David J. Samuelson, Ph.D.

Education:David J. Samuelson, Ph.D. 

B.S. in Animal Science, University of Minnesota-Twin Cities, St. Paul, Minnesota; 1985-1990
M.S. in Quantitative Genetics, Virginia Tech, Blacksburg, Virginia; 1990-1992
Ph.D. in Cancer Biology, University of Arizona, Tucson, Arizona; 1996-2001
Postdoctoral Training, Breast Cancer Genetics & Susceptibility, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin; 2001-2007

Curriculum Vitae 

Current Positions: 

Associate Professor with Tenure, Department of Biochemistry & Molecular Genetics, University of Louisville School of Medicine, Louisville, Kentucky
Director of Seminar Programs, Center for Genetics & Molecular Medicine, University of Louisville School of Medicine, Louisville, Kentucky
Member, James Graham Brown Cancer Center 

Contact Information: 

Department of Biochemistry & Molecular Biology
Delis B. Baxter Biomedical Sciences Research Building, 221C
580 South Preston Street
Louisville, KY 402020
Phone: 502/852-7797
Email: 

Research Description: 

Dr. Samuelson’s research laboratory is interested in breast cancer susceptibility and prevention. 

Literature Cited: 

  1. Duderstadt EL, Sanders MA, Samuelson DJ.  A method to pre-screen rat mammary gland whole-mounts prior to RNAscope.  Journal of Mammary Gland Biology & Neoplasia 2021 Apr 17.  doi: 10.1007/s10911-021-09484-5.  Epub ahead of print.  PMID: 33866475.
  2. Duderstadt EL, McQuaide SA, Sanders MA, Samuelson DJ.  Chemical carcinogen- induced rat mammary carcinogenesis is a potential model of p21-activated kinase positive female breast cancer.  Physiological Genomics 2021 Feb 1;53(2):61-68.  doi: 10.1152/physiolgenomics.00112.2020.  Epub 2020 Dec 21.  PMID: 33346690.  PMCID: PMC7948085.
  3. Le S, Martin ZC, Samuelson DJ.  Physical confirmation and comparative genomics of the rat Mammary carcinoma susceptibility 3 quantitative trait locus.  G3(Bethesda) 2017 Jun 7;7(6):1767-1773.  doi: 10.1534/g3.117.039388.  PMID: 28391240.  PMCID: PMC5473756.
  4. Stepp MW, Doll MA, Samuelson DJ, Sanders MA, States JC, Hein DW.  Congenic rats with higher arylamine N-acetyltransferase 2 activity exhibit greater carcinogen-induced mammary tumor susceptibility independent of carcinogen metabolism.  BMCCancer 2017 Mar 31;17(1):233.  doi: 10.1186/s12885-017-3221-9.  PMID: 28359264.  PMCID: PMC5374573.
  5. Xu X, Ren X, Wang H, Zhao Y, Yi Z, Wang K, Zhang S, Wang L, Samuelson DJ, Hu Z.  Identification and functional analysis of acute myeloid leukemia susceptibility associated single nucleotide polymorphisms at non-protein coding regions of RUNX1.  Leukemia & Lymphoma 2016;57(6):1442-9.  doi: 10.3109/10428194.2015.1094698.  Epub 2015 Oct 12.  PMID: 26374622.
  6. Xu X, Prough RA, Samuelson DJ.  Differential 12-O-tetradecanoylphorbol-13-acetate-induced activation of rat mammary carcinoma susceptibility Fbxo10 variant promoters via a PKC-AP1 pathway.  MolecularCarcinogenesis 2015 Feb;54(2):134-47.  doi: 10.1002/mc.22081.  Epub 2013 Sep 5.  PMID: 24008983.
  7. Sanders J, Samuelson DJ.  Significant overlap between human genome-wide association-study nominated breast cancer risk alleles and rat mammary cancer susceptibility loci.  Breast Cancer Research 2014 Jan 27;16(1):R14.  doi: 10.1186/bcr3607.  PMID: 24467842.  PMCID: PMC4054882.
