Education:

B.S., Applied Chemistry, Beijing Normal University, Beijing, China; 2002
Ph.D., Radiopharmaceutical Chemistry, Beijing Normal University, Beijing, China; 2007
Postdoctoral Fellowship, University of New Mexico, Albuquerque, NM; 2011

Curriculum Vitae

Current Positions:

Assistant Professor, Department of  Radiology

Contact Information:

Clinical Translational Research Building, Room 620
University of Louisville
505 South Hancock Street
Louisville, KY 40202, USA
Phone 502-852-5577
Fax 502-852-5468
Email: Haixun.guo@louisville.edu

Research Description:

Guo’s lab focuses on the theranostic applications of radiopharmaceuticals.  For diagnosis, we focus on the development of novel non-invasive PET (positron emission tomography) imaging biomarkers for early diagnosis and management of cancer and infection.  For therapy, we focus on developing novel targeted radiotherapy and radioimmunotherapy for melanoma, lung cancer, and pediatric brain tumor.

Representative Publications:

ImmunoPET of immune checkpoint for cancer immunotherapy

Caleb Bridgwater, Anne Geller, Xiaoling Hu, Joe Burlison, Huang-Ge Zhang, Jun Yan, Haixun Guo. (2020). 89Zr-labeled anti-PD-L1 antibody fragment for evaluating in vivo PD-L1 levels in melanoma mouse mode. Cancer Biother Radiopharm. 2020 35(8):549-557. PMID: 32315549

Molecular imaging agents for melanoma (MC1R)

Guo H, Yang J, Shenoy N, Miao Y.  Gallium-67-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide for primary and metastatic melanoma imaging.  Bioconjugate Chemistry 2009 Dec;20(12):2356-63. PMID: 19919057. PMCID: PMC3009454.

Guo H, Gallazzi F, Miao Y.  Gallium-67-labeled lactam bridge-cyclized alpha-MSH peptides with enhanced melanoma uptake and reduced renal uptake.  Bioconjugate Chemistry 2012 Jun 20;23(6):1314-48. PMID: 22621181. PMCID: PMC3440555.

Guo H, Yang J, Gallazzi F, Miao Y.  Reduction of the ring size of radiolabeled lactam bridge-cyclized alpha-MSH peptide resulting in enhanced melanoma uptake.  Journal of Nuclear Medicine 2010 Mar;51(3):418-26. PMID: 20150256. PMCID: PMC2998183.

Guo H, and Miao Y.  Introduction of an 8-aminooctanoic acid linker enhances uptake of 99mTc-labeled lactam bridge-cyclized α-MSH peptide in melanoma.  Journal of Nuclear Medicine 2014 Dec;55(12):2057-63. PMID: 25453052. PMCID: PMC4545635.

Structure optimization of peptide imaging agent

Guo H, Yang J, Gallazzi F, Prossnitz ER, Sklar LA, Miao Y.  Effect of DOTA position on melanoma targeting and pharmacokinetic properties of 111In-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide.  Bioconjugate Chemistry 2009 Nov;20(11):2162-8. PMID: 19817405. PMCID: PMC2786309.

Guo H, Yang J, Gallazzi F, Miao Y.  Effects of the amino acid linkers on the melanoma-targeting and pharmacokinetic properties of 111In-labeled lactam bridge-cyclized α-MSH peptides.  Journal of Nuclear Medicine 2011 Apr;52(4):608-16. PMID: 21421725. PMCID: PMC3065533.

Guo H, Miao Y.  Cu-64-labeled lactam bridge-cyclized α-MSH peptides for PET imaging of melanoma.  Molecular Pharmaceutics 2012 Aug 6;9(8):2322-30. PMID: 22780870. PMCID: PMC3480965.

Guo H, Miao Y.  Introduction of an 8-aminooctanoic acid linker enhances uptake of 99mTc-labeled lactam bridge-cyclized α-MSH peptide in melanoma.  Journal of Nuclear Medicine 2014 Dec;55(12):2057-63. PMID: 25453052. PMCID: PMC4545645.

GnRHR-targeting imaging agent

Guo H, Lu J, Hathaway H, Royce ME, Prossnitz ER, Miao Y.  Synthesis and evaluation of novel gonadotropin-releasing hormone receptor-targeting peptides.  Bioconjugate Chemistry 2011 Aug 17;22(8):1682-9. PMID: 21749045. PMCID: PMC3157568.

Guo H, Gallazzi F, Sklar LA, Miao Y.  A novel indium-111-labeled gonadotropin-releasing hormone peptide for human prostate cancer imaging.  Bioorganic & Medicinal Chemistry Letters 2011 Sep 15;21(18):5184-7. PMID: 21821417. PMCID: PMC3159814.

Guo H, Hathaway H, Royce ME, Prossnitz ER, Miao Y.  Influences of hydrocarbon linkers on the receptor binding affinities of gonadotropin-releasing hormone peptides.  Bioorganic & Medicinal Chemistry Letters 2013 Oct 15;23(20):5484-7. PMID: 24018188. PMCID: PMC3778074.

PubMed Information