Help for Treatment-resistant Depression

Because about 20% of persons with major depressive disorder develop chronic symptoms that do not respond to standard courses of antidepressants, a specialized treatment plan may be needed to work toward full recovery. Clinicians at the University of Louisville Depression Center use detailed treatment guidelines to chart a course of systematically attacking treatment-resistant depression. Use of multiple medications, augmenting strategies (combining antidepressants with other medications that can boost their effectiveness), psychotherapies which have been shown to be helpful in chronic depression, and advanced biological approaches may be recommended.