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Department of Medicine

Craig J. McClain, M.D.

by Puckett,Paul J — last modified Mar 25, 2013 04:00 PM

Craig J. McClain, M.D.





Craig J. McClain, M.D.

  • Professor of Medicine, Pharmacology and Toxicology
  • Chief of Research Affairs, Division of Gastroenterology, Hepatology and Nutrition
  • Associate Vice President for Translational Research
  • Distinguished University Scholar
University of Louisville Health Care Outpatient Center
401 East Chestnut Street, Ste. 310
Louisville, KY 40202

502-852-7963 - Academic Office
502-813-6500 - Patient Appointments



ULP Digestive & Liver Health

Clinical Expertise

Alcoholic Liver Disease; Non-alcholic steatohepatitis; Nutrition


Board Certifications

  • American Board of Internal Medicine - Internal Medicine / Gastroenterology

  • Certification Board for Nutrition Specialists

  • American Board of Physician Nutrition Specialists

 

Education and Training

  • Medical School: University of Tennessee

  • Residency: University of Pittsburgh Hospitals

  • Fellowship: University of Minnesota Hospitals


Recent Publications

  • Song M, Schuschke DA, Zhou Z, Chen T, Shi X, Zhang J, Zhang X, Pierce WM, Johnson WT, Vos MB, McClain CJ. Modest fructose beverage intake causes liver injury and fat accumulation in marginal copper deficient rats. Obesity (Silver Spring). 2013 Mar 20. doi: 10.1002/oby.20380. [Epub ahead of print] PubMed PMID: 23512597.

  • Deng ZB, Zhuang X, Ju S, Xiang X, Mu J, Liu Y, Jiang H, Zhang L, Mobley J, McClain C, Feng W, Grizzle W, Yan J, Miller D, Kronenberg M, Zhang HG. Exosome-like Nanoparticles from Intestinal Mucosal Cells Carry Prostaglandin E2 and Suppress Activation of Liver NKT Cells. J Immunol. 2013 Mar 6. [Epub ahead of print] PubMed PMID: 23467936.

  • Kirpich IA, Feng W, Wang Y, Liu Y, Beier JI, Arteel GE, Falkner KC, Barve SS, McClain CJ. Ethanol and dietary unsaturated fat (corn oil/linoleic acid enriched) cause intestinal inflammation and impaired intestinal barrier defense in mice chronically fed alcohol. Alcohol. 2013 Feb 26. doi:pii: S0741-8329(13)00023-2. 10.1016/j.alcohol.2013.01.005. [Epub ahead of print] PubMed PMID: 23453163.

  • Rodrigo A, Alberts S, Cranston K, Kingsolver J, Lapp H, McClain C, Smith R, Vision T, Weintraub J, Wiegmann B. Science incubators: synthesis centers and their role in the research ecosystem. PLoS Biol. 2013 Jan;11(1):e1001468. doi: 10.1371/journal.pbio.1001468. Epub 2013 Jan 15. PubMed PMID: 23335860; PubMed Central PMCID: PMC3545866.

  • Wei X, Shi X, Zhong W, Zhao Y, Tang Y, Sun W, Yin X, Bogdanov B, Kim S, McClain C, Zhou Z, Zhang X. Chronic alcohol exposure disturbs lipid homeostasis at the adipose tissue-liver axis in mice: analysis of triacylglycerols using high-resolution mass spectrometry in combination with in vivo metabolite deuterium labeling. PLoS One. 2013;8(2):e55382. doi: 10.1371/journal.pone.0055382. Epub 2013 Feb 6. PubMed PMID: 23405143; PubMed Central PMCID: PMC3566154.

  • Bull-Otterson L, Feng W, Kirpich I, Wang Y, Qin X, Liu Y, Gobejishvili L, Joshi-Barve S, Ayvaz T, Petrosino J, Kong M, Barker D, McClain C, Barve S. Metagenomic analyses of alcohol induced pathogenic alterations in the intestinal microbiome and the effect of Lactobacillus rhamnosus GG treatment. PLoS One. 2013;8(1):e53028. doi: 10.1371/journal.pone.0053028. Epub 2013 Jan 9. PubMed PMID: 23326376; PubMed Central PMCID: PMC3541399.

  • Wahlang B, Beier JI, Clair HB, Bellis-Jones HJ, Falkner KC, McClain CJ, Cave MC. Toxicant-associated Steatohepatitis. Toxicol Pathol. 2013;41(2):343-60. doi: 10.1177/0192623312468517. Epub 2012 Dec 21. PubMed PMID: 23262638.

  • Hurt RT, Matheson PJ, Smith JW, Zakaria el R, Shaheen SP, McClain CJ, Garrison RN. Preservation of hepatic blood flow by direct peritoneal resuscitation improves survival and prevents hepatic inflammation following hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol. 2012 Nov 15;303(10):G1144-52. doi: 10.1152/ajpgi.00278.2011. Epub 2012 Sep 20. PubMed PMID: 22997198; PubMed Central PMCID: PMC3517650.

  • Mohammad MK, Avila D, Zhang J, Barve S, Arteel G, McClain C, Joshi-Barve S. Acrolein cytotoxicity in hepatocytes involves endoplasmic reticulum stress, mitochondrial dysfunction and oxidative stress. Toxicol Appl Pharmacol. 2012 Nov 15;265(1):73-82. doi: 10.1016/j.taap.2012.09.021. Epub 2012 Sep 28. PubMed PMID:  23026831; PubMed Central PMCID: PMC3501104.

  • Liu Y, Wang C, Wang Y, Ma Z, Xiao J, McClain C, Li X, Feng W. Cobalt chloride decreases fibroblast growth factor-21 expression dependent on oxidative stress but not hypoxia-inducible factor in Caco-2 cells. Toxicol Appl Pharmacol. 2012 Oct 15;264(2):212-21. doi: 10.1016/j.taap.2012.08.003. Epub 2012 Aug 10. PubMed PMID: 22917661; PubMed Central PMCID: PMC3593348.

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