  8. Xu X, Powell DW, Lambring CJ, Puckett AH, Deschenes L, Prough RA, Poeschla EM, Samuelson DJ.  Human MCS5A1 candidate breast cancer susceptibility gene FBXO10 is induced by cellular stress and correlated with lens epithelium-derived growth factor (LEDGF).  MolecularCarcinogesis 2014 Apr;53(4):300-13.  doi: 10.1002/mc.21977.  Epub 2012 Nov 8.  PMID: 23138933.
  9. denDekker AD, Xu X, Vaughn MD, Puckett AH, Gardner LL, Lambring CJ, Deschenes L, Samuelson DJ.  Rat Mcs1b is concordant to the genome-wide association-identified breast cancer risk locus at human 5q11.2 and MIER3 is a candidate cancer susceptibility gene.  CancerResearch 2012 Nov 15;72(22):6002-12.  doi: 10.1158/0008-5472.CAN-12-0748.  Epub 2012 Sep 19.  PMID: 22993404.  PMCID: PMC3500408.
  10. Devapatla B, Sanders J, Samuelson DJ.  Genetically determined inflammatory- response related cytokine and chemokine transcript profiles between mammary carcinoma resistant and susceptible rat strains.  Cytokine 2012 Aug;59(2):223-7.  doi: 10.1016/j.cyto.2012.04.037.  Epub 2012 May 18.  PMID: 22609213.  PMCID: PMC3377790.
  11. Smits BM, Sharma D, Samuelson DJ, Woditschka S, Mau B, Haag JD, Gould MN.  The non-protein coding breast cancer susceptibility locus Mcs5a acts in a non- mammary cell-autonomous fashion through the immune system and modulates T-cell homeostasis and functions.  BreastCancerResearch 2011 Aug 16;13(4):R81.  doi: 10.1186/bcr2933.  PMID: 21846333.  PMCID: PMC3236344.
  12. Sanders J, Haag JD, Samuelson DJ.  Physical confirmation and mapping of overlapping rat mammary carcinoma susceptibility QTLs, Mcs2 and Mcs6.  PLoSOne 2011;6(5):e19891.  doi: 10.1371/journal.pone.0019891.  Epub 2011 May 18.  PMID: 21625632.  PMCID: PMC3097214.
  13. Veillet AL, Haag JD, Remfert JL, Meilahn AL, Samuelson DJ, Gould MN.  Mcs5c: a mammary carcinoma susceptibility locus located in a gene desert that associates with tenascin C expression.  CancerPreventionResearch(Phila) 2011 Jan;4(1):97-106.  doi: 10.1158/1940-6207.CAPR-10-0187.  PMID: 21205740.  PMCID: PMC3447625.
  14. Samuelson DJ, Hesselson SE, Aperavich BA, Zan Y, Haag JD, Trentham-Dietz A, Hampton JM, Mau B, Chen KS, Baynes C, Khaw KT, Luben R, Perkins B, Shah M, Pharoah PD, Dunning AM, Easton DF, Ponder BA, Gould MN.  Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk.  Proceedings of the National Academy of Sciences USA 2007 Apr 10;104(15):6299-304.  doi: 10.1073/pnas.0701687104.  Epub 2007 Apr 2.  PMID: 17404222; PMCID: PMC1847458.
  15. Samuelson DJ, Aperavich BA, Haag JD, Gould MN. Fine mapping reveals multiple loci and a possible epistatic interaction within the mammary carcinoma susceptibility quantitative trait locus, Mcs5.  CancerResearch 2005 Nov 1;65(21):9637-42.  doi: 10.1158/0008-5472.CAN-05-1498.  PMID: 16266982.
  16. Haag JD, Shepel LA, Kolman BD, Monson DM, Benton ME, Watts KT, Waller JL, Lopez-Guajardo CC, Samuelson DJ, Gould MN.  Congenic rats reveal three independent Copenhagen alleles within the Mcs1 quantitative trait locus that confer resistance to mammary cancer.  CancerResearch 2003 Sep 15;63(18):5808-12.  PMID: 14522903.
  17. Samuelson DJ, Haag JD, Lan H, Monson DM, Shultz MA, Kolman BD, Gould MN.  Physical evidence of Mcs5, a QTL controlling mammary carcinoma susceptibility, in congenic rats.  Carcinogenesis 2003 Sep;24(9):1455-60.  doi: 10.1093/carcin/bgg112.  Epub 2003 Jul 4.  PMID: 12844486.
  18. Samuelson DJ, Powell MB, Lluria-Prevatt M, Romagnolo DF.  Transcriptional activation of the gp91phox NADPH oxidase subunit by TPA in HL-60 cells.  Journal of Leukocyte Biology 2001 Jan;69(1):161-8.  PMID: 11200061.