Donald M. Miller, M.D., Ph.D.

Donald M. Miller, M.D., Ph.D. Professor of Medicine and Pharmacology Chief, Division of Medical Oncology and Hematology Director, James Graham Brown Cancer Center James Graham Brown Foundation Chair James Graham Brown Cancer Center 530 South Jackson Street Louisville, KY 40202 502-852-2522 - Academic Office 502-562-4370 - Patient Appointments

Clinical Expertise

Head and Neck; Medical Oncology; Skin Cancer; Melanoma

Board Certifications

• American Board of Internal Medicine - Internal Medicine

Education and Training

• Medical School: Duke University

• Residency: Peter Bent Brigham Hospital, Boston Mass.

• Fellowship: Harvard University

• Ph.D.: Duke University

Recent Publications

• Deng ZB, Zhuang X, Ju S, Xiang X, Mu J, Liu Y, Jiang H, Zhang L, Mobley J, McClain C, Feng W, Grizzle W, Yan J, Miller D, Kronenberg M, Zhang HG. Exosome-like Nanoparticles from Intestinal Mucosal Cells Carry Prostaglandin E2 and Suppress Activation of Liver NKT Cells. J Immunol. 2013 Apr 1;190(7):3579-89. doi: 10.4049/jimmunol.1203170. Epub 2013 Mar 6. PubMed PMID: 23467936.

• Deng ZB, Zhuang X, Ju S, Xiang X, Mu J, Wang Q, Jiang H, Zhang L, Kronenberg M, Yan J, Miller D, Zhang HG. Intestinal mucus-derived nanoparticle-mediated activation of Wnt/β-catenin signaling plays a role in induction of liver natural killer T cell anergy in mice. Hepatology. 2013 Mar;57(3):1250-61. doi: 10.1002/hep.26086. Epub 2013 Feb 11. PubMed PMID: 22991247.

• Islam MA, Thomas SD, Sedoris KJ, Slone SP, Alatassi H, Miller DM. Tumor-associated primo vascular system is derived from xenograft, not host. Exp Mol Pathol. 2013 Feb;94(1):84-90. doi: 10.1016/j.yexmp.2012.09.004. Epub 2012 Sep 19. PubMed PMID: 23000426.

• Miller DM, Thomas SD, Islam A, Muench D, Sedoris K. c-Myc and cancer metabolism. Clin Cancer Res. 2012 Oct 15;18(20):5546-53. doi: 10.1158/1078-0432.CCR-12-0977. PubMed PMID: 23071356; PubMed Central PMCID: PMC3505847.

• Deng Z, Cheng Z, Xiang X, Yan J, Zhuang X, Liu C, Jiang H, Ju S, Zhang L, Grizzle W, Mobley J, Roman J, Miller D, Zhang HG. Tumor cell cross talk with tumor-associated leukocytes leads to induction of tumor exosomal fibronectin and promotes tumor progression. Am J Pathol. 2012 Jan;180(1):390-8. doi: 10.1016/j.ajpath.2011.09.023. Epub 2011 Nov 7. PubMed PMID: 22067905.

• Sedoris KC, Thomas SD, Clarkson CR, Muench D, Islam A, Singh R, Miller DM. Genomic c-Myc quadruplex DNA selectively kills leukemia. Mol Cancer Ther. 2012 Jan;11(1):66-76. doi: 10.1158/1535-7163.MCT-11-0515. Epub 2011 Nov 14. PubMed PMID: 22084162.

• Xiang X, Deng Z, Zhuang X, Ju S, Mu J, Jiang H, Zhang L, Yan J, Miller D, Zhang HG. Grhl2 determines the epithelial phenotype of breast cancers and promotes tumor progression. PLoS One. 2012;7(12):e50781. doi: 10.1371/journal.pone.0050781. Epub 2012 Dec 17. PubMed PMID: 23284647; PubMed Central PMCID: PMC3524252.

• Telang S, Rasku MA, Clem AL, Carter K, Klarer AC, Badger WR, Milam RA, Rai SN, Pan J, Gragg H, Clem BF, McMasters KM, Miller DM, Chesney J. Phase II trial of the regulatory T cell-depleting agent, denileukin diftitox, in patients with unresectable stage IV melanoma. BMC Cancer. 2011 Dec 13;11:515. doi: 10.1186/1471-2407-11-515. PubMed PMID: 22165955; PubMed Central PMCID: PMC3293785.

• Natarajan N, Telang S, Miller D, Chesney J. Novel immunotherapeutic agents and small molecule antagonists of signalling kinases for the treatment of metastatic melanoma. Drugs. 2011 Jul 9;71(10):1233-50. doi: 10.2165/11591380-000000000-00000. Review. PubMed PMID: 21770473.

• Schwartzentruber DJ, Lawson DH, Richards JM, Conry RM, Miller DM, Treisman J, Gailani F, Riley L, Conlon K, Pockaj B, Kendra KL, White RL, Gonzalez R, Kuzel TM, Curti B, Leming PD, Whitman ED, Balkissoon J, Reintgen DS, Kaufman H, Marincola FM, Merino MJ, Rosenberg SA, Choyke P, Vena D, Hwu P. gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma. N Engl J Med. 2011 Jun 2;364(22):2119-27. doi: 10.1056/NEJMoa1012863. PubMed PMID: 21631324; PubMed Central PMCID: PMC3517182.