Division of Environmental Medicine

Welcome to University of Louisville's Division of Environmental Medicine, a division within the UofL Department of Medicine.

Mission

The Division of Environmental Medicine was created in 2018 within the Department of Medicine with the mission to understand the relationships between the environment and human health towards preventing and mitigating chronic disease through environmental adaptations and interventions. The division supports a multidisciplinary research program focused on studying how environmental conditions and characteristics relate to the development, mitigation, or prevention of cardiovascular and metabolic disease (e.g. heart disease, diabetes). Faculty within the division conduct place-based clinical and basic research, educate the next generation of environmental health and medicine scientists, and engage with Louisville communities.

 

Environmental Medicine

Environmental medicine is a multidisciplinary field involving environmental science, medicine, chemistry, toxicology, epidemiology, sociology, and other disciplines. It is a specialized form of environmental health, a branch of public health, which advances health and well-being by identifying and limiting exposure to hazardous agents in the environment. Environmental medicine scientists study how these environmental exposures are related to the causes and effects of disease and test interventions that can prevent and mitigate disease formation and progression.   

 

Research Foci

Natural Environment

  • Effects of green environments on cardiovascular and metabolic diseases
  • Relationships between components of nature, such as pollen and biodiversity, on human health  
  • How fundamental systems of the ecosphere (air, water, and soil) contribute to human health, wellbeing, or disease


Social Environment

  • Effects of ambient and roadway air pollution (PM2.5) on cardiovascular and metabolic disease progression
  • Effects of volatile organic compounds (VOCs) on the cardiovascular and metabolic disease progression
  • Developing methods to spatially visualize pollution and disease risk and burdens among communities


Personal Environment

  • Effects of tobacco and vaping on cardiovascular and metabolic disease progression
  • Relationships between lifestyle patterns (sleep, diet, exercise) and cardiovascular and metabolic disease progression
  • Developing novel approaches to measure environmental factors that impact human health, wellbeing, or disease

 

The Envirome

The Human Envirome is the complete set of natural, social, and personal conditions that shape each person's health. Unique to every person, over the course of their lifetime, their envirome regulates and influences development, disease risk, physical and mental health, and lifespan.

The Christina Lee Brown Envirome Institute is an affiliated research institute within the Division of Environmental Medicine. Researchers within the Envirome Institute study how conditions of the human envirome promote health or instigate disease.  Learn more about the Envirome Institute.

 

