Chin K. Ng, Ph.D.

Education:Chin K. Ng, Ph.D.

B.S., Physics, Purdue University-Fort Wayne, IN; 1981
M.S., Medical Physics, University of Wisconsin-Madison, WI; 1986
Ph.D., Medical Physics, University of Wisconsin-Madison, WI; 1989

Curriculum Vitae 

Current Positions: 

Professor, Department of Radiology, University of Louisville
Professor (Associate Appointment), Department of Pharmacology & Toxicology, University of Louisville
Member, James Graham Brown Cancer Centre

Contact Information: 

Department of Radiology
530 South Jackson Street, CCB-C07
University of Louisville
Louisville, KY 40202
Phone:  502/852-5875
Email: 

Research Description: 

The Ng laboratory has three primary areas of interest:

  • Validating and characterizing novel imaging probes for multimodality imaging (MRI, PET, SPECT, CT and Optical)
  • Exploring approaches for early detection and monitoring of treatment efficacy of multiple diseases such as infectious diseases, cancer, spinal cord injury, brain diseases, diabetes and heart diseases.
  • Developing thermal laser ablation devices for treating spinal metastases in a MRI environment. 

Literature Cited: 

  1. Calderon LE, Black CA, Rollins JD, Overbay B, Shiferawe S, Elliott A, Reitz S, Liu S, Li J, Ng CK, Ndinguri MW.  Synthesis of radiolabeled Technetium- and Rhenium-luteinizing hormone-releasing hormone (99mTc/Re-Acdien-LHRH) conjugates for targeted detection of breast cancer cells overexpressing the LHRH receptor.  ACS Omega 2021 Jan 8;6(3):1846-1856.  doi: 10.1021/acsomega.0c03991.  PMID: 33521425.  PMCID: PMC7841779.
  2. Liu L, Jin R, Hao J, Zeng J, Yin D, Yi Y, Zhu M, Mandal A, Hua Y, Ng CK, Egilmez NK, Sauter ER, Li B.  Consumption of the fish oil high-fat diet uncouples obesity and mammary tumor growth through induction of reactive oxygen species in protumor macrophages.  CancerResearch 2020 Jun 15;80(12):2564-2574.  doi: 10.1158/0008-5472.CAN-19-3184.  Epub 2020 Mar 25.  PMID: 32213543.  PMCID: PMC7299802.
  3. Li J, Gray BD, Pak KY, Ng CK.  Targeting phosphatidylethanolamine and phosphatidylserine for imaging apoptosis in cancer.  Nuclear Medicine & Biology 2019 Nov-Dec;78-79:23-30.  doi: 10.1016/j.nucmedbio.2019.10.002.  Epub 2019 Oct 21.  PMID: 31678784.
  4. Zhu M, Akimana C, Wang E, Ng CK.  1H-MRS quantitation of age-dependent taurine changes in mouse brain.  Molecular Imaging & Biology 2019 Oct;21(5):812-817.  doi: 10.1007/s11307-019-01333-6.  PMID: 30815791.
  5. Chauhan R, El-Baz N, Keynton RS, James KT, Malik DA, Zhu M, El-Baz A, Ng CK, Bates PJ, Malik MT, O'Toole MG.  Targeted gold nanoparticle⁻oligonucleotide contrast agents in combination with a new local voxel-wise MRI analysis algorithm for in vitro imaging of triple-negative breast cancer.  Nanomaterials (Basel) 2019 May 7;9(5):709.  doi: 10.3390/nano9050709.  PMID: 31067749.  PMCID: PMC6566234.
  6. Gossman MS, Zheng H, Evans JG, Li J, Ng CK.  Assessment of radiopharmaceutical retention for vascular access ports using positron emission tomography imaging.  Journal of  Applied Clinical Medical Physics 2017 Nov;18(6):244-249.  doi: 10.1002/acm2.12196.  Epub 2017 Oct 5.  PMID: 28984069.  PMCID: PMC5689912.
