The UofL Alcohol Research Center well represented at RSA 2019

The UofL Alcohol Research Center was well represented at RSA 2019. There were 9 poster presentations and five of our investigators gave talks and three organized meeting sessions.

RSA 2019—Posters

 

“Cathelicidin Deficiency Exacerbates Alcohol-Induced Liver Injury via Uric Acid-Mediated Inflammasome Activation”.  F Li, V Vatsalya, C McClain, W Feng

 

“Metagenomic analyses reveal a significant enrichment of “pro-inflammatory” Enterobacteriaceae associated with very heavy alcohol use and HIV infection”.  R Singhal, R Smith, K Stocke, S Ghare, M Vadhanam, D Lioznov, E Krupitsky, K Armah, N Gnatienko, J Samet, K Bryant, C McClain, M Freiberg, S Barve

 

“Association of elevated uric acid with liver injury, gut-barrier dysfunction and inflammation; and efficacy of abstinence, treatment with thiamine in early alcoholic liver disease”.  V Vatsalya, A Sutrawe, F Li, M Mishra, N Shah, W Feng, CJ McClain

 

“Sulforaphane Protects Against Ethanol-induced Apoptosis in Human Neural Crest Cells Through Epigenetically Modulating The Expression of Anti-apoptotic Genes”.  Y Li, F Yuan, T Wu, L Lu, J Liu, S-y Chen

 

“Exosomal shuttling of miR-126 from human neural crest cells mediated ethanol-induced repression of SDF1/CXCR4 and disruption of neural crest cell-placode interaction”. H Fan, F Yuan, T Wu, L Lu, JLiu, S-y Chen.

 

“Prenatal ethanol exposure induced global remodeling of the enhancer landscape in a zebrafish model of fetal alcohol spectrum disorders”.  F Yuan, Y Yun, H Fan, L Lu, T Wu, J Liu, S-y Chen.

 

“Disruption of maternal folate-producing gut microbiota is associated with ethanol-induced folate deficiency and teratogenesis”.  T Wu, F Yuan, Y Li, H Fan, L Lu, J Liu, S-y Chen 

 

“Interaction of Heavy Drinking Patterns and Depression Severity Predicts Efficacy of Q!uetiapine Fumarate XR in Lovering Alcohol Intake in Alcohol Dependent Patients”.  V Vatsalya, LM Marsano, KV Chandras, N Sinha, S Kumar, ML Schwandt, VA Ramchandani, CJ McClain

 

“Elevated Uric Acid is Associated with Liver Cell Death/Injury, Gut Barrier Dysfunction and Inflammation in Alcohol Dependents with Liver Injury”.  V Vatsalya, F Li, N Shah, W Feng, CJ McClain

 

 

RSA 2019—Talks/Symposium Organizer:

 

Shirish Barve:

Symposium Organizer: RSA 2019 Symposium: Alcohol and HIV-1 Induced Pathogenic Changes in the Gut-Liver-Brain Axis

 

Talk:  “Metagenomic Analyses of the Gut-Microbial Dysbiosis Among HIV-Positive Heavy Drinkers”  In: HIV, Alcohol and Comorbidity: From the Microbiome and Immunity to Clinical Outcomes.

 

Smita Ghare:

Talk:  “The role of alcohol and HIV-1 infection in gut and vaginal microbial dysbiosis in women and reproductive health”. 

In: Alcohol and HIV: Building a Global Alcohol Research Agenda for Reproductive Health of People Affected by HIV/AIDS.

 

Leila Gobejishvili:

Talk:  “Alcohol and HIV-1 Induced Pathogenic Changes in the Gut-Liver-Brain Axis”. In:  HIV, Alcohol and Comorbidity: From the Microbiome and Immunity to Clinical Outcomes.

 

Irina Kirpich

Symposium Organizer: RSA 2019 Symposium: Alcohol-induced alterations in the gut-liver axis: novel mechanistic insights into metabolic, immune, epithelial and microbial crosstalk.

 

Talk:  “Beneficial Effects of Lowering Ω-6:Ω-3 PUFA Ratio on Ethanol-Mediated Alterations in the Intestinal Homeostasis, Gut Microbiome and Liver Injury in Mice”

 

Craig McClain:

Symposium Organizer and Discussant: RSA 2019 Symposium: Alcohol-induced alterations in the gut-liver axis: novel mechanistic insights into metabolic, immune, epithelial and microbial crosstalk.

 

Talk:  “Nutrition:Alcohol:Gut/Microbiome Interactions and ALD In: Translating Microbiota Research Into Clinical Practice for Alcoholic Hepatitis.