Publications

Article TitleCitationDate
Considerations for using isolated cell systems to understand cardiac metabolism and biologyMcNally, Lindsey A., et al. "Considerations for using isolated cell systems to understand cardiac metabolism and biology." Journal of Molecular and Cellular Cardiology (2021).4/1/2021
Electronic Cigarette Solvents, Pulmonary Irritation and Endothelial Dysfunction:Role of Acetaldehyde and FormaldehydeJin, Lexiao, et al. "Electronic Cigarette Solvents, Pulmonary Irritation and Endothelial Dysfunction: Role of Acetaldehyde and Formaldehyde." American Journal of Physiology-Heart and Circulatory Physiology (2021).2/5/2021
Urinary Levels of the Acrolein Conjugates of Carnosine Are Associated with Cardiovascular Disease RiskO’Toole, Timothy E., et al. "Urinary Levels of the Acrolein Conjugates of Carnosine Are Associated with Cardiovascular Disease Risk." International Journal of Molecular Sciences 22.3 (2021): 1383.1/30/2021
Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvβ ProteinsOhanyan, Vahagn, et al. "Myocardial Blood Flow Control by Oxygen Sensing Vascular Kvβ Proteins." Circulation Research (2021).1/27/2021
Wastewater Surveillance Can Have a Second Act in COVID-19 Vaccine DistributionSmith, Ted, Gail Cassell, and Aruni Bhatnagar. "Wastewater Surveillance Can Have a Second Act in COVID-19 Vaccine Distribution." JAMA Health Forum. Vol. 2. No. 1. American Medical Association, 2021.1/11/2021
Residential Proximity to Greenness Mitigates the Hemodynamic Effects of Ambient Air PollutionRiggs, Daniel W., et al. "Residential Proximity to Greenness Mitigates the Hemodynamic Effects of Ambient Air Pollution." American Journal of Physiology-Heart and Circulatory Physiology.1/8/2021
Transient Cell Cycle Induction in Cardiomyocytes to Treat Ischemic Heart FailureAbouleisa, Riham, et al. "Transient Cell Cycle Induction in Cardiomyocytes to Treat Ischemic Heart Failure." (2020).12/28/2020
Environmental Health in the Time of COVID-19Silva, Raquel, and Natasha DeJarnett. "Environmental Health in the Time of COVID-19." APHA's 2020 VIRTUAL Annual Meeting and Expo (Oct. 24-28). American Public Health Association, 2020.12/24/2020
Emerging technology and platforms for cardiotoxicity testingMohamed, Tamer MA, and Daniel J. Conklin. "Emerging technology and platforms for cardiotoxicity testing." (2020): 115262.12/1/2020
Cardiomyocyte Oga haploinsufficiency increases O-GlcNAcylation but hastens ventricular dysfunction following myocardial infarctionDassanayaka, Sujith, et al. "Cardiomyocyte Oga haploinsufficiency increases O-GlcNAcylation but hastens ventricular dysfunction following myocardial infarction." Plos one 15.11 (2020): e0242250.11/30/2020
E-cigarette Aerosol Exposure Acutely Alters Cardiac Conduction and Autonomic Balance and Induces Arrhythmia in MiceCarll, Alex P., et al. "E-cigarette Aerosol Exposure Acutely Alters Cardiac Conduction and Autonomic Balance and Induces Arrhythmia in Mice." Circulation 142.Suppl_3 (2020): A17343-A17343.11/12/2020
Effects of Electronic Cigarette Solvents on Endothelial DysfunctionJin, Lexiao, et al. "Effects of Electronic Cigarette Solvents on Endothelial Dysfunction." Circulation 142.Suppl_3 (2020): A17100-A17100.11/12/2020
Influence of Cardiac Workload on Vascular Pyridine Nucleotide Redox StateDwenger, Marc, Joseph Moore, and Matthew A. Nystoriak. "Influence of Cardiac Workload on Vascular Pyridine Nucleotide Redox State." Circulation 142.Suppl_3 (2020): A17038-A17038.11/12/2020
Transient Cell Cycle Induction in Cardiomyocytes is a Promising Approach to Treat Ischemia Induced Heart FailureAbouleisa, Riham, et al. "Transient Cell Cycle Induction in Cardiomyocytes is a Promising Approach to Treat Ischemia Induced Heart Failure." Circulation 142.Suppl_3 (2020): A14391-A14391.11/12/2020
Urinary levels of the acrolein conjugates of carnosine are associated with inhaled toxicantsO’Toole, Timothy E., et al. "Urinary levels of the acrolein conjugates of carnosine are associated with inhaled toxicants." Inhalation Toxicology 32.13-14 (2020): 468-476.11/12/2020
