Kyung U. Hong, Ph.D.

Education: Kyung Hong, Ph.D.

B.S. (High Honors), Department of Environmental Toxicology, University of California @ Davis, Davis, CA; 1996
M.S., Toxicology Program, Department of Environmental Medicine, University of Rochester, School of Medicine & Dentistry, Rochester, NY; 2001
Ph.D., Toxicology Program, Department of Environmental Medicine, University of Rochester, School of Medicine & Dentistry, Rochester, NY; 2003
Postdoctoral Fellowship, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea; 2003-2007 

Curriculum Vitae

Current Positions: 

Assistant Professor, Department of Pharmacology & Toxicology, University of Louisville School of Medicine, Louisville, KY

Member, Experimental Therapeutics & Diagnostics Program, Brown Cancer Center

Contact Information: 

Department of Pharmacology & Toxicology
University of Louisville
Clinical & Translational Research Building, Rm 118
505 South Hancock Street
Louisville, KY 40202
Phone:  (502) 821-4077
Email: 

Research Description: 

Since 2018, Dr. Hong has been working closely with Dr. David W. Hein, who is a leading expert in arylamine N-acetyltransferase (NAT) biology.  His current research efforts are focused on:  1) contribution of NAT1 to breast cancer growth and metastasis; 2) the role of human NAT2 in cellular metabolism and insulin sensitivity in hepatocytes; 3) the novel link between dietary exposure to heterocyclic amines (HCAs) and development of insulin resistance; and, most recently, 4) the bladder cancer risk allele of NAT2, rs1495741.

Literature Cited: 

  1. Hong KU, Gardner JQ, Doll MA, Stepp MW, Wilkey DW, Benz FW, Cai J, Merchant ML, Hein DW.  Dataset for proteomic analysis of arylamine N-acetyltransferase 1 knockout MDA-MB-231 breast cancer cells.  Data in Brief 2022 Sep 24;45:108634.  doi: 10.1016/j.dib.2022.108634.  eCollection 2022 Dec.  PMID: 36426076.  PMCID: PMC9679541
  2. Hong KU, Tagnedji AH, Doll MA, Walls KM, Hein DW.  Upregulation of cytidine deaminase in NAT1 knockout breast cancer cells.  Journal of Cancer Research & Clinical Oncology 2022 Nov 3.  doi: 10.1007/s00432-022-04436-w .  Online ahead of print.  PMID: 36329350.
  3. Hong KU, Gardner JQ, Doll MA, Stepp MW, Wilkey DW, Benz FW, Cai J, Merchant ML, Hein DW.  Proteomic analysis of arylamine N-acetyltransferase 1 knockout breast cancer cells: Implications in immune evasion and mitochondrial biogenesis.  Toxicology Reports 2022 Jul 19;9:1566-1573.  doi: 10.1016/j.toxrep.2022.07.010.  eCollection 2022.  PMID: 36158865.  PMCID: PMC9500399
  4. Hong KU, Salazar-González RA, Walls KM, Hein DW.  Transcriptional regulation of human arylamine N-acetyltransferase 2 gene by glucose and insulin in liver cancer cell lines.  Toxicolotical Sciences 2022 Nov 23;190(2):158-172.  doi: 10.1093/toxsci/kfac103.  PMID: 36156098.  PMCID: PMC9702998 (available on 2023-09-26).
  5. Doll MA, Ray AR, Salazar-González RA, Shah PP, Vega AA, Sears SM, Krueger AM, Hong KU, Beverly LJ, Hein DW.  Deletion of arylamine N-acetyltransferase 1 in MDA-MB-231 human breast cancer cells reduces primary and secondary tumor growth in vivo with no significant effects on metastasis.  Molecular Carcinogenesis 2022 May;61(5):481-493.  doi: 10.1002/mc.23392.  Epub 2022 Feb 8.  PMID: 35133049.  PMCID: PMC9018511 (available on 2023-05-01).
  6. Hong KU, Doll MA, Lykoudi A, Salazar-González RA, Habil MR, Walls KM, Bakr AF, Ghare SS, Barve SS, Arteel GE, Hein DW.  Acetylator genotype-dependent dyslipidemia in rats congenic for N-acetyltransferase2.  Toxicology Reports 2020 Sep 28;7:1319-1330.  doi: 10.1016/j.toxrep.2020.09.011.  PMID: 33083237.  PMCID: PMC7553889.
  7. Carlisle SM, Trainor PJ, Hong KU, Doll MA, Hein DW.  CRISPR/Cas9 knockout of human arylamine N-acetyltransferase 1 in MDA-MB-231 breast cancer cells suggests a role in cellular metabolism.  Scientific Reports 2020 Jun 17;10(1):9804.  doi: 10.1038/s41598-020-66863-4.  PMID: 32555504.  PMCID: PMC7299936.
  8. Stepp MW, Salazar-González RA, Hong KU, Doll MA, Hein DW.  N-Acetyltransferase 1 knockout elevates acetyl coenzyme A levels and reduces anchorage-independent growth in human breast cancer cell lines.  Journal of Oncology 2019 Aug 20;2019:3860426.  doi: 10.1155/2019/3860426.  PMID: 31531019.  PMCID: PMC6720663
  9. Al-Maqtari T, Hong KU, Vajravelu BN, Moktar A, Cao P, Moore JB 4th, Bolli R.  Transcription factor-induced activation of cardiac gene expression in human c-kit+ cardiac progenitor cells.  PLoS One 2017 Mar 29;12(3):e0174242.  doi: 10.1371/journal.pone.0174242.  PMID: 28355297.  PMCID: PMC5371315
  10. Vajravelu BN, Hong KU, Al-Maqtari T, Cao P, Keith MC, Wysoczynski M, Zhao J, Moore JB 4th, Bolli R.  C-Kit promotes growth and migration of human cardiac progenitor cells via the PI3K-AKT and MEK-ERK pathways.  PLoS One 2015 Oct 6;10(10):e0140798. doi: 10.1371/journal.pone.0140798.  eCollection 2015.  PMID: 26474484.  PMCID: PMC4608800

 

Complete List of Published Work in MyBibliography:

https://www.ncbi.nlm.nih.gov/myncbi/1dGr9mB_Lu75k/bibliography/public/