-03164-5.  Epub 2019 Apr 22.  PMID: 31011934.  PMCID: PMC6727196.
  8. Lehman NL, Usubalieva A, Lin T, Allen SJ, Tran QT, Mobley BC, McLendon RE, Schniederjan MJ, Georgescu MM, Couce M, Dulai MS, Raisanen JM, Al Abbadi M, Palmer CA, Hattab EM, Orr BA.  Genomic analysis demonstrates that histologically-defined astroblastomas are molecularly heterogeneous and that tumors with MN1 rearrangement exhibit the most favorable prognosis.  ActaNeuropathologicaCommunications 2019 Mar 15;7(1):42.  doi: 10.1186/s40478-019-0689-3.  PMID: 30876455.  PMCID: PMC6419470.
  9. Russell L, Swanner J, Jaime-Ramirez AC, Wang Y, Sprague A, Banasavadi- Siddegowda Y, Yoo JY, Sizemore GM, Kladney R, Zhang J, Lehman NL, Ostrowski MC, Hong B, Caligiuri M, Yu J, Kaur B.  PTEN expression by an oncolytic herpesvirus directs T-cell mediated tumor clearance.  NatureCommunications 2018 Nov 27;9(1):5006.  doi: 10.1038/s41467-018-07344-1.  PMID: 30479334.  PMCID: PMC6258708.
  10. Zumbar CT, Usubalieva A, King PD, Li X, Mifsud CS, Dalton HM, Sak M, Urio S, Bryant WM, McElroy JP, Farmer G, Lehman NL.  The CNS penetrating taxane TPI 287 and the AURKA inhibitor alisertib induce synergistic apoptosis in glioblastoma cells.  Journal of Neurooncology 2018 May;137(3):481-492.  doi: 10.1007/s11060-018-2755-2.  Epub 2018 Feb 2.  PMID: 29396807.  PMCID: PMC6097628.