Guidance to Reduce the Cardiovascular Burden of Ambient Air Pollutants: A Policy Statement From the American Heart AssociationKaufman, Joel D., et al. "Guidance to reduce the cardiovascular burden of ambient air pollutants: a policy statement from the American Heart Association." Circulation 142.23 (2020): e432-e447.11/5/2020
Heart slice culture system reliably demonstrates clinical drug-related cardiotoxicityMiller, Jessica M., et al. "Heart slice culture system reliably demonstrates clinical drug-related cardiotoxicity." Toxicology and Applied Pharmacology 406 (2020): 115213.11/1/2020
Unraveling the Molecular Signature of Pregnancy Induced HypertrophyCollins, Helen E., et al. "Unraveling the Molecular Signature of Pregnancy Induced Hypertrophy." Circulation Research. Vol. 127. No. Suppl_1. Hagerstown, MD: Lippincott Williams & Wilkins, 2020.10/27/2020
Phosphofructokinase Coordinates Anabolic Pathways in the HeartFulghum, Kyle L., et al. "Phosphofructokinase Coordinates Anabolic Pathways in the Heart." Circulation Research. Vol. 127. No. Suppl_1. Hagerstown, MD: Lippincott Williams & Wilkins, 2020.10/27/2020
Metabolic Reprogramming is Essential for Cell Cycle Progression in CardiomyocytesAbouleisa, Riham, et al. "Metabolic Reprogramming is Essential for Cell Cycle Progression in Cardiomyocytes." Circulation Research. Vol. 127. No. Suppl_1. Hagerstown, MD: Lippincott Williams & Wilkins, 2020.10/27/2020
Substrate Dependence of Mitochondrial Supercomplex Abundance in Murine HeartAltamimi, Tariq R., et al. "Substrate Dependence of Mitochondrial Supercomplex Abundance in Murine Heart." Circulation Research. Vol. 127. No. Suppl_1. Hagerstown, MD: Lippincott Williams & Wilkins, 2020.10/27/2020
70 Years after Nuclear Bomb Testing: How Radioactive Waste Still Plagues a San Francisco Community and Threatens Public HealthDeJarnett, Natasha, and Katlyn McGraw. "70 Years after Nuclear Bomb Testing: How Radioactive Waste Still Plagues a San Francisco Community and Threatens Public Health." APHA's 2020 VIRTUAL Annual Meeting and Expo (Oct. 24-28). American Public Health Association, 2020.10/24/2020
168-OR: The Inverse Association between Cardiorespiratory Fitness and Inflammation Is Modified by Plasma Levels of Omega-3 Polyunsaturated Fatty AcidsFarley, Gabrielle, et al. "168-OR: The Inverse Association between Cardiorespiratory Fitness and Inflammation Is Modified by Plasma Levels of Omega-3 Polyunsaturated Fatty Acids." (2020).10/19/2020
Smoking Accelerates Atrioventricular Conduction in Humans Concordant with Increased Dopamine ReleaseIrfan, Affan B., et al. "Smoking Accelerates Atrioventricular Conduction in Humans Concordant with Increased Dopamine Release." Cardiovascular toxicology (2020): 1-10.10/12/2020
Intracellular pH Regulation of Skeletal Muscle in the Milieu of Insulin SignalingPosa, Dheeraj Kumar, and Shahid P. Baba. "Intracellular pH Regulation of Skeletal Muscle in the Milieu of Insulin Signaling." Nutrients 12.10 (2020): 2910.9/23/2020
Working Toward Elimination of Hepatitis C: The Kentucky Hepatitis Academic Mentorship ProgramCave, Barbra, et al. "working Toward elimination of Hepatitis C: The Kentucky Hepatitis academic Mentorship Program." Clinical Liver Disease 16.3 (2020): 123.9/22/2020
Administration of cardiac mesenchymal cells modulates innate immunity in the acute phase of myocardial infarction in miceKang, Yi, et al. "Administration of cardiac mesenchymal cells modulates innate immunity in the acute phase of myocardial infarction in mice." Scientific Reports 10.1 (2020): 1-13.9/8/2020
Acute and chronic vascular effects of inhaled crotonaldehyde in mice: Role of TRPA1Lynch, Jordan, et al. "Acute and chronic vascular effects of inhaled crotonaldehyde in mice: Role of TRPA1." Toxicology and Applied Pharmacology 402 (2020): 115120.9/1/2020
Statistical design of Phase II/III clinical trials for testing therapeutic interventions in COVID-19 patientsRai, Shesh N., et al. "Statistical design of Phase II/III clinical trials for testing therapeutic interventions in COVID-19 patients." BMC medical research methodology 20.1 (2020): 1-16.8/31/2020
Tobacco Smoke and Endothelial Dysfunction: Role of Aldehydes?Lynch, Jordan, et al. "Tobacco Smoke and Endothelial Dysfunction: Role of Aldehydes?." Current Hypertension Reports 22.9 (2020): 1-9.8/28/2020