  7. Zeng X, Li J, Ng CK, Hammond GB, Xu B.  (Radio)fluoroclick reaction enabled by a hydrogen-bonding cluster.  Angewandte Chemie International Edition in English 2018 Mar 5;57(11):2924-2928.  doi: 10.1002/anie.201711341.  Epub 2018 Feb 13.  PMID: 29276938.  PMCID: PMC6233894.
  8. Li J, Zheng H, Fodah R, Warawa JM, Ng CK.  Validation of 2-18F-fluorodeoxysorbitol as a potential radiopharmaceutical for imaging bacterial infection in the lung.  Journal of Nuclear Medicine 2018 Jan;59(1):134-139.  doi: 10.2967/jnumed.117.195420.  Epub 2017 Aug 28.  PMID: 28848037.
  9. Zhu M, Sun Z, Ng CK.  Image-guided thermal ablation with MR-based thermometry.  QuantitativeImagingin Medicine & Surgery 2017 Jun;7(3):356-368.  doi: 10.21037/qims.2017.06.06.  PMID: 28812002.  PMCID: PMC5537124.
  10. Malik MT, O'Toole MG, Casson LK, Thomas SD, Bardi GT, Reyes-Reyes EM, Ng CK, Kang KA, Bates PJ.  AS1411-conjugated gold nanospheres and their potential for breast cancer therapy.  Oncotarget 2015 Sep 8;6(26):22270-81.  doi: 10.18632/oncotarget.4207.  PMID: 26045302.  PMCID: PMC4673162.
  11. Li XF, Huang T, Jiang H, Wang X, Shen B, Wang X, Ng CK, Postel GC, Civelek AC.  Combined injection of (18)F-fluorodeoxyglucose and 3'-deoxy-3'-[(18)F]fluorothymidine PET achieves more complete identification of viable lung cancer cells in mice and patients than individual radiopharmaceutical: A proof-of-concept study.  Translational Oncology 2013 Dec 1;6(6):775-83.  doi: 10.1593/tlo.13577.  PMID: 24466381.  PMCID: PMC3890713.
  12. Li J, Zheng H, Bates PJ, Malik T, Li XF, Trent JO, Ng CK.  Aptamer imaging with Cu-64 labeled AS1411: preliminary assessment in lung cancer.  NuclearMedicine & Biology 2014 Feb;41(2):179-85.  doi: 10.1016/j.nucmedbio.2013.10.008.  Epub 2013 Oct 29.  PMID: 24373858.
  13. Downs RK, Bashir MH, Ng CK, Heidenreich JO.  Quantitative contrast ratio comparison between T1 (TSE at 1.5T, FLAIR at 3T), magnetization prepared rapid gradient echo and subtraction imaging at 1.5T and 3T.  QuantitativeImagingin Medicine & Surgery 2013 Jun;3(3):141-6.  doi: 10.3978/j.issn.2223-4292.2013.05.02.  PMID: 23833727.  PMCID: PMC3701100.
  14. Huang T, Civelek AC, Zheng H, Ng CK, Duan X, Li J, Postel GC, Shen B, Li XF.  (18)F-misonidazole PET imaging of hypoxia in micrometastases and macroscopic xenografts of human non-small cell lung cancer: a correlation with autoradiography and histological findings.  American Journal of Nuclear Medicine & Molecular Imaging 2013;3(2):142-53.  Epub 2013 Mar 8.  PMID: 23526377.  PMCID: PMC3601474.
  15. Li Y, Woodall C, Wo JM, Zheng H, Ng CK, Ray MB, Martin RC.  The use of dynamic positron emission tomography imaging for evaluating the carcinogenic progression of intestinal metaplasia to esophageal adenocarcinoma.  CancerInvestigation 2008 Apr-May;26(3):278-85.  doi: 10.1080/07357900701708401.  PMID: 18317969.