Wastewater sample site selection to estimate geographically-resolved community prevalence of COVID-19: A research protocolYeager, Ray A., et al. "Wastewater sample site selection to estimate geographically-resolved community prevalence of COVID-19: A research protocol." medRxiv (2020).8/25/2020
Evidence and magnitude of seasonality in SARS-CoV-2 transmission: Penny wise, pandemic foolish?Kaplin, Adam Ian, et al. "Evidence and magnitude of seasonality in SARS-CoV-2 transmission: Penny wise, pandemic foolish?." medRxiv (2020).8/18/2020
Space Flight Diet-Induced Deficiency and Response to Gravity-Free Resistive ExerciseBaba, Shahid, et al. "Space Flight Diet-Induced Deficiency and Response to Gravity-Free Resistive Exercise." Nutrients 12.8 (2020): 2400.8/11/2020
Endothelial Overexpression of Metallothionein Prevents Diabetes-Induced Impairment in Ischemia Angiogenesis Through Preservation of HIF-1α/SDF-1/VEGF Signaling in Endothelial Progenitor CellsWang, Kai, et al. "Endothelial Overexpression of Metallothionein Prevents Diabetes-Induced Impairment in Ischemia Angiogenesis Through Preservation of HIF-1α/SDF-1/VEGF Signaling in Endothelial Progenitor Cells." Diabetes 69.8 (2020): 1779-1792.8/1/2020
Macrophage Long Non-Coding RNAs in Pathogenesis of Cardiovascular DiseaseWysoczynski, Marcin, et al. "Macrophage Long Non-Coding RNAs in Pathogenesis of Cardiovascular Disease." Non-coding RNA 6.3 (2020): 28.7/11/2020
A realistic appraisal of the use of embryonic stem cell-based therapies for cardiac repairWysoczynski, Marcin, and Roberto Bolli. "A realistic appraisal of the use of embryonic stem cell-based therapies for cardiac repair." European heart journal 41.25 (2020): 2397-2404.7/1/2020
Environmental Health Leadership on Climate Solutions Amidst COVID-19Perkowitz, Robert M., et al. "Environmental Health Leadership on Climate Solutions Amidst COVID-19." Journal of Environmental Health 83.1 (2020): 38-40.7/1/2020
Association Between Volatile Organic Compounds and Endothelial Injury and RepairMalovichko, Marina, et al. "Association Between Volatile Organic Compounds and Endothelial Injury and Repair." Arteriosclerosis, Thrombosis, and Vascular Biology 40.Suppl_1 (2020): A322-A322.6/29/2020
Cardiac mesenchymal cells from failing and nonfailing hearts limit ventricular dilation when administered late after infarctionAudam, Timothy N., et al. "Cardiac mesenchymal cells from failing and nonfailing hearts limit ventricular dilation when administered late after infarction." American Journal of Physiology-Heart and Circulatory Physiology 319.1 (2020): H109-H122.6/24/2020
Space Flight Diet-Induced Deficiency and Response to Gravity-Free Resistive ExerciseBaba, Shahid, et al. "Space Flight Diet-Induced Deficiency and Response to Gravity-Free Resistive Exercise." Nutrients 12.8 (2020): 2400.6/12/2020
Cardiospecific Overexpression of ATPGD1 (Carnosine Synthase) Increases Histidine Dipeptide Levels and Prevents Myocardial Ischemia Reperfusion InjuryZhao, Jingjing, et al. "Cardiospecific overexpression of ATPGD1 (carnosine synthase) increases histidine dipeptide levels and prevents myocardial ischemia reperfusion injury." Journal of the American Heart Association 9.12 (2020): e015222.6/9/2020
The A-to-I RNA Editing Enzyme Adar1 Is Essential for Normal Embryonic Cardiac Growth and DevelopmentMoore IV, Joseph B., et al. "The A-to-I RNA Editing Enzyme Adar1 Is Essential for Normal Embryonic Cardiac Growth and Development." Circulation research 127.4 (2020): 550-552.5/4/2020
Functional characterization of long noncoding RNAsMoore IV, Joseph B., and Shizuka Uchida. "Functional characterization of long noncoding RNAs." Current opinion in cardiology 35.3 (2020): 199-206.5/1/2020
Regulation of cardiac O-GlcNAcylation: More than just nutrient availabilityCollins, Helen E., and John C. Chatham. "Regulation of cardiac O-GlcNAcylation: more than just nutrient availability." Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1866.5 (2020): 165712.5/1/2020
Exercise-stimulated resolvin biosynthesis in adipose tissue is abrogated by obesity-induced adrenergic dysfunctionHellmann, Jason, et al. "Exercise-stimulated resolvin biosynthesis in adipose tissue is abrogated by obesity-induced adrenergic dysfunction." (2020): 69-28.5/1/2020
Green environments and cardiovascular healthYeager, Ray A., Theodore R. Smith, and Aruni Bhatnagar. "Green environments and cardiovascular health." Trends in cardiovascular medicine 30.4 (2020): 241-246.5/1/2020
The Enzymatic Function of KVβ2 Contributes to Resistance Artery VasodilationRaph, Sean M., Aruni Bhatnagar, and Matthew A. Nystoriak. "The Enzymatic Function of KVβ2 Contributes to Resistance Artery Vasodilation." The FASEB Journal 34.S1 (2020): 1-1.4/19/2020
Role of Transient Receptor Potential Ankyrin‐1 (TRPA1) in Endothelial‐Specific Effects of Diverse AldehydesConklin, Daniel, and Lexiao Jin. "Role of Transient Receptor Potential Ankyrin‐1 (TRPA1) in Endothelial‐Specific Effects of Diverse Aldehydes." The FASEB Journal 34.S1 (2020): 1-1.4/18/2020
Role for NADH‐sensitive Kv channels in the myocardial‐vascular signaling axis.Nystoriak, Matthew A., et al. "Role for NADH‐sensitive Kv channels in the myocardial‐vascular signaling axis." The FASEB Journal 34.S1 (2020): 1-1.4/18/2020
Comparison of the Effects of Mainstream Cigarette Smoking and Nicotine on ElectrocardiogramIrfan, Affan, et al. "Comparison of the Effects of Mainstream Cigarette Smoking and Nicotine on Electrocardiogram." Journal of the American College of Cardiology 75.11_Supplement_1 (2020): 1901-1901.3/16/2020
Association between residential greenness and exposure to volatile organic compoundsYeager, Ray, et al. "Association between residential greenness and exposure to volatile organic compounds." Science of The Total Environment 707 (2020): 135435.3/10/2020
Environmental Determinants of Hypertension and Diabetes Mellitus: Sounding Off About the Effects of NoiseBasner, Mathias, Daniel W. Riggs, and Daniel J. Conklin. "Environmental determinants of hypertension and diabetes mellitus: sounding off about the effects of noise." (2020): e016048.3/9/2020
National secular trends in ambient air volatile organic compound levels and biomarkers of exposure in the United StatesKonkle, Stacey L., et al. "National secular trends in ambient air volatile organic compound levels and biomarkers of exposure in the United States." Environmental research 182 (2020): 108991.3/1/2020
Characterization of Volatile Organic Compound Metabolites in Cigarette Smokers, Electronic Nicotine Device Users, Dual Users, and Nonusers of TobaccoKeith, Rachel J., et al. "Characterization of volatile organic compound metabolites in cigarette smokers, electronic nicotine device users, dual users, and nonusers of tobacco." Nicotine and Tobacco Research 22.2 (2020): 264-272.2/1/2020
Inhalation of printer-emitted particles impairs cardiac conduction, hemodynamics, and autonomic regulation and induces arrhythmia and electrical remodeling in ratsCarll, Alex P., et al. "Inhalation of printer-emitted particles impairs cardiac conduction, hemodynamics, and autonomic regulation and induces arrhythmia and electrical remodeling in rats." Particle and fibre toxicology 17.1 (2020): 1-21.1/29/2020
Exposure to airborne fine particulate matter is associated with impaired endothelial function and biomarkers of oxidative stress and inflammationRiggs, Daniel W., et al. "Exposure to airborne fine particulate matter is associated with impaired endothelial function and biomarkers of oxidative stress and inflammation." Environmental research 180 (2020): 108890.1/1/2020
The Effect of Cardiogenic Factors on Cardiac Mesenchymal Cell Anti-Fibrogenic Paracrine Signaling and Therapeutic PerformanceHeidel, Justin S., et al. "The effect of cardiogenic factors on cardiac mesenchymal cell anti-fibrogenic paracrine signaling and therapeutic performance." Theranostics 10.4 (2020): 1514.1/1/2020
Protocol to assess the efficacy of carnosine supplementation in mitigating the adverse cardiovascular responses to particulate matter (PM) exposure: the Nucleophilic Defense Against PM Toxicity (NEAT) trialO'Toole, Timothy E., et al. "Protocol to assess the efficacy of carnosine supplementation in mitigating the adverse cardiovascular responses to particulate matter (PM) exposure: the Nucleophilic Defense Against PM Toxicity (NEAT) trial." BMJ open 10.12 (2020): e039118.1/1/2020